Skip navigation

Chemical Aminopterin

1–50 of 322 results.
  Chemical Phenotype Co-Mentioned Terms Interaction Organisms Anatomy Inference Network References
1. 10-propargyl-10-deazaaminopterin apoptotic process gemcitabine [10-propargyl-10-deazaaminopterin co-treated with gemcitabine] results in increased apoptotic process 1: Mus musculus Tumor Cells, Cultured 1 gene: CASP3 1
2. 10-propargyl-10-deazaaminopterin cell cycle gemcitabine [10-propargyl-10-deazaaminopterin co-treated with gemcitabine] affects cell cycle 1: Mus musculus Tumor Cells, Cultured   1
3. 10-propargyl-10-deazaaminopterin apoptotic process Cytarabine [Cytarabine co-treated with 10-propargyl-10-deazaaminopterin] results in increased apoptotic process 1: Homo sapiens Tumor Cells, Cultured 1 gene: CASP3 1
4. Aminopterin larval development Aminopterin results in decreased larval development 1: Lucilia cuprina     1
5. Methotrexate positive regulation of cell death Doxorubicin Methotrexate inhibits the reaction [Doxorubicin results in increased positive regulation of cell death] 1: Homo sapiens MCF-7 Cells
30 genes: ACER2 | ALOX12 | AXIN2 | BMP4 | CDKN1A | CDKN1B | CTGF | CYSLTR2 | DKK1 | DNMT3A | EEF1A1 | EGR1 | FAS | GRIN2A | HBA1 | HBB | HTRA2 | IL1B | IRF1 | LPAR1 | NOD1 | NRADD | PRNP | PTGS2 | RIPK2 | SLFN13 | TRIM13 | TXNRD1 | UCP2 | ZC3H12A
1
6. Methotrexate positive regulation of macrophage derived foam cell differentiation Methotrexate results in decreased positive regulation of macrophage derived foam cell differentiation 1: Homo sapiens Macrophages | Cell Line
6 genes: AGT | CSF1 | IL18 | MAPK9 | PF4 | PLA2G2A
1
7. Methotrexate response to antineoplastic agent Pemetrexed [Methotrexate results in decreased response to antineoplastic agent] which results in decreased susceptibility to Pemetrexed 1: Homo sapiens MCF-7 Cells
2 genes: ABCB1B | ABCC2
1
8. Methotrexate positive regulation of apoptotic process GSTM4 GSTM4 mRNA inhibits the reaction [Methotrexate results in increased positive regulation of apoptotic process] 1: Homo sapiens Bone and Bones | Cell Line, Tumor
129 genes: ADM | ADRB1 | ADRB2 | AIFM2 | AKT1 | ALDH1A1 | ALOX12 | APAF1 | APBB1 | ATM | B4GALT1 | BAD | BAK1 | BAX | BBC3 | BCL2L1 | BID | BIK | BMP2 | BMP4 | BNIP3 | C1QBP | CASP2 | CASP3 | CASP6 | CASP8 | CASP9 | CCK | CDK4 | CNR1 | CREB1 | CTNNB1 | CYCE | CYR61 | DAPK3 | DDIT3 | DNAJA1 | DUSP1 | E2F1 | EIF2B5 | EIF5A | ENDOG | FAS | FGD4 | FOXO1 | GADD45A | GADD45B | GADD45G | GRIN2A | GSK3B | GZMA | HMOX1 | HPGD | HSPD1 | HTRA2 | ID3 | IFNG | IGFBP3 | IL18 | IL1B | IL6 | IRF5 | ITGA6 | ITGB1 | JUN | KALRN | KCNMA1 | KLK1 | KLRK1 | KNG1 | LILRB1 | LPAR1 | LRP6 | MAP2K4 | MAP2K6 | MAP3K9 | MAPK8 | MAPK9 | MCF2L | MELK | MMP9 | MUC2 | NET1 | NGEF | NGF | NGFR | NOS2 | NOS3 | PIDD1 | PLA2G4A | PLSCR1 | PMAIP1 | PNMA2 | POU4F1 | PPARG | PPID | PPP1R15A | PRKCD | PSEN1 | PTEN | PTGS2 | RELA | RIPK2 | RPS6 | SEPT4 | SFRP1 | SOD1 | SP110 | SQSTM1 | SRC | TEX261 | TGFB1 | TLR3 | TLR4 | TNF | TNFAIP8 | TNFRSF12A | TNFSF10 | TOMM40 | TOP2A | TP53 | TP53INP1 | TRADD | TRP53 | TXNIP | UBD | VAV2 | VAV3 | WNT10B
1
9. Methotrexate positive regulation of JNK cascade Methotrexate results in increased positive regulation of JNK cascade 1: Homo sapiens Jurkat Cells
31 genes: APP | CCL19 | CCL21 | CEACAM1 | CTGF | F2RL1 | FCGR2B | FGF19 | GADD45A | GADD45B | GADD45G | IL1A | IL1B | IL3 | LMNB1 | LTBR | MAP3K7 | MAP4K4 | MYD88 | NOD1 | NOD2 | RIPK2 | SEMA3A | SLAMF1 | TAOK2 | TLR3 | TLR4 | TNF | TNFSF11 | WNT16 | WNT5A
1
10. Methotrexate positive regulation of cell death Fluorouracil Methotrexate inhibits the reaction [Fluorouracil results in increased positive regulation of cell death] 1: Homo sapiens MCF-7 Cells
30 genes: ACER2 | ALOX12 | AXIN2 | BMP4 | CDKN1A | CDKN1B | CTGF | CYSLTR2 | DKK1 | DNMT3A | EEF1A1 | EGR1 | FAS | GRIN2A | HBA1 | HBB | HTRA2 | IL1B | IRF1 | LPAR1 | NOD1 | NRADD | PRNP | PTGS2 | RIPK2 | SLFN13 | TRIM13 | TXNRD1 | UCP2 | ZC3H12A
1
11. Methotrexate positive regulation of adipose tissue development Leucovorin Leucovorin inhibits the reaction [Methotrexate results in increased positive regulation of adipose tissue development] 1: Rattus norvegicus Bone Marrow 1 gene: NR1H4 1
12. Methotrexate response to antineoplastic agent pirarubicin [Methotrexate results in decreased response to antineoplastic agent] which results in decreased susceptibility to pirarubicin 1: Homo sapiens Bone and Bones | Osteocytes | Cell Line, Tumor
2 genes: ABCB1B | ABCC2
1
13. Methotrexate positive regulation of cell proliferation ABCC5 ABCC5 protein inhibits the reaction [Methotrexate results in decreased positive regulation of cell proliferation] 1: Homo sapiens HEK293 Cells
163 genes: ACER2 | ADCYAP1 | ADM | ADORA2B | ADRB2 | AGT | AKT1 | ALOX12 | APLN | AR | AREG | ARRB1 | ATF3 | AVP | AVPR1A | BCL2 | BCL2L1 | BMP4 | CALR | CASR | CCK | CCND1 | CCND2 | CD47 | CD81 | CD86 | CDC20 | CDC25B | CDK2 | CDK4 | CDKN1B | CEACAM6 | CGA | CLCF1 | CLDN7 | CNOT7 | CSF1 | CSF1R | CTGF | CTNNB1 | CXCL10 | CXCL12 | CXCR2 | DLL1 | E2F3 | EDN1 | EDNRB | EFEMP1 | EGFR | EGR4 | EIF5A | ENPP2 | ERBB2 | EREG | F2 | FABP4 | FER | FGF1 | FGF19 | FGF20 | FGF3 | FGF7 | FGF8 | FGFR1 | FN1 | FOXM1 | FSHB | GATA3 | GLP1R | GLP2R | GNAI2 | HCK | HDAC1 | HDAC4 | HES1 | HILPDA | HMX2 | HOXC10 | ID3 | IFNG | IHH | IL11 | IL18 | IL1B | IL2 | IL3 | IL4 | IL6 | IL6R | IL6RA | IL7R | INS | INSR | ITGB1 | JUN | KIF14 | KITLG | KLK1 | KRAS | LEF1 | LEP | LIF | MAPK1 | MCTS1 | MDM2 | MFGE8 | MST1R | MYB | MYC | NAMPT | NGF | NMB | NOD2 | NOG | NOLC1 | NPM1 | NRG1 | NUDT16 | ODC1 | PDGFA | PDGFB | PGR | PKHD1 | PLA2G4A | PLAC8 | PLAU | PPARD | PRAMEF11 | PRC1 | PRKAA1 | PRL | PRTN3 | PTEN | PTGS2 | PTHLH | RELA | RRM2 | RTKN2 | RUNX2 | S1PR2 | SERTAD1 | SFRP1 | SLAMF1 | SMO | SPHK1 | SPHK2 | SRPK2 | STAT1 | STAT3 | STAT5A | STS | TET1 | TGFA | TGFB1 | TGFBR2 | THBS1 | TNC | TNF | TNFSF4 | VEGFA | VIPR1 | WNT10B | WNT5A
1
14. Methotrexate alkaline phosphatase activity Methotrexate results in increased alkaline phosphatase activity 1: Rattus norvegicus Serum
3 genes: ALPI | ALPP | ALPPL2
1
15. Methotrexate positive regulation of cell death SHH SHH protein alternative form inhibits the reaction [Methotrexate results in increased positive regulation of cell death] 1: Homo sapiens Precursor Cells, B-Lymphoid | Cell Line, Tumor
30 genes: ACER2 | ALOX12 | AXIN2 | BMP4 | CDKN1A | CDKN1B | CTGF | CYSLTR2 | DKK1 | DNMT3A | EEF1A1 | EGR1 | FAS | GRIN2A | HBA1 | HBB | HTRA2 | IL1B | IRF1 | LPAR1 | NOD1 | NRADD | PRNP | PTGS2 | RIPK2 | SLFN13 | TRIM13 | TXNRD1 | UCP2 | ZC3H12A
1
16. Methotrexate S-adenosylmethionine biosynthetic process Leucovorin Leucovorin inhibits the reaction [Methotrexate results in decreased S-adenosylmethionine biosynthetic process] 1: Homo sapiens Hep G2 Cells
2 genes: MAT1A | MAT2A
1
17. Methotrexate positive regulation of apoptotic process TGFA TGFA protein inhibits the reaction [Methotrexate results in increased positive regulation of apoptotic process] 1: Rattus norvegicus Enterocytes | Jejunum
129 genes: ADM | ADRB1 | ADRB2 | AIFM2 | AKT1 | ALDH1A1 | ALOX12 | APAF1 | APBB1 | ATM | B4GALT1 | BAD | BAK1 | BAX | BBC3 | BCL2L1 | BID | BIK | BMP2 | BMP4 | BNIP3 | C1QBP | CASP2 | CASP3 | CASP6 | CASP8 | CASP9 | CCK | CDK4 | CNR1 | CREB1 | CTNNB1 | CYCE | CYR61 | DAPK3 | DDIT3 | DNAJA1 | DUSP1 | E2F1 | EIF2B5 | EIF5A | ENDOG | FAS | FGD4 | FOXO1 | GADD45A | GADD45B | GADD45G | GRIN2A | GSK3B | GZMA | HMOX1 | HPGD | HSPD1 | HTRA2 | ID3 | IFNG | IGFBP3 | IL18 | IL1B | IL6 | IRF5 | ITGA6 | ITGB1 | JUN | KALRN | KCNMA1 | KLK1 | KLRK1 | KNG1 | LILRB1 | LPAR1 | LRP6 | MAP2K4 | MAP2K6 | MAP3K9 | MAPK8 | MAPK9 | MCF2L | MELK | MMP9 | MUC2 | NET1 | NGEF | NGF | NGFR | NOS2 | NOS3 | PIDD1 | PLA2G4A | PLSCR1 | PMAIP1 | PNMA2 | POU4F1 | PPARG | PPID | PPP1R15A | PRKCD | PSEN1 | PTEN | PTGS2 | RELA | RIPK2 | RPS6 | SEPT4 | SFRP1 | SOD1 | SP110 | SQSTM1 | SRC | TEX261 | TGFB1 | TLR3 | TLR4 | TNF | TNFAIP8 | TNFRSF12A | TNFSF10 | TOMM40 | TOP2A | TP53 | TP53INP1 | TRADD | TRP53 | TXNIP | UBD | VAV2 | VAV3 | WNT10B
1
18. Methotrexate positive regulation of cell death Ibuprofen Ibuprofen inhibits the reaction [Methotrexate results in increased positive regulation of cell death] 1: Homo sapiens Lung | Epithelial Cells | Cell Line, Tumor
30 genes: ACER2 | ALOX12 | AXIN2 | BMP4 | CDKN1A | CDKN1B | CTGF | CYSLTR2 | DKK1 | DNMT3A | EEF1A1 | EGR1 | FAS | GRIN2A | HBA1 | HBB | HTRA2 | IL1B | IRF1 | LPAR1 | NOD1 | NRADD | PRNP | PTGS2 | RIPK2 | SLFN13 | TRIM13 | TXNRD1 | UCP2 | ZC3H12A
1
19. Methotrexate positive regulation of DNA damage response, signal transduction by p53 class mediator [Methotrexate results in decreased susceptibility to Methotrexate] which results in decreased positive regulation of DNA damage response, signal transduction by p53 class mediator 1: Cricetulus griseus Lung | Cell Line
3 genes: ATM | DDX5 | PMAIP1
1
20. Methotrexate response to antineoplastic agent gemcitabine [Methotrexate results in decreased response to antineoplastic agent] which results in decreased susceptibility to gemcitabine 1: Homo sapiens MCF-7 Cells
2 genes: ABCB1B | ABCC2
1
21. Methotrexate positive regulation of apoptotic DNA fragmentation Methotrexate results in increased positive regulation of apoptotic DNA fragmentation 1: Homo sapiens HL-60 Cells
3 genes: BAX | ENDOG | IGFBP3
1
22. Methotrexate larval development Methotrexate results in decreased larval development 1: Lucilia cuprina  
3 genes: PPAN | PTEN | UNK
1
23. Methotrexate positive regulation of superoxide dismutase activity Aspartame [Aspartame co-treated with Methotrexate] results in increased positive regulation of superoxide dismutase activity 1: Rattus norvegicus Cerebellum 1 gene: TNF 1
24. Methotrexate positive regulation of apoptotic process Methotrexate results in increased positive regulation of apoptotic process 1: Homo sapiens T-Lymphocytes | Cell Line, Tumor
129 genes: ADM | ADRB1 | ADRB2 | AIFM2 | AKT1 | ALDH1A1 | ALOX12 | APAF1 | APBB1 | ATM | B4GALT1 | BAD | BAK1 | BAX | BBC3 | BCL2L1 | BID | BIK | BMP2 | BMP4 | BNIP3 | C1QBP | CASP2 | CASP3 | CASP6 | CASP8 | CASP9 | CCK | CDK4 | CNR1 | CREB1 | CTNNB1 | CYCE | CYR61 | DAPK3 | DDIT3 | DNAJA1 | DUSP1 | E2F1 | EIF2B5 | EIF5A | ENDOG | FAS | FGD4 | FOXO1 | GADD45A | GADD45B | GADD45G | GRIN2A | GSK3B | GZMA | HMOX1 | HPGD | HSPD1 | HTRA2 | ID3 | IFNG | IGFBP3 | IL18 | IL1B | IL6 | IRF5 | ITGA6 | ITGB1 | JUN | KALRN | KCNMA1 | KLK1 | KLRK1 | KNG1 | LILRB1 | LPAR1 | LRP6 | MAP2K4 | MAP2K6 | MAP3K9 | MAPK8 | MAPK9 | MCF2L | MELK | MMP9 | MUC2 | NET1 | NGEF | NGF | NGFR | NOS2 | NOS3 | PIDD1 | PLA2G4A | PLSCR1 | PMAIP1 | PNMA2 | POU4F1 | PPARG | PPID | PPP1R15A | PRKCD | PSEN1 | PTEN | PTGS2 | RELA | RIPK2 | RPS6 | SEPT4 | SFRP1 | SOD1 | SP110 | SQSTM1 | SRC | TEX261 | TGFB1 | TLR3 | TLR4 | TNF | TNFAIP8 | TNFRSF12A | TNFSF10 | TOMM40 | TOP2A | TP53 | TP53INP1 | TRADD | TRP53 | TXNIP | UBD | VAV2 | VAV3 | WNT10B
1
25. Methotrexate response to antineoplastic agent [Methotrexate results in decreased response to antineoplastic agent] which results in decreased susceptibility to Methotrexate 1: Homo sapiens Bone and Bones | Osteocytes | Cell Line, Tumor
2 genes: ABCB1B | ABCC2
1
26. Methotrexate lipid catabolic process Methotrexate results in increased lipid catabolic process 1: Rattus norvegicus Liver
19 genes: ABHD2 | ENPP2 | LIPC | PCK1 | PLA1A | PLA2G12A | PLA2G2A | PLA2G2C | PLA2G4A | PLA2G4C | PLCXD2 | PLD3 | PNLIP | PNLIPRP2 | PNPLA2 | PNPLA3 | PNPLA4 | SULT2A1 | TBL1XR1
2
27. Methotrexate positive regulation of apoptotic process Methotrexate results in increased positive regulation of apoptotic process 1: Homo sapiens Blood | Leukocytes, Mononuclear
129 genes: ADM | ADRB1 | ADRB2 | AIFM2 | AKT1 | ALDH1A1 | ALOX12 | APAF1 | APBB1 | ATM | B4GALT1 | BAD | BAK1 | BAX | BBC3 | BCL2L1 | BID | BIK | BMP2 | BMP4 | BNIP3 | C1QBP | CASP2 | CASP3 | CASP6 | CASP8 | CASP9 | CCK | CDK4 | CNR1 | CREB1 | CTNNB1 | CYCE | CYR61 | DAPK3 | DDIT3 | DNAJA1 | DUSP1 | E2F1 | EIF2B5 | EIF5A | ENDOG | FAS | FGD4 | FOXO1 | GADD45A | GADD45B | GADD45G | GRIN2A | GSK3B | GZMA | HMOX1 | HPGD | HSPD1 | HTRA2 | ID3 | IFNG | IGFBP3 | IL18 | IL1B | IL6 | IRF5 | ITGA6 | ITGB1 | JUN | KALRN | KCNMA1 | KLK1 | KLRK1 | KNG1 | LILRB1 | LPAR1 | LRP6 | MAP2K4 | MAP2K6 | MAP3K9 | MAPK8 | MAPK9 | MCF2L | MELK | MMP9 | MUC2 | NET1 | NGEF | NGF | NGFR | NOS2 | NOS3 | PIDD1 | PLA2G4A | PLSCR1 | PMAIP1 | PNMA2 | POU4F1 | PPARG | PPID | PPP1R15A | PRKCD | PSEN1 | PTEN | PTGS2 | RELA | RIPK2 | RPS6 | SEPT4 | SFRP1 | SOD1 | SP110 | SQSTM1 | SRC | TEX261 | TGFB1 | TLR3 | TLR4 | TNF | TNFAIP8 | TNFRSF12A | TNFSF10 | TOMM40 | TOP2A | TP53 | TP53INP1 | TRADD | TRP53 | TXNIP | UBD | VAV2 | VAV3 | WNT10B
1
28. Methotrexate positive regulation of reactive oxygen species biosynthetic process Methotrexate results in increased positive regulation of reactive oxygen species biosynthetic process 1: Homo sapiens Jurkat Cells
3 genes: HDAC4 | IL4 | TLR4
1
29. Methotrexate response to antineoplastic agent Doxorubicin [Methotrexate results in decreased response to antineoplastic agent] which results in decreased susceptibility to Doxorubicin 1: Homo sapiens MCF-7 Cells
2 genes: ABCB1B | ABCC2
1
30. Methotrexate cell death Methotrexate results in increased cell death 1: Homo sapiens Lung | Cell Line, Tumor
8 genes: AXIN2 | BNIP3 | CACNA1A | CDKN1B | GSDME | HMOX1 | IL17A | MAP3K9
1
31. Methotrexate glutathione metabolic process Aspartame [Aspartame co-treated with Methotrexate] results in increased glutathione metabolic process 1: Rattus norvegicus Hippocampus
16 genes: CTH | ETHE1 | G6PD | GCLC | GGT1 | GPX1 | GPX3 | GSR | GSTA1 | GSTA2 | GSTM1 | GSTM4 | HBB | MMACHC | SOD1 | SOD2
1
32. Methotrexate glycogen catabolic process Naproxen Naproxen inhibits the reaction [Methotrexate results in increased glycogen catabolic process] 1: Rattus norvegicus Liver 1 gene: ADRB1 1
33. Methotrexate apoptotic process Methotrexate results in increased apoptotic process 1: Homo sapiens T-Lymphocytes | Cell Line, Tumor
186 genes: ADORA2A | ADRB1 | AIM2 | AIMP2 | AKT1 | APAF1 | APBB1 | APLP1 | APP | ARG2 | ARRB1 | ATG4D | ATM | AVP | BAD | BAG3 | BAG6 | BAK1 | BAX | BBC3 | BCL2 | BCL2A1 | BCL2L1 | BCL2L12 | BECN1 | BID | BIK | BIRC3 | BNIP3 | BRCA1 | BUB1 | BUB1B | C1QBP | C5AR1 | CADM1 | CASP10 | CASP2 | CASP3 | CASP6 | CASP7 | CASP8 | CASP8AP2 | CASP9 | CASR | CCK | CCL6 | CD2 | CDK1 | CFLAR | CHEK1 | CXCR4 | CYCS | DAB2 | DAPK3 | DDIT3 | DDIT4 | DFFB | DLC1 | DNASE1 | DRAM1 | E2F1 | EIF5A | EPB41L3 | EPHA2 | ERN1 | FAS | FGF8 | FKBP8 | FOXO1 | GADD45A | GADD45B | GADD45G | GPX1 | GSN | GZMA | HIF3A | HMOX1 | HTRA2 | IFNG | IGFBP3 | IKBKG | IL17A | IL1A | IL1B | IL2RA | IRF1 | ITGB2 | ITPR1 | LCK | LMNB1 | LOK | LSP1 | LTBR | MALT1 | MAP2K4 | MAP2K6 | MAP3K7 | MAP3K9 | MAPK1 | MAPK14 | MAPK3 | MCL1 | MEF2C | MELK | MUC2 | MX1 | MYCS | MYD88 | NEK6 | NGFR | NOC2L | NOD1 | NR3C1 | NRADD | NSG1 | NUAK2 | PAK2 | PAK6 | PARP1 | PDCD7 | PDE1B | PERP | PIDD1 | PIM1 | PLAGL1 | PLSCR1 | PMAIP1 | PPARD | PPID | PPIF | PPP1R15A | PRKCA | PRKCB | PRKCD | PRKCE | PRUNE2 | PSEN1 | PSME3 | PTEN | RABEP1 | RB1 | RFFL | RIPK2 | RPS6KA3 | RPS6KB1 | S100A9 | SEMA3A | SEPT4 | SERPINB9 | SHB | SP110 | SQSTM1 | SULF1 | TAOK2 | TCHP | TGFBR2 | TICAM1 | TIGAR | TLR2 | TNF | TNFAIP3 | TNFAIP8 | TNFRSF10A | TNFRSF10B | TNFRSF11B | TNFRSF12A | TNFRSF1A | TNFRSF21 | TNFRSF25 | TNFRSF9 | TNFSF10 | TNFSF14 | TNFSF15 | TNFSF9 | TP53 | TP53INP1 | TRADD | TRAF1 | TRAF3 | TRAIP | TRIB3 | TRP53 | UXT | VIL1 | XAF1 | ZC3H12A
1
34. Methotrexate cell death FPGS [FPGS protein results in increased metabolism of Methotrexate] which results in increased cell death 1: Homo sapiens  
8 genes: AXIN2 | BNIP3 | CACNA1A | CDKN1B | GSDME | HMOX1 | IL17A | MAP3K9
1
35. Methotrexate positive regulation of cell death Tetramethylphenylenediamine Tetramethylphenylenediamine inhibits the reaction [Methotrexate results in increased positive regulation of cell death] 1: Homo sapiens Caco-2 Cells
30 genes: ACER2 | ALOX12 | AXIN2 | BMP4 | CDKN1A | CDKN1B | CTGF | CYSLTR2 | DKK1 | DNMT3A | EEF1A1 | EGR1 | FAS | GRIN2A | HBA1 | HBB | HTRA2 | IL1B | IRF1 | LPAR1 | NOD1 | NRADD | PRNP | PTGS2 | RIPK2 | SLFN13 | TRIM13 | TXNRD1 | UCP2 | ZC3H12A
1
36. Methotrexate glutathione metabolic process Aspartame | Glutathione [[Aspartame co-treated with Methotrexate] results in increased glutathione metabolic process] which results in decreased abundance of Glutathione 1: Rattus norvegicus Mesencephalon
16 genes: CTH | ETHE1 | G6PD | GCLC | GGT1 | GPX1 | GPX3 | GSR | GSTA1 | GSTA2 | GSTM1 | GSTM4 | HBB | MMACHC | SOD1 | SOD2
1
37. Methotrexate glutathione metabolic process Aspartame [Aspartame co-treated with Methotrexate] results in increased glutathione metabolic process 1: Rattus norvegicus Cerebellum
16 genes: CTH | ETHE1 | G6PD | GCLC | GGT1 | GPX1 | GPX3 | GSR | GSTA1 | GSTA2 | GSTM1 | GSTM4 | HBB | MMACHC | SOD1 | SOD2
1
38. Methotrexate positive regulation of apoptotic process ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate | PRL ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate inhibits the reaction [PRL protein inhibits the reaction [Methotrexate results in increased positive regulation of apoptotic process]] 1: Homo sapiens HL-60 Cells
129 genes: ADM | ADRB1 | ADRB2 | AIFM2 | AKT1 | ALDH1A1 | ALOX12 | APAF1 | APBB1 | ATM | B4GALT1 | BAD | BAK1 | BAX | BBC3 | BCL2L1 | BID | BIK | BMP2 | BMP4 | BNIP3 | C1QBP | CASP2 | CASP3 | CASP6 | CASP8 | CASP9 | CCK | CDK4 | CNR1 | CREB1 | CTNNB1 | CYCE | CYR61 | DAPK3 | DDIT3 | DNAJA1 | DUSP1 | E2F1 | EIF2B5 | EIF5A | ENDOG | FAS | FGD4 | FOXO1 | GADD45A | GADD45B | GADD45G | GRIN2A | GSK3B | GZMA | HMOX1 | HPGD | HSPD1 | HTRA2 | ID3 | IFNG | IGFBP3 | IL18 | IL1B | IL6 | IRF5 | ITGA6 | ITGB1 | JUN | KALRN | KCNMA1 | KLK1 | KLRK1 | KNG1 | LILRB1 | LPAR1 | LRP6 | MAP2K4 | MAP2K6 | MAP3K9 | MAPK8 | MAPK9 | MCF2L | MELK | MMP9 | MUC2 | NET1 | NGEF | NGF | NGFR | NOS2 | NOS3 | PIDD1 | PLA2G4A | PLSCR1 | PMAIP1 | PNMA2 | POU4F1 | PPARG | PPID | PPP1R15A | PRKCD | PSEN1 | PTEN | PTGS2 | RELA | RIPK2 | RPS6 | SEPT4 | SFRP1 | SOD1 | SP110 | SQSTM1 | SRC | TEX261 | TGFB1 | TLR3 | TLR4 | TNF | TNFAIP8 | TNFRSF12A | TNFSF10 | TOMM40 | TOP2A | TP53 | TP53INP1 | TRADD | TRP53 | TXNIP | UBD | VAV2 | VAV3 | WNT10B
1
39. Methotrexate apoptotic process Methotrexate results in increased apoptotic process 1: Mus musculus Embryo, Mammalian | Telencephalon | Neuroepithelial Cells
186 genes: ADORA2A | ADRB1 | AIM2 | AIMP2 | AKT1 | APAF1 | APBB1 | APLP1 | APP | ARG2 | ARRB1 | ATG4D | ATM | AVP | BAD | BAG3 | BAG6 | BAK1 | BAX | BBC3 | BCL2 | BCL2A1 | BCL2L1 | BCL2L12 | BECN1 | BID | BIK | BIRC3 | BNIP3 | BRCA1 | BUB1 | BUB1B | C1QBP | C5AR1 | CADM1 | CASP10 | CASP2 | CASP3 | CASP6 | CASP7 | CASP8 | CASP8AP2 | CASP9 | CASR | CCK | CCL6 | CD2 | CDK1 | CFLAR | CHEK1 | CXCR4 | CYCS | DAB2 | DAPK3 | DDIT3 | DDIT4 | DFFB | DLC1 | DNASE1 | DRAM1 | E2F1 | EIF5A | EPB41L3 | EPHA2 | ERN1 | FAS | FGF8 | FKBP8 | FOXO1 | GADD45A | GADD45B | GADD45G | GPX1 | GSN | GZMA | HIF3A | HMOX1 | HTRA2 | IFNG | IGFBP3 | IKBKG | IL17A | IL1A | IL1B | IL2RA | IRF1 | ITGB2 | ITPR1 | LCK | LMNB1 | LOK | LSP1 | LTBR | MALT1 | MAP2K4 | MAP2K6 | MAP3K7 | MAP3K9 | MAPK1 | MAPK14 | MAPK3 | MCL1 | MEF2C | MELK | MUC2 | MX1 | MYCS | MYD88 | NEK6 | NGFR | NOC2L | NOD1 | NR3C1 | NRADD | NSG1 | NUAK2 | PAK2 | PAK6 | PARP1 | PDCD7 | PDE1B | PERP | PIDD1 | PIM1 | PLAGL1 | PLSCR1 | PMAIP1 | PPARD | PPID | PPIF | PPP1R15A | PRKCA | PRKCB | PRKCD | PRKCE | PRUNE2 | PSEN1 | PSME3 | PTEN | RABEP1 | RB1 | RFFL | RIPK2 | RPS6KA3 | RPS6KB1 | S100A9 | SEMA3A | SEPT4 | SERPINB9 | SHB | SP110 | SQSTM1 | SULF1 | TAOK2 | TCHP | TGFBR2 | TICAM1 | TIGAR | TLR2 | TNF | TNFAIP3 | TNFAIP8 | TNFRSF10A | TNFRSF10B | TNFRSF11B | TNFRSF12A | TNFRSF1A | TNFRSF21 | TNFRSF25 | TNFRSF9 | TNFSF10 | TNFSF14 | TNFSF15 | TNFSF9 | TP53 | TP53INP1 | TRADD | TRAF1 | TRAF3 | TRAIP | TRIB3 | TRP53 | UXT | VIL1 | XAF1 | ZC3H12A
1
40. Methotrexate positive regulation of reactive oxygen species biosynthetic process sapropterin sapropterin inhibits the reaction [Methotrexate results in increased positive regulation of reactive oxygen species biosynthetic process] 1: Homo sapiens Jurkat Cells
3 genes: HDAC4 | IL4 | TLR4
1
41. Methotrexate cell death Methotrexate results in increased cell death 1: Homo sapiens Thorax | Cell Line, Tumor
8 genes: AXIN2 | BNIP3 | CACNA1A | CDKN1B | GSDME | HMOX1 | IL17A | MAP3K9
1
42. Methotrexate positive regulation of apoptotic process Tetramethylphenylenediamine Tetramethylphenylenediamine inhibits the reaction [Methotrexate results in increased positive regulation of apoptotic process] 1: Homo sapiens MCF-7 Cells
129 genes: ADM | ADRB1 | ADRB2 | AIFM2 | AKT1 | ALDH1A1 | ALOX12 | APAF1 | APBB1 | ATM | B4GALT1 | BAD | BAK1 | BAX | BBC3 | BCL2L1 | BID | BIK | BMP2 | BMP4 | BNIP3 | C1QBP | CASP2 | CASP3 | CASP6 | CASP8 | CASP9 | CCK | CDK4 | CNR1 | CREB1 | CTNNB1 | CYCE | CYR61 | DAPK3 | DDIT3 | DNAJA1 | DUSP1 | E2F1 | EIF2B5 | EIF5A | ENDOG | FAS | FGD4 | FOXO1 | GADD45A | GADD45B | GADD45G | GRIN2A | GSK3B | GZMA | HMOX1 | HPGD | HSPD1 | HTRA2 | ID3 | IFNG | IGFBP3 | IL18 | IL1B | IL6 | IRF5 | ITGA6 | ITGB1 | JUN | KALRN | KCNMA1 | KLK1 | KLRK1 | KNG1 | LILRB1 | LPAR1 | LRP6 | MAP2K4 | MAP2K6 | MAP3K9 | MAPK8 | MAPK9 | MCF2L | MELK | MMP9 | MUC2 | NET1 | NGEF | NGF | NGFR | NOS2 | NOS3 | PIDD1 | PLA2G4A | PLSCR1 | PMAIP1 | PNMA2 | POU4F1 | PPARG | PPID | PPP1R15A | PRKCD | PSEN1 | PTEN | PTGS2 | RELA | RIPK2 | RPS6 | SEPT4 | SFRP1 | SOD1 | SP110 | SQSTM1 | SRC | TEX261 | TGFB1 | TLR3 | TLR4 | TNF | TNFAIP8 | TNFRSF12A | TNFSF10 | TOMM40 | TOP2A | TP53 | TP53INP1 | TRADD | TRP53 | TXNIP | UBD | VAV2 | VAV3 | WNT10B
1
43. Methotrexate positive regulation of cell death ABCC4 ABCC4 protein inhibits the reaction [Methotrexate results in increased positive regulation of cell death] 1: Homo sapiens Prostate | Cell Line, Tumor
30 genes: ACER2 | ALOX12 | AXIN2 | BMP4 | CDKN1A | CDKN1B | CTGF | CYSLTR2 | DKK1 | DNMT3A | EEF1A1 | EGR1 | FAS | GRIN2A | HBA1 | HBB | HTRA2 | IL1B | IRF1 | LPAR1 | NOD1 | NRADD | PRNP | PTGS2 | RIPK2 | SLFN13 | TRIM13 | TXNRD1 | UCP2 | ZC3H12A
1
44. Methotrexate positive regulation of JNK cascade Methotrexate results in increased positive regulation of JNK cascade Nasal Mucosa
31 genes: APP | CCL19 | CCL21 | CEACAM1 | CTGF | F2RL1 | FCGR2B | FGF19 | GADD45A | GADD45B | GADD45G | IL1A | IL1B | IL3 | LMNB1 | LTBR | MAP3K7 | MAP4K4 | MYD88 | NOD1 | NOD2 | RIPK2 | SEMA3A | SLAMF1 | TAOK2 | TLR3 | TLR4 | TNF | TNFSF11 | WNT16 | WNT5A
1
45. Methotrexate positive regulation of cell death Celecoxib Celecoxib inhibits the reaction [Methotrexate results in increased positive regulation of cell death] 1: Homo sapiens Lung | Epithelial Cells | Cell Line, Tumor
30 genes: ACER2 | ALOX12 | AXIN2 | BMP4 | CDKN1A | CDKN1B | CTGF | CYSLTR2 | DKK1 | DNMT3A | EEF1A1 | EGR1 | FAS | GRIN2A | HBA1 | HBB | HTRA2 | IL1B | IRF1 | LPAR1 | NOD1 | NRADD | PRNP | PTGS2 | RIPK2 | SLFN13 | TRIM13 | TXNRD1 | UCP2 | ZC3H12A
1
46. Methotrexate negative regulation of mitotic cell cycle Methotrexate results in increased negative regulation of mitotic cell cycle 1: Homo sapiens Lung | Epithelial Cells | Cell Line, Tumor
12 genes: ANGEL2 | BCL2 | CDKN1B | EGFR | FOXC1 | HNF4A | IL10 | RB1 | TGFB1 | TNF | TP53 | TRP53
1
47. Methotrexate positive regulation of cell death Methotrexate results in increased positive regulation of cell death 1: Homo sapiens Hep G2 Cells
30 genes: ACER2 | ALOX12 | AXIN2 | BMP4 | CDKN1A | CDKN1B | CTGF | CYSLTR2 | DKK1 | DNMT3A | EEF1A1 | EGR1 | FAS | GRIN2A | HBA1 | HBB | HTRA2 | IL1B | IRF1 | LPAR1 | NOD1 | NRADD | PRNP | PTGS2 | RIPK2 | SLFN13 | TRIM13 | TXNRD1 | UCP2 | ZC3H12A
1
48. Methotrexate dihydrofolate biosynthetic process Methotrexate results in decreased dihydrofolate biosynthetic process 1: Homo sapiens Melanocytes | Cell Line, Tumor   1
49. Methotrexate positive regulation of apoptotic process Tetramethylphenylenediamine Tetramethylphenylenediamine inhibits the reaction [Methotrexate results in increased positive regulation of apoptotic process] 1: Homo sapiens Breast | Epithelial Cells | Cell Line, Tumor
129 genes: ADM | ADRB1 | ADRB2 | AIFM2 | AKT1 | ALDH1A1 | ALOX12 | APAF1 | APBB1 | ATM | B4GALT1 | BAD | BAK1 | BAX | BBC3 | BCL2L1 | BID | BIK | BMP2 | BMP4 | BNIP3 | C1QBP | CASP2 | CASP3 | CASP6 | CASP8 | CASP9 | CCK | CDK4 | CNR1 | CREB1 | CTNNB1 | CYCE | CYR61 | DAPK3 | DDIT3 | DNAJA1 | DUSP1 | E2F1 | EIF2B5 | EIF5A | ENDOG | FAS | FGD4 | FOXO1 | GADD45A | GADD45B | GADD45G | GRIN2A | GSK3B | GZMA | HMOX1 | HPGD | HSPD1 | HTRA2 | ID3 | IFNG | IGFBP3 | IL18 | IL1B | IL6 | IRF5 | ITGA6 | ITGB1 | JUN | KALRN | KCNMA1 | KLK1 | KLRK1 | KNG1 | LILRB1 | LPAR1 | LRP6 | MAP2K4 | MAP2K6 | MAP3K9 | MAPK8 | MAPK9 | MCF2L | MELK | MMP9 | MUC2 | NET1 | NGEF | NGF | NGFR | NOS2 | NOS3 | PIDD1 | PLA2G4A | PLSCR1 | PMAIP1 | PNMA2 | POU4F1 | PPARG | PPID | PPP1R15A | PRKCD | PSEN1 | PTEN | PTGS2 | RELA | RIPK2 | RPS6 | SEPT4 | SFRP1 | SOD1 | SP110 | SQSTM1 | SRC | TEX261 | TGFB1 | TLR3 | TLR4 | TNF | TNFAIP8 | TNFRSF12A | TNFSF10 | TOMM40 | TOP2A | TP53 | TP53INP1 | TRADD | TRP53 | TXNIP | UBD | VAV2 | VAV3 | WNT10B
1
50. Methotrexate cell proliferation resveratrol | SLC22A6 resveratrol inhibits the reaction [[SLC22A6 protein results in increased susceptibility to Methotrexate] which results in decreased cell proliferation] 1: Homo sapiens HEK293 Cells
115 genes: ACHE | AKT1 | AR | AREG | AXIN2 | BAD | BAK1 | BAX | BCL2 | BCL2L1 | BMP4 | BST2 | BUB1 | BUB1B | CD81 | CDC25A | CDC25C | CDK1 | CDK4 | CENPF | COL4A3 | CSF1 | CSF1R | CTNNB1 | CUZD1 | CXCL1 | CYR61 | DAB2 | DDIT4 | DLGAP5 | E2F8 | EGFR | ERBB2 | EREG | EVI5 | FER | FGF1 | FGF16 | FOXC1 | FPGS | FSCN1 | GAB1 | GNAI2 | GNAT1 | GPX1 | GSK3B | H3F3A | H3F3B | HDGFL3 | HHEX | IFNAR2 | IGFBP4 | IL12A | IL15RA | IL18 | IL18RAP | IL1A | IL2RA | ISG20 | KIF15 | KIF2C | KITLG | LRP2 | LY6E | MAP7 | MCM10 | MELK | MET | MKI67 | MXD1 | MYB | MYC | NDP | NRG1 | OGFOD1 | PCNA | PDK1 | PES1 | PIM1 | PLK1 | PPARD | PRDX1 | PRKAR1B | PRL | PTEN | PTMA | RAC1 | RPL23A | SH2D2A | SKI | SKP2 | SPHK2 | SRC | STAT3 | STAT4 | TACC2 | TACC3 | TACSTD2 | TGFA | TGFB1 | TGFBI | TNF | TNFSF9 | TOP1 | TOP2A | TP53 | TRAIP | TXNRD1 | UBA1 | UHRF1 | VEGFA | WNT2B | XRCC5 | ZEB1 | ZMYND11
1
1–50 of 322 results.