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Chemical Purines

These are exposure studies associated with the chemical and all of its children.

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1–15 of 15 results.
  Reference Associated Study Title Author's Summary Study Factors Stressor Receptors Country Medium Exposure Marker Measurements Outcome
1. Huang YF, et al. (2017). Our results support a role for exposure to 4-nonylphenol and bisphenol A and possibly inflammation in increasing oxidative/nitrative stress and decreasing antioxidant activity during pregnancy. 4-nonylphenol | bisphenol A Pregnant females Taiwan, Province of China blood | blood, cord | urine 4-nonylphenol | 8-epi-prostaglandin F2alpha | 8-nitroguanine | 8-oxo-7-hydrodeoxyguanosine | bisphenol A | GPX1 | TNF Details negative regulation of glutathione peroxidase activity | tumor necrosis factor production
2. Huang CY, et al. (2012). Higher urinary 8-hydroxydeoxyguanosine (8-OHdG, a marker of DNA damage) in an area without obvious arsenic exposure was a strong predictor of renal cell carcinoma; urinary 8-OHdG was significantly related to urinary total arsenic, and high levels of 8-OHdG combined with arsenic might be indicative of arsenic-induced renal cell carcinoma. 8-oxo-7-hydrodeoxyguanosine | Arsenic Controls for disease:Carcinoma, Renal Cell | Subjects with disease:Carcinoma, Renal Cell Taiwan, Province of China urine 8-oxo-7-hydrodeoxyguanosine | Arsenicals Details Carcinoma, Renal Cell
3. Ma L, et al. (2016). We reveal that specific histone modifications are associated with arsenic exposure and oxidative damage, and persistent dysregulation of these histone modifications could be a potential biomarker that evaluates the burden of arsenic exposure and predicts the adverse biological effects. Arsenic Study subjects China hair | lymphocyte | plasma | urine 8-oxo-7-hydrodeoxyguanosine | Arsenic | Malondialdehyde Details Arsenic Poisoning | positive regulation of histone H3-K14 acetylation | positive regulation of histone H3-K18 acetylation | positive regulation of histone H3-K36 trimethylation | positive regulation of histone H3-K9 dimethylation
4. Pi J, et al. (2005). A 13-month arsenic exposure reduction effectively reverses the arsenic-induced impairment of the nitric oxide/cyclic guanosine 3',5'-monophosphate pathway in both males and females and improves peripheral vascular function in males. Arsenic Study subjects China blood | urine | water Arsenic | Cyclic GMP Details Arsenic Poisoning | Vascular Diseases
5. Hiraku Y, et al. (2014). We demonstrate that 8-nitroguanine formation is associated with asbestos content in human lung tissues, raising the possibility that it might serve as a biomarker to evaluate asbestos exposure and carcinogenic risk. Asbestos, Amphibole | Asbestos Controls for disease:Mesothelioma, Malignant | Subjects with disease:Mesothelioma, Malignant Japan lung 8-nitroguanine | APEX1 | Asbestos, Amphibole | Asbestos, Serpentine Details
6. Yoshida R, et al. (2001). We show that 8-oxodG levels in asbestos-exposed construction workers were higher (although not statistically significant), and that levels tended to correlate with duration of suspected exposure; these results suggest that even low-level asbestos exposure may induce oxidative stress. Asbestos Workers Japan urine 8-oxo-7-hydrodeoxyguanosine Details cellular response to oxidative stress
7. Khan A, et al. (2017). Ewha Birth & Growth Cohort Study We conducted a high-resolution metabolomics study and detected elevated metabolites of steroidogenesis and amino acid metabolism in preadolescent female children with high urinary bisphenol A levels. sex bisphenol A Children Korea, Republic of urine 22-hydroxycholesterol | 3-methoxytyramine | aerobactin | Androstenedione | anthranilic acid | bisphenol A | Carnitine | Cholesterol | Corticosterone | cortolone | crotonyl-coenzyme A | Cytidine Monophosphate N-Acetylneuraminic Acid | cytidine monophosphate-N-glycoloylneuraminic acid | estrone sulfate | fructose-6-phosphate | glucosaminic acid | Hydrocortisone | isocaproaldehyde | Malonyl Coenzyme A | N-acetylmuramic acid | N-acetylserotonin | phenylacetylglycine | Pregnanediol | Progesterone | testosterone glucuronate Details regulation of cellular amino acid metabolic process | regulation of steroid biosynthetic process
8. Ellis JK, et al. (2012). This study shows evidence that metabolic profiling in an uncontrolled human population is capable of identifying intermediate biomarkers of response to cadmium at true environmental concentrations, paving the way for exposome research. Cadmium Study subjects United Kingdom urine 8-oxo-7-hydrodeoxyguanosine | beta-hydroxyisovaleric acid | Citric Acid | Creatine | Creatinine Details cellular response to oxidative stress
9. Wesselink AK, et al. (2016). Pregnancy Study Online (PRESTO) Total caffeine intake among males, but not females, was associated with fecundability, although the association was not monotonic; with respect to individual beverages, caffeinated black tea was associated with slight reductions among females, and caffeinated soda and energy drink were associated with reduced fecundability among males. diet | sex Caffeine Study subjects Canada|United States beverage, caffeinated | tea, black Caffeine Details female pregnancy
10. Go YM, et al. (2015). We examined quantification strategies to enhance the usefulness of high-resolution metabolomics data for cumulative exposome research; the results provide a simple reference standardization protocol in which individual chemical concentrations are estimated by comparison to a concurrently analyzed, pooled reference sample with known chemical concentrations. Caffeine | Chlorobenzoates | chlorsulfuron | Cotinine | Fyrol PCF | hippuric acid | meobal | octylphenol | pirimicarb | Styrene Study subjects United States plasma Caffeine | Chlorobenzoates | chlorsulfuron | Cotinine | Fyrol PCF | hippuric acid | meobal | octylphenol | pirimicarb | Styrene Details
11. Yang H, et al. (2015). Male Reproductive Health in Chongqing College students (MARHCS) The primary objectives of the MARHCS study are to investigate the associations of male reproductive health in young adults with sociopsychobehavioral factors, as well as changes of environmental exposure due to the relocation from rural campus (in University Town) to metro-campus (in central downtown). diet | tobacco Caffeine | Tobacco Smoke Pollution Study subjects China semen Details spermatogenesis | sperm motility
12. Kang S, et al. (2013). The present study was designed to determine urinary paraben levels among pregnant women and their matching newborn infants, and the association between paraben levels and stress markers; methylparaben was detected as the highest and butylparaben as the lowest in both pregnant women and their infants; levels of ethyl paraben were 4-9 fold higher than found in pregnant women of other countries. body mass index ethyl-p-hydroxybenzoate | methylparaben | Parabens Infants or newborns | Pregnant females Korea, Republic of urine 8-oxo-7-hydrodeoxyguanosine | butylparaben | ethyl-p-hydroxybenzoate | Malondialdehyde | methylparaben | propylparaben Details response to stress
13. Kataria A, et al. (2015). National Health and Nutrition Examination Survey (NHANES) Perfluoroalkyl acids are associated with a reduction in kidney function and increased uric acid levels in otherwise healthy adolescents. Fluorocarbons Children United States serum perfluorooctane sulfonic acid | perfluorooctanoic acid | Uric Acid Details glomerular filtration
14. Kasperczyk S, et al. (2014). We examined the effects of N-acetylcysteine administration on the non-enzymatic defense systems (e.g., uric acid, albumin, bilirubin and alpha-tocopherol) in male workers exposed to lead, over a 12 week study period. Lead Workers Poland blood ALB | alpha-Tocopherol | Bilirubin | Lead | Lipid Peroxides | Uric Acid | zinc protoporphyrin Details
15. Schreinemachers DM, et al. (2015). National Health and Nutrition Examination Survey (NHANES) This study investigated associations between urinary perchlorate and biomarkers of oxidative stress and iron homeostasis, including blood urea nitrogen, lymphocyte counts, serum uric acid, serum iron, and red blood cell counts. perchlorate Study subjects United States serum | urine Iron | perchlorate | Uric Acid Details erythrocyte homeostasis | iron ion homeostasis | lymphocyte homeostasis
1–15 of 15 results.