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Comparative Toxicogenomics Database

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These are exposure studies associated with the chemical and all of its children.

	Reference	Associated Study Title	Author's Summary	Study Factors	Stressor	Receptors	Country	Medium	Exposure Marker	Measurements	Outcome
1.	Liu L, et al. (2017).		In an experimental situation, ambient coarse particulate matter (and its biological constituents of endotoxin and beta-1,3-D-glucan) may influence neural biomarker levels that reflect perturbations of blood-brain barrier integrity and systemic stress response in volunteers.		beta-1,3-D-glucan | Endotoxins | Particulate Matter	Study subjects	Canada	blood | urine	Hydrocortisone | S100B | UCHL1 | Vanilmandelic Acid	Details
2.	Padhi BK, et al. (2017).		Burning of household fuels could be a major source of endotoxin in homes; we measured endotoxin levels in different size fractions of particulate matter (PM10, PM2.5, and PM1) in homes using LPG (propane) vs. biomass fuel (complex mixtures), and estimated the deposition of particle-bound endotoxin in the respiratory tract.		Complex Mixtures | Particulate Matter | Propane	Study subjects	India	air, indoor | lung	Carbon | Carbon Dioxide | Endotoxins | Particulate Matter	Details	Lung Diseases, Interstitial
3.	Zhang F, et al. (2015).		At the population level, there is a statistically significant association between cyanobacterial blooms and non-alcoholic liver disease in the contiguous United States.		cyanobacterial toxin	Study subjects	United States			Details	Non-alcoholic Fatty Liver Disease
4.	Stein MM, et al. (2016).		The results of our studies in humans and mice indicate that the Amish environment provides protection against asthma by engaging and shaping the innate immune response.		Dust | Endotoxins	Children	United States	air	Endotoxins	Details	Asthma | innate immune response
5.	Fessler MB, et al. (2017).	Agricultural Lung Health Study (ALHS) | National Health and Nutrition Examination Survey (NHANES)	We report an association between house dust endotoxin and leukocyte count in a national survey, and the finding was replicated in a farming population; peripheral leukocyte count may be influenced by residential endotoxin exposure in diverse settings.		Dust | Endotoxins	Study subjects | Subjects with gene influence:TLR4	United States	dust, house | dust, indoor	Endotoxins	Details	Leukocytosis | leukocyte differentiation | leukocyte homeostasis | lymphocyte differentiation | lymphocyte homeostasis | monocyte differentiation | monocyte homeostasis | neutrophil differentiation | neutrophil homeostasis
6.	Solomon GM, et al. (2006).		We assessed potential human exposure to mold spores and endotoxin in New Orleans after the flooding of the city; unlike mold spores, the airborne endotoxin concentrations did not vary with flooded status or between indoor and outdoor environments.		Endotoxins	Study subjects	United States	air, indoor | air, outdoor	Endotoxins	Details
7.	Wang Z, et al. (2012).		We examined the difference in airborne bioaerosol levels in residential indoor environments measured using a robotic personal sampling surrogate (PIPER Mk IV) and a stationary sampler equipped with identical sampling equipment. PIPER, which is designed to simulate resuspension of the dust from flooring by young children, measured significantly higher endotoxin concentrations compared to the stationary sampler.		Endotoxins	Children	United States	air	Endotoxins	Details
8.	Mendy A, et al. (2018).	National Health and Nutrition Examination Survey (NHANES)	In a population-based sample of U.S. adults, endotoxin levels in homes were associated with a self-reported history of CBE diagnosis and chronic bronchitis symptoms, with stronger associations among people sensitized to inhalant allergens.		Endotoxins	Study subjects	United States	dust, house	Endotoxins	Details	Bronchitis, Chronic | Emphysema
9.	Semple S, et al. (2010).		Airborne endotoxin concentrations in homes burning biomass fuels are orders of magnitude higher than those found in homes in developed countries where endotoxin exposure has been linked to respiratory illness in children.		Endotoxins | Particulate Matter		Malawi|Nepal		Endotoxins | Particulate Matter	Details
10.	Lai PS, et al. (2016).	Shanghai Textile Worker Study	In this workplace-based cohort of occupational organic dust and smoking exposure, we find that occupational endotoxin exposure is associated with persistent increases in lung density, lung mass, and airway thickening even after exposure cessation.		Endotoxins | Tobacco Smoke Pollution	Workers	China			Details	Lung Diseases | lung growth
11.	de Rooij MMT, et al. (2018).		The considerable spatial variation of ambient endotoxin concentrations measured in a livestock-dense area can largely be explained by land-use regression modeling based on livestock-related characteristics.		Particulate Matter		Netherlands	air	Endotoxins | Particulate Matter	Details