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Chemical Aminopterin

1–50 of 329 results.
  Chemical Phenotype Co-Mentioned Terms Interaction Organisms Anatomy Inference Network References
1. 10-propargyl-10-deazaaminopterin apoptotic process gemcitabine [10-propargyl-10-deazaaminopterin co-treated with gemcitabine] results in increased apoptotic process 1: Mus musculus Tumor Cells, Cultured 1 gene: CASP3 1
2. 10-propargyl-10-deazaaminopterin apoptotic process Cytarabine [Cytarabine co-treated with 10-propargyl-10-deazaaminopterin] results in increased apoptotic process 1: Homo sapiens Tumor Cells, Cultured 1 gene: CASP3 1
3. 10-propargyl-10-deazaaminopterin cell cycle gemcitabine [10-propargyl-10-deazaaminopterin co-treated with gemcitabine] affects cell cycle 1: Mus musculus Tumor Cells, Cultured   1
4. Aminopterin larval development Aminopterin results in decreased larval development 1: Lucilia cuprina     1
5. Methotrexate apoptotic process Methotrexate results in increased apoptotic process 1: Homo sapiens Cell Line, Tumor
189 genes: ADORA2A | ADRB1 | AIM2 | AIMP2 | AKT1 | APAF1 | APBB1 | APLP1 | APP | ARG2 | ARRB1 | ATG4D | ATM | AVP | BAD | BAG3 | BAG6 | BAK1 | BAX | BBC3 | BCL2 | BCL2A1 | BCL2L1 | BCL2L12 | BECN1 | BID | BIK | BIRC3 | BNIP3 | BRCA1 | BUB1 | BUB1B | C1QBP | C5AR1 | CADM1 | CASP2 | CASP3 | CASP6 | CASP7 | CASP8 | CASP8AP2 | CASP9 | CASR | CCK | CCL6 | CD2 | CDK1 | CEACAM5 | CEACAM6 | CFLAR | CHEK1 | CXCR4 | CYCS | DAB2 | DAPK3 | DDIT3 | DDIT4 | DFFB | DLC1 | DNASE1 | DRAM1 | E2F1 | EIF5A | EPB41L3 | EPHA2 | ERN1 | FAS | FGF8 | FKBP8 | FOXO1 | GADD45A | GADD45B | GADD45G | GPX1 | GSN | GZMA | HIF3A | HMOX1 | HTRA2 | IFI27 | IFI6 | IFNG | IGFBP3 | IKBKG | IL17A | IL1A | IL1B | IL2RA | IRF1 | ITGB2 | ITPR1 | LCK | LMNB1 | LOK | LSP1 | LTBR | MALT1 | MAP2K4 | MAP2K6 | MAP3K7 | MAP3K9 | MAPK1 | MAPK14 | MAPK3 | MCL1 | MEF2C | MELK | MUC2 | MX1 | MYCS | MYD88 | NEK6 | NGFR | NOC2L | NOD1 | NR3C1 | NRADD | NSG1 | NUAK2 | PAK2 | PAK6 | PARP1 | PDCD7 | PDE1B | PERP | PIDD1 | PIM1 | PLAGL1 | PLSCR1 | PMAIP1 | PPARD | PPID | PPIF | PPP1R15A | PRKCA | PRKCB | PRKCD | PRKCE | PSEN1 | PSME3 | PTEN | RABEP1 | RB1 | RELT | RFFL | RIPK2 | RPS6KA3 | RPS6KB1 | S100A9 | SEMA3A | SEPT4 | SERPINB9 | SHB | SP110 | SQSTM1 | SULF1 | TAOK2 | TCHP | TGFBR2 | TICAM1 | TIGAR | TLR2 | TNF | TNFAIP3 | TNFAIP8 | TNFRSF10A | TNFRSF10B | TNFRSF11B | TNFRSF12A | TNFRSF1A | TNFRSF21 | TNFRSF25 | TNFRSF9 | TNFSF10 | TNFSF14 | TNFSF15 | TNFSF9 | TP53 | TP53INP1 | TRADD | TRAF1 | TRAF3 | TRAIP | TRIB3 | TRP53 | UXT | VIL1 | XAF1 | ZC3H12A
1
6. Methotrexate cell proliferation Temozolomide [Methotrexate co-treated with Temozolomide] results in decreased cell proliferation 1: Homo sapiens Skin | Cell Line, Tumor
115 genes: ACHE | AKT1 | AR | AREG | AXIN2 | BAD | BAK1 | BAX | BCL2 | BCL2L1 | BMP4 | BST2 | BUB1 | BUB1B | CCN1 | CD81 | CDC25A | CDC25C | CDK1 | CDK4 | CENPF | COL4A3 | CSF1 | CSF1R | CTNNB1 | CUZD1 | CXCL1 | DAB2 | DDIT4 | DLGAP5 | E2F8 | EGFR | ERBB2 | EREG | EVI5 | FER | FGF1 | FGF16 | FOXC1 | FPGS | FSCN1 | GAB1 | GNAI2 | GNAT1 | GPX1 | GSK3B | H3F3A | H3F3B | HDGFL3 | HHEX | IFNAR2 | IGFBP4 | IL12A | IL15RA | IL18 | IL18RAP | IL1A | IL2RA | ISG20 | KIF15 | KIF2C | KITLG | LRP2 | LY6E | MAP7 | MCM10 | MELK | MET | MKI67 | MXD1 | MYB | MYC | NDP | NRG1 | OGFOD1 | PCNA | PDK1 | PES1 | PIM1 | PLK1 | PPARD | PRDX1 | PRKAR1B | PRL | PTEN | PTMA | RAC1 | RPL23A | SH2D2A | SKI | SKP2 | SPHK2 | SRC | STAT3 | STAT4 | TACC2 | TACC3 | TACSTD2 | TGFA | TGFB1 | TGFB2 | TGFBI | TNFSF9 | TOP1 | TOP2A | TP53 | TRAIP | TXNRD1 | UBA1 | UHRF1 | VEGFA | WNT2B | XRCC5 | ZEB1 | ZMYND11
1
7. Methotrexate cell proliferation Temozolomide [Methotrexate co-treated with Temozolomide] results in decreased cell proliferation 1: Homo sapiens Neuroglia | Cell Line, Tumor
115 genes: ACHE | AKT1 | AR | AREG | AXIN2 | BAD | BAK1 | BAX | BCL2 | BCL2L1 | BMP4 | BST2 | BUB1 | BUB1B | CCN1 | CD81 | CDC25A | CDC25C | CDK1 | CDK4 | CENPF | COL4A3 | CSF1 | CSF1R | CTNNB1 | CUZD1 | CXCL1 | DAB2 | DDIT4 | DLGAP5 | E2F8 | EGFR | ERBB2 | EREG | EVI5 | FER | FGF1 | FGF16 | FOXC1 | FPGS | FSCN1 | GAB1 | GNAI2 | GNAT1 | GPX1 | GSK3B | H3F3A | H3F3B | HDGFL3 | HHEX | IFNAR2 | IGFBP4 | IL12A | IL15RA | IL18 | IL18RAP | IL1A | IL2RA | ISG20 | KIF15 | KIF2C | KITLG | LRP2 | LY6E | MAP7 | MCM10 | MELK | MET | MKI67 | MXD1 | MYB | MYC | NDP | NRG1 | OGFOD1 | PCNA | PDK1 | PES1 | PIM1 | PLK1 | PPARD | PRDX1 | PRKAR1B | PRL | PTEN | PTMA | RAC1 | RPL23A | SH2D2A | SKI | SKP2 | SPHK2 | SRC | STAT3 | STAT4 | TACC2 | TACC3 | TACSTD2 | TGFA | TGFB1 | TGFB2 | TGFBI | TNFSF9 | TOP1 | TOP2A | TP53 | TRAIP | TXNRD1 | UBA1 | UHRF1 | VEGFA | WNT2B | XRCC5 | ZEB1 | ZMYND11
1
8. Methotrexate apoptotic process Methotrexate results in increased apoptotic process T-Lymphocytes
189 genes: ADORA2A | ADRB1 | AIM2 | AIMP2 | AKT1 | APAF1 | APBB1 | APLP1 | APP | ARG2 | ARRB1 | ATG4D | ATM | AVP | BAD | BAG3 | BAG6 | BAK1 | BAX | BBC3 | BCL2 | BCL2A1 | BCL2L1 | BCL2L12 | BECN1 | BID | BIK | BIRC3 | BNIP3 | BRCA1 | BUB1 | BUB1B | C1QBP | C5AR1 | CADM1 | CASP2 | CASP3 | CASP6 | CASP7 | CASP8 | CASP8AP2 | CASP9 | CASR | CCK | CCL6 | CD2 | CDK1 | CEACAM5 | CEACAM6 | CFLAR | CHEK1 | CXCR4 | CYCS | DAB2 | DAPK3 | DDIT3 | DDIT4 | DFFB | DLC1 | DNASE1 | DRAM1 | E2F1 | EIF5A | EPB41L3 | EPHA2 | ERN1 | FAS | FGF8 | FKBP8 | FOXO1 | GADD45A | GADD45B | GADD45G | GPX1 | GSN | GZMA | HIF3A | HMOX1 | HTRA2 | IFI27 | IFI6 | IFNG | IGFBP3 | IKBKG | IL17A | IL1A | IL1B | IL2RA | IRF1 | ITGB2 | ITPR1 | LCK | LMNB1 | LOK | LSP1 | LTBR | MALT1 | MAP2K4 | MAP2K6 | MAP3K7 | MAP3K9 | MAPK1 | MAPK14 | MAPK3 | MCL1 | MEF2C | MELK | MUC2 | MX1 | MYCS | MYD88 | NEK6 | NGFR | NOC2L | NOD1 | NR3C1 | NRADD | NSG1 | NUAK2 | PAK2 | PAK6 | PARP1 | PDCD7 | PDE1B | PERP | PIDD1 | PIM1 | PLAGL1 | PLSCR1 | PMAIP1 | PPARD | PPID | PPIF | PPP1R15A | PRKCA | PRKCB | PRKCD | PRKCE | PSEN1 | PSME3 | PTEN | RABEP1 | RB1 | RELT | RFFL | RIPK2 | RPS6KA3 | RPS6KB1 | S100A9 | SEMA3A | SEPT4 | SERPINB9 | SHB | SP110 | SQSTM1 | SULF1 | TAOK2 | TCHP | TGFBR2 | TICAM1 | TIGAR | TLR2 | TNF | TNFAIP3 | TNFAIP8 | TNFRSF10A | TNFRSF10B | TNFRSF11B | TNFRSF12A | TNFRSF1A | TNFRSF21 | TNFRSF25 | TNFRSF9 | TNFSF10 | TNFSF14 | TNFSF15 | TNFSF9 | TP53 | TP53INP1 | TRADD | TRAF1 | TRAF3 | TRAIP | TRIB3 | TRP53 | UXT | VIL1 | XAF1 | ZC3H12A
1
9. Methotrexate glycogen catabolic process Methotrexate results in increased glycogen catabolic process 1: Rattus norvegicus Liver 1 gene: ADRB1 1
10. Methotrexate glycogen catabolic process Naproxen Naproxen inhibits the reaction [Methotrexate results in increased glycogen catabolic process] 1: Rattus norvegicus Liver 1 gene: ADRB1 1
11. Methotrexate glycogen catabolic process Calcium Calcium affects the reaction [Methotrexate results in increased glycogen catabolic process] 1: Rattus norvegicus Liver 1 gene: ADRB1 1
12. Methotrexate apoptotic process Methotrexate results in increased apoptotic process Cerebral Cortex | Neurons
189 genes: ADORA2A | ADRB1 | AIM2 | AIMP2 | AKT1 | APAF1 | APBB1 | APLP1 | APP | ARG2 | ARRB1 | ATG4D | ATM | AVP | BAD | BAG3 | BAG6 | BAK1 | BAX | BBC3 | BCL2 | BCL2A1 | BCL2L1 | BCL2L12 | BECN1 | BID | BIK | BIRC3 | BNIP3 | BRCA1 | BUB1 | BUB1B | C1QBP | C5AR1 | CADM1 | CASP2 | CASP3 | CASP6 | CASP7 | CASP8 | CASP8AP2 | CASP9 | CASR | CCK | CCL6 | CD2 | CDK1 | CEACAM5 | CEACAM6 | CFLAR | CHEK1 | CXCR4 | CYCS | DAB2 | DAPK3 | DDIT3 | DDIT4 | DFFB | DLC1 | DNASE1 | DRAM1 | E2F1 | EIF5A | EPB41L3 | EPHA2 | ERN1 | FAS | FGF8 | FKBP8 | FOXO1 | GADD45A | GADD45B | GADD45G | GPX1 | GSN | GZMA | HIF3A | HMOX1 | HTRA2 | IFI27 | IFI6 | IFNG | IGFBP3 | IKBKG | IL17A | IL1A | IL1B | IL2RA | IRF1 | ITGB2 | ITPR1 | LCK | LMNB1 | LOK | LSP1 | LTBR | MALT1 | MAP2K4 | MAP2K6 | MAP3K7 | MAP3K9 | MAPK1 | MAPK14 | MAPK3 | MCL1 | MEF2C | MELK | MUC2 | MX1 | MYCS | MYD88 | NEK6 | NGFR | NOC2L | NOD1 | NR3C1 | NRADD | NSG1 | NUAK2 | PAK2 | PAK6 | PARP1 | PDCD7 | PDE1B | PERP | PIDD1 | PIM1 | PLAGL1 | PLSCR1 | PMAIP1 | PPARD | PPID | PPIF | PPP1R15A | PRKCA | PRKCB | PRKCD | PRKCE | PSEN1 | PSME3 | PTEN | RABEP1 | RB1 | RELT | RFFL | RIPK2 | RPS6KA3 | RPS6KB1 | S100A9 | SEMA3A | SEPT4 | SERPINB9 | SHB | SP110 | SQSTM1 | SULF1 | TAOK2 | TCHP | TGFBR2 | TICAM1 | TIGAR | TLR2 | TNF | TNFAIP3 | TNFAIP8 | TNFRSF10A | TNFRSF10B | TNFRSF11B | TNFRSF12A | TNFRSF1A | TNFRSF21 | TNFRSF25 | TNFRSF9 | TNFSF10 | TNFSF14 | TNFSF15 | TNFSF9 | TP53 | TP53INP1 | TRADD | TRAF1 | TRAF3 | TRAIP | TRIB3 | TRP53 | UXT | VIL1 | XAF1 | ZC3H12A
1
13. Methotrexate cell cycle Methotrexate results in increased cell cycle Cerebral Cortex | Neurons
140 genes: AHCTF1 | ANAPC1 | ANLN | ANXA11 | ASPM | ATM | AURKA | BECN1 | BRCA1 | BUB1 | BUB1B | BUB3 | CASP8AP2 | CCNA2 | CCNB1 | CCNB2 | CCND1 | CCND2 | CCNE1 | CCNE2 | CCNG1 | CDC14B | CDC20 | CDC25A | CDC25B | CDC25C | CDC34 | CDCA8 | CDK1 | CDK2 | CDK4 | CDK6 | CDKN1A | CDKN1B | CDKN3 | CGREF1 | CHEK1 | CHFR | CIT | CLSPN | CUZD1 | CYLD | DDIT3 | DLGAP5 | DUSP1 | DYRK3 | E2F1 | E2F3 | E2F8 | ERCC6L | ERH | EVI5 | FANCD2 | FIGN | FOXM1 | FOXN3 | GADD45A | GNAI2 | GPSM2 | H2AFX | HAUS4 | HMCN1 | KAT2B | KIF11 | KIF18B | KIF23 | KIF2B | KIF2C | KLHL21 | KNL1 | KRT18 | LIG1 | MAP3K8 | MAPK1 | MAPK3 | MAPK7 | MCM6 | MCTS1 | MELK | MICAL3 | MIS18A | MKI67 | NCAPG2 | NCAPH | NDC80 | NEK6 | NR3C1 | NUF2 | NUSAP1 | OIP5 | PARD3B | PHF8 | PIK3C3 | PIM1 | PIN1 | PLK1 | PMF1 | PRC1 | PRKCD | PRKCE | PSME3 | RAE1 | RAN | RB1 | RBL1 | RGS2 | RHOA | RIOK2 | RPS6KA3 | RPS6KB1 | SENP5 | SEPT4 | SIRT2 | SKA2 | SKA3 | SMARCB1 | SMC1A | SMC4 | SMPD3 | SNX18 | SPAG5 | SPC24 | SPC25 | SPIN2A | SRC | STK10 | STRADA | SYCP3 | TACC3 | TP53 | TRP53 | TXNIP | UBE2C | UBE2I | UHRF1 | USP2 | USP22 | USP3 | WAPL | ZMYND11
1
14. Methotrexate cell death FPGS [FPGS protein results in increased metabolism of Methotrexate] which results in increased cell death 1: Homo sapiens  
9 genes: AXIN2 | BNIP3 | CACNA1A | CDKN1B | GSDME | HMOX1 | IL17A | MAP3K9 | TGFB2
1
15. Methotrexate cell death Vorinostat [Vorinostat co-treated with Methotrexate] results in increased cell death 1: Homo sapiens B-Lymphocytes | Cell Line, Tumor
9 genes: AXIN2 | BNIP3 | CACNA1A | CDKN1B | GSDME | HMOX1 | IL17A | MAP3K9 | TGFB2
1
16. Methotrexate cell death Vorinostat [Vorinostat co-treated with Methotrexate] results in increased cell death 1: Homo sapiens T-Lymphocytes | Cell Line, Tumor
9 genes: AXIN2 | BNIP3 | CACNA1A | CDKN1B | GSDME | HMOX1 | IL17A | MAP3K9 | TGFB2
1
17. Methotrexate cell death Vorinostat [Vorinostat results in increased abundance of Methotrexate metabolite] which results in increased cell death 1: Homo sapiens Lymphocytes | Cell Line, Tumor
9 genes: AXIN2 | BNIP3 | CACNA1A | CDKN1B | GSDME | HMOX1 | IL17A | MAP3K9 | TGFB2
1
18. Methotrexate apoptotic process Methotrexate results in increased apoptotic process 1: Homo sapiens T-Lymphocytes | Cell Line, Tumor
189 genes: ADORA2A | ADRB1 | AIM2 | AIMP2 | AKT1 | APAF1 | APBB1 | APLP1 | APP | ARG2 | ARRB1 | ATG4D | ATM | AVP | BAD | BAG3 | BAG6 | BAK1 | BAX | BBC3 | BCL2 | BCL2A1 | BCL2L1 | BCL2L12 | BECN1 | BID | BIK | BIRC3 | BNIP3 | BRCA1 | BUB1 | BUB1B | C1QBP | C5AR1 | CADM1 | CASP2 | CASP3 | CASP6 | CASP7 | CASP8 | CASP8AP2 | CASP9 | CASR | CCK | CCL6 | CD2 | CDK1 | CEACAM5 | CEACAM6 | CFLAR | CHEK1 | CXCR4 | CYCS | DAB2 | DAPK3 | DDIT3 | DDIT4 | DFFB | DLC1 | DNASE1 | DRAM1 | E2F1 | EIF5A | EPB41L3 | EPHA2 | ERN1 | FAS | FGF8 | FKBP8 | FOXO1 | GADD45A | GADD45B | GADD45G | GPX1 | GSN | GZMA | HIF3A | HMOX1 | HTRA2 | IFI27 | IFI6 | IFNG | IGFBP3 | IKBKG | IL17A | IL1A | IL1B | IL2RA | IRF1 | ITGB2 | ITPR1 | LCK | LMNB1 | LOK | LSP1 | LTBR | MALT1 | MAP2K4 | MAP2K6 | MAP3K7 | MAP3K9 | MAPK1 | MAPK14 | MAPK3 | MCL1 | MEF2C | MELK | MUC2 | MX1 | MYCS | MYD88 | NEK6 | NGFR | NOC2L | NOD1 | NR3C1 | NRADD | NSG1 | NUAK2 | PAK2 | PAK6 | PARP1 | PDCD7 | PDE1B | PERP | PIDD1 | PIM1 | PLAGL1 | PLSCR1 | PMAIP1 | PPARD | PPID | PPIF | PPP1R15A | PRKCA | PRKCB | PRKCD | PRKCE | PSEN1 | PSME3 | PTEN | RABEP1 | RB1 | RELT | RFFL | RIPK2 | RPS6KA3 | RPS6KB1 | S100A9 | SEMA3A | SEPT4 | SERPINB9 | SHB | SP110 | SQSTM1 | SULF1 | TAOK2 | TCHP | TGFBR2 | TICAM1 | TIGAR | TLR2 | TNF | TNFAIP3 | TNFAIP8 | TNFRSF10A | TNFRSF10B | TNFRSF11B | TNFRSF12A | TNFRSF1A | TNFRSF21 | TNFRSF25 | TNFRSF9 | TNFSF10 | TNFSF14 | TNFSF15 | TNFSF9 | TP53 | TP53INP1 | TRADD | TRAF1 | TRAF3 | TRAIP | TRIB3 | TRP53 | UXT | VIL1 | XAF1 | ZC3H12A
1
19. Methotrexate cellular lipid catabolic process Methotrexate results in increased cellular lipid catabolic process 1: Rattus norvegicus Liver
2 genes: PNPLA2 | SIRT2
1
20. Methotrexate cellular lipid catabolic process Resveratrol Resveratrol inhibits the reaction [Methotrexate results in increased cellular lipid catabolic process] 1: Rattus norvegicus Liver
2 genes: PNPLA2 | SIRT2
1
21. Methotrexate folic acid metabolic process Methotrexate affects folic acid metabolic process 1: Rattus norvegicus Liver
8 genes: DHFR | FPGS | MTHFD1 | MTHFD1L | MTHFR | SHMT1 | SLC19A1 | SLC46A1
1
22. Methotrexate nucleoside metabolic process Methotrexate affects nucleoside metabolic process 1: Rattus norvegicus Liver
7 genes: ATIC | HPRT1 | MTAP | PPAT | PRPS2 | UMPS | UPP1
1
23. Methotrexate nucleobase metabolic process Methotrexate affects nucleobase metabolic process 1: Rattus norvegicus Liver   1
24. Methotrexate positive regulation of reactive oxygen species biosynthetic process Methotrexate results in increased positive regulation of reactive oxygen species biosynthetic process 1: Homo sapiens Blood | Leukocytes, Mononuclear
3 genes: HDAC4 | IL4 | TLR4
1
25. Methotrexate positive regulation of apoptotic process Methotrexate results in increased positive regulation of apoptotic process 1: Homo sapiens Blood | Leukocytes, Mononuclear
132 genes: ADM | ADRB1 | ADRB2 | AIFM2 | AKT1 | ALDH1A1 | ALOX12 | APAF1 | APBB1 | ATM | B4GALT1 | BAD | BAK1 | BAX | BBC3 | BCL2L1 | BID | BIK | BMP2 | BMP4 | BNIP3 | C1QBP | CASP2 | CASP3 | CASP6 | CASP8 | CASP9 | CCK | CCN1 | CDK4 | CNR1 | CREB1 | CTNNB1 | CYCE | DAPK3 | DDIT3 | DNAJA1 | DUSP1 | E2F1 | EIF2B5 | EIF5A | ENDOG | FAS | FGD4 | FOXO1 | GADD45A | GADD45B | GADD45G | GRIN2A | GSK3B | GZMA | HMOX1 | HPGD | HSPD1 | HTRA2 | ID3 | IFNG | IGFBP3 | IL18 | IL1B | IL6 | IRF5 | ITGA6 | ITGB1 | ITPR1 | JUN | KALRN | KCNMA1 | KLK1 | KLRK1 | KNG1 | LILRB1 | LPAR1 | LRP6 | MAP2K4 | MAP2K6 | MAP3K9 | MAPK8 | MAPK9 | MCF2L | MELK | MMP2 | MMP9 | MUC2 | NET1 | NGEF | NGF | NGFR | NOS2 | NOS3 | PIDD1 | PLA2G4A | PLSCR1 | PMAIP1 | PNMA2 | POU4F1 | PPARG | PPID | PPP1R15A | PRKCD | PSEN1 | PTEN | PTGS2 | RELA | RIPK2 | RPS6 | SEPT4 | SFRP1 | SOD1 | SP110 | SQSTM1 | SRC | TEX261 | TGFB1 | TGFB2 | TLR3 | TLR4 | TNF | TNFAIP8 | TNFRSF12A | TNFSF10 | TOMM40 | TOP2A | TP53 | TP53INP1 | TRADD | TRP53 | TXNIP | UBD | VAV2 | VAV3 | WNT10B
1
26. Methotrexate positive regulation of apoptotic process SOD2 SOD2 protein polymorphism affects the reaction [Methotrexate results in increased positive regulation of apoptotic process] 1: Homo sapiens Blood | Leukocytes, Mononuclear
132 genes: ADM | ADRB1 | ADRB2 | AIFM2 | AKT1 | ALDH1A1 | ALOX12 | APAF1 | APBB1 | ATM | B4GALT1 | BAD | BAK1 | BAX | BBC3 | BCL2L1 | BID | BIK | BMP2 | BMP4 | BNIP3 | C1QBP | CASP2 | CASP3 | CASP6 | CASP8 | CASP9 | CCK | CCN1 | CDK4 | CNR1 | CREB1 | CTNNB1 | CYCE | DAPK3 | DDIT3 | DNAJA1 | DUSP1 | E2F1 | EIF2B5 | EIF5A | ENDOG | FAS | FGD4 | FOXO1 | GADD45A | GADD45B | GADD45G | GRIN2A | GSK3B | GZMA | HMOX1 | HPGD | HSPD1 | HTRA2 | ID3 | IFNG | IGFBP3 | IL18 | IL1B | IL6 | IRF5 | ITGA6 | ITGB1 | ITPR1 | JUN | KALRN | KCNMA1 | KLK1 | KLRK1 | KNG1 | LILRB1 | LPAR1 | LRP6 | MAP2K4 | MAP2K6 | MAP3K9 | MAPK8 | MAPK9 | MCF2L | MELK | MMP2 | MMP9 | MUC2 | NET1 | NGEF | NGF | NGFR | NOS2 | NOS3 | PIDD1 | PLA2G4A | PLSCR1 | PMAIP1 | PNMA2 | POU4F1 | PPARG | PPID | PPP1R15A | PRKCD | PSEN1 | PTEN | PTGS2 | RELA | RIPK2 | RPS6 | SEPT4 | SFRP1 | SOD1 | SP110 | SQSTM1 | SRC | TEX261 | TGFB1 | TGFB2 | TLR3 | TLR4 | TNF | TNFAIP8 | TNFRSF12A | TNFSF10 | TOMM40 | TOP2A | TP53 | TP53INP1 | TRADD | TRP53 | TXNIP | UBD | VAV2 | VAV3 | WNT10B
1
27. Methotrexate apoptotic process Glucose Methotrexate inhibits the reaction [Glucose deficiency results in increased apoptotic process] 1: Homo sapiens Human Umbilical Vein Endothelial Cells
189 genes: ADORA2A | ADRB1 | AIM2 | AIMP2 | AKT1 | APAF1 | APBB1 | APLP1 | APP | ARG2 | ARRB1 | ATG4D | ATM | AVP | BAD | BAG3 | BAG6 | BAK1 | BAX | BBC3 | BCL2 | BCL2A1 | BCL2L1 | BCL2L12 | BECN1 | BID | BIK | BIRC3 | BNIP3 | BRCA1 | BUB1 | BUB1B | C1QBP | C5AR1 | CADM1 | CASP2 | CASP3 | CASP6 | CASP7 | CASP8 | CASP8AP2 | CASP9 | CASR | CCK | CCL6 | CD2 | CDK1 | CEACAM5 | CEACAM6 | CFLAR | CHEK1 | CXCR4 | CYCS | DAB2 | DAPK3 | DDIT3 | DDIT4 | DFFB | DLC1 | DNASE1 | DRAM1 | E2F1 | EIF5A | EPB41L3 | EPHA2 | ERN1 | FAS | FGF8 | FKBP8 | FOXO1 | GADD45A | GADD45B | GADD45G | GPX1 | GSN | GZMA | HIF3A | HMOX1 | HTRA2 | IFI27 | IFI6 | IFNG | IGFBP3 | IKBKG | IL17A | IL1A | IL1B | IL2RA | IRF1 | ITGB2 | ITPR1 | LCK | LMNB1 | LOK | LSP1 | LTBR | MALT1 | MAP2K4 | MAP2K6 | MAP3K7 | MAP3K9 | MAPK1 | MAPK14 | MAPK3 | MCL1 | MEF2C | MELK | MUC2 | MX1 | MYCS | MYD88 | NEK6 | NGFR | NOC2L | NOD1 | NR3C1 | NRADD | NSG1 | NUAK2 | PAK2 | PAK6 | PARP1 | PDCD7 | PDE1B | PERP | PIDD1 | PIM1 | PLAGL1 | PLSCR1 | PMAIP1 | PPARD | PPID | PPIF | PPP1R15A | PRKCA | PRKCB | PRKCD | PRKCE | PSEN1 | PSME3 | PTEN | RABEP1 | RB1 | RELT | RFFL | RIPK2 | RPS6KA3 | RPS6KB1 | S100A9 | SEMA3A | SEPT4 | SERPINB9 | SHB | SP110 | SQSTM1 | SULF1 | TAOK2 | TCHP | TGFBR2 | TICAM1 | TIGAR | TLR2 | TNF | TNFAIP3 | TNFAIP8 | TNFRSF10A | TNFRSF10B | TNFRSF11B | TNFRSF12A | TNFRSF1A | TNFRSF21 | TNFRSF25 | TNFRSF9 | TNFSF10 | TNFSF14 | TNFSF15 | TNFSF9 | TP53 | TP53INP1 | TRADD | TRAF1 | TRAF3 | TRAIP | TRIB3 | TRP53 | UXT | VIL1 | XAF1 | ZC3H12A
1
28. Methotrexate positive regulation of cell death Methotrexate results in increased positive regulation of cell death 1: Homo sapiens HT29 Cells
30 genes: ACER2 | ALOX12 | AXIN2 | BMP4 | CCN2 | CDKN1A | CDKN1B | CYSLTR2 | DKK1 | DNMT3A | EEF1A1 | EGR1 | FAS | GRIN2A | HBA1 | HBB | HTRA2 | IL1B | IRF1 | LPAR1 | NOD1 | NRADD | PRNP | PTGS2 | RIPK2 | SLFN13 | TRIM13 | TXNRD1 | UCP2 | ZC3H12A
2
29. Methotrexate positive regulation of cell death CAV1 CAV1 mRNA inhibits the reaction [Methotrexate results in increased positive regulation of cell death] 1: Homo sapiens HT29 Cells
30 genes: ACER2 | ALOX12 | AXIN2 | BMP4 | CCN2 | CDKN1A | CDKN1B | CYSLTR2 | DKK1 | DNMT3A | EEF1A1 | EGR1 | FAS | GRIN2A | HBA1 | HBB | HTRA2 | IL1B | IRF1 | LPAR1 | NOD1 | NRADD | PRNP | PTGS2 | RIPK2 | SLFN13 | TRIM13 | TXNRD1 | UCP2 | ZC3H12A
1
30. Methotrexate positive regulation of cell death ENO2 ENO2 mRNA inhibits the reaction [Methotrexate results in increased positive regulation of cell death] 1: Homo sapiens HT29 Cells
30 genes: ACER2 | ALOX12 | AXIN2 | BMP4 | CCN2 | CDKN1A | CDKN1B | CYSLTR2 | DKK1 | DNMT3A | EEF1A1 | EGR1 | FAS | GRIN2A | HBA1 | HBB | HTRA2 | IL1B | IRF1 | LPAR1 | NOD1 | NRADD | PRNP | PTGS2 | RIPK2 | SLFN13 | TRIM13 | TXNRD1 | UCP2 | ZC3H12A
1
31. Methotrexate positive regulation of cell death PRKCA PRKCA mRNA inhibits the reaction [Methotrexate results in increased positive regulation of cell death] 1: Homo sapiens HT29 Cells
30 genes: ACER2 | ALOX12 | AXIN2 | BMP4 | CCN2 | CDKN1A | CDKN1B | CYSLTR2 | DKK1 | DNMT3A | EEF1A1 | EGR1 | FAS | GRIN2A | HBA1 | HBB | HTRA2 | IL1B | IRF1 | LPAR1 | NOD1 | NRADD | PRNP | PTGS2 | RIPK2 | SLFN13 | TRIM13 | TXNRD1 | UCP2 | ZC3H12A
1
32. Methotrexate positive regulation of cell death DHFR DHFR mRNA inhibits the reaction [Methotrexate results in increased positive regulation of cell death] 1: Homo sapiens HT29 Cells
30 genes: ACER2 | ALOX12 | AXIN2 | BMP4 | CCN2 | CDKN1A | CDKN1B | CYSLTR2 | DKK1 | DNMT3A | EEF1A1 | EGR1 | FAS | GRIN2A | HBA1 | HBB | HTRA2 | IL1B | IRF1 | LPAR1 | NOD1 | NRADD | PRNP | PTGS2 | RIPK2 | SLFN13 | TRIM13 | TXNRD1 | UCP2 | ZC3H12A
1
33. Methotrexate positive regulation of cell death CDH1 CDH1 mRNA promotes the reaction [Methotrexate results in increased positive regulation of cell death] 1: Homo sapiens HT29 Cells
30 genes: ACER2 | ALOX12 | AXIN2 | BMP4 | CCN2 | CDKN1A | CDKN1B | CYSLTR2 | DKK1 | DNMT3A | EEF1A1 | EGR1 | FAS | GRIN2A | HBA1 | HBB | HTRA2 | IL1B | IRF1 | LPAR1 | NOD1 | NRADD | PRNP | PTGS2 | RIPK2 | SLFN13 | TRIM13 | TXNRD1 | UCP2 | ZC3H12A
1
34. Methotrexate positive regulation of adipose tissue development Methotrexate results in increased positive regulation of adipose tissue development 1: Rattus norvegicus Bone Marrow 1 gene: NR1H4 1
35. Methotrexate positive regulation of adipose tissue development Leucovorin Leucovorin inhibits the reaction [Methotrexate results in increased positive regulation of adipose tissue development] 1: Rattus norvegicus Bone Marrow 1 gene: NR1H4 1
36. Methotrexate canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation Leucovorin [Methotrexate co-treated with Leucovorin] results in increased canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation 1: Rattus norvegicus Bone Marrow   1
37. Methotrexate positive regulation of cell death Methotrexate results in increased positive regulation of cell death 1: Homo sapiens Stomach | Cell Line, Tumor
30 genes: ACER2 | ALOX12 | AXIN2 | BMP4 | CCN2 | CDKN1A | CDKN1B | CYSLTR2 | DKK1 | DNMT3A | EEF1A1 | EGR1 | FAS | GRIN2A | HBA1 | HBB | HTRA2 | IL1B | IRF1 | LPAR1 | NOD1 | NRADD | PRNP | PTGS2 | RIPK2 | SLFN13 | TRIM13 | TXNRD1 | UCP2 | ZC3H12A
1
38. Methotrexate positive regulation of cell death Mycophenolic Acid Mycophenolic Acid promotes the reaction [Methotrexate results in increased positive regulation of cell death] 1: Homo sapiens Stomach | Cell Line, Tumor
30 genes: ACER2 | ALOX12 | AXIN2 | BMP4 | CCN2 | CDKN1A | CDKN1B | CYSLTR2 | DKK1 | DNMT3A | EEF1A1 | EGR1 | FAS | GRIN2A | HBA1 | HBB | HTRA2 | IL1B | IRF1 | LPAR1 | NOD1 | NRADD | PRNP | PTGS2 | RIPK2 | SLFN13 | TRIM13 | TXNRD1 | UCP2 | ZC3H12A
1
39. Methotrexate positive regulation of cell death ZNRD1 ZNRD1 protein inhibits the reaction [Methotrexate results in increased positive regulation of cell death] 1: Homo sapiens Stomach | Cell Line, Tumor
30 genes: ACER2 | ALOX12 | AXIN2 | BMP4 | CCN2 | CDKN1A | CDKN1B | CYSLTR2 | DKK1 | DNMT3A | EEF1A1 | EGR1 | FAS | GRIN2A | HBA1 | HBB | HTRA2 | IL1B | IRF1 | LPAR1 | NOD1 | NRADD | PRNP | PTGS2 | RIPK2 | SLFN13 | TRIM13 | TXNRD1 | UCP2 | ZC3H12A
1
40. Methotrexate positive regulation of cellular senescence Methotrexate results in increased positive regulation of cellular senescence 1: Homo sapiens Colon | Cell Line, Tumor
4 genes: ARG2 | HLA-G | KRAS | MIR22
1
41. Methotrexate folic acid metabolic process Methotrexate results in decreased folic acid metabolic process 1: Homo sapiens Endothelial Cells | Cell Line
8 genes: DHFR | FPGS | MTHFD1 | MTHFD1L | MTHFR | SHMT1 | SLC19A1 | SLC46A1
1
42. Methotrexate folic acid metabolic process 5,6,7,8-tetrahydrofolic acid [Methotrexate results in decreased folic acid metabolic process] which results in decreased abundance of 5,6,7,8-tetrahydrofolic acid 1: Homo sapiens Endothelial Cells | Cell Line
8 genes: DHFR | FPGS | MTHFD1 | MTHFD1L | MTHFR | SHMT1 | SLC19A1 | SLC46A1
1
43. Methotrexate folic acid metabolic process 5-methyltetrahydrofolate [Methotrexate results in decreased folic acid metabolic process] which results in decreased abundance of 5-methyltetrahydrofolate 1: Homo sapiens Endothelial Cells | Cell Line
8 genes: DHFR | FPGS | MTHFD1 | MTHFD1L | MTHFR | SHMT1 | SLC19A1 | SLC46A1
1
44. Methotrexate folic acid metabolic process Formyltetrahydrofolates [Methotrexate results in decreased folic acid metabolic process] which results in decreased abundance of Formyltetrahydrofolates 1: Homo sapiens Endothelial Cells | Cell Line
8 genes: DHFR | FPGS | MTHFD1 | MTHFD1L | MTHFR | SHMT1 | SLC19A1 | SLC46A1
1
45. Methotrexate positive regulation of cell death Methotrexate results in increased positive regulation of cell death 1: Homo sapiens Synovial Membrane | Fibroblasts | Cell Line
30 genes: ACER2 | ALOX12 | AXIN2 | BMP4 | CCN2 | CDKN1A | CDKN1B | CYSLTR2 | DKK1 | DNMT3A | EEF1A1 | EGR1 | FAS | GRIN2A | HBA1 | HBB | HTRA2 | IL1B | IRF1 | LPAR1 | NOD1 | NRADD | PRNP | PTGS2 | RIPK2 | SLFN13 | TRIM13 | TXNRD1 | UCP2 | ZC3H12A
2
46. Methotrexate response to antineoplastic agent Cisplatin | Paclitaxel [[Cisplatin co-treated with Paclitaxel] results in decreased response to antineoplastic agent] which results in decreased susceptibility to Methotrexate 1: Homo sapiens Ovary | Cell Line, Tumor
2 genes: ABCB1B | ABCC2
1
47. Methotrexate positive regulation of cell death Cisplatin | Paclitaxel [Cisplatin co-treated with Paclitaxel] inhibits the reaction [Methotrexate results in increased positive regulation of cell death] 1: Homo sapiens Ovary | Cell Line, Tumor
30 genes: ACER2 | ALOX12 | AXIN2 | BMP4 | CCN2 | CDKN1A | CDKN1B | CYSLTR2 | DKK1 | DNMT3A | EEF1A1 | EGR1 | FAS | GRIN2A | HBA1 | HBB | HTRA2 | IL1B | IRF1 | LPAR1 | NOD1 | NRADD | PRNP | PTGS2 | RIPK2 | SLFN13 | TRIM13 | TXNRD1 | UCP2 | ZC3H12A
1
48. Methotrexate positive regulation of cell death Methotrexate results in increased positive regulation of cell death 1: Homo sapiens Ovary | Cell Line, Tumor
30 genes: ACER2 | ALOX12 | AXIN2 | BMP4 | CCN2 | CDKN1A | CDKN1B | CYSLTR2 | DKK1 | DNMT3A | EEF1A1 | EGR1 | FAS | GRIN2A | HBA1 | HBB | HTRA2 | IL1B | IRF1 | LPAR1 | NOD1 | NRADD | PRNP | PTGS2 | RIPK2 | SLFN13 | TRIM13 | TXNRD1 | UCP2 | ZC3H12A
1
49. Methotrexate positive regulation of apoptotic DNA fragmentation Methotrexate results in increased positive regulation of apoptotic DNA fragmentation 1: Homo sapiens HL-60 Cells
3 genes: BAX | ENDOG | IGFBP3
1
50. Methotrexate positive regulation of apoptotic process PRL PRL protein inhibits the reaction [Methotrexate results in increased positive regulation of apoptotic process] 1: Homo sapiens HL-60 Cells
132 genes: ADM | ADRB1 | ADRB2 | AIFM2 | AKT1 | ALDH1A1 | ALOX12 | APAF1 | APBB1 | ATM | B4GALT1 | BAD | BAK1 | BAX | BBC3 | BCL2L1 | BID | BIK | BMP2 | BMP4 | BNIP3 | C1QBP | CASP2 | CASP3 | CASP6 | CASP8 | CASP9 | CCK | CCN1 | CDK4 | CNR1 | CREB1 | CTNNB1 | CYCE | DAPK3 | DDIT3 | DNAJA1 | DUSP1 | E2F1 | EIF2B5 | EIF5A | ENDOG | FAS | FGD4 | FOXO1 | GADD45A | GADD45B | GADD45G | GRIN2A | GSK3B | GZMA | HMOX1 | HPGD | HSPD1 | HTRA2 | ID3 | IFNG | IGFBP3 | IL18 | IL1B | IL6 | IRF5 | ITGA6 | ITGB1 | ITPR1 | JUN | KALRN | KCNMA1 | KLK1 | KLRK1 | KNG1 | LILRB1 | LPAR1 | LRP6 | MAP2K4 | MAP2K6 | MAP3K9 | MAPK8 | MAPK9 | MCF2L | MELK | MMP2 | MMP9 | MUC2 | NET1 | NGEF | NGF | NGFR | NOS2 | NOS3 | PIDD1 | PLA2G4A | PLSCR1 | PMAIP1 | PNMA2 | POU4F1 | PPARG | PPID | PPP1R15A | PRKCD | PSEN1 | PTEN | PTGS2 | RELA | RIPK2 | RPS6 | SEPT4 | SFRP1 | SOD1 | SP110 | SQSTM1 | SRC | TEX261 | TGFB1 | TGFB2 | TLR3 | TLR4 | TNF | TNFAIP8 | TNFRSF12A | TNFSF10 | TOMM40 | TOP2A | TP53 | TP53INP1 | TRADD | TRP53 | TXNIP | UBD | VAV2 | VAV3 | WNT10B
1
1–50 of 329 results.