1. |
7-hydroxymitragynine
|
small intestine smooth muscle contraction
|
|
7-hydroxymitragynine affects small intestine smooth muscle contraction |
1: Cavia porcellus |
Ileum |
|
1 |
2. |
7-hydroxymitragynine
|
smooth muscle contraction
|
|
7-hydroxymitragynine affects smooth muscle contraction |
1: Mus musculus |
Vas Deferens |
|
1 |
3. |
9-methoxy-N(2)-methylellipticinium
|
positive regulation of cell death
|
|
9-methoxy-N(2)-methylellipticinium results in increased positive regulation of cell death |
1: Rattus norvegicus |
Brain |
|
1 |
4. |
9-methoxy-N(2)-methylellipticinium
|
positive regulation of cell death
|
Reserpine
|
Reserpine inhibits the reaction [9-methoxy-N(2)-methylellipticinium results in increased positive regulation of cell death] |
1: Rattus norvegicus |
Brain |
|
1 |
5. |
9-methoxy-N(2)-methylellipticinium
|
positive regulation of cell death
|
Dopamine Uptake Inhibitors
|
Dopamine Uptake Inhibitors inhibits the reaction [9-methoxy-N(2)-methylellipticinium results in increased positive regulation of cell death] |
1: Rattus norvegicus |
Brain |
|
1 |
6. |
9-methoxy-N(2)-methylellipticinium
|
positive regulation of cell death
|
Serotonin Uptake Inhibitors
|
Serotonin Uptake Inhibitors inhibits the reaction [9-methoxy-N(2)-methylellipticinium results in increased positive regulation of cell death] |
1: Rattus norvegicus |
Brain |
|
1 |
7. |
9-methoxy-N(2)-methylellipticinium
|
positive regulation of cell death
|
Piperonyl Butoxide
|
Piperonyl Butoxide inhibits the reaction [9-methoxy-N(2)-methylellipticinium results in increased positive regulation of cell death] |
1: Rattus norvegicus |
Brain |
|
1 |
8. |
9-methoxy-N(2)-methylellipticinium
|
positive regulation of cell death
|
Metyrapone
|
Metyrapone inhibits the reaction [9-methoxy-N(2)-methylellipticinium results in increased positive regulation of cell death] |
1: Rattus norvegicus |
Brain |
|
1 |
9. |
9-methoxy-N(2)-methylellipticinium
|
positive regulation of cell death
|
Phenobarbital
|
Phenobarbital promotes the reaction [9-methoxy-N(2)-methylellipticinium results in increased positive regulation of cell death] |
1: Rattus norvegicus |
Brain |
|
1 |
10. |
Ajmaline
|
glycolytic process
|
|
Ajmaline results in increased glycolytic process |
1: Oryctolagus cuniculus |
Heart |
|
1 |
11. |
Ajmaline
|
regulation of heart rate
|
|
Ajmaline results in decreased regulation of heart rate |
1: Homo sapiens |
Heart |
1 gene: SCN5A
|
1 |
12. |
Ajmaline
|
regulation of heart rate
|
|
Ajmaline results in decreased regulation of heart rate |
1: Rattus norvegicus |
Cardiovascular System |
1 gene: SCN5A
|
1 |
13. |
brucine
|
cell death
|
Antimycin A
|
brucine inhibits the reaction [Antimycin A results in increased cell death] |
|
Kidney Tubules, Proximal |
1 gene: CTSD
|
1 |
14. |
brucine
|
angiogenesis
|
Diethylnitrosamine
|
brucine inhibits the reaction [Diethylnitrosamine results in increased angiogenesis] |
1: Rattus norvegicus |
|
3 genes: FN1 | MMP2 | PTGS2
|
1 |
15. |
brucine
|
apoptotic process
|
Diethylnitrosamine
|
[Diethylnitrosamine co-treated with brucine] results in increased apoptotic process |
1: Rattus norvegicus |
|
5 genes: BAX | BCL2 | CASP3 | CASP9 | TNF
|
1 |
16. |
brucine
|
negative regulation of cell migration
|
|
brucine affects negative regulation of cell migration |
1: Homo sapiens |
Hep G2 Cells |
1 gene: BCL2
|
1 |
17. |
brucine
|
negative regulation of cell migration
|
|
brucine affects negative regulation of cell migration |
1: Homo sapiens |
Liver | Tumor Cells, Cultured |
1 gene: BCL2
|
1 |
18. |
brucine
|
negative regulation of cellular response to hypoxia
|
|
brucine affects negative regulation of cellular response to hypoxia |
1: Homo sapiens |
Hep G2 Cells |
|
1 |
19. |
brucine
|
negative regulation of cellular response to hypoxia
|
|
brucine affects negative regulation of cellular response to hypoxia |
1: Mus musculus |
|
|
1 |
20. |
ellipticine
|
positive regulation of cell death
|
|
ellipticine results in increased positive regulation of cell death |
1: Homo sapiens |
HCT116 Cells |
2 genes: CDKN1A | CDKN1B
|
1 |
21. |
ellipticine
|
DNA modification
|
|
ellipticine results in increased DNA modification |
1: Homo sapiens |
HCT116 Cells |
1 gene: CYP1B1
|
1 |
22. |
ellipticine
|
benzene-containing compound metabolic process
|
|
ellipticine results in decreased benzene-containing compound metabolic process |
1: Homo sapiens |
HCT116 Cells |
1 gene: CYP1B1
|
1 |
23. |
ellipticine
|
benzene-containing compound metabolic process
|
benzo(a)pyrene 7,8-dihydrodiol
|
[ellipticine results in decreased benzene-containing compound metabolic process] which results in decreased chemical synthesis of benzo(a)pyrene 7,8-dihydrodiol |
1: Homo sapiens |
HCT116 Cells |
1 gene: CYP1B1
|
1 |
24. |
Ibogaine
|
positive regulation of protein maturation
|
Brefeldin A
|
Brefeldin A inhibits the reaction [Ibogaine results in increased positive regulation of protein maturation] |
1: Homo sapiens |
HEK293 Cells |
|
1 |
25. |
Ibogaine
|
positive regulation of protein maturation
|
Brefeldin A
| SLC6A3
|
Brefeldin A inhibits the reaction [[Ibogaine results in increased positive regulation of protein maturation] which affects the N-linked glycosylation of and results in increased transport of SLC6A3 protein mutant form] |
1: Homo sapiens |
HEK293 Cells |
|
1 |
26. |
Ibogaine
|
positive regulation of protein localization to cell surface
|
|
Ibogaine results in increased positive regulation of protein localization to cell surface |
1: Homo sapiens |
HEK293 Cells |
|
1 |
27. |
Ibogaine
|
positive regulation of protein localization to cell surface
|
SLC6A3
|
[Ibogaine results in increased positive regulation of protein localization to cell surface] which results in increased transport of and affects the localization of SLC6A3 protein |
1: Homo sapiens |
HEK293 Cells |
|
1 |
28. |
Ibogaine
|
positive regulation of protein localization to cell surface
|
SLC6A3
|
[Ibogaine results in increased positive regulation of protein localization to cell surface] which results in increased transport of and affects the localization of SLC6A3 protein mutant form |
1: Homo sapiens |
HEK293 Cells |
|
1 |
29. |
Ibogaine
|
positive regulation of protein maturation
|
|
Ibogaine results in increased positive regulation of protein maturation |
1: Homo sapiens |
HEK293 Cells |
|
1 |
30. |
Ibogaine
|
positive regulation of protein maturation
|
SLC6A3
|
[Ibogaine results in increased positive regulation of protein maturation] which affects the N-linked glycosylation of SLC6A3 protein |
1: Homo sapiens |
HEK293 Cells |
|
1 |
31. |
Ibogaine
|
positive regulation of protein maturation
|
SLC6A3
|
[Ibogaine results in increased positive regulation of protein maturation] which affects the N-linked glycosylation of SLC6A3 protein mutant form |
1: Homo sapiens |
HEK293 Cells |
|
1 |
32. |
Ibogaine
|
positive regulation of protein maturation
|
SEC24D
|
SEC24D protein promotes the reaction [Ibogaine results in increased positive regulation of protein maturation] |
1: Homo sapiens |
HEK293 Cells |
|
1 |
33. |
Ibogaine
|
positive regulation of protein maturation
|
SEC24D
| SLC6A3
|
SEC24D protein promotes the reaction [[Ibogaine results in increased positive regulation of protein maturation] which affects the N-linked glycosylation of SLC6A3 protein mutant form] |
1: Homo sapiens |
HEK293 Cells |
|
1 |
34. |
Ibogaine
|
positive regulation of protein localization to cell surface
|
SEC24D
|
SEC24D protein promotes the reaction [Ibogaine results in increased positive regulation of protein localization to cell surface] |
1: Homo sapiens |
HEK293 Cells |
|
1 |
35. |
Ibogaine
|
positive regulation of protein localization to cell surface
|
SEC24D
| SLC6A3
|
SEC24D protein promotes the reaction [[Ibogaine results in increased positive regulation of protein localization to cell surface] which results in increased transport of and affects the localization of SLC6A3 protein mutant form] |
1: Homo sapiens |
HEK293 Cells |
|
1 |
36. |
Ibogaine
|
positive regulation of protein localization to cell surface
|
Dopamine
| SLC6A3
|
[[Ibogaine results in increased positive regulation of protein localization to cell surface] which affects the localization of SLC6A3 protein] which results in increased import of Dopamine |
1: Homo sapiens |
HEK293 Cells |
|
1 |
37. |
Ibogaine
|
positive regulation of protein localization to cell surface
|
Dopamine
| SLC6A3
|
[[Ibogaine results in increased positive regulation of protein localization to cell surface] which affects the localization of SLC6A3 protein mutant form] which results in increased import of Dopamine |
1: Homo sapiens |
HEK293 Cells |
|
1 |
38. |
methyl 2-(3-ethyl-9-fluoro-7a-hydroxy-8-methoxy-1,2,3,4,6,7,7a,12,12a,12b-decahydroindolo(2,3-a)quinolizin-2-yl)-3-methoxyacrylate
|
regulation of small intestine smooth muscle contraction
|
|
methyl 2-(3-ethyl-9-fluoro-7a-hydroxy-8-methoxy-1,2,3,4,6,7,7a,12,12a,12b-decahydroindolo(2,3-a)quinolizin-2-yl)-3-methoxyacrylate affects regulation of small intestine smooth muscle contraction |
1: Sus scrofa |
Ileum |
|
1 |
39. |
methyl 2-(3-ethyl-9-fluoro-7a-hydroxy-8-methoxy-1,2,3,4,6,7,7a,12,12a,12b-decahydroindolo(2,3-a)quinolizin-2-yl)-3-methoxyacrylate
|
small intestine smooth muscle contraction
|
|
methyl 2-(3-ethyl-9-fluoro-7a-hydroxy-8-methoxy-1,2,3,4,6,7,7a,12,12a,12b-decahydroindolo(2,3-a)quinolizin-2-yl)-3-methoxyacrylate affects small intestine smooth muscle contraction |
1: Cavia porcellus |
Ileum |
|
1 |
40. |
methyl 2-(3-ethyl-9-fluoro-7a-hydroxy-8-methoxy-1,2,3,4,6,7,7a,12,12a,12b-decahydroindolo(2,3-a)quinolizin-2-yl)-3-methoxyacrylate
|
smooth muscle contraction
|
|
methyl 2-(3-ethyl-9-fluoro-7a-hydroxy-8-methoxy-1,2,3,4,6,7,7a,12,12a,12b-decahydroindolo(2,3-a)quinolizin-2-yl)-3-methoxyacrylate affects smooth muscle contraction |
1: Mus musculus |
Vas Deferens |
|
1 |
41. |
methyl 2-(3-ethyl-9-fluoro-7a-hydroxy-8-methoxy-1,2,3,4,6,7,7a,12,12a,12b-decahydroindolo(2,3-a)quinolizin-2-yl)-3-methoxyacrylate
|
smooth muscle contraction
|
cyprodime
| norbinaltorphimine
|
[cyprodime co-treated with norbinaltorphimine] inhibits the reaction [methyl 2-(3-ethyl-9-fluoro-7a-hydroxy-8-methoxy-1,2,3,4,6,7,7a,12,12a,12b-decahydroindolo(2,3-a)quinolizin-2-yl)-3-methoxyacrylate affects smooth muscle contraction] |
1: Mus musculus |
Vas Deferens |
|
1 |
42. |
methyl 2-(3-ethyl-9-fluoro-7a-hydroxy-8-methoxy-1,2,3,4,6,7,7a,12,12a,12b-decahydroindolo(2,3-a)quinolizin-2-yl)-3-methoxyacrylate
|
smooth muscle contraction
|
cyprodime
| naltrindole
| norbinaltorphimine
|
naltrindole promotes the reaction [[cyprodime co-treated with norbinaltorphimine] inhibits the reaction [methyl 2-(3-ethyl-9-fluoro-7a-hydroxy-8-methoxy-1,2,3,4,6,7,7a,12,12a,12b-decahydroindolo(2,3-a)quinolizin-2-yl)-3-methoxyacrylate affects smooth muscle contraction]] |
1: Mus musculus |
Vas Deferens |
|
1 |
43. |
mitragynine
|
delayed rectifier potassium channel activity
|
|
mitragynine affects delayed rectifier potassium channel activity |
1: Homo sapiens |
Myocytes, Cardiac |
1 gene: KCNH2
|
1 |
44. |
mitragynine
|
regulation of action potential
|
|
mitragynine affects regulation of action potential |
1: Homo sapiens |
Myocytes, Cardiac |
|
1 |
45. |
mitragynine
|
cAMP biosynthetic process
|
Colforsin
|
mitragynine affects the reaction [Colforsin results in increased cAMP biosynthetic process] |
1: Homo sapiens |
Cell Line, Tumor |
1 gene: ADORA2A
|
1 |
46. |
mitragynine
|
cAMP biosynthetic process
|
Colforsin
| Morphine
|
[mitragynine co-treated with Morphine] affects the reaction [Colforsin results in increased cAMP biosynthetic process] |
1: Homo sapiens |
Cell Line, Tumor |
1 gene: ADORA2A
|
1 |
47. |
Reserpine
|
vasoconstriction
|
|
Reserpine affects vasoconstriction |
1: Rattus norvegicus |
Mesentery |
2 genes: HTR1A | SLC6A4
|
1 |
48. |
Reserpine
|
vasoconstriction
|
Amphetamine
|
Amphetamine affects the reaction [Reserpine affects vasoconstriction] |
1: Rattus norvegicus |
Mesentery |
2 genes: HTR1A | SLC6A4
|
1 |
49. |
Reserpine
|
regulation of blood pressure
|
Dextroamphetamine
|
Reserpine inhibits the reaction [Dextroamphetamine results in increased regulation of blood pressure] |
1: Rattus norvegicus |
Cardiovascular System |
8 genes: AGTR2 | CHGA | GCH1 | LEP | NPY | POMC | PTGS2 | TAC1
|
1 |
50. |
Reserpine
|
regulation of blood pressure
|
Dextroamphetamine
|
Reserpine promotes the reaction [Dextroamphetamine results in increased regulation of blood pressure] |
1: Rattus norvegicus |
Cardiovascular System |
8 genes: AGTR2 | CHGA | GCH1 | LEP | NPY | POMC | PTGS2 | TAC1
|
1 |