Skip navigation

Disease Cholestasis, Extrahepatic

These phenotypes are associated with Cholestasis, Extrahepatic. A phenotype has an inferred association via a curated chemical interaction or a gene-GO annotation or both.

1–50 of 1,677 results.
  Phenotype Disease Chemical Inference Network Gene Inference Network References
1. cell proliferation Cholestasis, Extrahepatic Inferred via 9 chemicals: Bile Acids and Salts | Bilirubin | Diosmin | Glutathione | Phenytoin | rosmarinic acid | Sildenafil Citrate | Taurine | Zinc Inferred via 2 genes: TGFB1 | TNF 23
2. apoptotic process Cholestasis, Extrahepatic Inferred via 8 chemicals: Bilirubin | Diosmin | Glutathione | Malondialdehyde | Phenytoin | rosmarinic acid | Sildenafil Citrate | Zinc Inferred via 7 genes: IL1B | MAP3K7 | MAPK1 | MAPK14 | MAPK3 | MYD88 | TNF 58
3. positive regulation of cell death Cholestasis, Extrahepatic Inferred via 8 chemicals: Bilirubin | Glutathione | Malondialdehyde | Phenytoin | rosmarinic acid | Taurine | Zinc | Zinc Acetate Inferred via 3 genes: CCN2 | HMGB1 | IL1B 19
4. membrane lipid catabolic process Cholestasis, Extrahepatic Inferred via 7 chemicals: Bilirubin | Diosmin | Glutathione | Malondialdehyde | Sildenafil Citrate | Taurine | Zinc   37
5. response to oxidative stress Cholestasis, Extrahepatic Inferred via 6 chemicals: Bilirubin | Diosmin | Glutathione | Sildenafil Citrate | Taurine | Zinc Inferred via 6 genes: CYGB | KEAP1 | MMP2 | MMP9 | MPO | TLR4 28
6. glutathione biosynthetic process Cholestasis, Extrahepatic Inferred via 6 chemicals: Bilirubin | Glutathione | Phenytoin | rosmarinic acid | Taurine | Zinc   20
7. lipid oxidation Cholestasis, Extrahepatic Inferred via 6 chemicals: Glutathione | Malondialdehyde | rosmarinic acid | Taurine | Zinc | Zinc Acetate   258
8. DNA damage response, detection of DNA damage Cholestasis, Extrahepatic Inferred via 6 chemicals: Diosmin | Glutathione | Phenytoin | rosmarinic acid | Taurine | Zinc   14
9. positive regulation of apoptotic process Cholestasis, Extrahepatic Inferred via 5 chemicals: Bilirubin | Glutathione | Taurine | Zinc | Zinc Acetate Inferred via 14 genes: HMGB1 | IL1B | IL6 | JUN | MAPK8 | MAPK9 | MMP2 | MMP9 | NOS2 | NOS3 | RELA | TGFB1 | TLR4 | TNF 12
10. cell death Cholestasis, Extrahepatic Inferred via 5 chemicals: Glutathione | Phenytoin | Taurine | Zinc | Zinc Acetate   28
11. regulation of mitochondrial membrane potential Cholestasis, Extrahepatic Inferred via 5 chemicals: Glutathione | Phenytoin | Sildenafil Citrate | Taurine | Zinc   13
12. reactive oxygen species biosynthetic process Cholestasis, Extrahepatic Inferred via 5 chemicals: Bilirubin | Glutathione | rosmarinic acid | Sildenafil Citrate | Taurine   13
13. glutathione metabolic process Cholestasis, Extrahepatic Inferred via 5 chemicals: Glutathione | rosmarinic acid | Taurine | Zinc | Zinc Acetate   267
14. lipid catabolic process Cholestasis, Extrahepatic Inferred via 5 chemicals: Bilirubin | Glutathione | rosmarinic acid | Taurine | Zinc   19
15. positive regulation of reactive oxygen species biosynthetic process Cholestasis, Extrahepatic Inferred via 4 chemicals: Glutathione | Malondialdehyde | Taurine | Zinc Inferred via 1 gene: TLR4 13
16. positive regulation of superoxide dismutase activity Cholestasis, Extrahepatic Inferred via 4 chemicals: Glutathione | Taurine | Zinc | Zinc Acetate Inferred via 1 gene: TNF 6
17. reactive oxygen species metabolic process Cholestasis, Extrahepatic Inferred via 4 chemicals: Bilirubin | Diosmin | Glutathione | Phenytoin Inferred via 1 gene: CCN2 8
18. superoxide dismutase activity Cholestasis, Extrahepatic Inferred via 4 chemicals: Bilirubin | Glutathione | Taurine | Zinc   10
19. bilirubin transport Cholestasis, Extrahepatic Inferred via 4 chemicals: Bilirubin | Taurine | Zinc | Zinc Acetate   8
20. positive regulation of cell proliferation Cholestasis, Extrahepatic Inferred via 3 chemicals: Diosmin | Glutathione | Zinc Inferred via 10 genes: CCN2 | HMGB1 | IL1B | IL6 | JUN | MAPK1 | RELA | TGFB1 | TIMP1 | TNF 7
21. superoxide anion generation Cholestasis, Extrahepatic Inferred via 3 chemicals: Diosmin | Sildenafil Citrate | Taurine   5
22. glutathione peroxidase activity Cholestasis, Extrahepatic Inferred via 3 chemicals: Malondialdehyde | Taurine | Zinc   8
23. mitotic cell cycle arrest Cholestasis, Extrahepatic Inferred via 3 chemicals: Glutathione | Taurine | Zinc   5
24. positive regulation of glutathione peroxidase activity Cholestasis, Extrahepatic Inferred via 3 chemicals: Glutathione | Taurine | Zinc   6
25. negative regulation of superoxide dismutase activity Cholestasis, Extrahepatic Inferred via 3 chemicals: Glutathione | Taurine | Zinc   5
26. intrahepatic bile duct development Cholestasis, Extrahepatic Inferred via 3 chemicals: Taurine | Zinc | Zinc Acetate   1
27. protein oxidation Cholestasis, Extrahepatic Inferred via 3 chemicals: Glutathione | Taurine | Zinc   7
28. zinc ion homeostasis Cholestasis, Extrahepatic Inferred via 3 chemicals: Taurine | Zinc | Zinc Acetate   8
29. drug metabolic process Cholestasis, Extrahepatic Inferred via 3 chemicals: Glutathione | Phenytoin | Zinc   7
30. detection of oxidative stress Cholestasis, Extrahepatic Inferred via 3 chemicals: Phenytoin | Sildenafil Citrate | Zinc   8
31. positive regulation of NF-kappaB transcription factor activity Cholestasis, Extrahepatic Inferred via 2 chemicals: Bilirubin | rosmarinic acid Inferred via 7 genes: IL1B | MAP3K7 | MYD88 | RELA | TGFB1 | TLR4 | TNF 3
32. regulation of blood pressure Cholestasis, Extrahepatic Inferred via 2 chemicals: Glutathione | Sildenafil Citrate Inferred via 3 genes: ACTA2 | NOS2 | NOS3 13
33. vasodilation Cholestasis, Extrahepatic Inferred via 2 chemicals: Glutathione | Sildenafil Citrate Inferred via 2 genes: ALB | NOS3 25
34. positive regulation of cytokine production involved in inflammatory response Cholestasis, Extrahepatic Inferred via 2 chemicals: Glutathione | Zinc Inferred via 2 genes: MYD88 | TLR4 5
35. nitric oxide biosynthetic process Cholestasis, Extrahepatic Inferred via 2 chemicals: rosmarinic acid | Taurine Inferred via 2 genes: NOS2 | NOS3 6
36. apoptotic DNA fragmentation Cholestasis, Extrahepatic Inferred via 2 chemicals: Taurine | Zinc Inferred via 1 gene: HMGB1 6
37. spermatogenesis Cholestasis, Extrahepatic Inferred via 2 chemicals: Glutathione | Zinc Inferred via 1 gene: TIMP2 5
38. glucose homeostasis Cholestasis, Extrahepatic Inferred via 2 chemicals: Taurine | Zinc Inferred via 1 gene: IL6 4
39. insulin metabolic process Cholestasis, Extrahepatic Inferred via 2 chemicals: Taurine | Zinc   3
40. positive regulation of necrotic cell death Cholestasis, Extrahepatic Inferred via 2 chemicals: Taurine | Zinc   2
41. positive regulation of mitochondrial membrane potential Cholestasis, Extrahepatic Inferred via 2 chemicals: Glutathione | Zinc   5
42. apoptotic chromosome condensation Cholestasis, Extrahepatic Inferred via 2 chemicals: Glutathione | Taurine   4
43. regulation of metabolic process Cholestasis, Extrahepatic Inferred via 2 chemicals: Bilirubin | Glutathione   3
44. positive regulation of meiotic cell cycle process involved in oocyte maturation Cholestasis, Extrahepatic Inferred via 2 chemicals: Glutathione | Zinc   3
45. leukocyte migration involved in inflammatory response Cholestasis, Extrahepatic Inferred via 2 chemicals: Taurine | Zinc   2
46. hydrogen peroxide biosynthetic process Cholestasis, Extrahepatic Inferred via 2 chemicals: Glutathione | Taurine   5
47. response to stress Cholestasis, Extrahepatic Inferred via 2 chemicals: Malondialdehyde | Zinc   5
48. xenobiotic metabolic process Cholestasis, Extrahepatic Inferred via 2 chemicals: Glutathione | Phenytoin   4
49. glutathione transferase activity Cholestasis, Extrahepatic Inferred via 2 chemicals: Taurine | Zinc   6
50. positive regulation of response to drug Cholestasis, Extrahepatic Inferred via 2 chemicals: Diosmin | Sildenafil Citrate   1
1–50 of 1,677 results.