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Chemical Pyrimidines

1–50 of 3,371 results.
  Chemical Phenotype Co-Mentioned Terms Interaction Organisms Anatomy Inference Network References
1. 1-hexylcarbamoyl-5-fluorouracil multicellular organism reproduction 1-hexylcarbamoyl-5-fluorouracil results in decreased multicellular organism reproduction 1: Daphnia magna     1
2. 2,4,6-triaminopyrimidine ion transport 2,4,6-triaminopyrimidine results in decreased ion transport 1: unclassified Anura Skin   1
3. 2,4,6-triaminopyrimidine ion transport 2,4,6-triaminopyrimidine results in decreased ion transport 1: Rattus norvegicus Kidney   1
4. 2,4,6-triaminopyrimidine renal sodium excretion 2,4,6-triaminopyrimidine results in increased renal sodium excretion 1: Rattus norvegicus Kidney   1
5. 2-(7-(3,4-dimethoxyphenyl)imidazo(1,2-c)pyrimidin-5-ylamino)nicotinamide positive regulation of retinoic acid receptor signaling pathway Vitamin A 2-(7-(3,4-dimethoxyphenyl)imidazo(1,2-c)pyrimidin-5-ylamino)nicotinamide inhibits the reaction [Vitamin A results in increased positive regulation of retinoic acid receptor signaling pathway] 1: Mus musculus Embryo, Mammalian | Fibroblasts | Cell Line   1
6. 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one negative regulation of phosphatidylinositol 3-kinase activity 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one affects negative regulation of phosphatidylinositol 3-kinase activity 1: Homo sapiens Liver | Cell Line, Tumor 1 gene: PTEN 1
7. 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one negative regulation of phosphatidylinositol 3-kinase activity 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one affects negative regulation of phosphatidylinositol 3-kinase activity 1: Homo sapiens Hep G2 Cells 1 gene: PTEN 1
8. 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one positive regulation of cell cycle arrest 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one affects positive regulation of cell cycle arrest 1: Homo sapiens Liver | Cell Line, Tumor   1
9. 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one positive regulation of cell cycle arrest 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one affects positive regulation of cell cycle arrest 1: Homo sapiens Hep G2 Cells   1
10. 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one negative regulation of cell proliferation 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one affects negative regulation of cell proliferation 1: Homo sapiens Hep G2 Cells
3 genes: CDKN1B | PTEN | STAT3
1
11. 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one negative regulation of cell proliferation 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one affects negative regulation of cell proliferation 1: Homo sapiens Liver | Cell Line, Tumor
3 genes: CDKN1B | PTEN | STAT3
1
12. 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one positive regulation of apoptotic process 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one affects positive regulation of apoptotic process 1: Homo sapiens Liver | Cell Line, Tumor
5 genes: AKT1 | CASP3 | CASP9 | HIF1A | PTEN
1
13. 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one positive regulation of apoptotic process 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one affects positive regulation of apoptotic process 1: Homo sapiens Hep G2 Cells
5 genes: AKT1 | CASP3 | CASP9 | HIF1A | PTEN
1
14. 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one activation of cysteine-type endopeptidase activity involved in apoptotic process 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one results in increased activation of cysteine-type endopeptidase activity involved in apoptotic process 1: Homo sapiens Liver | Cell Line, Tumor
2 genes: CASP3 | CASP9
1
15. 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one activation of cysteine-type endopeptidase activity involved in apoptotic process 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one results in increased activation of cysteine-type endopeptidase activity involved in apoptotic process 1: Homo sapiens Hep G2 Cells
2 genes: CASP3 | CASP9
1
16. 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one positive regulation of apoptotic process benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one affects positive regulation of apoptotic process] 1: Homo sapiens Liver | Cell Line, Tumor
5 genes: AKT1 | CASP3 | CASP9 | HIF1A | PTEN
1
17. 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one positive regulation of apoptotic process benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one affects positive regulation of apoptotic process] 1: Homo sapiens Hep G2 Cells
5 genes: AKT1 | CASP3 | CASP9 | HIF1A | PTEN
1
18. 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one positive regulation of intrinsic apoptotic signaling pathway 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one affects positive regulation of intrinsic apoptotic signaling pathway 1: Homo sapiens Liver | Cell Line, Tumor   1
19. 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one positive regulation of intrinsic apoptotic signaling pathway 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one affects positive regulation of intrinsic apoptotic signaling pathway 1: Homo sapiens Hep G2 Cells   1
20. 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one tube formation 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one results in decreased tube formation 1: Homo sapiens Human Umbilical Vein Endothelial Cells | Cells, Cultured 1 gene: VEGFA 1
21. 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one negative regulation of cell migration 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one affects negative regulation of cell migration 1: Homo sapiens Human Umbilical Vein Endothelial Cells | Cells, Cultured 1 gene: PTEN 1
22. 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one positive regulation of cell cycle arrest 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one affects positive regulation of cell cycle arrest 1: Homo sapiens Human Umbilical Vein Endothelial Cells | Cells, Cultured   1
23. 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one negative regulation of tyrosine phosphorylation of STAT protein 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one affects negative regulation of tyrosine phosphorylation of STAT protein 1: Homo sapiens Human Umbilical Vein Endothelial Cells | Cells, Cultured   1
24. 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one negative regulation of cellular response to vascular endothelial growth factor stimulus 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one affects negative regulation of cellular response to vascular endothelial growth factor stimulus 1: Homo sapiens Human Umbilical Vein Endothelial Cells | Cells, Cultured   1
25. 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one negative regulation of angiogenesis 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one affects negative regulation of angiogenesis 1: Homo sapiens Human Umbilical Vein Endothelial Cells | Cells, Cultured   1
26. 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one negative regulation of angiogenesis 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one affects negative regulation of angiogenesis 1: Homo sapiens Hep G2 Cells   1
27. 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one cell proliferation Vemurafenib [2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one results in increased susceptibility to Vemurafenib] which results in decreased cell proliferation 1: Homo sapiens Skin | Cell Line, Tumor
4 genes: AKT1 | PTEN | STAT3 | VEGFA
1
28. 2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one apoptotic process Vemurafenib [2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one results in increased susceptibility to Vemurafenib] which results in increased apoptotic process 1: Homo sapiens Skin | Cell Line, Tumor
5 genes: AKT1 | CASP3 | CASP9 | PARP1 | PTEN
1
29. 2'-deoxycytidine 5'-triphosphate pyrimidine deoxyribonucleoside triphosphate metabolic process Methotrexate [Methotrexate affects pyrimidine deoxyribonucleoside triphosphate metabolic process] which results in decreased abundance of 2'-deoxycytidine 5'-triphosphate 1: Homo sapiens Melanocytes | Cell Line, Tumor   1
30. 2'-deoxy-N4-(2-(4-nitrophenyl)ethoxycarbonyl)-5-azacytidine DNA methylation 2'-deoxy-N4-(2-(4-nitrophenyl)ethoxycarbonyl)-5-azacytidine results in decreased DNA methylation 1: Homo sapiens Liver | Cell Line, Tumor   1
31. 2'-deoxyuridylic acid drug transmembrane transport 2'-deoxyuridylic acid results in decreased drug transmembrane transport 1: Homo sapiens HEK293 Cells | Cell-Free System   1
32. 2'-deoxyuridylic acid drug transmembrane transport Fluorodeoxyuridylate [2'-deoxyuridylic acid results in decreased drug transmembrane transport] which results in decreased export of Fluorodeoxyuridylate 1: Homo sapiens HEK293 Cells | Cell-Free System   1
33. 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-(4-(4-ethylpiperazin-1-yl)-phenylamino)pyrimidin-4-yl)-1-methylurea cell proliferation 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-(4-(4-ethylpiperazin-1-yl)-phenylamino)pyrimidin-4-yl)-1-methylurea results in decreased cell proliferation 1: Homo sapiens Urinary Bladder | Cell Line, Tumor   1
34. 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-(4-(4-ethylpiperazin-1-yl)-phenylamino)pyrimidin-4-yl)-1-methylurea cell proliferation FGFR3 [FGFR3 protein results in increased susceptibility to 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-(4-(4-ethylpiperazin-1-yl)-phenylamino)pyrimidin-4-yl)-1-methylurea] promotes the reaction [3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-(4-(4-ethylpiperazin-1-yl)-phenylamino)pyrimidin-4-yl)-1-methylurea results in decreased cell proliferation] 1: Homo sapiens Urinary Bladder | Cell Line, Tumor   1
35. 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-(4-(4-ethylpiperazin-1-yl)-phenylamino)pyrimidin-4-yl)-1-methylurea angiogenesis FGF2 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-(4-(4-ethylpiperazin-1-yl)-phenylamino)pyrimidin-4-yl)-1-methylurea inhibits the reaction [FGF2 protein results in increased angiogenesis] 1: Mus musculus  
2 genes: FGFR1 | FGFR2
1
36. 3-methylcytidine tRNA methylation METTL2 [METTL2 results in increased tRNA methylation] which results in increased abundance of 3-methylcytidine 1: Mus musculus Brain   1
37. 3-methylcytidine tRNA methylation METTL2 [METTL2 results in increased tRNA methylation] which results in increased abundance of 3-methylcytidine 1: Mus musculus Liver   1
38. 3-methylcytidine tRNA methylation METTL2B [METTL2B results in increased tRNA methylation] which results in increased abundance of 3-methylcytidine 1: Homo sapiens HEK293 Cells   1
39. 3-methylcytidine tRNA methylation METTL6 [METTL6 results in increased tRNA methylation] which results in increased abundance of 3-methylcytidine 1: Mus musculus Brain   1
40. 3-methylcytidine tRNA methylation METTL6 [METTL6 results in increased tRNA methylation] which results in increased abundance of 3-methylcytidine 1: Mus musculus Liver   1
41. 3-methylcytidine mRNA methylation METTL8 [METTL8 results in increased mRNA methylation] which results in increased abundance of 3-methylcytidine 1: Mus musculus Liver   1
42. 3-methylcytidine mRNA methylation METTL8 [METTL8 results in increased mRNA methylation] which results in increased abundance of 3-methylcytidine 1: Homo sapiens HCT116 Cells   1
43. 3-methylcytidine mRNA methylation METTL8 [METTL8 results in increased mRNA methylation] which results in increased abundance of 3-methylcytidine 1: Homo sapiens HeLa Cells   1
44. 3-methylcytosine DNA dealkylation involved in DNA repair ALKBH2 [ALKBH2 protein results in increased DNA dealkylation involved in DNA repair] which results in decreased abundance of 3-methylcytosine 1: Homo sapiens     1
45. 3-methylcytosine DNA dealkylation involved in DNA repair ALKBH3 [ALKBH3 protein results in increased DNA dealkylation involved in DNA repair] which results in decreased abundance of 3-methylcytosine 1: Homo sapiens     1
46. 3-methylthymine DNA dealkylation involved in DNA repair ALKBH2 [ALKBH2 protein results in increased DNA dealkylation involved in DNA repair] which results in decreased abundance of 3-methylthymine 1: Homo sapiens     1
47. 4-(2-phenyl-5,7-bis(trifluoromethyl)pyrazolo(1,5-a)pyrimidin-3-yl)phenol cardiac muscle cell contraction bis(4-hydroxyphenyl)sulfone 4-(2-phenyl-5,7-bis(trifluoromethyl)pyrazolo(1,5-a)pyrimidin-3-yl)phenol inhibits the reaction [bis(4-hydroxyphenyl)sulfone results in increased cardiac muscle cell contraction] 1: Rattus norvegicus Heart Ventricles | Myocytes, Cardiac | Cells, Cultured   1
48. 4-(2-phenyl-5,7-bis(trifluoromethyl)pyrazolo(1,5-a)pyrimidin-3-yl)phenol release of sequestered calcium ion into cytosol by sarcoplasmic reticulum bis(4-hydroxyphenyl)sulfone 4-(2-phenyl-5,7-bis(trifluoromethyl)pyrazolo(1,5-a)pyrimidin-3-yl)phenol inhibits the reaction [bis(4-hydroxyphenyl)sulfone results in increased release of sequestered calcium ion into cytosol by sarcoplasmic reticulum] 1: Rattus norvegicus Heart Ventricles | Myocytes, Cardiac | Cells, Cultured 1 gene: RYR2 1
49. 4-(2-phenyl-5,7-bis(trifluoromethyl)pyrazolo(1,5-a)pyrimidin-3-yl)phenol positive regulation of ERK1 and ERK2 cascade Cadmium Chloride 4-(2-phenyl-5,7-bis(trifluoromethyl)pyrazolo(1,5-a)pyrimidin-3-yl)phenol inhibits the reaction [Cadmium Chloride results in increased positive regulation of ERK1 and ERK2 cascade] 1: Homo sapiens Lung | Cell Line, Tumor
3 genes: ESR1 | ESR2 | MAPK3
1
50. 4-(2-phenyl-5,7-bis(trifluoromethyl)pyrazolo(1,5-a)pyrimidin-3-yl)phenol positive regulation of ERK1 and ERK2 cascade Estradiol 4-(2-phenyl-5,7-bis(trifluoromethyl)pyrazolo(1,5-a)pyrimidin-3-yl)phenol inhibits the reaction [Estradiol results in increased positive regulation of ERK1 and ERK2 cascade] 1: Homo sapiens Lung | Cell Line, Tumor
3 genes: ESR1 | ESR2 | MAPK3
1
1–50 of 3,371 results.