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Disease Cholestasis, Extrahepatic

These phenotypes are associated with Cholestasis, Extrahepatic. A phenotype has an inferred association via a curated chemical interaction or a gene-GO annotation or both.

1–50 of 1,692 results.
  Phenotype Disease Chemical Inference Network Gene Inference Network References
1. cell proliferation Cholestasis, Extrahepatic Inferred via 9 chemicals: Bile Acids and Salts | Bilirubin | Diosmin | Glutathione | Phenytoin | rosmarinic acid | Sildenafil Citrate | Taurine | Zinc Inferred via 1 gene: TGFB1 23
2. apoptotic process Cholestasis, Extrahepatic Inferred via 8 chemicals: Bilirubin | Diosmin | Glutathione | Malondialdehyde | Phenytoin | rosmarinic acid | Sildenafil Citrate | Zinc Inferred via 7 genes: IL1B | MAP3K7 | MAPK1 | MAPK14 | MAPK3 | MYD88 | TNF 58
3. positive regulation of cell death Cholestasis, Extrahepatic Inferred via 8 chemicals: Bilirubin | Glutathione | Malondialdehyde | Phenytoin | rosmarinic acid | Taurine | Zinc | Zinc Acetate Inferred via 3 genes: CCN2 | HMGB1 | IL1B 19
4. membrane lipid catabolic process Cholestasis, Extrahepatic Inferred via 7 chemicals: Bilirubin | Diosmin | Glutathione | Malondialdehyde | Sildenafil Citrate | Taurine | Zinc   37
5. response to oxidative stress Cholestasis, Extrahepatic Inferred via 6 chemicals: Bilirubin | Diosmin | Glutathione | Sildenafil Citrate | Taurine | Zinc Inferred via 6 genes: CYGB | KEAP1 | MMP2 | MMP9 | MPO | TLR4 28
6. DNA damage response, detection of DNA damage Cholestasis, Extrahepatic Inferred via 6 chemicals: Diosmin | Glutathione | Phenytoin | rosmarinic acid | Taurine | Zinc   14
7. lipid oxidation Cholestasis, Extrahepatic Inferred via 6 chemicals: Glutathione | Malondialdehyde | rosmarinic acid | Taurine | Zinc | Zinc Acetate   297
8. glutathione biosynthetic process Cholestasis, Extrahepatic Inferred via 6 chemicals: Bilirubin | Glutathione | Phenytoin | rosmarinic acid | Taurine | Zinc   20
9. positive regulation of apoptotic process Cholestasis, Extrahepatic Inferred via 5 chemicals: Bilirubin | Glutathione | Taurine | Zinc | Zinc Acetate Inferred via 14 genes: HMGB1 | IL1B | IL6 | JUN | MAPK8 | MAPK9 | MMP2 | MMP9 | NOS2 | NOS3 | RELA | TGFB1 | TLR4 | TNF 12
10. lipid catabolic process Cholestasis, Extrahepatic Inferred via 5 chemicals: Bilirubin | Glutathione | rosmarinic acid | Taurine | Zinc   19
11. reactive oxygen species biosynthetic process Cholestasis, Extrahepatic Inferred via 5 chemicals: Bilirubin | Glutathione | rosmarinic acid | Sildenafil Citrate | Taurine   15
12. cell death Cholestasis, Extrahepatic Inferred via 5 chemicals: Glutathione | Phenytoin | Taurine | Zinc | Zinc Acetate   29
13. glutathione metabolic process Cholestasis, Extrahepatic Inferred via 5 chemicals: Glutathione | rosmarinic acid | Taurine | Zinc | Zinc Acetate   294
14. regulation of mitochondrial membrane potential Cholestasis, Extrahepatic Inferred via 5 chemicals: Glutathione | Phenytoin | Sildenafil Citrate | Taurine | Zinc   13
15. reactive oxygen species metabolic process Cholestasis, Extrahepatic Inferred via 4 chemicals: Bilirubin | Diosmin | Glutathione | Phenytoin Inferred via 1 gene: CCN2 8
16. positive regulation of superoxide dismutase activity Cholestasis, Extrahepatic Inferred via 4 chemicals: Glutathione | Taurine | Zinc | Zinc Acetate Inferred via 1 gene: TNF 6
17. positive regulation of reactive oxygen species biosynthetic process Cholestasis, Extrahepatic Inferred via 4 chemicals: Glutathione | Malondialdehyde | Taurine | Zinc Inferred via 1 gene: TLR4 13
18. superoxide dismutase activity Cholestasis, Extrahepatic Inferred via 4 chemicals: Bilirubin | Glutathione | Taurine | Zinc   10
19. bilirubin transport Cholestasis, Extrahepatic Inferred via 4 chemicals: Bilirubin | Taurine | Zinc | Zinc Acetate   12
20. positive regulation of cell proliferation Cholestasis, Extrahepatic Inferred via 3 chemicals: Diosmin | Glutathione | Zinc Inferred via 10 genes: CCN2 | HMGB1 | IL1B | IL6 | JUN | MAPK1 | RELA | TGFB1 | TIMP1 | TNF 7
21. mitotic cell cycle arrest Cholestasis, Extrahepatic Inferred via 3 chemicals: Glutathione | Taurine | Zinc   5
22. negative regulation of superoxide dismutase activity Cholestasis, Extrahepatic Inferred via 3 chemicals: Glutathione | Taurine | Zinc   6
23. intrahepatic bile duct development Cholestasis, Extrahepatic Inferred via 3 chemicals: Taurine | Zinc | Zinc Acetate   1
24. zinc ion homeostasis Cholestasis, Extrahepatic Inferred via 3 chemicals: Taurine | Zinc | Zinc Acetate   8
25. protein oxidation Cholestasis, Extrahepatic Inferred via 3 chemicals: Glutathione | Taurine | Zinc   7
26. glutathione peroxidase activity Cholestasis, Extrahepatic Inferred via 3 chemicals: Malondialdehyde | Taurine | Zinc   8
27. detection of oxidative stress Cholestasis, Extrahepatic Inferred via 3 chemicals: Phenytoin | Sildenafil Citrate | Zinc   8
28. drug metabolic process Cholestasis, Extrahepatic Inferred via 3 chemicals: Glutathione | Phenytoin | Zinc   7
29. superoxide anion generation Cholestasis, Extrahepatic Inferred via 3 chemicals: Diosmin | Sildenafil Citrate | Taurine   5
30. positive regulation of glutathione peroxidase activity Cholestasis, Extrahepatic Inferred via 3 chemicals: Glutathione | Taurine | Zinc   6
31. positive regulation of NF-kappaB transcription factor activity Cholestasis, Extrahepatic Inferred via 2 chemicals: Bilirubin | rosmarinic acid Inferred via 7 genes: IL1B | MAP3K7 | MYD88 | RELA | TGFB1 | TLR4 | TNF 3
32. regulation of blood pressure Cholestasis, Extrahepatic Inferred via 2 chemicals: Glutathione | Sildenafil Citrate Inferred via 3 genes: ACTA2 | NOS2 | NOS3 13
33. vasodilation Cholestasis, Extrahepatic Inferred via 2 chemicals: Glutathione | Sildenafil Citrate Inferred via 3 genes: ALB | NOS3 | TNF 26
34. nitric oxide biosynthetic process Cholestasis, Extrahepatic Inferred via 2 chemicals: rosmarinic acid | Taurine Inferred via 2 genes: NOS2 | NOS3 6
35. positive regulation of collagen biosynthetic process Cholestasis, Extrahepatic Inferred via 2 chemicals: rosmarinic acid | Taurine Inferred via 2 genes: CCN2 | TGFB1 4
36. positive regulation of cytokine production involved in inflammatory response Cholestasis, Extrahepatic Inferred via 2 chemicals: Glutathione | Zinc Inferred via 2 genes: MYD88 | TLR4 5
37. spermatogenesis Cholestasis, Extrahepatic Inferred via 2 chemicals: Glutathione | Zinc Inferred via 1 gene: TIMP2 5
38. response to gamma radiation Cholestasis, Extrahepatic Inferred via 2 chemicals: Glutathione | Malondialdehyde Inferred via 1 gene: IL1B 3
39. positive regulation of hepatic stellate cell activation Cholestasis, Extrahepatic Inferred via 2 chemicals: rosmarinic acid | Taurine Inferred via 1 gene: ACTA2 3
40. apoptotic DNA fragmentation Cholestasis, Extrahepatic Inferred via 2 chemicals: Taurine | Zinc Inferred via 1 gene: HMGB1 6
41. glucose homeostasis Cholestasis, Extrahepatic Inferred via 2 chemicals: Taurine | Zinc Inferred via 1 gene: IL6 4
42. glycogen catabolic process Cholestasis, Extrahepatic Inferred via 2 chemicals: Glutathione | Sildenafil Citrate   3
43. response to stress Cholestasis, Extrahepatic Inferred via 2 chemicals: Malondialdehyde | Zinc   5
44. xenobiotic metabolic process Cholestasis, Extrahepatic Inferred via 2 chemicals: Glutathione | Phenytoin   4
45. cholesterol homeostasis Cholestasis, Extrahepatic Inferred via 2 chemicals: Taurine | Zinc   1
46. glutathione transferase activity Cholestasis, Extrahepatic Inferred via 2 chemicals: Taurine | Zinc   6
47. positive regulation of response to drug Cholestasis, Extrahepatic Inferred via 2 chemicals: Diosmin | Sildenafil Citrate   1
48. positive regulation of necrotic cell death Cholestasis, Extrahepatic Inferred via 2 chemicals: Taurine | Zinc   2
49. positive regulation of cellular extravasation Cholestasis, Extrahepatic Inferred via 2 chemicals: Taurine | Zinc   2
50. regulation of metabolic process Cholestasis, Extrahepatic Inferred via 2 chemicals: Bilirubin | Glutathione   3
1–50 of 1,692 results.