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Chemical Aminopterin

1–50 of 322 results.
  Chemical Phenotype Co-Mentioned Terms Interaction Organisms Anatomy Inference Network References
1. 10-propargyl-10-deazaaminopterin apoptotic process gemcitabine [10-propargyl-10-deazaaminopterin co-treated with gemcitabine] results in increased apoptotic process 1: Mus musculus Tumor Cells, Cultured 1 gene: CASP3 1
2. 10-propargyl-10-deazaaminopterin apoptotic process Cytarabine [Cytarabine co-treated with 10-propargyl-10-deazaaminopterin] results in increased apoptotic process 1: Homo sapiens Tumor Cells, Cultured 1 gene: CASP3 1
3. 10-propargyl-10-deazaaminopterin cell cycle gemcitabine [10-propargyl-10-deazaaminopterin co-treated with gemcitabine] affects cell cycle 1: Mus musculus Tumor Cells, Cultured   1
4. Aminopterin larval development Aminopterin results in decreased larval development 1: Lucilia cuprina     1
5. Methotrexate lipid catabolic process Methotrexate results in increased lipid catabolic process 1: Rattus norvegicus Liver
19 genes: ABHD2 | ENPP2 | LIPC | PCK1 | PLA1A | PLA2G12A | PLA2G2A | PLA2G2C | PLA2G4A | PLA2G4C | PLCXD2 | PLD3 | PNLIP | PNLIPRP2 | PNPLA2 | PNPLA3 | PNPLA4 | SULT2A1 | TBL1XR1
2
6. Methotrexate positive regulation of cell death Cisplatin | Paclitaxel [Cisplatin co-treated with Paclitaxel] inhibits the reaction [Methotrexate results in increased positive regulation of cell death] 1: Homo sapiens Ovary | Cell Line, Tumor
30 genes: ACER2 | ALOX12 | AXIN2 | BMP4 | CDKN1A | CDKN1B | CTGF | CYSLTR2 | DKK1 | DNMT3A | EEF1A1 | EGR1 | FAS | GRIN2A | HBA1 | HBB | HTRA2 | IL1B | IRF1 | LPAR1 | NOD1 | NRADD | PRNP | PTGS2 | RIPK2 | SLFN13 | TRIM13 | TXNRD1 | UCP2 | ZC3H12A
1
7. Methotrexate protein oxidation Aspartame [Aspartame co-treated with Methotrexate] results in increased protein oxidation 1: Rattus norvegicus Hippocampus 1 gene: GPX1 1
8. Methotrexate folic acid metabolic process 5,6,7,8-tetrahydrofolic acid [Methotrexate results in decreased folic acid metabolic process] which results in decreased abundance of 5,6,7,8-tetrahydrofolic acid 1: Homo sapiens Endothelial Cells | Cell Line
8 genes: DHFR | FPGS | MTHFD1 | MTHFD1L | MTHFR | SHMT1 | SLC19A1 | SLC46A1
1
9. Methotrexate positive regulation of glutathione peroxidase activity Methotrexate results in decreased positive regulation of glutathione peroxidase activity 1: Rattus norvegicus Ileum   1
10. Methotrexate negative regulation of mitotic cell cycle Aspirin Aspirin inhibits the reaction [Methotrexate results in increased negative regulation of mitotic cell cycle] 1: Homo sapiens Lung | Epithelial Cells | Cell Line, Tumor
12 genes: ANGEL2 | BCL2 | CDKN1B | EGFR | FOXC1 | HNF4A | IL10 | RB1 | TGFB1 | TNF | TP53 | TRP53
1
11. Methotrexate positive regulation of cell death Methotrexate results in increased positive regulation of cell death 1: Homo sapiens Prostate | Cell Line, Tumor
30 genes: ACER2 | ALOX12 | AXIN2 | BMP4 | CDKN1A | CDKN1B | CTGF | CYSLTR2 | DKK1 | DNMT3A | EEF1A1 | EGR1 | FAS | GRIN2A | HBA1 | HBB | HTRA2 | IL1B | IRF1 | LPAR1 | NOD1 | NRADD | PRNP | PTGS2 | RIPK2 | SLFN13 | TRIM13 | TXNRD1 | UCP2 | ZC3H12A
1
12. Methotrexate cell growth N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide [N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide results in increased susceptibility to Methotrexate] which results in decreased cell growth 1: Homo sapiens A549 Cells   1
13. Methotrexate positive regulation of glutathione peroxidase activity Aspartame [Aspartame co-treated with Methotrexate] results in increased positive regulation of glutathione peroxidase activity 1: Rattus norvegicus Hippocampus   1
14. Methotrexate positive regulation of apoptotic process TNFSF10 | TP53 TP53 protein promotes the reaction [Methotrexate promotes the reaction [TNFSF10 protein results in increased positive regulation of apoptotic process]] 1: Homo sapiens T-Lymphocytes | Cell Line, Tumor
129 genes: ADM | ADRB1 | ADRB2 | AIFM2 | AKT1 | ALDH1A1 | ALOX12 | APAF1 | APBB1 | ATM | B4GALT1 | BAD | BAK1 | BAX | BBC3 | BCL2L1 | BID | BIK | BMP2 | BMP4 | BNIP3 | C1QBP | CASP2 | CASP3 | CASP6 | CASP8 | CASP9 | CCK | CDK4 | CNR1 | CREB1 | CTNNB1 | CYCE | CYR61 | DAPK3 | DDIT3 | DNAJA1 | DUSP1 | E2F1 | EIF2B5 | EIF5A | ENDOG | FAS | FGD4 | FOXO1 | GADD45A | GADD45B | GADD45G | GRIN2A | GSK3B | GZMA | HMOX1 | HPGD | HSPD1 | HTRA2 | ID3 | IFNG | IGFBP3 | IL18 | IL1B | IL6 | IRF5 | ITGA6 | ITGB1 | JUN | KALRN | KCNMA1 | KLK1 | KLRK1 | KNG1 | LILRB1 | LPAR1 | LRP6 | MAP2K4 | MAP2K6 | MAP3K9 | MAPK8 | MAPK9 | MCF2L | MELK | MMP9 | MUC2 | NET1 | NGEF | NGF | NGFR | NOS2 | NOS3 | PIDD1 | PLA2G4A | PLSCR1 | PMAIP1 | PNMA2 | POU4F1 | PPARG | PPID | PPP1R15A | PRKCD | PSEN1 | PTEN | PTGS2 | RELA | RIPK2 | RPS6 | SEPT4 | SFRP1 | SOD1 | SP110 | SQSTM1 | SRC | TEX261 | TGFB1 | TLR3 | TLR4 | TNF | TNFAIP8 | TNFRSF12A | TNFSF10 | TOMM40 | TOP2A | TP53 | TP53INP1 | TRADD | TRP53 | TXNIP | UBD | VAV2 | VAV3 | WNT10B
1
15. Methotrexate cell proliferation temozolomide [Methotrexate co-treated with temozolomide] results in decreased cell proliferation 1: Homo sapiens Neuroglia | Cell Line, Tumor
115 genes: ACHE | AKT1 | AR | AREG | AXIN2 | BAD | BAK1 | BAX | BCL2 | BCL2L1 | BMP4 | BST2 | BUB1 | BUB1B | CD81 | CDC25A | CDC25C | CDK1 | CDK4 | CENPF | COL4A3 | CSF1 | CSF1R | CTNNB1 | CUZD1 | CXCL1 | CYR61 | DAB2 | DDIT4 | DLGAP5 | E2F8 | EGFR | ERBB2 | EREG | EVI5 | FER | FGF1 | FGF16 | FOXC1 | FPGS | FSCN1 | GAB1 | GNAI2 | GNAT1 | GPX1 | GSK3B | H3F3A | H3F3B | HDGFL3 | HHEX | IFNAR2 | IGFBP4 | IL12A | IL15RA | IL18 | IL18RAP | IL1A | IL2RA | ISG20 | KIF15 | KIF2C | KITLG | LRP2 | LY6E | MAP7 | MCM10 | MELK | MET | MKI67 | MXD1 | MYB | MYC | NDP | NRG1 | OGFOD1 | PCNA | PDK1 | PES1 | PIM1 | PLK1 | PPARD | PRDX1 | PRKAR1B | PRL | PTEN | PTMA | RAC1 | RPL23A | SH2D2A | SKI | SKP2 | SPHK2 | SRC | STAT3 | STAT4 | TACC2 | TACC3 | TACSTD2 | TGFA | TGFB1 | TGFBI | TNF | TNFSF9 | TOP1 | TOP2A | TP53 | TRAIP | TXNRD1 | UBA1 | UHRF1 | VEGFA | WNT2B | XRCC5 | ZEB1 | ZMYND11
1
16. Methotrexate cell death vorinostat [vorinostat co-treated with Methotrexate] results in increased cell death 1: Homo sapiens T-Lymphocytes | Cell Line, Tumor
8 genes: AXIN2 | BNIP3 | CACNA1A | CDKN1B | GSDME | HMOX1 | IL17A | MAP3K9
1
17. Methotrexate glutathione metabolic process Aspartame [Aspartame co-treated with Methotrexate] results in increased glutathione metabolic process 1: Rattus norvegicus Pons
16 genes: CTH | ETHE1 | G6PD | GCLC | GGT1 | GPX1 | GPX3 | GSR | GSTA1 | GSTA2 | GSTM1 | GSTM4 | HBB | MMACHC | SOD1 | SOD2
1
18. Methotrexate cell proliferation Methotrexate results in decreased cell proliferation 1: Homo sapiens Jurkat Cells
115 genes: ACHE | AKT1 | AR | AREG | AXIN2 | BAD | BAK1 | BAX | BCL2 | BCL2L1 | BMP4 | BST2 | BUB1 | BUB1B | CD81 | CDC25A | CDC25C | CDK1 | CDK4 | CENPF | COL4A3 | CSF1 | CSF1R | CTNNB1 | CUZD1 | CXCL1 | CYR61 | DAB2 | DDIT4 | DLGAP5 | E2F8 | EGFR | ERBB2 | EREG | EVI5 | FER | FGF1 | FGF16 | FOXC1 | FPGS | FSCN1 | GAB1 | GNAI2 | GNAT1 | GPX1 | GSK3B | H3F3A | H3F3B | HDGFL3 | HHEX | IFNAR2 | IGFBP4 | IL12A | IL15RA | IL18 | IL18RAP | IL1A | IL2RA | ISG20 | KIF15 | KIF2C | KITLG | LRP2 | LY6E | MAP7 | MCM10 | MELK | MET | MKI67 | MXD1 | MYB | MYC | NDP | NRG1 | OGFOD1 | PCNA | PDK1 | PES1 | PIM1 | PLK1 | PPARD | PRDX1 | PRKAR1B | PRL | PTEN | PTMA | RAC1 | RPL23A | SH2D2A | SKI | SKP2 | SPHK2 | SRC | STAT3 | STAT4 | TACC2 | TACC3 | TACSTD2 | TGFA | TGFB1 | TGFBI | TNF | TNFSF9 | TOP1 | TOP2A | TP53 | TRAIP | TXNRD1 | UBA1 | UHRF1 | VEGFA | WNT2B | XRCC5 | ZEB1 | ZMYND11
1
19. Methotrexate cell proliferation resveratrol | SLC22A8 resveratrol inhibits the reaction [[SLC22A8 protein results in increased susceptibility to Methotrexate] which results in decreased cell proliferation] 1: Homo sapiens HEK293 Cells
115 genes: ACHE | AKT1 | AR | AREG | AXIN2 | BAD | BAK1 | BAX | BCL2 | BCL2L1 | BMP4 | BST2 | BUB1 | BUB1B | CD81 | CDC25A | CDC25C | CDK1 | CDK4 | CENPF | COL4A3 | CSF1 | CSF1R | CTNNB1 | CUZD1 | CXCL1 | CYR61 | DAB2 | DDIT4 | DLGAP5 | E2F8 | EGFR | ERBB2 | EREG | EVI5 | FER | FGF1 | FGF16 | FOXC1 | FPGS | FSCN1 | GAB1 | GNAI2 | GNAT1 | GPX1 | GSK3B | H3F3A | H3F3B | HDGFL3 | HHEX | IFNAR2 | IGFBP4 | IL12A | IL15RA | IL18 | IL18RAP | IL1A | IL2RA | ISG20 | KIF15 | KIF2C | KITLG | LRP2 | LY6E | MAP7 | MCM10 | MELK | MET | MKI67 | MXD1 | MYB | MYC | NDP | NRG1 | OGFOD1 | PCNA | PDK1 | PES1 | PIM1 | PLK1 | PPARD | PRDX1 | PRKAR1B | PRL | PTEN | PTMA | RAC1 | RPL23A | SH2D2A | SKI | SKP2 | SPHK2 | SRC | STAT3 | STAT4 | TACC2 | TACC3 | TACSTD2 | TGFA | TGFB1 | TGFBI | TNF | TNFSF9 | TOP1 | TOP2A | TP53 | TRAIP | TXNRD1 | UBA1 | UHRF1 | VEGFA | WNT2B | XRCC5 | ZEB1 | ZMYND11
1
20. Methotrexate positive regulation of cell proliferation Folic Acid Folic Acid deficiency promotes the reaction [Methotrexate results in decreased positive regulation of cell proliferation] 1: Homo sapiens Caco-2 Cells
163 genes: ACER2 | ADCYAP1 | ADM | ADORA2B | ADRB2 | AGT | AKT1 | ALOX12 | APLN | AR | AREG | ARRB1 | ATF3 | AVP | AVPR1A | BCL2 | BCL2L1 | BMP4 | CALR | CASR | CCK | CCND1 | CCND2 | CD47 | CD81 | CD86 | CDC20 | CDC25B | CDK2 | CDK4 | CDKN1B | CEACAM6 | CGA | CLCF1 | CLDN7 | CNOT7 | CSF1 | CSF1R | CTGF | CTNNB1 | CXCL10 | CXCL12 | CXCR2 | DLL1 | E2F3 | EDN1 | EDNRB | EFEMP1 | EGFR | EGR4 | EIF5A | ENPP2 | ERBB2 | EREG | F2 | FABP4 | FER | FGF1 | FGF19 | FGF20 | FGF3 | FGF7 | FGF8 | FGFR1 | FN1 | FOXM1 | FSHB | GATA3 | GLP1R | GLP2R | GNAI2 | HCK | HDAC1 | HDAC4 | HES1 | HILPDA | HMX2 | HOXC10 | ID3 | IFNG | IHH | IL11 | IL18 | IL1B | IL2 | IL3 | IL4 | IL6 | IL6R | IL6RA | IL7R | INS | INSR | ITGB1 | JUN | KIF14 | KITLG | KLK1 | KRAS | LEF1 | LEP | LIF | MAPK1 | MCTS1 | MDM2 | MFGE8 | MST1R | MYB | MYC | NAMPT | NGF | NMB | NOD2 | NOG | NOLC1 | NPM1 | NRG1 | NUDT16 | ODC1 | PDGFA | PDGFB | PGR | PKHD1 | PLA2G4A | PLAC8 | PLAU | PPARD | PRAMEF11 | PRC1 | PRKAA1 | PRL | PRTN3 | PTEN | PTGS2 | PTHLH | RELA | RRM2 | RTKN2 | RUNX2 | S1PR2 | SERTAD1 | SFRP1 | SLAMF1 | SMO | SPHK1 | SPHK2 | SRPK2 | STAT1 | STAT3 | STAT5A | STS | TET1 | TGFA | TGFB1 | TGFBR2 | THBS1 | TNC | TNF | TNFSF4 | VEGFA | VIPR1 | WNT10B | WNT5A
1
21. Methotrexate glutathione metabolic process Aspartame | Glutathione [[Aspartame co-treated with Methotrexate] results in increased glutathione metabolic process] which results in decreased abundance of Glutathione 1: Rattus norvegicus Hippocampus
16 genes: CTH | ETHE1 | G6PD | GCLC | GGT1 | GPX1 | GPX3 | GSR | GSTA1 | GSTA2 | GSTM1 | GSTM4 | HBB | MMACHC | SOD1 | SOD2
1
22. Methotrexate glutathione metabolic process Aspartame | Glutathione [[Aspartame co-treated with Methotrexate] results in increased glutathione metabolic process] which results in decreased abundance of Glutathione 1: Rattus norvegicus Hypothalamus
16 genes: CTH | ETHE1 | G6PD | GCLC | GGT1 | GPX1 | GPX3 | GSR | GSTA1 | GSTA2 | GSTM1 | GSTM4 | HBB | MMACHC | SOD1 | SOD2
1
23. Methotrexate positive regulation of apoptotic process Methotrexate results in increased positive regulation of apoptotic process 1: Homo sapiens MCF-7 Cells
129 genes: ADM | ADRB1 | ADRB2 | AIFM2 | AKT1 | ALDH1A1 | ALOX12 | APAF1 | APBB1 | ATM | B4GALT1 | BAD | BAK1 | BAX | BBC3 | BCL2L1 | BID | BIK | BMP2 | BMP4 | BNIP3 | C1QBP | CASP2 | CASP3 | CASP6 | CASP8 | CASP9 | CCK | CDK4 | CNR1 | CREB1 | CTNNB1 | CYCE | CYR61 | DAPK3 | DDIT3 | DNAJA1 | DUSP1 | E2F1 | EIF2B5 | EIF5A | ENDOG | FAS | FGD4 | FOXO1 | GADD45A | GADD45B | GADD45G | GRIN2A | GSK3B | GZMA | HMOX1 | HPGD | HSPD1 | HTRA2 | ID3 | IFNG | IGFBP3 | IL18 | IL1B | IL6 | IRF5 | ITGA6 | ITGB1 | JUN | KALRN | KCNMA1 | KLK1 | KLRK1 | KNG1 | LILRB1 | LPAR1 | LRP6 | MAP2K4 | MAP2K6 | MAP3K9 | MAPK8 | MAPK9 | MCF2L | MELK | MMP9 | MUC2 | NET1 | NGEF | NGF | NGFR | NOS2 | NOS3 | PIDD1 | PLA2G4A | PLSCR1 | PMAIP1 | PNMA2 | POU4F1 | PPARG | PPID | PPP1R15A | PRKCD | PSEN1 | PTEN | PTGS2 | RELA | RIPK2 | RPS6 | SEPT4 | SFRP1 | SOD1 | SP110 | SQSTM1 | SRC | TEX261 | TGFB1 | TLR3 | TLR4 | TNF | TNFAIP8 | TNFRSF12A | TNFSF10 | TOMM40 | TOP2A | TP53 | TP53INP1 | TRADD | TRP53 | TXNIP | UBD | VAV2 | VAV3 | WNT10B
2
24. Methotrexate glycogen catabolic process Methotrexate results in increased glycogen catabolic process 1: Rattus norvegicus Liver 1 gene: ADRB1 1
25. Methotrexate lipid oxidation Aspartame [Aspartame co-treated with Methotrexate] results in increased lipid oxidation 1: Rattus norvegicus Pons   1
26. Methotrexate response to antineoplastic agent vinorelbine [Methotrexate results in decreased response to antineoplastic agent] which results in decreased susceptibility to vinorelbine 1: Homo sapiens MCF-7 Cells
2 genes: ABCB1B | ABCC2
1
27. Methotrexate response to antineoplastic agent Methotrexate results in decreased response to antineoplastic agent 1: Homo sapiens Bone and Bones | Osteocytes | Cell Line, Tumor
2 genes: ABCB1B | ABCC2
1
28. Methotrexate positive regulation of apoptotic process 7-hydroxystaurosporine [Methotrexate co-treated with 7-hydroxystaurosporine] results in increased positive regulation of apoptotic process 1: Mus musculus Melanocytes | Cell Line, Tumor
129 genes: ADM | ADRB1 | ADRB2 | AIFM2 | AKT1 | ALDH1A1 | ALOX12 | APAF1 | APBB1 | ATM | B4GALT1 | BAD | BAK1 | BAX | BBC3 | BCL2L1 | BID | BIK | BMP2 | BMP4 | BNIP3 | C1QBP | CASP2 | CASP3 | CASP6 | CASP8 | CASP9 | CCK | CDK4 | CNR1 | CREB1 | CTNNB1 | CYCE | CYR61 | DAPK3 | DDIT3 | DNAJA1 | DUSP1 | E2F1 | EIF2B5 | EIF5A | ENDOG | FAS | FGD4 | FOXO1 | GADD45A | GADD45B | GADD45G | GRIN2A | GSK3B | GZMA | HMOX1 | HPGD | HSPD1 | HTRA2 | ID3 | IFNG | IGFBP3 | IL18 | IL1B | IL6 | IRF5 | ITGA6 | ITGB1 | JUN | KALRN | KCNMA1 | KLK1 | KLRK1 | KNG1 | LILRB1 | LPAR1 | LRP6 | MAP2K4 | MAP2K6 | MAP3K9 | MAPK8 | MAPK9 | MCF2L | MELK | MMP9 | MUC2 | NET1 | NGEF | NGF | NGFR | NOS2 | NOS3 | PIDD1 | PLA2G4A | PLSCR1 | PMAIP1 | PNMA2 | POU4F1 | PPARG | PPID | PPP1R15A | PRKCD | PSEN1 | PTEN | PTGS2 | RELA | RIPK2 | RPS6 | SEPT4 | SFRP1 | SOD1 | SP110 | SQSTM1 | SRC | TEX261 | TGFB1 | TLR3 | TLR4 | TNF | TNFAIP8 | TNFRSF12A | TNFSF10 | TOMM40 | TOP2A | TP53 | TP53INP1 | TRADD | TRP53 | TXNIP | UBD | VAV2 | VAV3 | WNT10B
1
29. Methotrexate positive regulation of apoptotic process Ferrosoferric Oxide | polylactide-polyethylene glycol-polylactide [Methotrexate co-treated with [Ferrosoferric Oxide binds to polylactide-polyethylene glycol-polylactide]] results in increased positive regulation of apoptotic process 1: Homo sapiens Bone and Bones | Cell Line, Tumor
129 genes: ADM | ADRB1 | ADRB2 | AIFM2 | AKT1 | ALDH1A1 | ALOX12 | APAF1 | APBB1 | ATM | B4GALT1 | BAD | BAK1 | BAX | BBC3 | BCL2L1 | BID | BIK | BMP2 | BMP4 | BNIP3 | C1QBP | CASP2 | CASP3 | CASP6 | CASP8 | CASP9 | CCK | CDK4 | CNR1 | CREB1 | CTNNB1 | CYCE | CYR61 | DAPK3 | DDIT3 | DNAJA1 | DUSP1 | E2F1 | EIF2B5 | EIF5A | ENDOG | FAS | FGD4 | FOXO1 | GADD45A | GADD45B | GADD45G | GRIN2A | GSK3B | GZMA | HMOX1 | HPGD | HSPD1 | HTRA2 | ID3 | IFNG | IGFBP3 | IL18 | IL1B | IL6 | IRF5 | ITGA6 | ITGB1 | JUN | KALRN | KCNMA1 | KLK1 | KLRK1 | KNG1 | LILRB1 | LPAR1 | LRP6 | MAP2K4 | MAP2K6 | MAP3K9 | MAPK8 | MAPK9 | MCF2L | MELK | MMP9 | MUC2 | NET1 | NGEF | NGF | NGFR | NOS2 | NOS3 | PIDD1 | PLA2G4A | PLSCR1 | PMAIP1 | PNMA2 | POU4F1 | PPARG | PPID | PPP1R15A | PRKCD | PSEN1 | PTEN | PTGS2 | RELA | RIPK2 | RPS6 | SEPT4 | SFRP1 | SOD1 | SP110 | SQSTM1 | SRC | TEX261 | TGFB1 | TLR3 | TLR4 | TNF | TNFAIP8 | TNFRSF12A | TNFSF10 | TOMM40 | TOP2A | TP53 | TP53INP1 | TRADD | TRP53 | TXNIP | UBD | VAV2 | VAV3 | WNT10B
1
30. Methotrexate positive regulation of reactive oxygen species biosynthetic process Methotrexate results in increased positive regulation of reactive oxygen species biosynthetic process 1: Homo sapiens Blood | Leukocytes, Mononuclear
3 genes: HDAC4 | IL4 | TLR4
1
31. Methotrexate cell death vorinostat [vorinostat co-treated with Methotrexate] results in increased cell death 1: Homo sapiens B-Lymphocytes | Cell Line, Tumor
8 genes: AXIN2 | BNIP3 | CACNA1A | CDKN1B | GSDME | HMOX1 | IL17A | MAP3K9
1
32. Methotrexate cell proliferation Methotrexate results in decreased cell proliferation 1: Mus musculus Embryo, Mammalian | Telencephalon | Neuroepithelial Cells
115 genes: ACHE | AKT1 | AR | AREG | AXIN2 | BAD | BAK1 | BAX | BCL2 | BCL2L1 | BMP4 | BST2 | BUB1 | BUB1B | CD81 | CDC25A | CDC25C | CDK1 | CDK4 | CENPF | COL4A3 | CSF1 | CSF1R | CTNNB1 | CUZD1 | CXCL1 | CYR61 | DAB2 | DDIT4 | DLGAP5 | E2F8 | EGFR | ERBB2 | EREG | EVI5 | FER | FGF1 | FGF16 | FOXC1 | FPGS | FSCN1 | GAB1 | GNAI2 | GNAT1 | GPX1 | GSK3B | H3F3A | H3F3B | HDGFL3 | HHEX | IFNAR2 | IGFBP4 | IL12A | IL15RA | IL18 | IL18RAP | IL1A | IL2RA | ISG20 | KIF15 | KIF2C | KITLG | LRP2 | LY6E | MAP7 | MCM10 | MELK | MET | MKI67 | MXD1 | MYB | MYC | NDP | NRG1 | OGFOD1 | PCNA | PDK1 | PES1 | PIM1 | PLK1 | PPARD | PRDX1 | PRKAR1B | PRL | PTEN | PTMA | RAC1 | RPL23A | SH2D2A | SKI | SKP2 | SPHK2 | SRC | STAT3 | STAT4 | TACC2 | TACC3 | TACSTD2 | TGFA | TGFB1 | TGFBI | TNF | TNFSF9 | TOP1 | TOP2A | TP53 | TRAIP | TXNRD1 | UBA1 | UHRF1 | VEGFA | WNT2B | XRCC5 | ZEB1 | ZMYND11
1
33. Methotrexate positive regulation of activation-induced cell death of T cells sapropterin sapropterin inhibits the reaction [Methotrexate results in increased positive regulation of activation-induced cell death of T cells] 1: Homo sapiens Jurkat Cells 1 gene: CEACAM1 1
34. Methotrexate positive regulation of cell death Methotrexate results in increased positive regulation of cell death 1: Homo sapiens Epithelial Cells | Cell Line, Tumor
30 genes: ACER2 | ALOX12 | AXIN2 | BMP4 | CDKN1A | CDKN1B | CTGF | CYSLTR2 | DKK1 | DNMT3A | EEF1A1 | EGR1 | FAS | GRIN2A | HBA1 | HBB | HTRA2 | IL1B | IRF1 | LPAR1 | NOD1 | NRADD | PRNP | PTGS2 | RIPK2 | SLFN13 | TRIM13 | TXNRD1 | UCP2 | ZC3H12A
1
35. Methotrexate response to antineoplastic agent Paclitaxel [Methotrexate results in decreased response to antineoplastic agent] which results in decreased susceptibility to Paclitaxel 1: Homo sapiens MCF-7 Cells
2 genes: ABCB1B | ABCC2
1
36. Methotrexate positive regulation of JNK cascade Methotrexate results in increased positive regulation of JNK cascade 1: Homo sapiens Lymphocytes
31 genes: APP | CCL19 | CCL21 | CEACAM1 | CTGF | F2RL1 | FCGR2B | FGF19 | GADD45A | GADD45B | GADD45G | IL1A | IL1B | IL3 | LMNB1 | LTBR | MAP3K7 | MAP4K4 | MYD88 | NOD1 | NOD2 | RIPK2 | SEMA3A | SLAMF1 | TAOK2 | TLR3 | TLR4 | TNF | TNFSF11 | WNT16 | WNT5A
1
37. Methotrexate positive regulation of macrophage chemotaxis Lipids [Methotrexate analog binds to Lipids] which results in decreased positive regulation of macrophage chemotaxis 1: Oryctolagus cuniculus Aorta | Tunica Intima
9 genes: C5AR1 | CCL2 | CCL5 | CSF1 | MAPK14 | MAPK3 | PTPRJ | SLAMF1 | THBS1
1
38. Methotrexate positive regulation of apoptotic process Veratridine Veratridine promotes the reaction [Methotrexate results in increased positive regulation of apoptotic process] 1: Homo sapiens MCF-7 Cells
129 genes: ADM | ADRB1 | ADRB2 | AIFM2 | AKT1 | ALDH1A1 | ALOX12 | APAF1 | APBB1 | ATM | B4GALT1 | BAD | BAK1 | BAX | BBC3 | BCL2L1 | BID | BIK | BMP2 | BMP4 | BNIP3 | C1QBP | CASP2 | CASP3 | CASP6 | CASP8 | CASP9 | CCK | CDK4 | CNR1 | CREB1 | CTNNB1 | CYCE | CYR61 | DAPK3 | DDIT3 | DNAJA1 | DUSP1 | E2F1 | EIF2B5 | EIF5A | ENDOG | FAS | FGD4 | FOXO1 | GADD45A | GADD45B | GADD45G | GRIN2A | GSK3B | GZMA | HMOX1 | HPGD | HSPD1 | HTRA2 | ID3 | IFNG | IGFBP3 | IL18 | IL1B | IL6 | IRF5 | ITGA6 | ITGB1 | JUN | KALRN | KCNMA1 | KLK1 | KLRK1 | KNG1 | LILRB1 | LPAR1 | LRP6 | MAP2K4 | MAP2K6 | MAP3K9 | MAPK8 | MAPK9 | MCF2L | MELK | MMP9 | MUC2 | NET1 | NGEF | NGF | NGFR | NOS2 | NOS3 | PIDD1 | PLA2G4A | PLSCR1 | PMAIP1 | PNMA2 | POU4F1 | PPARG | PPID | PPP1R15A | PRKCD | PSEN1 | PTEN | PTGS2 | RELA | RIPK2 | RPS6 | SEPT4 | SFRP1 | SOD1 | SP110 | SQSTM1 | SRC | TEX261 | TGFB1 | TLR3 | TLR4 | TNF | TNFAIP8 | TNFRSF12A | TNFSF10 | TOMM40 | TOP2A | TP53 | TP53INP1 | TRADD | TRP53 | TXNIP | UBD | VAV2 | VAV3 | WNT10B
1
39. Methotrexate positive regulation of histone deacetylase activity Methotrexate results in increased positive regulation of histone deacetylase activity 1: Homo sapiens Lung | Epithelial Cells | Cell Line, Tumor 1 gene: VEGFA 1
40. Methotrexate lactate dehydrogenase activity 18alpha-glycyrrhetinic acid 18alpha-glycyrrhetinic acid inhibits the reaction [Methotrexate results in increased lactate dehydrogenase activity] 1: Rattus norvegicus Serum   1
41. Methotrexate glutathione derivative biosynthetic process Aspartame [Aspartame co-treated with Methotrexate] results in increased glutathione derivative biosynthetic process 1: Rattus norvegicus Pons
4 genes: GSTA1 | GSTA2 | GSTM1 | GSTM4
1
42. Methotrexate cell death resveratrol | SLC22A6 resveratrol inhibits the reaction [[SLC22A6 protein results in increased susceptibility to Methotrexate] which results in increased cell death] 1: Homo sapiens HEK293 Cells
8 genes: AXIN2 | BNIP3 | CACNA1A | CDKN1B | GSDME | HMOX1 | IL17A | MAP3K9
1
43. Methotrexate cell proliferation resveratrol | SLC22A6 resveratrol inhibits the reaction [[SLC22A6 protein results in increased susceptibility to Methotrexate] which results in decreased cell proliferation] 1: Homo sapiens HEK293 Cells
115 genes: ACHE | AKT1 | AR | AREG | AXIN2 | BAD | BAK1 | BAX | BCL2 | BCL2L1 | BMP4 | BST2 | BUB1 | BUB1B | CD81 | CDC25A | CDC25C | CDK1 | CDK4 | CENPF | COL4A3 | CSF1 | CSF1R | CTNNB1 | CUZD1 | CXCL1 | CYR61 | DAB2 | DDIT4 | DLGAP5 | E2F8 | EGFR | ERBB2 | EREG | EVI5 | FER | FGF1 | FGF16 | FOXC1 | FPGS | FSCN1 | GAB1 | GNAI2 | GNAT1 | GPX1 | GSK3B | H3F3A | H3F3B | HDGFL3 | HHEX | IFNAR2 | IGFBP4 | IL12A | IL15RA | IL18 | IL18RAP | IL1A | IL2RA | ISG20 | KIF15 | KIF2C | KITLG | LRP2 | LY6E | MAP7 | MCM10 | MELK | MET | MKI67 | MXD1 | MYB | MYC | NDP | NRG1 | OGFOD1 | PCNA | PDK1 | PES1 | PIM1 | PLK1 | PPARD | PRDX1 | PRKAR1B | PRL | PTEN | PTMA | RAC1 | RPL23A | SH2D2A | SKI | SKP2 | SPHK2 | SRC | STAT3 | STAT4 | TACC2 | TACC3 | TACSTD2 | TGFA | TGFB1 | TGFBI | TNF | TNFSF9 | TOP1 | TOP2A | TP53 | TRAIP | TXNRD1 | UBA1 | UHRF1 | VEGFA | WNT2B | XRCC5 | ZEB1 | ZMYND11
1
44. Methotrexate positive regulation of cell death Methotrexate results in increased positive regulation of cell death 1: Homo sapiens Caco-2 Cells
30 genes: ACER2 | ALOX12 | AXIN2 | BMP4 | CDKN1A | CDKN1B | CTGF | CYSLTR2 | DKK1 | DNMT3A | EEF1A1 | EGR1 | FAS | GRIN2A | HBA1 | HBB | HTRA2 | IL1B | IRF1 | LPAR1 | NOD1 | NRADD | PRNP | PTGS2 | RIPK2 | SLFN13 | TRIM13 | TXNRD1 | UCP2 | ZC3H12A
1
45. Methotrexate positive regulation of p38MAPK cascade Methotrexate results in increased positive regulation of p38MAPK cascade Nasal Mucosa
11 genes: BMP2 | DHX15 | GADD45A | GADD45B | GADD45G | IL1B | LEP | MET | OPRK1 | VEGFA | ZC3H12A
1
46. Methotrexate positive regulation of apoptotic process Methotrexate results in increased positive regulation of apoptotic process 1: Homo sapiens U937 Cells
129 genes: ADM | ADRB1 | ADRB2 | AIFM2 | AKT1 | ALDH1A1 | ALOX12 | APAF1 | APBB1 | ATM | B4GALT1 | BAD | BAK1 | BAX | BBC3 | BCL2L1 | BID | BIK | BMP2 | BMP4 | BNIP3 | C1QBP | CASP2 | CASP3 | CASP6 | CASP8 | CASP9 | CCK | CDK4 | CNR1 | CREB1 | CTNNB1 | CYCE | CYR61 | DAPK3 | DDIT3 | DNAJA1 | DUSP1 | E2F1 | EIF2B5 | EIF5A | ENDOG | FAS | FGD4 | FOXO1 | GADD45A | GADD45B | GADD45G | GRIN2A | GSK3B | GZMA | HMOX1 | HPGD | HSPD1 | HTRA2 | ID3 | IFNG | IGFBP3 | IL18 | IL1B | IL6 | IRF5 | ITGA6 | ITGB1 | JUN | KALRN | KCNMA1 | KLK1 | KLRK1 | KNG1 | LILRB1 | LPAR1 | LRP6 | MAP2K4 | MAP2K6 | MAP3K9 | MAPK8 | MAPK9 | MCF2L | MELK | MMP9 | MUC2 | NET1 | NGEF | NGF | NGFR | NOS2 | NOS3 | PIDD1 | PLA2G4A | PLSCR1 | PMAIP1 | PNMA2 | POU4F1 | PPARG | PPID | PPP1R15A | PRKCD | PSEN1 | PTEN | PTGS2 | RELA | RIPK2 | RPS6 | SEPT4 | SFRP1 | SOD1 | SP110 | SQSTM1 | SRC | TEX261 | TGFB1 | TLR3 | TLR4 | TNF | TNFAIP8 | TNFRSF12A | TNFSF10 | TOMM40 | TOP2A | TP53 | TP53INP1 | TRADD | TRP53 | TXNIP | UBD | VAV2 | VAV3 | WNT10B
1
47. Methotrexate lactate dehydrogenase activity Chlorogenic Acid Chlorogenic Acid inhibits the reaction [Methotrexate results in increased lactate dehydrogenase activity] 1: Rattus norvegicus Serum   1
48. Methotrexate positive regulation of cell proliferation ABCC5 ABCC5 protein inhibits the reaction [Methotrexate results in decreased positive regulation of cell proliferation] 1: Homo sapiens HEK293 Cells
163 genes: ACER2 | ADCYAP1 | ADM | ADORA2B | ADRB2 | AGT | AKT1 | ALOX12 | APLN | AR | AREG | ARRB1 | ATF3 | AVP | AVPR1A | BCL2 | BCL2L1 | BMP4 | CALR | CASR | CCK | CCND1 | CCND2 | CD47 | CD81 | CD86 | CDC20 | CDC25B | CDK2 | CDK4 | CDKN1B | CEACAM6 | CGA | CLCF1 | CLDN7 | CNOT7 | CSF1 | CSF1R | CTGF | CTNNB1 | CXCL10 | CXCL12 | CXCR2 | DLL1 | E2F3 | EDN1 | EDNRB | EFEMP1 | EGFR | EGR4 | EIF5A | ENPP2 | ERBB2 | EREG | F2 | FABP4 | FER | FGF1 | FGF19 | FGF20 | FGF3 | FGF7 | FGF8 | FGFR1 | FN1 | FOXM1 | FSHB | GATA3 | GLP1R | GLP2R | GNAI2 | HCK | HDAC1 | HDAC4 | HES1 | HILPDA | HMX2 | HOXC10 | ID3 | IFNG | IHH | IL11 | IL18 | IL1B | IL2 | IL3 | IL4 | IL6 | IL6R | IL6RA | IL7R | INS | INSR | ITGB1 | JUN | KIF14 | KITLG | KLK1 | KRAS | LEF1 | LEP | LIF | MAPK1 | MCTS1 | MDM2 | MFGE8 | MST1R | MYB | MYC | NAMPT | NGF | NMB | NOD2 | NOG | NOLC1 | NPM1 | NRG1 | NUDT16 | ODC1 | PDGFA | PDGFB | PGR | PKHD1 | PLA2G4A | PLAC8 | PLAU | PPARD | PRAMEF11 | PRC1 | PRKAA1 | PRL | PRTN3 | PTEN | PTGS2 | PTHLH | RELA | RRM2 | RTKN2 | RUNX2 | S1PR2 | SERTAD1 | SFRP1 | SLAMF1 | SMO | SPHK1 | SPHK2 | SRPK2 | STAT1 | STAT3 | STAT5A | STS | TET1 | TGFA | TGFB1 | TGFBR2 | THBS1 | TNC | TNF | TNFSF4 | VEGFA | VIPR1 | WNT10B | WNT5A
1
49. Methotrexate positive regulation of adipose tissue development Leucovorin Leucovorin inhibits the reaction [Methotrexate results in increased positive regulation of adipose tissue development] 1: Rattus norvegicus Bone Marrow 1 gene: NR1H4 1
50. Methotrexate positive regulation of cell death Methotrexate inhibits the reaction [Methotrexate results in increased positive regulation of cell death] 1: Homo sapiens MCF-7 Cells
30 genes: ACER2 | ALOX12 | AXIN2 | BMP4 | CDKN1A | CDKN1B | CTGF | CYSLTR2 | DKK1 | DNMT3A | EEF1A1 | EGR1 | FAS | GRIN2A | HBA1 | HBB | HTRA2 | IL1B | IRF1 | LPAR1 | NOD1 | NRADD | PRNP | PTGS2 | RIPK2 | SLFN13 | TRIM13 | TXNRD1 | UCP2 | ZC3H12A
1
1–50 of 322 results.