Illuminating how chemicals affect human health.
Comparative Toxicogenomics Database

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	Chemical	Phenotype	Co-Mentioned Terms	Interaction	Organisms	Anatomy	Inference Network	References
1.	10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone	transmission of nerve impulse		10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone results in increased transmission of nerve impulse	1: Rattus norvegicus	Hippocampus | Neurons | Cells, Cultured	1 gene: KCNQ2	1
2.	10-((3-hydroxy-4-methoxybenzylidene))-9(10H)-anthracenone	release from viral latency		10-((3-hydroxy-4-methoxybenzylidene))-9(10H)-anthracenone results in increased release from viral latency	1: Homo sapiens	Cell Line, Transformed		1
3.	10-((3-hydroxy-4-methoxybenzylidene))-9(10H)-anthracenone	release from viral latency	bryostatin 1	bryostatin 1 promotes the reaction [10-((3-hydroxy-4-methoxybenzylidene))-9(10H)-anthracenone results in increased release from viral latency]	1: Homo sapiens	Cell Line, Transformed		1
4.	10-((3-hydroxy-4-methoxybenzylidene))-9(10H)-anthracenone	release from viral latency	prostratin	prostratin promotes the reaction [10-((3-hydroxy-4-methoxybenzylidene))-9(10H)-anthracenone results in increased release from viral latency]	1: Homo sapiens	Cell Line, Transformed		1
5.	1,12-benzoperylene	DNA modification		1,12-benzoperylene results in increased DNA modification	1: Mus musculus	Lung	1 gene: CYP1B1	1
6.	1,12-benzoperylene	vesicle budding from membrane		1,12-benzoperylene results in increased vesicle budding from membrane	1: Homo sapiens	Bronchi | Cell Line		1
7.	1,12-benzoperylene	cell proliferation		1,12-benzoperylene results in decreased cell proliferation	1: Homo sapiens	Bronchi | Cell Line	6 genes: CYP1A1 | HHEX | MDM4 | NUMB | PTEN | TGFB2	1
8.	1,12-benzoperylene	cell proliferation	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [1,12-benzoperylene results in decreased cell proliferation]	1: Homo sapiens	Bronchi | Cell Line	6 genes: CYP1A1 | HHEX | MDM4 | NUMB | PTEN | TGFB2	1
9.	1,12-benzoperylene	detection of oxidative stress		1,12-benzoperylene results in increased detection of oxidative stress	1: Homo sapiens	Bronchi | Cell Line		1
10.	1,12-benzoperylene	detection of oxidative stress	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide promotes the reaction [1,12-benzoperylene results in increased detection of oxidative stress]	1: Homo sapiens	Bronchi | Cell Line		1
11.	1,12-benzoperylene	negative regulation of superoxide dismutase activity		1,12-benzoperylene results in increased negative regulation of superoxide dismutase activity	1: Homo sapiens	Alveolar Epithelial Cells | Cell Line		1
12.	1,12-benzoperylene	glutathione metabolic process		1,12-benzoperylene results in increased glutathione metabolic process	1: Homo sapiens	Alveolar Epithelial Cells | Cell Line		1
13.	1,12-benzoperylene	glutathione metabolic process	Glutathione	[1,12-benzoperylene results in increased glutathione metabolic process] which results in decreased abundance of Glutathione	1: Homo sapiens	Alveolar Epithelial Cells | Cell Line		1
14.	1,12-benzoperylene	positive regulation of reactive oxygen species biosynthetic process		1,12-benzoperylene results in increased positive regulation of reactive oxygen species biosynthetic process	1: Homo sapiens	Alveolar Epithelial Cells | Cell Line		1
15.	1,12-benzoperylene	negative regulation of cell proliferation		1,12-benzoperylene results in increased negative regulation of cell proliferation	1: Homo sapiens	Alveolar Epithelial Cells | Cell Line	11 genes: CDKN1A | CDKN2C | CYP1B1 | GPER1 | INHBA | MDM4 | NFIB | PTEN | SFRP2 | SFRP5 | TGFB2	1
16.	1,12-benzoperylene	positive regulation of execution phase of apoptosis		1,12-benzoperylene results in increased positive regulation of execution phase of apoptosis	1: Homo sapiens	Alveolar Epithelial Cells | Cell Line		1
17.	1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane	positive regulation of neuron apoptotic process	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | Probenecid	1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in increased positive regulation of neuron apoptotic process]	1: Mus musculus	Substantia Nigra | Dopaminergic Neurons	3 genes: ATF4 | CASP3 | DDIT3	1
18.	1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane	positive regulation of I-kappaB kinase/NF-kappaB signaling	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | Probenecid	1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in increased positive regulation of I-kappaB kinase/NF-kappaB signaling]	1: Mus musculus	Substantia Nigra | Dopaminergic Neurons	1 gene: CASP8	1
19.	1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane	cell proliferation		1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in decreased cell proliferation	1: Homo sapiens	Kidney | Cell Line, Tumor	4 genes: AXIN2 | BCL2 | EGFR | TGFB1	1
20.	1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane	cell proliferation	NR4A1	NR4A1 protein affects the reaction [1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in decreased cell proliferation]	1: Homo sapiens	Kidney | Cell Line, Tumor	4 genes: AXIN2 | BCL2 | EGFR | TGFB1	1
21.	1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane	apoptotic process		1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased apoptotic process	1: Homo sapiens	Kidney | Cell Line, Tumor	12 genes: BCL2 | BID | BIRC5 | CASP3 | CASP7 | CASP8 | DDIT3 | EP300 | NR4A1 | PARP1 | RPS6KB1 | XBP1	1
22.	1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane	reactive oxygen species biosynthetic process		1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased reactive oxygen species biosynthetic process	1: Homo sapiens	Kidney | Cell Line, Tumor		1
23.	1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane	cell adhesion	FN1	1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane inhibits the reaction [FN1 protein results in increased cell adhesion]	1: Homo sapiens	Breast | Cell Line, Tumor	2 genes: ITGB1 | ITGB3	1
24.	1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane	cell adhesion	FN1	1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane inhibits the reaction [FN1 protein results in increased cell adhesion]	1: Homo sapiens	MCF-7 Cells	2 genes: ITGB1 | ITGB3	1
25.	1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane	cell migration		1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in decreased cell migration	1: Homo sapiens	Breast | Cell Line, Tumor	3 genes: ITGB1 | RPS6KB1 | TGFB1	1
26.	1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane	cell migration	NR4A1	NR4A1 protein affects the reaction [1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in decreased cell migration]	1: Homo sapiens	Breast | Cell Line, Tumor	3 genes: ITGB1 | RPS6KB1 | TGFB1	1
27.	1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane	cell migration	ITGB1	ITGB1 protein affects the reaction [1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in decreased cell migration]	1: Homo sapiens	Breast | Cell Line, Tumor	3 genes: ITGB1 | RPS6KB1 | TGFB1	1
28.	1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane	cell migration	TGFB1	1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane inhibits the reaction [TGFB1 protein results in increased cell migration]	1: Homo sapiens	Breast | Cell Line, Tumor	3 genes: ITGB1 | RPS6KB1 | TGFB1	1
29.	1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane	DNA damage response, detection of DNA damage		1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased DNA damage response, detection of DNA damage	1: Homo sapiens	Pancreas | Cell Line, Tumor	1 gene: PARP1	1
30.	1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane	calcium ion homeostasis		1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane affects calcium ion homeostasis	1: Homo sapiens	Pancreas | Cell Line, Tumor		1
31.	1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane	reactive oxygen species biosynthetic process		1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased reactive oxygen species biosynthetic process	1: Homo sapiens	Pancreas | Cell Line, Tumor		1
32.	1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane	reactive oxygen species biosynthetic process	Glutathione	Glutathione inhibits the reaction [1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased reactive oxygen species biosynthetic process]	1: Homo sapiens	Pancreas | Cell Line, Tumor		1
33.	1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane	cell proliferation	NR4A1	1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane affects the reaction [NR4A1 protein affects cell proliferation]	1: Homo sapiens	Pancreas | Cell Line, Tumor	4 genes: AXIN2 | BCL2 | EGFR | TGFB1	1
34.	1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane	cell proliferation		1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in decreased cell proliferation	1: Homo sapiens	Pancreas | Cell Line, Tumor	4 genes: AXIN2 | BCL2 | EGFR | TGFB1	1
35.	1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane	apoptotic process		1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased apoptotic process	1: Homo sapiens	Pancreas | Cell Line, Tumor	12 genes: BCL2 | BID | BIRC5 | CASP3 | CASP7 | CASP8 | DDIT3 | EP300 | NR4A1 | PARP1 | RPS6KB1 | XBP1	1
36.	1,1-bis(3'-indolyl)-1-(p-anisyl)methane	positive regulation of neuron apoptotic process	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | Probenecid	1,1-bis(3'-indolyl)-1-(p-anisyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in increased positive regulation of neuron apoptotic process]	1: Mus musculus	Substantia Nigra | Dopaminergic Neurons		1
37.	1,1-bis(3'-indolyl)-1-(p-anisyl)methane	locomotory behavior	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | Probenecid	1,1-bis(3'-indolyl)-1-(p-anisyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in decreased locomotory behavior]	1: Mus musculus		2 genes: SLC6A3 | TH	1
38.	1,1-bis(3'-indolyl)-1-(p-anisyl)methane	positive regulation of I-kappaB kinase/NF-kappaB signaling	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | Probenecid	1,1-bis(3'-indolyl)-1-(p-anisyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in increased positive regulation of I-kappaB kinase/NF-kappaB signaling]	1: Mus musculus	Substantia Nigra | Dopaminergic Neurons	1 gene: IL1A	1
39.	1,1-bis(4-hydroxyphenyl)cyclohexane	positive regulation of cell proliferation		1,1-bis(4-hydroxyphenyl)cyclohexane results in increased positive regulation of cell proliferation	1: Homo sapiens	Cell Line, Tumor	3 genes: AR | PGR | THRB	1
40.	1,1-bis(4-hydroxyphenyl)cyclohexane	positive regulation of cell proliferation		1,1-bis(4-hydroxyphenyl)cyclohexane results in increased positive regulation of cell proliferation	1: Rattus norvegicus	Pituitary Gland | Cell Line	3 genes: AR | PGR | THRB	1
41.	1,1-bis(4-hydroxyphenyl)cyclohexane	positive regulation of cell proliferation	Triiodothyronine	1,1-bis(4-hydroxyphenyl)cyclohexane promotes the reaction [Triiodothyronine results in increased positive regulation of cell proliferation]	1: Rattus norvegicus	Pituitary Gland | Cell Line	3 genes: AR | PGR | THRB	1
42.	1,1-diphenyl-2-picrylhydrazyl	cell redox homeostasis	Resveratrol	[Resveratrol analog results in increased cell redox homeostasis] which results in decreased abundance of 1,1-diphenyl-2-picrylhydrazyl				1
43.	1,1-diphenyl-2-picrylhydrazyl	cell redox homeostasis	Resveratrol	[Resveratrol results in increased cell redox homeostasis] which results in decreased abundance of 1,1-diphenyl-2-picrylhydrazyl				1
44.	1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea	cellular response to food	Dietary Fats	1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Dietary Fats results in increased cellular response to food]	1: Mus musculus	Liver | Endoplasmic Reticulum		1
45.	1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea	cellular response to food	Dietary Fats	1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Dietary Fats results in increased cellular response to food]	1: Mus musculus	Adipose Tissue | Endoplasmic Reticulum		1
46.	1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea	cell proliferation	Diazepam | tetramethylenedisulfotetramine	[Diazepam co-treated with 1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea] promotes the reaction [tetramethylenedisulfotetramine results in increased cell proliferation]	1: Mus musculus	Hippocampus | Astrocytes	2 genes: AKT1 | CYP1A1	1
47.	1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea	microglial cell activation	Diazepam | tetramethylenedisulfotetramine	[Diazepam co-treated with 1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea] inhibits the reaction [tetramethylenedisulfotetramine results in increased microglial cell activation]	1: Mus musculus	Hippocampus | Microglia		1
48.	1,2,3,4,6,7-hexachlorinated naphthalene	DNA damage response, detection of DNA damage		1,2,3,4,6,7-hexachlorinated naphthalene results in increased DNA damage response, detection of DNA damage	1: Homo sapiens	MCF-7 Cells		1
49.	1,2,3,5,6,7-hexachloronaphthalene	lipid oxidation		1,2,3,5,6,7-hexachloronaphthalene results in increased lipid oxidation	1: Rattus norvegicus	Liver		1
50.	1,2,3,5,6,7-hexachloronaphthalene	lipid oxidation	Malondialdehyde	[1,2,3,5,6,7-hexachloronaphthalene results in increased lipid oxidation] which results in increased abundance of Malondialdehyde	1: Rattus norvegicus	Liver		1

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