1. |
10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone
|
transmission of nerve impulse
|
|
10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone results in increased transmission of nerve impulse |
1: Rattus norvegicus |
Hippocampus | Neurons | Cells, Cultured |
1 gene: KCNQ2
|
1 |
2. |
10-((3-hydroxy-4-methoxybenzylidene))-9(10H)-anthracenone
|
release from viral latency
|
|
10-((3-hydroxy-4-methoxybenzylidene))-9(10H)-anthracenone results in increased release from viral latency |
1: Homo sapiens |
Cell Line, Transformed |
|
1 |
3. |
10-((3-hydroxy-4-methoxybenzylidene))-9(10H)-anthracenone
|
release from viral latency
|
bryostatin 1
|
bryostatin 1 promotes the reaction [10-((3-hydroxy-4-methoxybenzylidene))-9(10H)-anthracenone results in increased release from viral latency] |
1: Homo sapiens |
Cell Line, Transformed |
|
1 |
4. |
10-((3-hydroxy-4-methoxybenzylidene))-9(10H)-anthracenone
|
release from viral latency
|
prostratin
|
prostratin promotes the reaction [10-((3-hydroxy-4-methoxybenzylidene))-9(10H)-anthracenone results in increased release from viral latency] |
1: Homo sapiens |
Cell Line, Transformed |
|
1 |
5. |
1,12-benzoperylene
|
DNA modification
|
|
1,12-benzoperylene results in increased DNA modification |
1: Mus musculus |
Lung |
1 gene: CYP1B1
|
1 |
6. |
1,12-benzoperylene
|
vesicle budding from membrane
|
|
1,12-benzoperylene results in increased vesicle budding from membrane |
1: Homo sapiens |
Bronchi | Cell Line |
|
1 |
7. |
1,12-benzoperylene
|
cell proliferation
|
|
1,12-benzoperylene results in decreased cell proliferation |
1: Homo sapiens |
Bronchi | Cell Line |
6 genes: CYP1A1 | HHEX | MDM4 | NUMB | PTEN | TGFB2
|
1 |
8. |
1,12-benzoperylene
|
cell proliferation
|
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide
|
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [1,12-benzoperylene results in decreased cell proliferation] |
1: Homo sapiens |
Bronchi | Cell Line |
6 genes: CYP1A1 | HHEX | MDM4 | NUMB | PTEN | TGFB2
|
1 |
9. |
1,12-benzoperylene
|
detection of oxidative stress
|
|
1,12-benzoperylene results in increased detection of oxidative stress |
1: Homo sapiens |
Bronchi | Cell Line |
|
1 |
10. |
1,12-benzoperylene
|
detection of oxidative stress
|
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide
|
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide promotes the reaction [1,12-benzoperylene results in increased detection of oxidative stress] |
1: Homo sapiens |
Bronchi | Cell Line |
|
1 |
11. |
1,12-benzoperylene
|
negative regulation of superoxide dismutase activity
|
|
1,12-benzoperylene results in increased negative regulation of superoxide dismutase activity |
1: Homo sapiens |
Alveolar Epithelial Cells | Cell Line |
|
1 |
12. |
1,12-benzoperylene
|
glutathione metabolic process
|
|
1,12-benzoperylene results in increased glutathione metabolic process |
1: Homo sapiens |
Alveolar Epithelial Cells | Cell Line |
|
1 |
13. |
1,12-benzoperylene
|
glutathione metabolic process
|
Glutathione
|
[1,12-benzoperylene results in increased glutathione metabolic process] which results in decreased abundance of Glutathione |
1: Homo sapiens |
Alveolar Epithelial Cells | Cell Line |
|
1 |
14. |
1,12-benzoperylene
|
positive regulation of reactive oxygen species biosynthetic process
|
|
1,12-benzoperylene results in increased positive regulation of reactive oxygen species biosynthetic process |
1: Homo sapiens |
Alveolar Epithelial Cells | Cell Line |
|
1 |
15. |
1,12-benzoperylene
|
negative regulation of cell proliferation
|
|
1,12-benzoperylene results in increased negative regulation of cell proliferation |
1: Homo sapiens |
Alveolar Epithelial Cells | Cell Line |
11 genes: CDKN1A | CDKN2C | CYP1B1 | GPER1 | INHBA | MDM4 | NFIB | PTEN | SFRP2 | SFRP5 | TGFB2
|
1 |
16. |
1,12-benzoperylene
|
positive regulation of execution phase of apoptosis
|
|
1,12-benzoperylene results in increased positive regulation of execution phase of apoptosis |
1: Homo sapiens |
Alveolar Epithelial Cells | Cell Line |
|
1 |
17. |
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane
|
positive regulation of neuron apoptotic process
|
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
| Probenecid
|
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in increased positive regulation of neuron apoptotic process] |
1: Mus musculus |
Substantia Nigra | Dopaminergic Neurons |
3 genes: ATF4 | CASP3 | DDIT3
|
1 |
18. |
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane
|
positive regulation of I-kappaB kinase/NF-kappaB signaling
|
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
| Probenecid
|
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in increased positive regulation of I-kappaB kinase/NF-kappaB signaling] |
1: Mus musculus |
Substantia Nigra | Dopaminergic Neurons |
1 gene: CASP8
|
1 |
19. |
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane
|
cell proliferation
|
|
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in decreased cell proliferation |
1: Homo sapiens |
Kidney | Cell Line, Tumor |
4 genes: AXIN2 | BCL2 | EGFR | TGFB1
|
1 |
20. |
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane
|
cell proliferation
|
NR4A1
|
NR4A1 protein affects the reaction [1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in decreased cell proliferation] |
1: Homo sapiens |
Kidney | Cell Line, Tumor |
4 genes: AXIN2 | BCL2 | EGFR | TGFB1
|
1 |
21. |
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane
|
apoptotic process
|
|
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased apoptotic process |
1: Homo sapiens |
Kidney | Cell Line, Tumor |
12 genes: BCL2 | BID | BIRC5 | CASP3 | CASP7 | CASP8 | DDIT3 | EP300 | NR4A1 | PARP1 | RPS6KB1 | XBP1
|
1 |
22. |
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane
|
reactive oxygen species biosynthetic process
|
|
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased reactive oxygen species biosynthetic process |
1: Homo sapiens |
Kidney | Cell Line, Tumor |
|
1 |
23. |
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane
|
cell adhesion
|
FN1
|
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane inhibits the reaction [FN1 protein results in increased cell adhesion] |
1: Homo sapiens |
Breast | Cell Line, Tumor |
2 genes: ITGB1 | ITGB3
|
1 |
24. |
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane
|
cell adhesion
|
FN1
|
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane inhibits the reaction [FN1 protein results in increased cell adhesion] |
1: Homo sapiens |
MCF-7 Cells |
2 genes: ITGB1 | ITGB3
|
1 |
25. |
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane
|
cell migration
|
|
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in decreased cell migration |
1: Homo sapiens |
Breast | Cell Line, Tumor |
3 genes: ITGB1 | RPS6KB1 | TGFB1
|
1 |
26. |
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane
|
cell migration
|
NR4A1
|
NR4A1 protein affects the reaction [1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in decreased cell migration] |
1: Homo sapiens |
Breast | Cell Line, Tumor |
3 genes: ITGB1 | RPS6KB1 | TGFB1
|
1 |
27. |
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane
|
cell migration
|
ITGB1
|
ITGB1 protein affects the reaction [1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in decreased cell migration] |
1: Homo sapiens |
Breast | Cell Line, Tumor |
3 genes: ITGB1 | RPS6KB1 | TGFB1
|
1 |
28. |
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane
|
cell migration
|
TGFB1
|
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane inhibits the reaction [TGFB1 protein results in increased cell migration] |
1: Homo sapiens |
Breast | Cell Line, Tumor |
3 genes: ITGB1 | RPS6KB1 | TGFB1
|
1 |
29. |
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane
|
DNA damage response, detection of DNA damage
|
|
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased DNA damage response, detection of DNA damage |
1: Homo sapiens |
Pancreas | Cell Line, Tumor |
1 gene: PARP1
|
1 |
30. |
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane
|
calcium ion homeostasis
|
|
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane affects calcium ion homeostasis |
1: Homo sapiens |
Pancreas | Cell Line, Tumor |
|
1 |
31. |
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane
|
reactive oxygen species biosynthetic process
|
|
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased reactive oxygen species biosynthetic process |
1: Homo sapiens |
Pancreas | Cell Line, Tumor |
|
1 |
32. |
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane
|
reactive oxygen species biosynthetic process
|
Glutathione
|
Glutathione inhibits the reaction [1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased reactive oxygen species biosynthetic process] |
1: Homo sapiens |
Pancreas | Cell Line, Tumor |
|
1 |
33. |
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane
|
cell proliferation
|
NR4A1
|
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane affects the reaction [NR4A1 protein affects cell proliferation] |
1: Homo sapiens |
Pancreas | Cell Line, Tumor |
4 genes: AXIN2 | BCL2 | EGFR | TGFB1
|
1 |
34. |
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane
|
cell proliferation
|
|
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in decreased cell proliferation |
1: Homo sapiens |
Pancreas | Cell Line, Tumor |
4 genes: AXIN2 | BCL2 | EGFR | TGFB1
|
1 |
35. |
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane
|
apoptotic process
|
|
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased apoptotic process |
1: Homo sapiens |
Pancreas | Cell Line, Tumor |
12 genes: BCL2 | BID | BIRC5 | CASP3 | CASP7 | CASP8 | DDIT3 | EP300 | NR4A1 | PARP1 | RPS6KB1 | XBP1
|
1 |
36. |
1,1-bis(3'-indolyl)-1-(p-anisyl)methane
|
positive regulation of neuron apoptotic process
|
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
| Probenecid
|
1,1-bis(3'-indolyl)-1-(p-anisyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in increased positive regulation of neuron apoptotic process] |
1: Mus musculus |
Substantia Nigra | Dopaminergic Neurons |
|
1 |
37. |
1,1-bis(3'-indolyl)-1-(p-anisyl)methane
|
locomotory behavior
|
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
| Probenecid
|
1,1-bis(3'-indolyl)-1-(p-anisyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in decreased locomotory behavior] |
1: Mus musculus |
|
2 genes: SLC6A3 | TH
|
1 |
38. |
1,1-bis(3'-indolyl)-1-(p-anisyl)methane
|
positive regulation of I-kappaB kinase/NF-kappaB signaling
|
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
| Probenecid
|
1,1-bis(3'-indolyl)-1-(p-anisyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in increased positive regulation of I-kappaB kinase/NF-kappaB signaling] |
1: Mus musculus |
Substantia Nigra | Dopaminergic Neurons |
1 gene: IL1A
|
1 |
39. |
1,1-bis(4-hydroxyphenyl)cyclohexane
|
positive regulation of cell proliferation
|
|
1,1-bis(4-hydroxyphenyl)cyclohexane results in increased positive regulation of cell proliferation |
1: Homo sapiens |
Cell Line, Tumor |
3 genes: AR | PGR | THRB
|
1 |
40. |
1,1-bis(4-hydroxyphenyl)cyclohexane
|
positive regulation of cell proliferation
|
|
1,1-bis(4-hydroxyphenyl)cyclohexane results in increased positive regulation of cell proliferation |
1: Rattus norvegicus |
Pituitary Gland | Cell Line |
3 genes: AR | PGR | THRB
|
1 |
41. |
1,1-bis(4-hydroxyphenyl)cyclohexane
|
positive regulation of cell proliferation
|
Triiodothyronine
|
1,1-bis(4-hydroxyphenyl)cyclohexane promotes the reaction [Triiodothyronine results in increased positive regulation of cell proliferation] |
1: Rattus norvegicus |
Pituitary Gland | Cell Line |
3 genes: AR | PGR | THRB
|
1 |
42. |
1,1-diphenyl-2-picrylhydrazyl
|
cell redox homeostasis
|
Resveratrol
|
[Resveratrol analog results in increased cell redox homeostasis] which results in decreased abundance of 1,1-diphenyl-2-picrylhydrazyl |
|
|
|
1 |
43. |
1,1-diphenyl-2-picrylhydrazyl
|
cell redox homeostasis
|
Resveratrol
|
[Resveratrol results in increased cell redox homeostasis] which results in decreased abundance of 1,1-diphenyl-2-picrylhydrazyl |
|
|
|
1 |
44. |
1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea
|
cellular response to food
|
Dietary Fats
|
1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Dietary Fats results in increased cellular response to food] |
1: Mus musculus |
Liver | Endoplasmic Reticulum |
|
1 |
45. |
1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea
|
cellular response to food
|
Dietary Fats
|
1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Dietary Fats results in increased cellular response to food] |
1: Mus musculus |
Adipose Tissue | Endoplasmic Reticulum |
|
1 |
46. |
1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea
|
cell proliferation
|
Diazepam
| tetramethylenedisulfotetramine
|
[Diazepam co-treated with 1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea] promotes the reaction [tetramethylenedisulfotetramine results in increased cell proliferation] |
1: Mus musculus |
Hippocampus | Astrocytes |
2 genes: AKT1 | CYP1A1
|
1 |
47. |
1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea
|
microglial cell activation
|
Diazepam
| tetramethylenedisulfotetramine
|
[Diazepam co-treated with 1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea] inhibits the reaction [tetramethylenedisulfotetramine results in increased microglial cell activation] |
1: Mus musculus |
Hippocampus | Microglia |
|
1 |
48. |
1,2,3,4,6,7-hexachlorinated naphthalene
|
DNA damage response, detection of DNA damage
|
|
1,2,3,4,6,7-hexachlorinated naphthalene results in increased DNA damage response, detection of DNA damage |
1: Homo sapiens |
MCF-7 Cells |
|
1 |
49. |
1,2,3,5,6,7-hexachloronaphthalene
|
lipid oxidation
|
|
1,2,3,5,6,7-hexachloronaphthalene results in increased lipid oxidation |
1: Rattus norvegicus |
Liver |
|
1 |
50. |
1,2,3,5,6,7-hexachloronaphthalene
|
lipid oxidation
|
Malondialdehyde
|
[1,2,3,5,6,7-hexachloronaphthalene results in increased lipid oxidation] which results in increased abundance of Malondialdehyde |
1: Rattus norvegicus |
Liver |
|
1 |