1. |
Klebsiella O3 lipopolysaccharide
|
leukocyte migration involved in inflammatory response
|
|
Klebsiella O3 lipopolysaccharide results in increased leukocyte migration involved in inflammatory response |
1: Mus musculus |
Lung |
|
1 |
2. |
lipopolysaccharide, E. coli O26-B6
|
positive regulation of inflammatory response
|
|
lipopolysaccharide, E. coli O26-B6 affects positive regulation of inflammatory response |
1: Mus musculus |
Microglia | Cell Line |
18 genes: AGT | CCL1 | CCL24 | CCL3 | CCR2 | IL12B | MIR155 | MIR21 | NFKBIA | NLRP12 | TLR2 | TLR4 | TLR6 | TLR7 | TLR9 | TNF | TNFRSF1A | TRADD
|
1 |
3. |
lipopolysaccharide, E. coli O26-B6
|
positive regulation of inflammatory response
|
schizandrol B
|
schizandrol B inhibits the reaction [lipopolysaccharide, E. coli O26-B6 affects positive regulation of inflammatory response] |
1: Mus musculus |
Microglia | Cell Line |
18 genes: AGT | CCL1 | CCL24 | CCL3 | CCR2 | IL12B | MIR155 | MIR21 | NFKBIA | NLRP12 | TLR2 | TLR4 | TLR6 | TLR7 | TLR9 | TNF | TNFRSF1A | TRADD
|
1 |
4. |
lipopolysaccharide, E. coli O26-B6
|
nitric oxide production involved in inflammatory response
|
|
lipopolysaccharide, E. coli O26-B6 results in increased nitric oxide production involved in inflammatory response |
1: Mus musculus |
Microglia | Cell Line |
1 gene: TLR4
|
1 |
5. |
lipopolysaccharide, E. coli O26-B6
|
nitric oxide production involved in inflammatory response
|
schizandrol B
|
schizandrol B inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased nitric oxide production involved in inflammatory response] |
1: Mus musculus |
Microglia | Cell Line |
1 gene: TLR4
|
1 |
6. |
lipopolysaccharide, E. coli O26-B6
|
prostaglandin production involved in inflammatory response
|
|
lipopolysaccharide, E. coli O26-B6 results in increased prostaglandin production involved in inflammatory response |
1: Mus musculus |
Microglia | Cell Line |
|
1 |
7. |
lipopolysaccharide, E. coli O26-B6
|
prostaglandin production involved in inflammatory response
|
schizandrol B
|
schizandrol B inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased prostaglandin production involved in inflammatory response] |
1: Mus musculus |
Microglia | Cell Line |
|
1 |
8. |
lipopolysaccharide, E. coli O26-B6
|
positive regulation of tumor necrosis factor production
|
|
lipopolysaccharide, E. coli O26-B6 affects positive regulation of tumor necrosis factor production |
1: Mus musculus |
Microglia | Cell Line |
16 genes: CCL19 | CCL2 | CCL3 | CCL4 | CCR2 | CCR7 | FADD | IFNG | IL12B | MYD88 | NOD1 | TICAM1 | TLR2 | TLR4 | TLR9 | TNFRSF1A
|
1 |
9. |
lipopolysaccharide, E. coli O26-B6
|
positive regulation of interleukin-1 beta production
|
|
lipopolysaccharide, E. coli O26-B6 affects positive regulation of interleukin-1 beta production |
1: Mus musculus |
Microglia | Cell Line |
1 gene: NOD1
|
1 |
10. |
lipopolysaccharide, E. coli O26-B6
|
positive regulation of interleukin-6 production
|
|
lipopolysaccharide, E. coli O26-B6 affects positive regulation of interleukin-6 production |
1: Mus musculus |
Microglia | Cell Line |
14 genes: DDX58 | IL1A | IL1B | IL1F8 | IL1F9 | IL6 | MYD88 | NOD1 | TICAM1 | TLR2 | TLR4 | TLR7 | TLR9 | TNF
|
1 |
11. |
lipopolysaccharide, E. coli O26-B6
|
positive regulation of tumor necrosis factor production
|
schizandrol B
|
schizandrol B inhibits the reaction [lipopolysaccharide, E. coli O26-B6 affects positive regulation of tumor necrosis factor production] |
1: Mus musculus |
Microglia | Cell Line |
16 genes: CCL19 | CCL2 | CCL3 | CCL4 | CCR2 | CCR7 | FADD | IFNG | IL12B | MYD88 | NOD1 | TICAM1 | TLR2 | TLR4 | TLR9 | TNFRSF1A
|
1 |
12. |
lipopolysaccharide, E. coli O26-B6
|
positive regulation of interleukin-1 beta production
|
schizandrol B
|
schizandrol B inhibits the reaction [lipopolysaccharide, E. coli O26-B6 affects positive regulation of interleukin-1 beta production] |
1: Mus musculus |
Microglia | Cell Line |
1 gene: NOD1
|
1 |
13. |
lipopolysaccharide, E. coli O26-B6
|
positive regulation of interleukin-6 production
|
schizandrol B
|
schizandrol B inhibits the reaction [lipopolysaccharide, E. coli O26-B6 affects positive regulation of interleukin-6 production] |
1: Mus musculus |
Microglia | Cell Line |
14 genes: DDX58 | IL1A | IL1B | IL1F8 | IL1F9 | IL6 | MYD88 | NOD1 | TICAM1 | TLR2 | TLR4 | TLR7 | TLR9 | TNF
|
1 |
14. |
lipopolysaccharide, E. coli O26-B6
|
regulation of reactive oxygen species metabolic process
|
|
lipopolysaccharide, E. coli O26-B6 affects regulation of reactive oxygen species metabolic process |
1: Mus musculus |
Microglia | Cell Line |
4 genes: BIRC2 | FOXO3 | MIR21 | TNF
|
1 |
15. |
lipopolysaccharide, E. coli O26-B6
|
regulation of reactive oxygen species metabolic process
|
schizandrol B
|
schizandrol B inhibits the reaction [lipopolysaccharide, E. coli O26-B6 affects regulation of reactive oxygen species metabolic process] |
1: Mus musculus |
Microglia | Cell Line |
4 genes: BIRC2 | FOXO3 | MIR21 | TNF
|
1 |
16. |
lipopolysaccharide, E. coli O26-B6
|
positive regulation of I-kappaB kinase/NF-kappaB signaling
|
schizandrol B
|
schizandrol B inhibits the reaction [lipopolysaccharide, E. coli O26-B6 affects positive regulation of I-kappaB kinase/NF-kappaB signaling] |
1: Mus musculus |
Microglia | Cell Line |
32 genes: BIRC2 | CASP1 | CCL19 | CCR7 | CD40 | CFLAR | CHUK | F2R | FADD | GJA1 | HMOX1 | HTR2B | IKBKB | IKBKE | IL1A | IL1B | LPAR1 | LTBR | MYD88 | NOD1 | REL | RELA | TICAM1 | TLR4 | TLR6 | TLR9 | TNF | TNFRSF10B | TNFRSF1A | TNFSF10 | TNFSF11 | TRADD
|
1 |
17. |
lipopolysaccharide, E. coli O26-B6
|
positive regulation of I-kappaB kinase/NF-kappaB signaling
|
|
lipopolysaccharide, E. coli O26-B6 affects positive regulation of I-kappaB kinase/NF-kappaB signaling |
1: Mus musculus |
Microglia | Cell Line |
32 genes: BIRC2 | CASP1 | CCL19 | CCR7 | CD40 | CFLAR | CHUK | F2R | FADD | GJA1 | HMOX1 | HTR2B | IKBKB | IKBKE | IL1A | IL1B | LPAR1 | LTBR | MYD88 | NOD1 | REL | RELA | TICAM1 | TLR4 | TLR6 | TLR9 | TNF | TNFRSF10B | TNFRSF1A | TNFSF10 | TNFSF11 | TRADD
|
1 |
18. |
lipopolysaccharide, E. coli O26-B6
|
positive regulation of MAPK cascade
|
schizandrol B
|
schizandrol B inhibits the reaction [lipopolysaccharide, E. coli O26-B6 affects positive regulation of MAPK cascade] |
1: Mus musculus |
Microglia | Cell Line |
5 genes: AGT | F2R | IL6 | LPAR1 | TLR9
|
1 |
19. |
lipopolysaccharide, E. coli O26-B6
|
positive regulation of MAPK cascade
|
|
lipopolysaccharide, E. coli O26-B6 affects positive regulation of MAPK cascade |
1: Mus musculus |
Microglia | Cell Line |
5 genes: AGT | F2R | IL6 | LPAR1 | TLR9
|
1 |
20. |
lipopolysaccharide, E. coli O26-B6
|
positive regulation of DNA-binding transcription factor activity
|
|
lipopolysaccharide, E. coli O26-B6 results in increased positive regulation of DNA-binding transcription factor activity |
1: Homo sapiens |
Epidermis | Cell Line, Tumor |
10 genes: CSF3 | DDX58 | EDN1 | IL10 | IL1B | IL6 | JUN | TLR4 | TNF | TNFSF11
|
1 |
21. |
lipopolysaccharide, E. coli O26-B6
|
prostaglandin production involved in inflammatory response
|
triflusal
|
triflusal inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased prostaglandin production involved in inflammatory response] |
1: Homo sapiens |
Blood | Leukocytes, Mononuclear |
|
1 |
22. |
lipopolysaccharide, E. coli O26-B6
|
prostaglandin production involved in inflammatory response
|
Dinoprostone
| triflusal
|
triflusal inhibits the reaction [[lipopolysaccharide, E. coli O26-B6 results in increased prostaglandin production involved in inflammatory response] which results in increased secretion of Dinoprostone] |
1: Homo sapiens |
Blood | Leukocytes, Mononuclear |
|
1 |
23. |
lipopolysaccharide, E. coli O26-B6
|
positive regulation of NF-kappaB transcription factor activity
|
triflusal
|
triflusal inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased positive regulation of NF-kappaB transcription factor activity] |
1: Homo sapiens |
Blood | Leukocytes, Mononuclear |
28 genes: AGT | CAT | CD40 | CD40LG | CFLAR | CHUK | CX3CR1 | ICAM1 | IKBKB | IL1B | IL6 | IRAK2 | ITGB2 | MYD88 | NFKB1 | NFKB2 | NOD1 | RELA | RELB | TGFB1 | TICAM1 | TLR2 | TLR4 | TLR6 | TLR9 | TNF | TNFSF11 | TRADD
|
1 |
24. |
lipopolysaccharide, E. coli O26-B6
|
prostaglandin production involved in inflammatory response
|
4-trifluoromethylsalicylic acid
|
4-trifluoromethylsalicylic acid inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased prostaglandin production involved in inflammatory response] |
1: Homo sapiens |
Blood | Leukocytes, Mononuclear |
|
1 |
25. |
lipopolysaccharide, E. coli O26-B6
|
prostaglandin production involved in inflammatory response
|
4-trifluoromethylsalicylic acid
| Dinoprostone
|
4-trifluoromethylsalicylic acid inhibits the reaction [[lipopolysaccharide, E. coli O26-B6 results in increased prostaglandin production involved in inflammatory response] which results in increased secretion of Dinoprostone] |
1: Homo sapiens |
Blood | Leukocytes, Mononuclear |
|
1 |
26. |
lipopolysaccharide, E. coli O26-B6
|
positive regulation of NF-kappaB transcription factor activity
|
4-trifluoromethylsalicylic acid
|
4-trifluoromethylsalicylic acid inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased positive regulation of NF-kappaB transcription factor activity] |
1: Homo sapiens |
Blood | Leukocytes, Mononuclear |
28 genes: AGT | CAT | CD40 | CD40LG | CFLAR | CHUK | CX3CR1 | ICAM1 | IKBKB | IL1B | IL6 | IRAK2 | ITGB2 | MYD88 | NFKB1 | NFKB2 | NOD1 | RELA | RELB | TGFB1 | TICAM1 | TLR2 | TLR4 | TLR6 | TLR9 | TNF | TNFSF11 | TRADD
|
1 |
27. |
lipopolysaccharide, E. coli O26-B6
|
prostaglandin production involved in inflammatory response
|
Aspirin
|
Aspirin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased prostaglandin production involved in inflammatory response] |
1: Homo sapiens |
Blood | Leukocytes, Mononuclear |
|
1 |
28. |
lipopolysaccharide, E. coli O26-B6
|
prostaglandin production involved in inflammatory response
|
Aspirin
| Dinoprostone
|
Aspirin inhibits the reaction [[lipopolysaccharide, E. coli O26-B6 results in increased prostaglandin production involved in inflammatory response] which results in increased secretion of Dinoprostone] |
1: Homo sapiens |
Blood | Leukocytes, Mononuclear |
|
1 |
29. |
lipopolysaccharide, E. coli O26-B6
|
positive regulation of NF-kappaB transcription factor activity
|
Aspirin
|
Aspirin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased positive regulation of NF-kappaB transcription factor activity] |
1: Homo sapiens |
Blood | Leukocytes, Mononuclear |
28 genes: AGT | CAT | CD40 | CD40LG | CFLAR | CHUK | CX3CR1 | ICAM1 | IKBKB | IL1B | IL6 | IRAK2 | ITGB2 | MYD88 | NFKB1 | NFKB2 | NOD1 | RELA | RELB | TGFB1 | TICAM1 | TLR2 | TLR4 | TLR6 | TLR9 | TNF | TNFSF11 | TRADD
|
1 |
30. |
lipopolysaccharide, E. coli O26-B6
|
positive regulation of NF-kappaB transcription factor activity
|
Sodium Salicylate
|
Sodium Salicylate inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased positive regulation of NF-kappaB transcription factor activity] |
1: Homo sapiens |
Blood | Leukocytes, Mononuclear |
28 genes: AGT | CAT | CD40 | CD40LG | CFLAR | CHUK | CX3CR1 | ICAM1 | IKBKB | IL1B | IL6 | IRAK2 | ITGB2 | MYD88 | NFKB1 | NFKB2 | NOD1 | RELA | RELB | TGFB1 | TICAM1 | TLR2 | TLR4 | TLR6 | TLR9 | TNF | TNFSF11 | TRADD
|
1 |
31. |
lipopolysaccharide, E. coli O26-B6
|
prostaglandin production involved in inflammatory response
|
|
lipopolysaccharide, E. coli O26-B6 results in increased prostaglandin production involved in inflammatory response |
1: Homo sapiens |
Blood | Leukocytes, Mononuclear |
|
1 |
32. |
lipopolysaccharide, E. coli O26-B6
|
prostaglandin production involved in inflammatory response
|
Dinoprostone
|
[lipopolysaccharide, E. coli O26-B6 results in increased prostaglandin production involved in inflammatory response] which results in increased secretion of Dinoprostone |
1: Homo sapiens |
Blood | Leukocytes, Mononuclear |
|
1 |
33. |
lipopolysaccharide, E. coli O26-B6
|
positive regulation of NF-kappaB transcription factor activity
|
|
lipopolysaccharide, E. coli O26-B6 results in increased positive regulation of NF-kappaB transcription factor activity |
1: Homo sapiens |
Blood | Leukocytes, Mononuclear |
28 genes: AGT | CAT | CD40 | CD40LG | CFLAR | CHUK | CX3CR1 | ICAM1 | IKBKB | IL1B | IL6 | IRAK2 | ITGB2 | MYD88 | NFKB1 | NFKB2 | NOD1 | RELA | RELB | TGFB1 | TICAM1 | TLR2 | TLR4 | TLR6 | TLR9 | TNF | TNFSF11 | TRADD
|
1 |
34. |
lipopolysaccharide, E. coli O26-B6
|
prostaglandin production involved in inflammatory response
|
N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide
|
N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased prostaglandin production involved in inflammatory response] |
1: Homo sapiens |
Blood | Leukocytes, Mononuclear |
|
1 |
35. |
lipopolysaccharide, E. coli O26-B6
|
prostaglandin production involved in inflammatory response
|
Dinoprostone
| N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide
|
N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [[lipopolysaccharide, E. coli O26-B6 results in increased prostaglandin production involved in inflammatory response] which results in increased secretion of Dinoprostone] |
1: Homo sapiens |
Blood | Leukocytes, Mononuclear |
|
1 |
36. |
lipopolysaccharide, E. coli O26-B6
|
apoptotic process
|
|
lipopolysaccharide, E. coli O26-B6 results in decreased apoptotic process |
1: Homo sapiens |
Neutrophils |
33 genes: BCL2 | BIRC2 | CASP1 | CFLAR | FADD | FOXO3 | GJA1 | HMOX1 | IFNG | IL1A | IL1B | ITGB2 | LTA | LTBR | MAPK1 | MAPK3 | MYD88 | NFKB1 | NFKBIA | NOD1 | PARP1 | TICAM1 | TLR2 | TNF | TNFAIP3 | TNFRSF10A | TNFRSF10B | TNFRSF11B | TNFRSF1A | TNFSF10 | TNFSF14 | TRADD | TSPO
|
1 |
37. |
lipopolysaccharide, E. coli O26-B6
|
apoptotic process
|
Quercetin
|
Quercetin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in decreased apoptotic process] |
1: Homo sapiens |
Neutrophils |
33 genes: BCL2 | BIRC2 | CASP1 | CFLAR | FADD | FOXO3 | GJA1 | HMOX1 | IFNG | IL1A | IL1B | ITGB2 | LTA | LTBR | MAPK1 | MAPK3 | MYD88 | NFKB1 | NFKBIA | NOD1 | PARP1 | TICAM1 | TLR2 | TNF | TNFAIP3 | TNFRSF10A | TNFRSF10B | TNFRSF11B | TNFRSF1A | TNFSF10 | TNFSF14 | TRADD | TSPO
|
1 |
38. |
lipopolysaccharide, E. coli O26-B6
|
superoxide anion generation
|
N-Formylmethionine Leucyl-Phenylalanine
|
lipopolysaccharide, E. coli O26-B6 promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased superoxide anion generation] |
1: Homo sapiens |
Neutrophils |
3 genes: CYBB | EDN1 | SOD2
|
1 |
39. |
lipopolysaccharide, E. coli O26-B6
|
superoxide anion generation
|
N-Formylmethionine Leucyl-Phenylalanine
| Quercetin
|
Quercetin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased superoxide anion generation]] |
1: Homo sapiens |
Neutrophils |
3 genes: CYBB | EDN1 | SOD2
|
1 |
40. |
lipopolysaccharide, E. coli O26-B6
|
leukocyte migration involved in inflammatory response
|
|
lipopolysaccharide, E. coli O26-B6 results in increased leukocyte migration involved in inflammatory response |
1: Rattus norvegicus |
Lung |
6 genes: C5 | CCL2 | CCR6 | ITGAM | ITGB2 | SELE
|
1 |
41. |
lipopolysaccharide, E. coli O26-B6
|
leukocyte migration involved in inflammatory response
|
Quercetin
|
Quercetin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased leukocyte migration involved in inflammatory response] |
1: Rattus norvegicus |
Lung |
6 genes: C5 | CCL2 | CCR6 | ITGAM | ITGB2 | SELE
|
1 |
42. |
lipopolysaccharide, E. coli O26-B6
|
lipid catabolic process
|
|
lipopolysaccharide, E. coli O26-B6 results in increased lipid catabolic process |
1: Rattus norvegicus |
Lung |
|
1 |
43. |
lipopolysaccharide, E. coli O26-B6
|
lipid catabolic process
|
Quercetin
|
Quercetin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased lipid catabolic process] |
1: Rattus norvegicus |
Lung |
|
1 |
44. |
lipopolysaccharide, E. coli O26-B6
|
superoxide dismutase activity
|
|
lipopolysaccharide, E. coli O26-B6 results in decreased superoxide dismutase activity |
1: Rattus norvegicus |
Lung |
2 genes: NQO1 | SOD2
|
1 |
45. |
lipopolysaccharide, E. coli O26-B6
|
glutathione peroxidase activity
|
|
lipopolysaccharide, E. coli O26-B6 results in decreased glutathione peroxidase activity |
1: Rattus norvegicus |
Lung |
|
1 |
46. |
lipopolysaccharide, E. coli O26-B6
|
superoxide dismutase activity
|
Quercetin
|
Quercetin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in decreased superoxide dismutase activity] |
1: Rattus norvegicus |
Lung |
2 genes: NQO1 | SOD2
|
1 |
47. |
lipopolysaccharide, E. coli O26-B6
|
glutathione peroxidase activity
|
Quercetin
|
Quercetin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in decreased glutathione peroxidase activity] |
1: Rattus norvegicus |
Lung |
|
1 |
48. |
lipopolysaccharide, E. coli O26-B6
|
cell adhesion molecule production
|
|
lipopolysaccharide, E. coli O26-B6 results in increased cell adhesion molecule production |
1: Rattus norvegicus |
Microvessels | Endothelial Cells | Cells, Cultured |
|
1 |
49. |
lipopolysaccharide, E. coli O26-B6
|
heterotypic cell-cell adhesion
|
|
lipopolysaccharide, E. coli O26-B6 results in increased heterotypic cell-cell adhesion |
1: Rattus norvegicus |
Microvessels | Endothelial Cells | Cells, Cultured |
2 genes: ITGB2 | VCAM1
|
1 |
50. |
lipopolysaccharide, E. coli O26-B6
|
heterotypic cell-cell adhesion
|
Chlorogenic Acid
|
Chlorogenic Acid inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased heterotypic cell-cell adhesion] |
1: Rattus norvegicus |
Microvessels | Endothelial Cells | Cells, Cultured |
2 genes: ITGB2 | VCAM1
|
1 |