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Chemical Diclofenac

1–50 of 292 results.
  Chemical Phenotype Co-Mentioned Terms Interaction Organisms Anatomy Inference Network References
1. 1-O-(2-((2',6'-dichlorophenyl)amino)phenylacetyl)glucopyranuronic acid protein modification process 1-O-(2-((2',6'-dichlorophenyl)amino)phenylacetyl)glucopyranuronic acid results in increased protein modification process 1: Homo sapiens Microsomes, Liver   1
2. 4'-hydroxydiclofenac glutathione derivative biosynthetic process Glutathione | Hydrogen Peroxide | MPO 4'-hydroxydiclofenac promotes the reaction [[Hydrogen Peroxide co-treated with MPO protein co-treated with Glutathione] results in increased glutathione derivative biosynthetic process] 1: Homo sapiens   1 gene: GSTP1 1
3. 4'-hydroxydiclofenac positive regulation of ATP biosynthetic process Hydrogen Peroxide [4'-hydroxydiclofenac results in increased susceptibility to Hydrogen Peroxide] which results in decreased positive regulation of ATP biosynthetic process 1: Homo sapiens HL-60 Cells   1
4. 4'-hydroxydiclofenac cell death 4'-hydroxydiclofenac results in increased cell death 1: Homo sapiens Monocytes   1
5. 4'-hydroxydiclofenac positive regulation of ATP biosynthetic process Hydrogen Peroxide [Hydrogen Peroxide results in increased susceptibility to 4'-hydroxydiclofenac] which results in decreased positive regulation of ATP biosynthetic process 1: Homo sapiens HL-60 Cells   1
6. 4'-hydroxydiclofenac glutathione metabolic process Glutathione | Hydrogen Peroxide [[4'-hydroxydiclofenac results in increased susceptibility to Hydrogen Peroxide] which affects glutathione metabolic process] which results in decreased abundance of Glutathione 1: Homo sapiens HL-60 Cells 1 gene: GSTP1 1
7. 4'-hydroxydiclofenac positive regulation of cell death Hydrogen Peroxide [4'-hydroxydiclofenac results in increased susceptibility to Hydrogen Peroxide] which results in increased positive regulation of cell death 1: Homo sapiens HL-60 Cells   1
8. 4'-hydroxydiclofenac positive regulation of mitochondrial membrane potential Hydrogen Peroxide [4'-hydroxydiclofenac results in increased susceptibility to Hydrogen Peroxide] which results in decreased positive regulation of mitochondrial membrane potential 1: Homo sapiens HL-60 Cells   1
9. 4'-hydroxydiclofenac glutathione metabolic process Hydrogen Peroxide [4'-hydroxydiclofenac results in increased susceptibility to Hydrogen Peroxide] which affects glutathione metabolic process 1: Homo sapiens HL-60 Cells 1 gene: GSTP1 1
10. 4'-hydroxydiclofenac positive regulation of peroxidase activity Hydrogen Peroxide 4'-hydroxydiclofenac promotes the reaction [Hydrogen Peroxide results in increased positive regulation of peroxidase activity] 1: Homo sapiens     1
11. 4'-hydroxydiclofenac positive regulation of cell death Hydrogen Peroxide [Hydrogen Peroxide results in increased susceptibility to 4'-hydroxydiclofenac] which results in increased positive regulation of cell death 1: Homo sapiens HL-60 Cells   1
12. 4'-hydroxydiclofenac positive regulation of mitochondrial membrane potential Hydrogen Peroxide [Hydrogen Peroxide results in increased susceptibility to 4'-hydroxydiclofenac] which results in decreased positive regulation of mitochondrial membrane potential 1: Homo sapiens HL-60 Cells   1
13. 4'-hydroxydiclofenac drug metabolic process Ketoconazole [Ketoconazole results in decreased drug metabolic process] which results in decreased chemical synthesis of 4'-hydroxydiclofenac 1: Rattus norvegicus Hepatocytes | Cells, Cultured
2 genes: CYP2C9 | CYP2D6
1
14. 4'-hydroxydiclofenac glutathione metabolic process Hydrogen Peroxide [Hydrogen Peroxide results in increased susceptibility to 4'-hydroxydiclofenac] which affects glutathione metabolic process 1: Homo sapiens HL-60 Cells 1 gene: GSTP1 1
15. 4'-hydroxydiclofenac positive regulation of cell death 4'-hydroxydiclofenac results in increased positive regulation of cell death 1: Homo sapiens HL-60 Cells   1
16. 4'-hydroxydiclofenac glutathione metabolic process Glutathione | Hydrogen Peroxide [[Hydrogen Peroxide results in increased susceptibility to 4'-hydroxydiclofenac] which affects glutathione metabolic process] which results in decreased abundance of Glutathione 1: Homo sapiens HL-60 Cells 1 gene: GSTP1 1
17. 4'-hydroxydiclofenac drug metabolic process Tranylcypromine [Tranylcypromine results in decreased drug metabolic process] which results in decreased chemical synthesis of 4'-hydroxydiclofenac 1: Rattus norvegicus Hepatocytes | Cells, Cultured
2 genes: CYP2C9 | CYP2D6
1
18. 5-hydroxydiclofenac drug metabolic process Ketoconazole [Ketoconazole results in decreased drug metabolic process] which results in decreased chemical synthesis of 5-hydroxydiclofenac 1: Rattus norvegicus Hepatocytes | Cells, Cultured
4 genes: CYP2B6 | CYP2C19 | CYP2D6 | CYP3A4
1
19. 5-hydroxydiclofenac positive regulation of mitochondrial membrane potential Hydrogen Peroxide [Hydrogen Peroxide results in increased susceptibility to 5-hydroxydiclofenac] which results in decreased positive regulation of mitochondrial membrane potential 1: Homo sapiens HL-60 Cells   1
20. 5-hydroxydiclofenac positive regulation of cell death Hydrogen Peroxide [5-hydroxydiclofenac results in increased susceptibility to Hydrogen Peroxide] which results in increased positive regulation of cell death 1: Homo sapiens HL-60 Cells   1
21. 5-hydroxydiclofenac positive regulation of mitochondrial membrane potential Hydrogen Peroxide [5-hydroxydiclofenac results in increased susceptibility to Hydrogen Peroxide] which results in decreased positive regulation of mitochondrial membrane potential 1: Homo sapiens HL-60 Cells   1
22. 5-hydroxydiclofenac positive regulation of ATP biosynthetic process Hydrogen Peroxide [Hydrogen Peroxide results in increased susceptibility to 5-hydroxydiclofenac] which results in decreased positive regulation of ATP biosynthetic process 1: Homo sapiens HL-60 Cells   1
23. 5-hydroxydiclofenac positive regulation of cell death Hydrogen Peroxide [Hydrogen Peroxide results in increased susceptibility to 5-hydroxydiclofenac] which results in increased positive regulation of cell death 1: Homo sapiens HL-60 Cells   1
24. 5-hydroxydiclofenac positive regulation of cell death 5-hydroxydiclofenac results in increased positive regulation of cell death 1: Homo sapiens HL-60 Cells   1
25. 5-hydroxydiclofenac apoptotic process 5-hydroxydiclofenac results in increased apoptotic process 2: Homo sapiens | Rattus norvegicus Hepatocytes | Cells, Cultured   1
26. 5-hydroxydiclofenac positive regulation of ATP biosynthetic process Hydrogen Peroxide [5-hydroxydiclofenac results in increased susceptibility to Hydrogen Peroxide] which results in decreased positive regulation of ATP biosynthetic process 1: Homo sapiens HL-60 Cells   1
27. Diclofenac positive regulation of reactive oxygen species biosynthetic process Diclofenac results in increased positive regulation of reactive oxygen species biosynthetic process 1: Homo sapiens Hep G2 Cells
3 genes: CYBA | FOXO3 | IL4
1
28. Diclofenac regulation of membrane potential Diclofenac affects regulation of membrane potential 1: Rattus norvegicus Myoblasts | Cells, Cultured
4 genes: ALOX15 | ASIC1 | ASIC2 | NEDD4L
1
29. Diclofenac glutathione peroxidase activity Freund's Adjuvant Diclofenac inhibits the reaction [Freund's Adjuvant results in decreased glutathione peroxidase activity] 1: Rattus norvegicus Membranes
6 genes: GPX1 | GPX2 | GSTA1 | GSTM2 | GSTP1 | GSTT1
1
30. Diclofenac glutathione biosynthetic process Freund's Adjuvant Diclofenac inhibits the reaction [Freund's Adjuvant results in decreased glutathione biosynthetic process] 1: Rattus norvegicus Membranes
4 genes: CHAC1 | GCLC | GCLM | GGT1
1
31. Diclofenac positive regulation of superoxide anion generation Diclofenac results in increased positive regulation of superoxide anion generation 1: Homo sapiens Hep G2 Cells | Mitochondria
8 genes: CRP | CXCL1 | CYBA | EGFR | FPR2 | GSTP1 | ITGAM | ITGB2
1
32. Diclofenac lipid oxidation Fluoxetine | Ibuprofen [Ibuprofen co-treated with Diclofenac co-treated with Fluoxetine] results in increased lipid oxidation 1: Mytilus galloprovincialis Gills 1 gene: PLA2G7 1
33. Diclofenac positive regulation of vitellogenesis Copper | Fluoxetine | Ibuprofen [Ibuprofen co-treated with Diclofenac co-treated with Fluoxetine co-treated with Copper] results in increased positive regulation of vitellogenesis 1: Mytilus galloprovincialis Gonads   1
34. Diclofenac positive regulation of ERK1 and ERK2 cascade 2-aminoethoxydiphenyl borate 2-aminoethoxydiphenyl borate inhibits the reaction [Diclofenac results in increased positive regulation of ERK1 and ERK2 cascade] 1: Homo sapiens Hep G2 Cells
40 genes: ABL2 | ACKR3 | AGER | ALOX15 | ARHGEF2 | BMP4 | BRAF | CCL3 | CCR1 | CD44 | CFLAR | CSF1R | DDT | EGFR | EPO | FGB | FGG | FPR2 | GATA4 | HMGB1 | HRAS | ICAM1 | IL1A | IL1B | IL6 | ITGB3 | JUN | MAPK3 | MARCO | NRP1 | PDGFRB | PRKCA | PTEN | PYCARD | SERPINF2 | SRC | TIRAP | TLR2 | TNF | VEGFA
1
35. Diclofenac positive regulation of apoptotic process DDIT3 | TNF DDIT3 affects the reaction [[TNF protein co-treated with Diclofenac] results in increased positive regulation of apoptotic process] 1: Homo sapiens Hep G2 Cells
96 genes: ACIN1 | ADRB2 | AGER | AIFM1 | AKT1 | APAF1 | ARHGEF2 | ARHGEF3 | ARHGEF7 | ATF4 | BAK1 | BARD1 | BAX | BCL2L1 | BCL2L11 | BCL6 | BID | BMP4 | CAMK1D | CAPN10 | CASP1 | CASP2 | CASP3 | CASP6 | CASP8 | CASP9 | CLU | CTLA4 | CTNNB1 | CYP1B1 | CYR61 | DDIT3 | DFFA | DNAJA1 | DNAJA3 | DUSP1 | E2F1 | ECT2 | ENDOG | FAS | FASL | FOXA1 | FOXO1 | FOXO3 | GADD45A | GADD45G | GATA6 | GNA13 | GNAQ | GPLD1 | GSK3B | HIF1A | HMGB1 | HMOX1 | HPGD | ID3 | IFNG | IGFBP3 | IL1B | IL6 | ITGB1 | JUN | KLK1 | KNG1 | LDHA | MAP2K6 | MAP3K1 | MAPK8 | MNDA | NOS2 | P2RX7 | PDGFRB | PHLDA1 | PLSCR1 | PMAIP1 | PPARG | PPP1R15A | PTEN | PTGS2 | PYCARD | RACK1 | RELA | RHOB | SNCA | SOS1 | SOS2 | SRC | TCF7L2 | TGFB2 | TNF | TP53 | TRP53 | TRP53INP1 | TSC22D1 | TXNIP | UBC
1
36. Diclofenac positive regulation of apoptotic process Diclofenac results in increased positive regulation of apoptotic process 1: Homo sapiens Hep G2 Cells
96 genes: ACIN1 | ADRB2 | AGER | AIFM1 | AKT1 | APAF1 | ARHGEF2 | ARHGEF3 | ARHGEF7 | ATF4 | BAK1 | BARD1 | BAX | BCL2L1 | BCL2L11 | BCL6 | BID | BMP4 | CAMK1D | CAPN10 | CASP1 | CASP2 | CASP3 | CASP6 | CASP8 | CASP9 | CLU | CTLA4 | CTNNB1 | CYP1B1 | CYR61 | DDIT3 | DFFA | DNAJA1 | DNAJA3 | DUSP1 | E2F1 | ECT2 | ENDOG | FAS | FASL | FOXA1 | FOXO1 | FOXO3 | GADD45A | GADD45G | GATA6 | GNA13 | GNAQ | GPLD1 | GSK3B | HIF1A | HMGB1 | HMOX1 | HPGD | ID3 | IFNG | IGFBP3 | IL1B | IL6 | ITGB1 | JUN | KLK1 | KNG1 | LDHA | MAP2K6 | MAP3K1 | MAPK8 | MNDA | NOS2 | P2RX7 | PDGFRB | PHLDA1 | PLSCR1 | PMAIP1 | PPARG | PPP1R15A | PTEN | PTGS2 | PYCARD | RACK1 | RELA | RHOB | SNCA | SOS1 | SOS2 | SRC | TCF7L2 | TGFB2 | TNF | TP53 | TRP53 | TRP53INP1 | TSC22D1 | TXNIP | UBC
2
37. Diclofenac vasodilation Carbachol | Cyclosporine Diclofenac inhibits the reaction [Cyclosporine inhibits the reaction [Carbachol results in increased vasodilation]] 1: Rattus norvegicus Kidney | Blood Vessels
8 genes: ADORA2A | ALB | CALCA | DRD1 | GPX1 | KNG1 | P2RX4 | SOD2
1
38. Diclofenac hepatocyte differentiation Dimethyl Sulfoxide [Dimethyl Sulfoxide results in increased hepatocyte differentiation] which results in decreased susceptibility to Diclofenac 1: Homo sapiens Hepatocytes | Cell Line
6 genes: CYP1A1 | HHEX | HNF4A | ITGA2 | MIR122 | PCK1
1
39. Diclofenac lipid catabolic process Ranitidine [Ranitidine co-treated with Diclofenac] results in increased lipid catabolic process 1: Rattus norvegicus Intestines
16 genes: APOA4 | CES1D | CYP39A1 | ENPP2 | IRS1 | LIPC | LPL | MGLL | NAPEPLD | PCK1 | PLA2G12A | PLA2G4C | PLA2G7 | PLCG1 | PLD1 | PNLIPRP2
1
40. Diclofenac leukocyte tethering or rolling Enalapril Enalapril inhibits the reaction [Diclofenac results in decreased leukocyte tethering or rolling] 1: Rattus norvegicus Leukocytes
8 genes: CHST4 | ITGB1 | ROCK1 | SELE | SELL | SELP | TNF | VCAM1
1
41. Diclofenac positive regulation of cell death Diclofenac affects positive regulation of cell death 1: Homo sapiens Hep G2 Cells
17 genes: AIFM1 | BCL2L11 | BMP4 | CDKN1A | CDKN1B | DKK1 | EGR1 | EIF4G1 | FAS | HBB | HMGB1 | HP | IL1B | PAX6 | PTGS2 | TXNRD1 | UCP2
1
42. Diclofenac membrane lipid catabolic process Diclofenac results in decreased membrane lipid catabolic process 1: Rattus norvegicus Microsomes, Liver 1 gene: CYP1B1 1
43. Diclofenac positive regulation of apoptotic process salubrinal | TNF salubrinal inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased positive regulation of apoptotic process] 1: Homo sapiens Hep G2 Cells
96 genes: ACIN1 | ADRB2 | AGER | AIFM1 | AKT1 | APAF1 | ARHGEF2 | ARHGEF3 | ARHGEF7 | ATF4 | BAK1 | BARD1 | BAX | BCL2L1 | BCL2L11 | BCL6 | BID | BMP4 | CAMK1D | CAPN10 | CASP1 | CASP2 | CASP3 | CASP6 | CASP8 | CASP9 | CLU | CTLA4 | CTNNB1 | CYP1B1 | CYR61 | DDIT3 | DFFA | DNAJA1 | DNAJA3 | DUSP1 | E2F1 | ECT2 | ENDOG | FAS | FASL | FOXA1 | FOXO1 | FOXO3 | GADD45A | GADD45G | GATA6 | GNA13 | GNAQ | GPLD1 | GSK3B | HIF1A | HMGB1 | HMOX1 | HPGD | ID3 | IFNG | IGFBP3 | IL1B | IL6 | ITGB1 | JUN | KLK1 | KNG1 | LDHA | MAP2K6 | MAP3K1 | MAPK8 | MNDA | NOS2 | P2RX7 | PDGFRB | PHLDA1 | PLSCR1 | PMAIP1 | PPARG | PPP1R15A | PTEN | PTGS2 | PYCARD | RACK1 | RELA | RHOB | SNCA | SOS1 | SOS2 | SRC | TCF7L2 | TGFB2 | TNF | TP53 | TRP53 | TRP53INP1 | TSC22D1 | TXNIP | UBC
1
44. Diclofenac hepatocyte differentiation Acetylcysteine | CASP8 | Dimethyl Sulfoxide Acetylcysteine inhibits the reaction [[[Dimethyl Sulfoxide results in increased hepatocyte differentiation] which results in decreased susceptibility to Diclofenac] affects the reaction [Diclofenac results in increased activity of CASP8 protein]] 1: Homo sapiens Hepatocytes | Cell Line
6 genes: CYP1A1 | HHEX | HNF4A | ITGA2 | MIR122 | PCK1
1
45. Diclofenac regulation of mitochondrial membrane potential 1,2-Dimethylhydrazine Diclofenac affects the reaction [1,2-Dimethylhydrazine affects regulation of mitochondrial membrane potential] 1: Rattus norvegicus Colon
7 genes: ADORA2A | BAK1 | BAX | BCL2L1 | SLC25A33 | SOD2 | UCP2
1
46. Diclofenac hepatocyte differentiation CRP | Dimethyl Sulfoxide | TNF [TNF protein inhibits the reaction [[Dimethyl Sulfoxide results in increased hepatocyte differentiation] which results in decreased susceptibility to Diclofenac]] which results in decreased expression of CRP mRNA 1: Homo sapiens Hepatocytes | Cell Line
6 genes: CYP1A1 | HHEX | HNF4A | ITGA2 | MIR122 | PCK1
1
47. Diclofenac positive regulation of JNK cascade 2-aminoethoxydiphenyl borate 2-aminoethoxydiphenyl borate inhibits the reaction [Diclofenac results in increased positive regulation of JNK cascade] 1: Homo sapiens Hep G2 Cells
16 genes: AGER | FZD7 | GADD45A | GADD45G | HMGB1 | HRAS | IL1A | IL1B | MAP3K7 | MAP4K4 | MYD88 | NCF1 | PYCARD | SERPINF2 | TIRAP | TNF
1
48. Diclofenac lipid oxidation Diclofenac results in increased lipid oxidation 1: Rattus norvegicus Intestine, Small 1 gene: PLA2G7 1
49. Diclofenac positive regulation of apoptotic process TNF | Tunicamycin Tunicamycin inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased positive regulation of apoptotic process] 1: Homo sapiens Hep G2 Cells
96 genes: ACIN1 | ADRB2 | AGER | AIFM1 | AKT1 | APAF1 | ARHGEF2 | ARHGEF3 | ARHGEF7 | ATF4 | BAK1 | BARD1 | BAX | BCL2L1 | BCL2L11 | BCL6 | BID | BMP4 | CAMK1D | CAPN10 | CASP1 | CASP2 | CASP3 | CASP6 | CASP8 | CASP9 | CLU | CTLA4 | CTNNB1 | CYP1B1 | CYR61 | DDIT3 | DFFA | DNAJA1 | DNAJA3 | DUSP1 | E2F1 | ECT2 | ENDOG | FAS | FASL | FOXA1 | FOXO1 | FOXO3 | GADD45A | GADD45G | GATA6 | GNA13 | GNAQ | GPLD1 | GSK3B | HIF1A | HMGB1 | HMOX1 | HPGD | ID3 | IFNG | IGFBP3 | IL1B | IL6 | ITGB1 | JUN | KLK1 | KNG1 | LDHA | MAP2K6 | MAP3K1 | MAPK8 | MNDA | NOS2 | P2RX7 | PDGFRB | PHLDA1 | PLSCR1 | PMAIP1 | PPARG | PPP1R15A | PTEN | PTGS2 | PYCARD | RACK1 | RELA | RHOB | SNCA | SOS1 | SOS2 | SRC | TCF7L2 | TGFB2 | TNF | TP53 | TRP53 | TRP53INP1 | TSC22D1 | TXNIP | UBC
1
50. Diclofenac cell differentiation Diclofenac results in decreased cell differentiation 1: Mus musculus Neural Stem Cells | Cells, Cultured
60 genes: AGGF1 | AGO2 | AKT1 | ANG | APAF1 | ARHGEF2 | ARNT | BMP4 | BMP6 | BRAF | CDK6 | CEBPB | CHL1 | CREB3L4 | CSF1 | CTBP2 | CTNNB1 | DPYSL2 | ECT2 | EIF2AK4 | EPAS1 | FGF1 | FGF3 | FNBP1 | FOXA3 | FOXO1 | FZD5 | GADD45G | GNA13 | GSK3B | HES6 | HHEX | HIF1A | HNF4A | HS6ST2 | INHBB | LGALS3 | MECOM | MEF2A | NEDD4L | NR6A1 | NRP1 | PAX6 | PDILT | PIK3CD | RHOB | RORC | SARM1 | SEMA4B | SERPINE2 | SMARCB1 | SRD5A1 | STMN1 | SUV39H1 | TCF3 | TDRD7 | TP53 | VEGFA | XBP1 | ZEB1
1
1–50 of 292 results.