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Chemical Nucleic Acids, Nucleotides, and Nucleosides

These are exposure studies associated with the chemical and all of its children.

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1–10 of 10 results.
  Reference Associated Study Title Author's Summary Study Factors Stressor Receptors Country Medium Exposure Marker Measurements Outcome
1. Huang YF, et al. (2017). Our results support a role for exposure to 4-nonylphenol and bisphenol A and possibly inflammation in increasing oxidative/nitrative stress and decreasing antioxidant activity during pregnancy. 4-nonylphenol | bisphenol A Pregnant females Taiwan, Province of China blood | blood, cord | urine 4-nonylphenol | 8-epi-prostaglandin F2alpha | 8-nitroguanine | 8-oxo-7-hydrodeoxyguanosine | bisphenol A | GPX1 | TNF Details negative regulation of glutathione peroxidase activity | tumor necrosis factor production
2. Huang CY, et al. (2012). Higher urinary 8-hydroxydeoxyguanosine (8-OHdG, a marker of DNA damage) in an area without obvious arsenic exposure was a strong predictor of renal cell carcinoma; urinary 8-OHdG was significantly related to urinary total arsenic, and high levels of 8-OHdG combined with arsenic might be indicative of arsenic-induced renal cell carcinoma. 8-oxo-7-hydrodeoxyguanosine | Arsenic Controls for disease:Carcinoma, Renal Cell | Subjects with disease:Carcinoma, Renal Cell Taiwan, Province of China urine 8-oxo-7-hydrodeoxyguanosine | Arsenicals Details Carcinoma, Renal Cell
3. Altemose B, et al. (2017). Health Effects of an Air Pollution Reduction Trial (HEART) Using data collected before, during, and after the 2008 Summer Olympics (Beijing, China), this study examines associations between sources of air pollution and biomarkers of blood coagulation (VWF, SELP, and CD40LG), pulmonary inflammation (exhaled nitrites), and systemic oxidative stress (8-oxo-7-hydrodeoxyguanosine). Air Pollutants Study subjects China air, breath, exhaled | blood | urine 8-oxo-7-hydrodeoxyguanosine | CD40LG | Nitric Oxide | Nitrites | SELP | VWF Details
4. Mannan T, et al. (2018). Maternal and Infant Nutrition Interventions in Matlab (MINIMat) Our findings suggest that chronic arsenic exposure from early life (from drinking water and food) can result in telomere length attrition and lower production of naive T-cells potentially leading to immunosenescence and immunodeficiency. diet Arsenic Children Bangladesh plasma | urine 8-oxo-7-hydrodeoxyguanosine | Arsenicals | monomethylarsonic acid Details regulation of telomere maintenance via telomere lengthening | somatic recombination of T cell receptor gene segments
5. Pi J, et al. (2005). A 13-month arsenic exposure reduction effectively reverses the arsenic-induced impairment of the nitric oxide/cyclic guanosine 3',5'-monophosphate pathway in both males and females and improves peripheral vascular function in males. Arsenic Study subjects China blood | urine | water Arsenic | Cyclic GMP Details Arsenic Poisoning | Vascular Diseases
6. Ma L, et al. (2016). We reveal that specific histone modifications are associated with arsenic exposure and oxidative damage, and persistent dysregulation of these histone modifications could be a potential biomarker that evaluates the burden of arsenic exposure and predicts the adverse biological effects. Arsenic Study subjects China hair | lymphocyte | plasma | urine 8-oxo-7-hydrodeoxyguanosine | Arsenic | Malondialdehyde Details Arsenic Poisoning | positive regulation of histone H3-K14 acetylation | positive regulation of histone H3-K18 acetylation | positive regulation of histone H3-K36 trimethylation | positive regulation of histone H3-K9 dimethylation
7. Yoshida R, et al. (2001). We show that 8-oxodG levels in asbestos-exposed construction workers were higher (although not statistically significant), and that levels tended to correlate with duration of suspected exposure; these results suggest that even low-level asbestos exposure may induce oxidative stress. Asbestos Workers Japan urine 8-oxo-7-hydrodeoxyguanosine Details cellular response to oxidative stress
8. Khan A, et al. (2017). Ewha Birth & Growth Cohort Study We conducted a high-resolution metabolomics study and detected elevated metabolites of steroidogenesis and amino acid metabolism in preadolescent female children with high urinary bisphenol A levels. sex bisphenol A Children Korea, Republic of urine 22-hydroxycholesterol | 3-methoxytyramine | aerobactin | Androstenedione | anthranilic acid | bisphenol A | Carnitine | Cholesterol | Corticosterone | cortolone | crotonyl-coenzyme A | Cytidine Monophosphate N-Acetylneuraminic Acid | cytidine monophosphate-N-glycoloylneuraminic acid | estrone sulfate | fructose-6-phosphate | glucosaminic acid | Hydrocortisone | isocaproaldehyde | Malonyl Coenzyme A | N-acetylmuramic acid | N-acetylserotonin | phenylacetylglycine | Pregnanediol | Progesterone | testosterone glucuronate Details regulation of cellular amino acid metabolic process | regulation of steroid biosynthetic process
9. Ellis JK, et al. (2012). This study shows evidence that metabolic profiling in an uncontrolled human population is capable of identifying intermediate biomarkers of response to cadmium at true environmental concentrations, paving the way for exposome research. Cadmium Study subjects United Kingdom urine 8-oxo-7-hydrodeoxyguanosine | beta-hydroxyisovaleric acid | Citric Acid | Creatine | Creatinine Details cellular response to oxidative stress
10. Kang S, et al. (2013). The present study was designed to determine urinary paraben levels among pregnant women and their matching newborn infants, and the association between paraben levels and stress markers; methylparaben was detected as the highest and butylparaben as the lowest in both pregnant women and their infants; levels of ethyl paraben were 4-9 fold higher than found in pregnant women of other countries. body mass index ethyl-p-hydroxybenzoate | methylparaben | Parabens Infants or newborns | Pregnant females Korea, Republic of urine 8-oxo-7-hydrodeoxyguanosine | butylparaben | ethyl-p-hydroxybenzoate | Malondialdehyde | methylparaben | propylparaben Details response to stress
1–10 of 10 results.