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Chemical Diclofenac

1–50 of 319 results.
  Chemical Phenotype Co-Mentioned Terms Interaction Organisms Anatomy Inference Network References
1. 1-O-(2-((2',6'-dichlorophenyl)amino)phenylacetyl)glucopyranuronic acid protein modification process 1-O-(2-((2',6'-dichlorophenyl)amino)phenylacetyl)glucopyranuronic acid results in increased protein modification process 1: Homo sapiens Microsomes, Liver   1
2. 4'-hydroxydiclofenac positive regulation of cell death 4'-hydroxydiclofenac results in increased positive regulation of cell death 1: Homo sapiens HL-60 Cells   1
3. 4'-hydroxydiclofenac positive regulation of cell death Hydrogen Peroxide [Hydrogen Peroxide results in increased susceptibility to 4'-hydroxydiclofenac] which results in increased positive regulation of cell death 1: Homo sapiens HL-60 Cells   1
4. 4'-hydroxydiclofenac drug metabolic process Tranylcypromine [Tranylcypromine results in decreased drug metabolic process] which results in decreased chemical synthesis of 4'-hydroxydiclofenac 1: Rattus norvegicus Hepatocytes | Cells, Cultured
2 genes: CYP2C9 | CYP2D6
1
5. 4'-hydroxydiclofenac positive regulation of mitochondrial membrane potential Hydrogen Peroxide [4'-hydroxydiclofenac results in increased susceptibility to Hydrogen Peroxide] which results in decreased positive regulation of mitochondrial membrane potential 1: Homo sapiens HL-60 Cells   1
6. 4'-hydroxydiclofenac drug metabolic process Ketoconazole [Ketoconazole results in decreased drug metabolic process] which results in decreased chemical synthesis of 4'-hydroxydiclofenac 1: Rattus norvegicus Hepatocytes | Cells, Cultured
2 genes: CYP2C9 | CYP2D6
1
7. 4'-hydroxydiclofenac glutathione metabolic process Hydrogen Peroxide [Hydrogen Peroxide results in increased susceptibility to 4'-hydroxydiclofenac] which affects glutathione metabolic process 1: Homo sapiens HL-60 Cells 1 gene: GSTP1 1
8. 4'-hydroxydiclofenac glutathione metabolic process Glutathione | Hydrogen Peroxide [[Hydrogen Peroxide results in increased susceptibility to 4'-hydroxydiclofenac] which affects glutathione metabolic process] which results in decreased abundance of Glutathione 1: Homo sapiens HL-60 Cells 1 gene: GSTP1 1
9. 4'-hydroxydiclofenac glutathione derivative biosynthetic process Glutathione | Hydrogen Peroxide | MPO 4'-hydroxydiclofenac promotes the reaction [[Hydrogen Peroxide co-treated with MPO protein co-treated with Glutathione] results in increased glutathione derivative biosynthetic process] 1: Homo sapiens   1 gene: GSTP1 1
10. 4'-hydroxydiclofenac positive regulation of mitochondrial membrane potential Hydrogen Peroxide [Hydrogen Peroxide results in increased susceptibility to 4'-hydroxydiclofenac] which results in decreased positive regulation of mitochondrial membrane potential 1: Homo sapiens HL-60 Cells   1
11. 4'-hydroxydiclofenac cell death 4'-hydroxydiclofenac results in increased cell death 1: Homo sapiens Monocytes   1
12. 4'-hydroxydiclofenac positive regulation of ATP biosynthetic process Hydrogen Peroxide [Hydrogen Peroxide results in increased susceptibility to 4'-hydroxydiclofenac] which results in decreased positive regulation of ATP biosynthetic process 1: Homo sapiens HL-60 Cells   1
13. 4'-hydroxydiclofenac positive regulation of ATP biosynthetic process Hydrogen Peroxide [4'-hydroxydiclofenac results in increased susceptibility to Hydrogen Peroxide] which results in decreased positive regulation of ATP biosynthetic process 1: Homo sapiens HL-60 Cells   1
14. 4'-hydroxydiclofenac positive regulation of cell death Hydrogen Peroxide [4'-hydroxydiclofenac results in increased susceptibility to Hydrogen Peroxide] which results in increased positive regulation of cell death 1: Homo sapiens HL-60 Cells   1
15. 4'-hydroxydiclofenac glutathione metabolic process Hydrogen Peroxide [4'-hydroxydiclofenac results in increased susceptibility to Hydrogen Peroxide] which affects glutathione metabolic process 1: Homo sapiens HL-60 Cells 1 gene: GSTP1 1
16. 4'-hydroxydiclofenac positive regulation of peroxidase activity Hydrogen Peroxide 4'-hydroxydiclofenac promotes the reaction [Hydrogen Peroxide results in increased positive regulation of peroxidase activity] 1: Homo sapiens     1
17. 4'-hydroxydiclofenac glutathione metabolic process Glutathione | Hydrogen Peroxide [[4'-hydroxydiclofenac results in increased susceptibility to Hydrogen Peroxide] which affects glutathione metabolic process] which results in decreased abundance of Glutathione 1: Homo sapiens HL-60 Cells 1 gene: GSTP1 1
18. 5-hydroxydiclofenac positive regulation of mitochondrial membrane potential Hydrogen Peroxide [5-hydroxydiclofenac results in increased susceptibility to Hydrogen Peroxide] which results in decreased positive regulation of mitochondrial membrane potential 1: Homo sapiens HL-60 Cells   1
19. 5-hydroxydiclofenac positive regulation of cell death Hydrogen Peroxide [5-hydroxydiclofenac results in increased susceptibility to Hydrogen Peroxide] which results in increased positive regulation of cell death 1: Homo sapiens HL-60 Cells   1
20. 5-hydroxydiclofenac positive regulation of ATP biosynthetic process Hydrogen Peroxide [Hydrogen Peroxide results in increased susceptibility to 5-hydroxydiclofenac] which results in decreased positive regulation of ATP biosynthetic process 1: Homo sapiens HL-60 Cells   1
21. 5-hydroxydiclofenac positive regulation of mitochondrial membrane potential Hydrogen Peroxide [Hydrogen Peroxide results in increased susceptibility to 5-hydroxydiclofenac] which results in decreased positive regulation of mitochondrial membrane potential 1: Homo sapiens HL-60 Cells   1
22. 5-hydroxydiclofenac positive regulation of cell death Hydrogen Peroxide [Hydrogen Peroxide results in increased susceptibility to 5-hydroxydiclofenac] which results in increased positive regulation of cell death 1: Homo sapiens HL-60 Cells   1
23. 5-hydroxydiclofenac drug metabolic process Ketoconazole [Ketoconazole results in decreased drug metabolic process] which results in decreased chemical synthesis of 5-hydroxydiclofenac 1: Rattus norvegicus Hepatocytes | Cells, Cultured
4 genes: CYP2B6 | CYP2C19 | CYP2D6 | CYP3A4
1
24. 5-hydroxydiclofenac apoptotic process 5-hydroxydiclofenac results in increased apoptotic process 2: Homo sapiens | Rattus norvegicus Hepatocytes | Cells, Cultured   1
25. 5-hydroxydiclofenac positive regulation of cell death 5-hydroxydiclofenac results in increased positive regulation of cell death 1: Homo sapiens HL-60 Cells   1
26. 5-hydroxydiclofenac positive regulation of ATP biosynthetic process Hydrogen Peroxide [5-hydroxydiclofenac results in increased susceptibility to Hydrogen Peroxide] which results in decreased positive regulation of ATP biosynthetic process 1: Homo sapiens HL-60 Cells   1
27. Diclofenac response to toxic substance 2-chloroethyl ethyl sulfide [Diclofenac results in decreased response to toxic substance] which results in decreased susceptibility to 2-chloroethyl ethyl sulfide 1: Mus musculus Ear | Skin
49 genes: ABCB4 | AHR | AIFM1 | ARNT | ASL | ASNS | ASS1 | ATF4 | BAX | BDH1 | BRIP1 | CASP1 | CAT | CCL3 | CDH1 | CDK2 | CDKN1A | CES1D | CHKA | CHUK | CYP17A1 | CYP1A1 | CYP1B1 | DDIT3 | EPHX1 | FAS | FOS | FOSL2 | GATA6 | GPX1 | GSTP1 | IKBKB | INMT | MAOB | MAPK1 | MAPK3 | MDM2 | NQO1 | NR1I2 | PDGFRB | PRKCA | RAD51 | RELN | SLC22A8 | SLC23A1 | SLC7A11 | SLC7A8 | TK1 | TLR2
1
28. Diclofenac positive regulation of apoptotic process TNF [Diclofenac co-treated with TNF protein] results in increased positive regulation of apoptotic process 1: Homo sapiens Hep G2 Cells
97 genes: ACIN1 | ADRB2 | AGER | AIFM1 | AKT1 | APAF1 | ARHGEF2 | ARHGEF3 | ARHGEF7 | ATF4 | BAK1 | BARD1 | BAX | BCL2L1 | BCL2L11 | BCL6 | BID | BMP4 | CAMK1D | CAPN10 | CASP1 | CASP2 | CASP3 | CASP6 | CASP8 | CASP9 | CLU | CTLA4 | CTNNB1 | CYP1B1 | CYR61 | DDIT3 | DFFA | DNAJA1 | DNAJA3 | DUSP1 | E2F1 | ECT2 | ENDOG | FAS | FASL | FOXA1 | FOXO1 | FOXO3 | GADD45A | GADD45G | GATA6 | GNA13 | GNAQ | GPLD1 | GSK3B | HIF1A | HMGB1 | HMOX1 | HPGD | ID3 | IFNG | IGFBP3 | IL1B | IL6 | ITGB1 | JUN | KLK1 | KNG1 | LDHA | MAP2K6 | MAP3K1 | MAPK8 | MNDA | NOS2 | P2RX7 | PDGFRB | PHLDA1 | PLSCR1 | PMAIP1 | PPARG | PPP1R15A | PTEN | PTGS2 | PYCARD | RACK1 | RELA | RHOB | SNCA | SOD1 | SOS1 | SOS2 | SRC | TCF7L2 | TGFB2 | TNF | TP53 | TRP53 | TRP53INP1 | TSC22D1 | TXNIP | UBC
1
29. Diclofenac positive regulation of cell death Diclofenac results in increased positive regulation of cell death 1: Homo sapiens HL-60 Cells
17 genes: AIFM1 | BCL2L11 | BMP4 | CDKN1A | CDKN1B | DKK1 | EGR1 | EIF4G1 | FAS | HBB | HMGB1 | HP | IL1B | PAX6 | PTGS2 | TXNRD1 | UCP2
1
30. Diclofenac positive regulation of cell death Diclofenac affects positive regulation of cell death 1: Homo sapiens Hep G2 Cells
17 genes: AIFM1 | BCL2L11 | BMP4 | CDKN1A | CDKN1B | DKK1 | EGR1 | EIF4G1 | FAS | HBB | HMGB1 | HP | IL1B | PAX6 | PTGS2 | TXNRD1 | UCP2
1
31. Diclofenac superoxide dismutase activity Freund's Adjuvant Diclofenac inhibits the reaction [Freund's Adjuvant results in decreased superoxide dismutase activity] 1: Rattus norvegicus Membranes
3 genes: NQO1 | SOD1 | SOD2
1
32. Diclofenac cell death Arachidonic Acid Arachidonic Acid promotes the reaction [Diclofenac results in increased cell death] 1: Homo sapiens Cell Line, Tumor
6 genes: CAMP | CDKN1B | FOSL2 | HMOX1 | IL17A | TGFB2
1
33. Diclofenac positive regulation of eating behavior Curcumin Curcumin inhibits the reaction [Diclofenac results in decreased positive regulation of eating behavior] 1: Rattus norvegicus     1
34. Diclofenac hepatocyte differentiation Acetylcysteine | CASP8 | Dimethyl Sulfoxide | TNF Acetylcysteine inhibits the reaction [TNF protein inhibits the reaction [[[Dimethyl Sulfoxide results in increased hepatocyte differentiation] which results in decreased susceptibility to Diclofenac] inhibits the reaction [Diclofenac results in increased activity of CASP8 protein]]] 1: Homo sapiens Hepatocytes | Cell Line
6 genes: CYP1A1 | HHEX | HNF4A | ITGA2 | MIR122 | PCK1
1
35. Diclofenac positive regulation of ATP biosynthetic process Hydrogen Peroxide [Hydrogen Peroxide results in increased susceptibility to Diclofenac] which results in decreased positive regulation of ATP biosynthetic process 1: Homo sapiens HL-60 Cells
5 genes: BCL2L1 | ENO1 | MYC | PPARGC1A | STAT3
1
36. Diclofenac membrane lipid catabolic process Salicylic Acid Diclofenac inhibits the reaction [Salicylic Acid results in increased membrane lipid catabolic process] 1: Rattus norvegicus Microsomes, Liver 1 gene: CYP1B1 1
37. Diclofenac positive regulation of lipid storage 1-Methyl-3-isobutylxanthine | Dexamethasone | INS Diclofenac promotes the reaction [[Dexamethasone co-treated with INS protein co-treated with 1-Methyl-3-isobutylxanthine] results in increased positive regulation of lipid storage] 1: Mus musculus 3T3-L1 Cells
3 genes: AKT1 | IKBKE | NFKB1
1
38. Diclofenac maintenance of gastrointestinal epithelium Curcumin Curcumin inhibits the reaction [Diclofenac results in decreased maintenance of gastrointestinal epithelium] 1: Rattus norvegicus Stomach   1
39. Diclofenac glutathione metabolic process Fluoxetine | Ibuprofen [Ibuprofen co-treated with Diclofenac co-treated with Fluoxetine] results in increased glutathione metabolic process 1: Mytilus galloprovincialis Digestive System
20 genes: CTH | GCLC | GCLM | GGT1 | GPX1 | GSR | GSTA1 | GSTA3 | GSTA4 | GSTA5 | GSTM1 | GSTM2 | GSTM3 | GSTM4 | GSTP1 | GSTT1 | GSTT3 | HBB | SOD1 | SOD2
1
40. Diclofenac hepatocyte differentiation benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone | CASP8 | Dimethyl Sulfoxide benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [[[Dimethyl Sulfoxide results in increased hepatocyte differentiation] which results in decreased susceptibility to Diclofenac] affects the reaction [Diclofenac results in increased activity of CASP8 protein]] 1: Homo sapiens Hepatocytes | Cell Line
6 genes: CYP1A1 | HHEX | HNF4A | ITGA2 | MIR122 | PCK1
1
41. Diclofenac cell proliferation Diclofenac analog results in decreased cell proliferation 1: Homo sapiens Human Umbilical Vein Endothelial Cells
60 genes: ACVR2B | AKT1 | BAK1 | BAX | BCL2L1 | BMP4 | CDK5 | CDK7 | CSF1 | CSF1R | CTNNB1 | CXCL1 | CYP1A1 | CYR61 | DDIT4 | DTYMK | EGFR | ENTPD5 | EPO | FER | FGF1 | GAB1 | GNAT1 | GPX1 | GSK3B | HHEX | HRAS | IL1A | ISG20 | ITGA2 | LY6E | MCM7 | MET | MVP | MXD1 | MYC | NCF1 | NR6A1 | PCNA | PRG4 | PRL | PROK2 | PTEN | SMAD4 | SRC | STAT3 | STAT4 | TCF7L2 | TFDP1 | TGFA | TGFB2 | TNF | TP53 | TXN | TXNRD1 | TYR | USP28 | VEGFA | WNT3A | ZEB1
1
42. Diclofenac hepatocyte differentiation DDIT3 | Dimethyl Sulfoxide [[Dimethyl Sulfoxide results in increased hepatocyte differentiation] which results in decreased susceptibility to Diclofenac] inhibits the reaction [Diclofenac results in increased expression of DDIT3 mRNA] 1: Homo sapiens Hepatocytes | Cell Line
6 genes: CYP1A1 | HHEX | HNF4A | ITGA2 | MIR122 | PCK1
1
43. Diclofenac lipid catabolic process Ranitidine Ranitidine inhibits the reaction [Diclofenac results in increased lipid catabolic process] 1: Rattus norvegicus Stomach
16 genes: APOA4 | CES1D | CYP39A1 | ENPP2 | IRS1 | LIPC | LPL | MGLL | NAPEPLD | PCK1 | PLA2G12A | PLA2G4C | PLA2G7 | PLCG1 | PLD1 | PNLIPRP2
1
44. Diclofenac glycogen biosynthetic process Diclofenac affects glycogen biosynthetic process 1: Mus musculus Liver
3 genes: AKT1 | AKT2 | GCK
1
45. Diclofenac hepatocyte differentiation CXCL8 | Dimethyl Sulfoxide | TNF [TNF protein inhibits the reaction [[Dimethyl Sulfoxide results in increased hepatocyte differentiation] which results in decreased susceptibility to Diclofenac]] which results in decreased expression of CXCL8 mRNA 1: Homo sapiens Hepatocytes | Cell Line
6 genes: CYP1A1 | HHEX | HNF4A | ITGA2 | MIR122 | PCK1
1
46. Diclofenac positive regulation of cell death CYP2C9 CYP2C9 protein promotes the reaction [Diclofenac results in increased positive regulation of cell death] 1: Homo sapiens Hep G2 Cells
17 genes: AIFM1 | BCL2L11 | BMP4 | CDKN1A | CDKN1B | DKK1 | EGR1 | EIF4G1 | FAS | HBB | HMGB1 | HP | IL1B | PAX6 | PTGS2 | TXNRD1 | UCP2
1
47. Diclofenac cell differentiation rosiglitazone Diclofenac inhibits the reaction [rosiglitazone results in increased cell differentiation] Adipocytes
60 genes: AGGF1 | AGO2 | AKT1 | ANG | APAF1 | ARHGEF2 | ARNT | BMP4 | BMP6 | BRAF | CDK6 | CEBPB | CHL1 | CREB3L4 | CSF1 | CTBP2 | CTNNB1 | DPYSL2 | ECT2 | EIF2AK4 | EPAS1 | FGF1 | FGF3 | FNBP1 | FOXA3 | FOXO1 | FZD5 | GADD45G | GNA13 | GSK3B | HES6 | HHEX | HIF1A | HNF4A | HS6ST2 | INHBB | LGALS3 | MECOM | MEF2A | NEDD4L | NR6A1 | NRP1 | PAX6 | PDILT | PIK3CD | RHOB | RORC | SARM1 | SEMA4B | SERPINE2 | SMARCB1 | SRD5A1 | STMN1 | SUV39H1 | TCF3 | TDRD7 | TP53 | VEGFA | XBP1 | ZEB1
1
48. Diclofenac positive regulation of JNK cascade 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Diclofenac results in increased positive regulation of JNK cascade] 1: Homo sapiens Hep G2 Cells
16 genes: AGER | FZD7 | GADD45A | GADD45G | HMGB1 | HRAS | IL1A | IL1B | MAP3K7 | MAP4K4 | MYD88 | NCF1 | PYCARD | SERPINF2 | TIRAP | TNF
1
49. Diclofenac positive regulation of apoptotic process EIF4A1 | TNF EIF4A1 affects the reaction [[TNF protein co-treated with Diclofenac] results in increased positive regulation of apoptotic process] 1: Homo sapiens Hep G2 Cells
97 genes: ACIN1 | ADRB2 | AGER | AIFM1 | AKT1 | APAF1 | ARHGEF2 | ARHGEF3 | ARHGEF7 | ATF4 | BAK1 | BARD1 | BAX | BCL2L1 | BCL2L11 | BCL6 | BID | BMP4 | CAMK1D | CAPN10 | CASP1 | CASP2 | CASP3 | CASP6 | CASP8 | CASP9 | CLU | CTLA4 | CTNNB1 | CYP1B1 | CYR61 | DDIT3 | DFFA | DNAJA1 | DNAJA3 | DUSP1 | E2F1 | ECT2 | ENDOG | FAS | FASL | FOXA1 | FOXO1 | FOXO3 | GADD45A | GADD45G | GATA6 | GNA13 | GNAQ | GPLD1 | GSK3B | HIF1A | HMGB1 | HMOX1 | HPGD | ID3 | IFNG | IGFBP3 | IL1B | IL6 | ITGB1 | JUN | KLK1 | KNG1 | LDHA | MAP2K6 | MAP3K1 | MAPK8 | MNDA | NOS2 | P2RX7 | PDGFRB | PHLDA1 | PLSCR1 | PMAIP1 | PPARG | PPP1R15A | PTEN | PTGS2 | PYCARD | RACK1 | RELA | RHOB | SNCA | SOD1 | SOS1 | SOS2 | SRC | TCF7L2 | TGFB2 | TNF | TP53 | TRP53 | TRP53INP1 | TSC22D1 | TXNIP | UBC
1
50. Diclofenac positive regulation of prostaglandin biosynthetic process Oligomycins Diclofenac inhibits the reaction [Oligomycins results in increased positive regulation of prostaglandin biosynthetic process] 1: Homo sapiens Synovial Membrane | Fibroblasts | Cells, Cultured
2 genes: PPARG | PTGS2
1
1–50 of 319 results.