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Chemical Heterocyclic Compounds, Bridged-Ring

1–50 of 1,359 results.
  Chemical Phenotype Co-Mentioned Terms Interaction Organisms Anatomy Inference Network References
1. (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane cell death Sodium Selenite [Sodium Selenite results in increased susceptibility to (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane] which results in increased cell death 1: Homo sapiens A549 Cells   1
2. (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane cell proliferation (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane results in decreased cell proliferation 1: Homo sapiens A549 Cells
6 genes: BAX | BCL2 | CDK1 | CDK4 | TXN | TXNRD1
1
3. (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane cell proliferation (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane results in decreased cell proliferation 1: Homo sapiens Lung | Cell Line, Tumor
6 genes: BAX | BCL2 | CDK1 | CDK4 | TXN | TXNRD1
1
4. (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane cell proliferation Sodium Selenite Sodium Selenite promotes the reaction [(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane results in decreased cell proliferation] 1: Homo sapiens A549 Cells
6 genes: BAX | BCL2 | CDK1 | CDK4 | TXN | TXNRD1
1
5. (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane cell proliferation Sodium Selenite Sodium Selenite promotes the reaction [(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane results in decreased cell proliferation] 1: Homo sapiens Lung | Cell Line, Tumor
6 genes: BAX | BCL2 | CDK1 | CDK4 | TXN | TXNRD1
1
6. (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane cell proliferation Sodium Selenite (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane promotes the reaction [Sodium Selenite results in decreased cell proliferation] 1: Homo sapiens A549 Cells
6 genes: BAX | BCL2 | CDK1 | CDK4 | TXN | TXNRD1
1
7. (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane cell proliferation Sodium Selenite (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane promotes the reaction [Sodium Selenite results in decreased cell proliferation] 1: Homo sapiens Lung | Cell Line, Tumor
6 genes: BAX | BCL2 | CDK1 | CDK4 | TXN | TXNRD1
1
8. (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane apoptotic process (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane results in increased apoptotic process 1: Homo sapiens A549 Cells
5 genes: BAX | BCL2 | CASP3 | CDK1 | SQSTM1
1
9. (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane apoptotic process Sodium Selenite Sodium Selenite promotes the reaction [(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane results in increased apoptotic process] 1: Homo sapiens A549 Cells
5 genes: BAX | BCL2 | CASP3 | CDK1 | SQSTM1
1
10. (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane necrotic cell death (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane results in increased necrotic cell death 1: Homo sapiens A549 Cells   1
11. (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane necrotic cell death Sodium Selenite Sodium Selenite promotes the reaction [(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane results in increased necrotic cell death] 1: Homo sapiens A549 Cells   1
12. (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane cell proliferation 3-methyladenine | Sodium Selenite 3-methyladenine inhibits the reaction [Sodium Selenite promotes the reaction [(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane results in decreased cell proliferation]] 1: Homo sapiens A549 Cells
6 genes: BAX | BCL2 | CDK1 | CDK4 | TXN | TXNRD1
1
13. (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane cell proliferation Chloroquine | Sodium Selenite Chloroquine inhibits the reaction [Sodium Selenite promotes the reaction [(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane results in decreased cell proliferation]] 1: Homo sapiens A549 Cells
6 genes: BAX | BCL2 | CDK1 | CDK4 | TXN | TXNRD1
1
14. (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane cell proliferation Chloroquine | Sodium Selenite Chloroquine inhibits the reaction [(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane promotes the reaction [Sodium Selenite results in decreased cell proliferation]] 1: Homo sapiens A549 Cells
6 genes: BAX | BCL2 | CDK1 | CDK4 | TXN | TXNRD1
1
15. (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane cell proliferation 3-methyladenine | Sodium Selenite 3-methyladenine inhibits the reaction [(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane promotes the reaction [Sodium Selenite results in decreased cell proliferation]] 1: Homo sapiens A549 Cells
6 genes: BAX | BCL2 | CDK1 | CDK4 | TXN | TXNRD1
1
16. (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane autophagy Sodium Selenite [Sodium Selenite co-treated with (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane] results in increased autophagy 1: Homo sapiens A549 Cells
2 genes: MAP1LC3B | SQSTM1
1
17. (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane mitotic cell cycle arrest (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane results in increased mitotic cell cycle arrest 1: Homo sapiens A549 Cells 1 gene: CDKN1A 1
18. (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane mitotic cell cycle arrest Sodium Selenite Sodium Selenite promotes the reaction [(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane results in increased mitotic cell cycle arrest] 1: Homo sapiens A549 Cells 1 gene: CDKN1A 1
19. (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane cell proliferation TXNRD1 [TXNRD1 protein results in increased susceptibility to (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane] which results in decreased cell proliferation 1: Homo sapiens HEK293 Cells
6 genes: BAX | BCL2 | CDK1 | CDK4 | TXN | TXNRD1
1
20. (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane cell proliferation Sodium Selenite | TXNRD1 Sodium Selenite promotes the reaction [[TXNRD1 protein results in increased susceptibility to (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane] which results in decreased cell proliferation] 1: Homo sapiens HEK293 Cells
6 genes: BAX | BCL2 | CDK1 | CDK4 | TXN | TXNRD1
1
21. 1-(6-((2-(dimethylamino)ethyl)(methyl)amino)-1,3-dimethyl-1H-pyrazolo(3,4-b)pyridine-5-carbonyl)-3-(3-isopropoxyphenyl)urea monocyte chemotaxis CCL2 1-(6-((2-(dimethylamino)ethyl)(methyl)amino)-1,3-dimethyl-1H-pyrazolo(3,4-b)pyridine-5-carbonyl)-3-(3-isopropoxyphenyl)urea inhibits the reaction [CCL2 protein results in increased monocyte chemotaxis] 1: Homo sapiens Monocytes | Cell Line, Tumor   1
22. 1-(6-((2-(dimethylamino)ethyl)(methyl)amino)-1,3-dimethyl-1H-pyrazolo(3,4-b)pyridine-5-carbonyl)-3-(3-isopropoxyphenyl)urea chemotaxis CCL4 1-(6-((2-(dimethylamino)ethyl)(methyl)amino)-1,3-dimethyl-1H-pyrazolo(3,4-b)pyridine-5-carbonyl)-3-(3-isopropoxyphenyl)urea affects the reaction [CCL4 protein results in increased chemotaxis] 1: Homo sapiens Blood | Leukocytes, Mononuclear   1
23. 2-(6-((3,4-dihydro-2H-chromen-2-ylmethyl)amino)hexyl)tetrahydro-1H-pyrrolo(1,2-c)imidazole-1,3(2H)-dione cell death Glucose | Oxygen 2-(6-((3,4-dihydro-2H-chromen-2-ylmethyl)amino)hexyl)tetrahydro-1H-pyrrolo(1,2-c)imidazole-1,3(2H)-dione inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased cell death] 1: Rattus norvegicus Hippocampus | Cells, Cultured   1
24. 2-fluoro-N-methyl-4-(7-(quinolin-6-yl-methyl)imidazo(1,2-b)(1,2,4)triazin-2-yl)benzamide positive regulation of monocyte chemotaxis Diethylnitrosamine 2-fluoro-N-methyl-4-(7-(quinolin-6-yl-methyl)imidazo(1,2-b)(1,2,4)triazin-2-yl)benzamide inhibits the reaction [Diethylnitrosamine results in increased positive regulation of monocyte chemotaxis] 1: Mus musculus Liver   1
25. 2-fluoro-N-methyl-4-(7-(quinolin-6-yl-methyl)imidazo(1,2-b)(1,2,4)triazin-2-yl)benzamide positive regulation of neutrophil chemotaxis Diethylnitrosamine 2-fluoro-N-methyl-4-(7-(quinolin-6-yl-methyl)imidazo(1,2-b)(1,2,4)triazin-2-yl)benzamide inhibits the reaction [Diethylnitrosamine results in increased positive regulation of neutrophil chemotaxis] 1: Mus musculus Liver
2 genes: IL1B | IL23A
1
26. 2-fluoro-N-methyl-4-(7-(quinolin-6-yl-methyl)imidazo(1,2-b)(1,2,4)triazin-2-yl)benzamide lipid oxidation Diethylnitrosamine 2-fluoro-N-methyl-4-(7-(quinolin-6-yl-methyl)imidazo(1,2-b)(1,2,4)triazin-2-yl)benzamide inhibits the reaction [Diethylnitrosamine results in increased lipid oxidation] 1: Mus musculus Liver   1
27. 2-fluoro-N-methyl-4-(7-(quinolin-6-yl-methyl)imidazo(1,2-b)(1,2,4)triazin-2-yl)benzamide lipid oxidation Diethylnitrosamine | Malondialdehyde 2-fluoro-N-methyl-4-(7-(quinolin-6-yl-methyl)imidazo(1,2-b)(1,2,4)triazin-2-yl)benzamide inhibits the reaction [[Diethylnitrosamine results in increased lipid oxidation] which results in increased abundance of Malondialdehyde] 1: Mus musculus Liver   1
28. 2-fluoro-N-methyl-4-(7-(quinolin-6-yl-methyl)imidazo(1,2-b)(1,2,4)triazin-2-yl)benzamide lipid oxidation 4-hydroxy-2-nonenal | Diethylnitrosamine 2-fluoro-N-methyl-4-(7-(quinolin-6-yl-methyl)imidazo(1,2-b)(1,2,4)triazin-2-yl)benzamide inhibits the reaction [[Diethylnitrosamine results in increased lipid oxidation] which results in increased abundance of 4-hydroxy-2-nonenal] 1: Mus musculus Liver   1
29. 2-fluoro-N-methyl-4-(7-(quinolin-6-yl-methyl)imidazo(1,2-b)(1,2,4)triazin-2-yl)benzamide positive regulation of apoptotic process Diethylnitrosamine 2-fluoro-N-methyl-4-(7-(quinolin-6-yl-methyl)imidazo(1,2-b)(1,2,4)triazin-2-yl)benzamide promotes the reaction [Diethylnitrosamine results in increased positive regulation of apoptotic process] 1: Mus musculus Liver
3 genes: IFNG | IL1B | TNF
1
30. 2-fluoro-N-methyl-4-(7-(quinolin-6-yl-methyl)imidazo(1,2-b)(1,2,4)triazin-2-yl)benzamide positive regulation of cell proliferation 2-fluoro-N-methyl-4-(7-(quinolin-6-yl-methyl)imidazo(1,2-b)(1,2,4)triazin-2-yl)benzamide results in increased positive regulation of cell proliferation 1: Mus musculus Liver
3 genes: IFNG | IL1B | TNF
1
31. 2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one apoptotic process vemurafenib [2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one results in increased susceptibility to vemurafenib] which results in increased apoptotic process 1: Homo sapiens Skin | Cell Line, Tumor
16 genes: AATF | BAX | BNIP3 | CASP3 | DFFA | GADD45B | GAPDH | MAPK1 | MCL1 | NISCH | PEA15 | PMAIP1 | SHISA5 | STK11 | TP53 | XBP1
1
32. 2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one cell proliferation vemurafenib [2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one results in increased susceptibility to vemurafenib] which results in decreased cell proliferation 1: Homo sapiens Skin | Cell Line, Tumor
5 genes: BAX | CD81 | FOXC1 | TP53 | VEGFA
1
33. 2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one cell proliferation vemurafenib [2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one co-treated with vemurafenib] results in decreased cell proliferation 1: Homo sapiens Skin | Cell Line, Tumor
5 genes: BAX | CD81 | FOXC1 | TP53 | VEGFA
1
34. 2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one mitotic cell cycle arrest 2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one results in increased mitotic cell cycle arrest 1: Homo sapiens Bone and Bones | Cell Line, Tumor
2 genes: CDKN1A | TP53
1
35. 2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one actin filament fragmentation 2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one results in increased actin filament fragmentation 1: Homo sapiens Bone and Bones | Cell Line, Tumor   1
36. 2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one actin cytoskeleton organization 2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one results in decreased actin cytoskeleton organization 1: Homo sapiens Bone and Bones | Cell Line, Tumor 1 gene: NISCH 1
37. 2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one actin cytoskeleton organization TP53 TP53 protein affects the reaction [2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one results in decreased actin cytoskeleton organization] 1: Homo sapiens Bone and Bones | Cell Line, Tumor 1 gene: NISCH 1
38. 2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one cell growth Cisplatin | Oxygen 2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one inhibits the reaction [[Oxygen deficiency results in decreased susceptibility to Cisplatin] which results in increased cell growth] 1: Homo sapiens Lung | Cell Line, Tumor   1
39. 2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one cell growth Cisplatin 2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one promotes the reaction [Cisplatin results in decreased cell growth] 1: Homo sapiens Lung | Cell Line, Tumor   1
40. 2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one cell growth Cisplatin | Oxygen 2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one inhibits the reaction [Oxygen deficiency inhibits the reaction [Cisplatin results in decreased cell growth]] 1: Homo sapiens Lung | Cell Line, Tumor   1
41. 2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one apoptotic process Cisplatin 2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one promotes the reaction [Cisplatin results in increased apoptotic process] 1: Homo sapiens Lung | Cell Line, Tumor
16 genes: AATF | BAX | BNIP3 | CASP3 | DFFA | GADD45B | GAPDH | MAPK1 | MCL1 | NISCH | PEA15 | PMAIP1 | SHISA5 | STK11 | TP53 | XBP1
1
42. 2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one apoptotic process Cisplatin | Oxygen Oxygen deficiency promotes the reaction [2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one promotes the reaction [Cisplatin results in increased apoptotic process]] 1: Homo sapiens Lung | Cell Line, Tumor
16 genes: AATF | BAX | BNIP3 | CASP3 | DFFA | GADD45B | GAPDH | MAPK1 | MCL1 | NISCH | PEA15 | PMAIP1 | SHISA5 | STK11 | TP53 | XBP1
1
43. 2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one glutathione biosynthetic process 2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one results in decreased glutathione biosynthetic process 1: Homo sapiens Lung | Cell Line, Tumor   1
44. 2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one glutathione biosynthetic process Oxygen Oxygen deficiency promotes the reaction [2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one results in decreased glutathione biosynthetic process] 1: Homo sapiens Lung | Cell Line, Tumor   1
45. 2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one glutathione biosynthetic process Cisplatin [Cisplatin co-treated with 2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one] results in decreased glutathione biosynthetic process 1: Homo sapiens Lung | Cell Line, Tumor   1
46. 2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one glutathione biosynthetic process Cisplatin | Oxygen [Cisplatin co-treated with Oxygen deficiency] promotes the reaction [2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one results in decreased glutathione biosynthetic process] 1: Homo sapiens Lung | Cell Line, Tumor   1
47. 2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one reactive oxygen species biosynthetic process Cisplatin | Oxygen 2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one promotes the reaction [[Cisplatin co-treated with Oxygen deficiency] results in increased reactive oxygen species biosynthetic process] 1: Homo sapiens Lung | Cell Line, Tumor   1
48. 2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one reactive oxygen species biosynthetic process Acetylcysteine | Cisplatin | Oxygen Acetylcysteine inhibits the reaction [2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one promotes the reaction [[Cisplatin co-treated with Oxygen deficiency] results in increased reactive oxygen species biosynthetic process]] 1: Homo sapiens Lung | Cell Line, Tumor   1
49. 2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one cell growth Oxygen [Oxygen deficiency co-treated with 2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one] results in decreased cell growth 1: Homo sapiens Lung | Cell Line, Tumor   1
50. 2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one cell growth Cisplatin | Oxygen Cisplatin promotes the reaction [[Oxygen deficiency co-treated with 2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one] results in decreased cell growth] 1: Homo sapiens Lung | Cell Line, Tumor   1
1–50 of 1,359 results.