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Chemical Gonadal Hormones

These are exposure studies associated with the chemical and all of its children.

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1–18 of 18 results.
  Reference Associated Study Title Author's Summary Study Factors Stressor Receptors Country Medium Exposure Marker Measurements Outcome
1. Vested A, et al. (2014). The objective of this study was to investigate whether maternal serum concentrations of polychlorinated biphenyls (PCBs) and p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) during pregnancy are associated with son's semen quality and reproductive hormone levels. 2,2',3,3',4,4',5-heptachlorobiphenyl | 2,2',3',4,4',5-hexachlorobiphenyl | 2,3,3',4,4',5-hexachlorobiphenyl | 2,3',4,4',5-pentachlorobiphenyl | 2,4,5,2',4',5'-hexachlorobiphenyl | Dichlorodiphenyl Dichloroethylene | PCB 180 | Polychlorinated Biphenyls Mothers | Study subjects Denmark semen | serum 2,2',3,3',4,4',5-heptachlorobiphenyl | 2,2',3',4,4',5-hexachlorobiphenyl | 2,3,3',4,4',5-hexachlorobiphenyl | 2,3',4,4',5-pentachlorobiphenyl | 2,4,5,2',4',5'-hexachlorobiphenyl | Dichlorodiphenyl Dichloroethylene | Estradiol | FSHB | INHBB | LHB | PCB 180 | SHBG | Testosterone Details spermatogenesis | sperm motility
2. Turyk ME, et al. (2008). Consortium for the health assessment of Great Lakes sport fish consumption Polychlorinated biphenyls exposure, at levels comparable with those of the general U.S. population, was associated with increased thyroglobulin antibodies and increased T(4) in adult males. 2,2',4,4',5-brominated diphenyl ether | 2,2',4,4'-tetrabromodiphenyl ether | Dichlorodiphenyl Dichloroethylene | Halogenated Diphenyl Ethers | hexabrominated diphenyl ether 153 | pentabrominated diphenyl ether 100 | Polychlorinated Biphenyls Study subjects United States serum | urine 2,2',4,4',5-brominated diphenyl ether | 2,2',4,4'-tetrabromodiphenyl ether | Dichlorodiphenyl Dichloroethylene | Halogenated Diphenyl Ethers | hexabrominated diphenyl ether 153 | pentabrominated diphenyl ether 100 | Polychlorinated Biphenyls | SERPINA7 | Testosterone | Thyrotropin | Thyroxine | Triiodothyronine Details immunoglobulin production | testosterone biosynthetic process | thyroid hormone metabolic process
3. Ferguson KK, et al. (2014). Early Life Exposure in Mexico to Environmental Toxicants (ELEMENT) We explored the relationship of prenatal and childhood exposures to phthalates and bisphenol A with pubertal onset and sex hormones in boys (ages 8-14); prenatal exposure was associated with decreased dehydroepiandrosterone sulfate, decreased inhibin B, increased SHBG, greatly reduced odds of adrenarche, and slightly reduced odds of puberty, while childhood exposure was not associated with adrenarche or puberty, but some exposures were associated with increased SHBG levels and decreased testosterone levels. age | sex 2-ethyl-5-carboxypentyl phthalate | bisphenol A | mono(2-ethyl-5-hydroxyhexyl) phthalate | mono(2-ethyl-5-oxohexyl)phthalate | mono-(2-ethylhexyl)phthalate | mono-benzyl phthalate | monobutyl phthalate | monoethyl phthalate | mono-isobutyl phthalate | Phthalic Acids Children | Fetuses | Pregnant females Mexico serum | urine 2-ethyl-5-carboxypentyl phthalate | bisphenol A | Dehydroepiandrosterone Sulfate | INHBB | mono(2-ethyl-5-hydroxyhexyl) phthalate | mono(2-ethyl-5-oxohexyl)phthalate | mono-(2-ethylhexyl)phthalate | mono-benzyl phthalate | monobutyl phthalate | monoethyl phthalate | mono-isobutyl phthalate | SHBG | Testosterone Details dehydroepiandrosterone secretion | development of secondary male sexual characteristics | inhibin secretion | testosterone secretion
4. Fénichel P, et al. (2012). The presence of unconjugated bisphenol A in all cord blood samples suggests placental transfer and fetal exposure. Androstenedione | bisphenol A | Estradiol | Estriol | Estrone | Testosterone Controls for disease:Cryptorchidism | Subjects with disease:Cryptorchidism | Infants or newborns France blood, cord Androstenedione | bisphenol A | Estradiol | Estriol | Estrone | Testosterone Details
5. Lassen TH, et al. (2014). We found that 98% of young men from the general population had detectable urinary levels of bisphenol A, and this was associated with altered levels of reproductive hormones and decreased motile spermatozoa. bisphenol A Study subjects Denmark serum | urine bisphenol A | Estradiol | LHB | Testosterone Details estradiol secretion | luteinizing hormone secretion | sperm motility | testosterone biosynthetic process | testosterone secretion
6. Khan A, et al. (2017). Ewha Birth & Growth Cohort Study We conducted a high-resolution metabolomics study and detected elevated metabolites of steroidogenesis and amino acid metabolism in preadolescent female children with high urinary bisphenol A levels. sex bisphenol A Children Korea, Republic of urine 22-hydroxycholesterol | 3-methoxytyramine | aerobactin | Androstenedione | anthranilic acid | bisphenol A | Carnitine | Cholesterol | Corticosterone | cortolone | crotonyl-coenzyme A | Cytidine Monophosphate N-Acetylneuraminic Acid | cytidine monophosphate-N-glycoloylneuraminic acid | estrone sulfate | fructose-6-phosphate | glucosaminic acid | Hydrocortisone | isocaproaldehyde | Malonyl Coenzyme A | N-acetylmuramic acid | N-acetylserotonin | phenylacetylglycine | Pregnanediol | Progesterone | testosterone glucuronate Details regulation of cellular amino acid metabolic process | regulation of steroid biosynthetic process
7. Watkins DJ, et al. (2017). Early Life Exposure in Mexico to Environmental Toxicants (ELEMENT) Associations between in utero phthalate and bisphenol A exposure and peripubertal measures of male reproductive development are dependent on the timing of that exposure during gestation. age | sex bisphenol A | Dibutyl Phthalate | Diethylhexyl Phthalate | mono-benzyl phthalate | monoethyl phthalate | Phthalic Acids Children | Fetuses | Pregnant females Mexico serum | urine 2-ethyl-5-carboxypentyl phthalate | bisphenol A | Dehydroepiandrosterone Sulfate | Dibutyl Phthalate | Diethylhexyl Phthalate | Estradiol | INHBB | mono(2-ethyl-5-hydroxyhexyl) phthalate | mono(2-ethyl-5-oxohexyl)phthalate | mono-(2-ethylhexyl)phthalate | mono-benzyl phthalate | monobutyl phthalate | monoethyl phthalate | mono-isobutyl phthalate | SHBG Details Prenatal Exposure Delayed Effects | dehydroepiandrosterone secretion | development of secondary male sexual characteristics | estradiol secretion | inhibin secretion
8. Omoruyi IM, et al. (2014). In this study, we investigated the presence of mutagens and chemicals exhibiting estrogenic activity in the daily diet of Nigerians, using in vitro assays. bisphenol A | Estradiol Nigeria water bisphenol A | Estradiol Details
9. Scinicariello F, et al. (2016). National Health and Nutrition Examination Survey (NHANES) We examined the association of bisphenol A (BPA), benzophenone-3 (BP-3), triclosan (TCS), and parabens with serum total testosterone (TT) levels in child and adolescent participants (ages 6-19 years) in the National Health and Nutrition Examination Survey (NHANES) 2011-2012. sex bisphenol A | oxybenzone | Parabens | Triclosan Children United States serum | urine bisphenol A | Cotinine | Creatinine | oxybenzone | Parabens | Testosterone | Triclosan Details testosterone biosynthetic process
10. Ajayi OO, et al. (2012). Results suggest that elevated serum heavy metals (cadmium and lead) and reduction of essential micronutrients (zinc, copper and vitamin E) may contribute to recurrent spontaneous abortion. Cadmium | Chromium | Copper | Iron | Lead | Magnesium | Manganese | Progesterone | Selenium | Tocopherols | Zinc Controls for disease:Abortion, Spontaneous | Subjects with disease:Abortion, Spontaneous | Pregnant females Nigeria serum Cadmium | Chromium | Copper | Iron | Lead | Magnesium | Manganese | Progesterone | Selenium | Tocopherols | Zinc Details
11. Ihde ES, et al. (2015). Endocrine disrupting environmental chemicals were detected in all children in the study, with measurable levels of 4-nonylphenol in nearly one third of subjects; this is the first known published study of 4-nonylphenol levels in American children; no associations were found between the urine levels of these chemicals tested and estrogen metabolites. Endocrine Disruptors Children United States urine 16-hydroxyestrone | 2-hydroxyestradiol | 2-hydroxyestrone | 2-methoxyestrone | 4-hydroxyestrone-4-methyl ether | 4-hydroxyestrone | 4-nonylphenol | bisphenol A | butylparaben | Estrogens | ethyl-p-hydroxybenzoate | methylparaben | mono(2-ethyl-5-hydroxyhexyl) phthalate | mono(2-ethyl-5-oxohexyl)phthalate | mono-(2-ethylhexyl)phthalate | monoethyl phthalate | propylparaben | Triclosan Details estrogen metabolic process
12. Caldwell DJ, et al. (2010). The consistently large margins of exposure and margins of safety strongly suggest that prescribed and total estrogens that may potentially be present in drinking water in the United States are not causing adverse effects in residents, including sensitive subpopulations. Estrogens Children | Study subjects United States water, drinking Estradiol | Estriol | Estrogens | Estrone | Ethinyl Estradiol Details
13. Lopez-Espinosa MJ, et al. (2016). C8 Health Project (C8HP) We found serum perfluoroalkyl substances concentrations to be associated with lower levels of sex hormones and IGF-1 in children aged 6-9 years. Fluorocarbons | perfluorohexanesulfonic acid | perfluorononanoic acid | perfluorooctane sulfonic acid | perfluorooctanoic acid Children United States serum Estradiol | IGF1 | perfluorohexanesulfonic acid | perfluorononanoic acid | perfluorooctane sulfonic acid | perfluorooctanoic acid | Testosterone Details estradiol secretion | gene expression | testosterone secretion
14. Goudarzi H, et al. (2017). Sapporo Cohort, Hokkaido Study on Environment and Child Health Our results indicate that prenatal exposure to perfluorinated chemicals is significantly associated with glucocorticoid and dehydroepiandrosterone levels in cord blood. tobacco Fluorocarbons | perfluorooctane sulfonic acid | perfluorooctanoic acid Fetuses | Infants or newborns | Pregnant females Japan blood, cord | serum Androstenedione | Cortisone | Dehydroepiandrosterone | Hydrocortisone | perfluorooctane sulfonic acid | perfluorooctanoic acid Details cortisol secretion | dehydroepiandrosterone secretion
15. Giwercman AH, et al. (2006). Gonadotropin levels and sex hormone-binding globulin seem to be affected by persistent organohalogen pollutant exposure, but the pattern of endocrine response is the subject of considerable geographic variation. Hydrocarbons, Halogenated Study subjects Greenland|Poland|
Sweden|Ukraine
serum 2,4,5,2',4',5'-hexachlorobiphenyl | Dichlorodiphenyl Dichloroethylene | Estradiol | FSHB | INHBB | LHB | Testosterone Details
16. Sancini A, et al. (2014). The correlation between the values of urinary nickel and plasma testosterone was found negative; we suggest that occupational exposure to low doses of nickel present in the urban environment is able to influence some lines of the hypothalamic-pituitary-gonadal axis in exposed workers. Nickel Workers Italy air, personal | plasma | urine Nickel | Testosterone Details
17. Toft G, et al. (2016). Environmental perfluorooctane sulfonate exposure was associated with steroid hormone and INSL3 concentrations in amniotic fluid, but was not associated with cryptorchidism or hypospadias in our study population. perfluorooctane sulfonic acid Pregnant females Denmark amniotic fluid 17-alpha-Hydroxyprogesterone | Androstenedione | Dehydroepiandrosterone Sulfate | Hydrocortisone | INSL3 | Progesterone | Testosterone Details Cryptorchidism | Hypospadias | regulation of gene expression | regulation of testosterone biosynthetic process
18. Sancini A, et al. (2014). Urinary 1-hydroxypyrene (a biomarker for exposure to polycyclic aromatic hydrocarbons) was measured in non-smoker male workers and was related to an increase in plasma estradiol; we believe that polycyclic aromatic hydrocarbons can interact with the hypothalamic-pituitary axis. Polycyclic Aromatic Hydrocarbons Workers Italy plasma | urine 1-hydroxypyrene | Estradiol Details
1–18 of 18 results.