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Disease Genital Diseases, Male

These are exposure studies associated with the disease and all of its children.

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1–50 of 51 results.
  Reference Associated Study Title Author's Summary Study Factors Stressor Receptors Country Medium Exposure Marker Measurements Outcome
1. Ji G, et al. (2010). Nanjing Medical University Infertile Study These findings provided the first evidence that polymorphisms of XRCC1 may modify sperm Polycyclic Aromatic Hydrocarbons-DNA adduct levels and may be useful biomarkers to identify individuals susceptible to DNA damage resulting from PAHs exposure. genetics 1-hydroxypyrene Subjects with disease:Infertility, Male China urine 1-hydroxypyrene Details Infertility, Male
2. Meeker JD, et al. (2004). In the present study we found associations between urinary metabolites of contemporary-use insecticides and decreased sperm concentration and motility in humans. 1-naphthol | 3,5,6-trichloro-2-pyridinol | Insecticides Subjects with disease:Infertility, Male United States semen | urine 1-naphthol | 3,5,6-trichloro-2-pyridinol Details Infertility, Male | spermatogenesis | sperm motility
3. Main KM, et al. (2007). Two different proxies were used for prenatal polybrominated diphenyl ethers exposure, and levels in breast milk, but not in placenta, showed an association with congenital cryptorchidism. 2,2',3,4,4',5',6-heptabromodiphenyl ether | 2,2',4,4',5,5'-hexabrominated diphenyl ether | 2,2',4,4',5-brominated diphenyl ether | 2,2',4,4'-tetrabromodiphenyl ether | Halogenated Diphenyl Ethers | hexabromodiphenyl ether 154 | pentabrominated diphenyl ether 100 | pentabromodiphenyl ether | tribromodiphenyl ether 28 Infants or newborns | Mothers Denmark|Finland milk, human | placenta 2,2',3,4,4',5',6-heptabromodiphenyl ether | 2,2',4,4',5,5'-hexabrominated diphenyl ether | 2,2',4,4',5-brominated diphenyl ether | 2,2',4,4'-tetrabromodiphenyl ether | Halogenated Diphenyl Ethers | hexabromodiphenyl ether 154 | pentabrominated diphenyl ether 100 | pentabromodiphenyl ether | tribromodiphenyl ether 28 Details Cryptorchidism
4. Koutros S, et al. (2011). Agricultural Health Study (AHS) We evaluated pesticide-single nucleotide polymorphism (SNP) interactions between 45 pesticides and 1913 xenobiotic metabolic enzyme SNPs with respect to prostrate cancer among 776 cases and 1444 controls in the Agricultural Health Study. genetics 2,4,5-Trichlorophenoxyacetic Acid | Carbaryl | Diazinon | Dieldrin | Fonofos | Hexachlorocyclohexane | methyl bromide | Petroleum | Phorate | terbufos Subjects with gene influence:GCLC | Workers United States Details Agricultural Workers' Diseases | Prostatic Neoplasms
5. Swan SH, et al. (2003). Study for Future Families (SFF) This is the first population-based study to demonstrate links between specific biomarkers of environmental exposures and biomarkers of male reproduction in humans. 2,4-Dichlorophenoxyacetic Acid | acetochlor | alachlor | Atrazine | DEET | Diazinon | Malathion | metolachlor Controls for disease:Infertility, Male | Subjects with disease:Infertility, Male | Study subjects United States semen 2,4-Dichlorophenoxyacetic Acid | acetochlor | alachlor | Atrazine | DEET | Diazinon | Malathion | metolachlor Details Infertility, Male
6. Zafar MB, et al. (2001). Agent Orange may have a role in the causation of some types of cancer but we identified no significant relationship of prostate cancer with Agent Orange exposure in patients referred for prostate biopsy. Agent Orange | Defoliants, Chemical Veterans United States Details Prostatic Neoplasms
7. Chamie K, et al. (2008). Individuals who were exposed to Agent Orange had an increased incidence of prostate cancer, developed the disease at a younger age, and had a more aggressive variant than their unexposed counterparts. Agent Orange | Defoliants, Chemical Veterans United States Details Prostatic Neoplasms
8. Christensen CH, et al. (2016). Agricultural Health Study (AHS) In this case-control study nested within the Agricultural Health Study cohort, we evaluated evidence of statistical interaction between pesticide exposure and single nucleotide polymorphisms in genes involved in steroid hormone signaling, metabolism, or regulation with the risk of prostate cancer. genetics alachlor | butylate | Carbaryl | Dicamba | Fonofos | Malathion | terbufos Subjects with gene influence:ESR1 | Subjects with gene influence:HSD17B4 | Subjects with gene influence:SHBG | Subjects with gene influence:SRD5A1 | Subjects with gene influence:SULT2A1 | Workers United States Details Prostatic Neoplasms
9. Koutros S, et al. (2013). Agricultural Health Study (AHS) In this analysis, we observed significant increases in the risk of aggressive prostate cancer associated with 4 insecticides: fonofos (organophosphate), malathion (organophosphate), terbufos (organophosphate), and aldrin (organochlorine). Aldrin | Fonofos | Malathion | terbufos Workers United States Details Agricultural Workers' Diseases | Prostatic Neoplasms
10. Koutros S, et al. (2013). Agricultural Health Study (AHS) We observed four quantitative interactions between genome-wide association studies loci and select pesticide use and risk of prostate cancer. genetics Aldrin | Malathion Subjects with gene influence:EHBP1 | Subjects with gene influence:TET2 | Workers United States Details Prostatic Neoplasms
11. Fénichel P, et al. (2012). The presence of unconjugated bisphenol A in all cord blood samples suggests placental transfer and fetal exposure. Androstenedione | bisphenol A | Estradiol | Estriol | Estrone | Testosterone Controls for disease:Cryptorchidism | Subjects with disease:Cryptorchidism | Infants or newborns France blood, cord Androstenedione | bisphenol A | Estradiol | Estriol | Estrone | Testosterone Details
12. Hsieh FI, et al. (2008). Results suggested that chronic arsenic exposure has a negative impact on erectile function. age Arsenic Study subjects Taiwan, Province of China Details Erectile Dysfunction | regulation of hormone metabolic process
13. Loeb S, et al. (2015). Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Trial This study suggests that selenium supplements may reduce genetic risk of advanced prostate cancer, whereas aspirin, ibuprofen, and vegetables may reduce genetic risk of nonadvanced prostate cancer. genetics Aspirin | Ibuprofen | Selenium Controls for disease:Prostatic Neoplasms | Subjects with disease:Prostatic Neoplasms United States Details Prostatic Neoplasms
14. Freeman LE, et al. (2011). Agricultural Health Study (AHS) In this report, we extend a previous Agricultural Health Study analysis of cancer risk associated with self-reported atrazine use with six additional years of follow-up and more than twice as many cancer cases. Atrazine Workers United States Details Breast Neoplasms | Leukemia | Lymphoma, Non-Hodgkin | Neoplasms | Ovarian Neoplasms | Prostatic Neoplasms | Thyroid Neoplasms
15. Andreotti G, et al. (2012). Agricultural Health Study (AHS) In this nested case-control study, we evaluated the interaction between pesticide use and single nucleotide polymorphisms in genes related to lipid metabolism. genetics Atrazine | Carbofuran | EPTC | Fonofos | glyphosate | Petroleum | terbufos Subjects with gene influence:A4GALT | Subjects with gene influence:ABCG8 | Subjects with gene influence:ACSL5 | Subjects with gene influence:ADIPOR1 | Subjects with gene influence:ALOX15 | Subjects with gene influence:ALOX5AP | Subjects with gene influence:ALOX5 | Subjects with gene influence:ALOXE3 | Subjects with gene influence:LDLR | Subjects with gene influence:LRP1 | Subjects with gene influence:SEC14L2 | Workers United States Details Prostatic Neoplasms
16. Karami S, et al. (2013). Agricultural Health Study (AHS) In this study, genetic variations in vitamin D pathway genes, particularly GC rs7041, a single nucleotide polymorphism previously linked to lower circulating vitamin D levels, modified pesticide associations with prostate cancer risk. genetics Atrazine | metribuzin | Parathion | Petroleum | terbufos Subjects with gene influence:GC | Subjects with gene influence:RXRA | Subjects with gene influence:RXRB | Subjects with gene influence:VDR | Workers United States Details Agricultural Workers' Diseases | Prostatic Neoplasms
17. Pierik FH, et al. (2007). Collaborative Perinatal Project (CPP) These results provide little support for an association of cryptorchidism with exposure to low levels of heptachlor epoxide or hexachlorobenzene. For beta-hexachlorocyclohexane the findings were somewhat suggestive of an association but were inconclusive. beta-hexachlorocyclohexane | Dichlorodiphenyl Dichloroethylene | Heptachlor Epoxide | Hexachlorobenzene Pregnant females United States serum beta-hexachlorocyclohexane | Dichlorodiphenyl Dichloroethylene | Heptachlor Epoxide | Hexachlorobenzene Details Cryptorchidism
18. Li DK, et al. (2010). Our results reveal a correlation between a biological measure of urine bisphenol A level and declining male sexual function. bisphenol A Workers China urine bisphenol A Details Erectile Dysfunction | penile erection
19. Meeker JD, et al. (2010). We found that urinary bisphenol A concentrations measured in spot urine samples collected on the same day as a semen sample were associated with suggestive declines in semen quality parameters and with increased sperm DNA damage (measured as Tail%). bisphenol A Subjects with disease:Infertility, Male | Study subjects United States urine bisphenol A Details Infertility, Male | spermatogenesis | sperm motility
20. Lynch SM, et al. (2009). Agricultural Health Study (AHS) We examined butylate use and cancer risk more broadly in the Agricultural Health Study, a cohort of licensed pesticide applicators in Iowa and North Carolina. butylate Workers United States Details Agricultural Workers' Diseases | Hematologic Neoplasms | Lymphoma, Non-Hodgkin | Prostatic Neoplasms
21. Alavanja MC, et al. (2003). Agricultural Health Study (AHS) Use of chlorinated pesticides among applicators over 50 years of age and methyl bromide use were significantly associated with prostate cancer risk. age butylate | Chlorpyrifos | Coumaphos | Fonofos | methyl bromide | Permethrin | Phorate Workers United States Details Agricultural Workers' Diseases | Prostatic Neoplasms
22. Barry KH, et al. (2012). Agricultural Health Study (AHS) Although we did not observe highly significant nucleotide excision repair (NER) single-nucleotide polymorphism (SNP) main effects, our interaction findings between SNPs tagging ERCC1 and CDK7 and fonofos and carbofuran, respectively, suggest the importance of the NER pathway in prostate cancer risk in the presence of certain pesticide exposures. genetics Carbofuran | Dichlorvos | Fonofos | Parathion | Petroleum Subjects with gene influence:CDK7 | Subjects with gene influence:DDB2 | Subjects with gene influence:ERCC1 | Subjects with gene influence:ERCC4 | Workers | Subjects with gene influence:XAB2 United States Details Agricultural Workers' Diseases | Prostatic Neoplasms
23. Hardell L, et al. (2003). Blood concentrations of certain persistent organic pollutants are higher in mothers of patients with testicular cancer (case mothers) compared to mothers of subjects without testicular cancer (control mothers), supporiting the possibility that the disease might be initiated from exposure during the fetal period. Chlordan | Dichlorodiphenyl Dichloroethylene | Hexachlorobenzene | oxychlordane | Polychlorinated Biphenyls Mothers | Controls for disease:Testicular Neoplasms | Subjects with disease:Testicular Neoplasms Sweden blood Chlordan | Dichlorodiphenyl Dichloroethylene | Hexachlorobenzene | oxychlordane | Polychlorinated Biphenyls Details Prenatal Exposure Delayed Effects | Testicular Neoplasms
24. Multigner L, et al. (2016). We review the findings of various, previous epidemiological studies conducted in the French West Indies to assess the impact of environmental exposure to chlordecone on the health of the population. Chlordecone Infants or newborns | Mothers | Pregnant females | Subjects with disease:Prostatic Neoplasms | Workers Guadeloupe blood | blood, cord | colostrum | milk, human | plasma | subcutaneous fat, abdominal Chlordecone Details Infertility, Male | Prostatic Neoplasms
25. Christensen CH, et al. (2010). Agricultural Health Study (AHS) We observed an increased risk of prostate cancer in association with coumaphos exposure among men with a family history of prostate cancer but not among men without a family history in both early (1993-1999) and later periods in cohort follow-up (2000-2005), although the interaction rate ratio in the early period is stronger than in the later period. genetics Coumaphos Workers United States Details Prostatic Neoplasms
26. Koutros S, et al. (2010). Agricultural Health Study (AHS) In this study we evaluated the interaction between pesticide use, genetic variation on chromosome 8q24, and risk of prostate cancer in 2,220 Agricultural Health Study subjects. genetics Coumaphos | Fonofos | Permethrin | Phorate | terbufos Workers United States Details Prostatic Neoplasms
27. Lynch SM, et al. (2006). Agricultural Health Study (AHS) We did not find any clear, consistent associations between cyanazine exposure and any cancer analyzed. cyanazine Workers United States Details Colonic Neoplasms | Hematologic Neoplasms | Lung Neoplasms | Lymphoma, Non-Hodgkin | Neoplasms | Prostatic Neoplasms
28. Jones RR, et al. (2015). Agricultural Health Study (AHS) Our updated evaluation of diazinon provides additional evidence of an association with lung cancer risk; newly identified links to kidney cancer and associations with aggressive prostate cancer require further evaluation. Diazinon Workers United States Details Agricultural Workers' Diseases | Kidney Neoplasms | Lung Neoplasms | Prostatic Neoplasms
29. Mínguez-Alarcón L, et al. (2016). Russian Children's Study (RCS) Our prospective cohort study showed that higher peripubertal serum 2,3,7,8-tetrachlorodibenzo-p-dioxin and polychlorinated dibenzo-p-dioxins toxic equivalents were associated with lower sperm concentration, total sperm count, and total motile sperm count measured 10 years later in healthy young men. Dibenzofurans, Polychlorinated | Dioxins | Furans | Polychlorinated Biphenyls | Polychlorinated Dibenzodioxins | Tetrachlorodibenzodioxin Children | Study subjects Russian Federation serum Dibenzofurans, Polychlorinated | Polychlorinated Biphenyls | Polychlorinated Dibenzodioxins | Tetrachlorodibenzodioxin Details Infertility, Male | spermatogenesis | sperm motility
30. Perry MJ, et al. (2011). We investigated whether there was an association between urinary organophosphorous insecticide metabolites and sperm concentration and motility in newly married men from a rural area of eastern People's Republic of China. diethyl phosphate | dimethyl phosphate | O,O-diethyl dithiophosphate | O,O-dimethyl phosphorodithioate | O,O-dimethyl phosphorothionate | thiophosphoric acid Controls for disease:Infertility, Male | Subjects with disease:Infertility, Male China urine diethyl phosphate | dimethyl phosphate | O,O-diethyl dithiophosphate | O,O-dimethyl phosphorodithioate | O,O-dimethyl phosphorothionate | thiophosphoric acid Details spermatid development | sperm motility
31. Mahajan R, et al. (2006). Agricultural Health Study (AHS) In this study we evaluated cumulative lifetime fonofos exposure until enrollment as a risk factor for incident cancer occurring between the end of enrollment through 2002. genetics Fonofos Workers United States Details Leukemia | Prostatic Neoplasms
32. Barry KH, et al. (2011). Agricultural Health Study (AHS) In this nested case-control study of white male pesticide applicators within the Agricultural Health Study cohort, we observed notable interactions between several pesticides and base excision repair gene variants with respect to prostate cancer. genetics Fonofos Subjects with gene influence:NEIL3 | Workers United States Details Agricultural Workers' Diseases | Prostatic Neoplasms
33. Hardell L, et al. (2006). We studied the blood concentrations of persistent organic pollutants in testicular cancer cases and controls; furthermore, case and control mothers also participated, and while no significant differences were found between cases and controls, case mothers had in general higher concentrations, indicating that in utero exposure to certain pollutants may be of etiologic significance for testicular cancer. Halogenated Diphenyl Ethers | Hexachlorobenzene | Polychlorinated Biphenyls Mothers Sweden blood Hexachlorobenzene | Polybrominated Biphenyls | Polychlorinated Biphenyls Details Prenatal Exposure Delayed Effects | Testicular Neoplasms
34. McAuliffe ME, et al. (2012). Our findings suggest that exposure to Dichlorodiphenyl Dichloroethylene (p,p'-DDE) may be associated with increased rates of XX, XY, and total sex-chromosome disomy, whereas exposure to polychlorinated biphenyls may be associated with increased rates of YY, XY, and total sex-chromosome disomy, as well as an inverse association with XX disomy. Hydrocarbons, Chlorinated | Polychlorinated Biphenyls Subjects with disease:Infertility, Male United States serum Dichlorodiphenyl Dichloroethylene | Polychlorinated Biphenyls Details Sex Chromosome Aberrations
35. Purdue MP, et al. (2009). Our study provides additional (elevated serum concentrations), but qualified (odds ratios not statistically significant), evidence supporting an association for exposures to certain organochlorine compounds, and possibly some polychlorinated biphenyl congeners, with the risk of testicular germ cell tumors and seminomas. Insecticides | Polychlorinated Biphenyls Controls for disease:Seminoma | Subjects with disease:Seminoma | Controls for disease:Testicular Germ Cell Tumor | Subjects with disease:Testicular Germ Cell Tumor Norway serum 2,2',3',4,4',5-hexachlorobiphenyl | 2,2',4,4',5-pentachlorobiphenyl | 2,4,5,2',4',5'-hexachlorobiphenyl | 2,5,2',5'-tetrachlorobiphenyl | beta-hexachlorocyclohexane | DDT | Dichlorodiphenyl Dichloroethylene | Dieldrin | Heptachlor Epoxide | Hexachlorobenzene | Hexachlorocyclohexane | Mirex | nonachlor | o,p'-DDT | oxychlordane | Polychlorinated Biphenyls Details Testicular Germ Cell Tumor
36. Barry KH, et al. (2012). Agricultural Health Study (AHS) In summary, in this population of primarily white male private applicators in the Agricultural Health Study with follow-up from 1993 through 2007, we observed little evidence of associations between methyl bromide and most cancers examined; however, there were small numbers of exposed cases for many sites. methyl bromide Workers United States Details Agricultural Workers' Diseases | Prostatic Neoplasms | Stomach Neoplasms
37. Cockburn M, et al. (2011). This study provides evidence of an association between prostate cancer and ambient pesticide exposures in and around homes in intensely agricultural areas. The associations appear specific to compounds with a plausible biologic role in prostate carcinogenesis. methyl bromide Study subjects United States Details Prostatic Neoplasms
38. Harte CB, et al. (2008). Isolated nicotine can significantly attenuate physiological sexual arousal in healthy nonsmoking men. tobacco Nicotine Study subjects United States Nicotine Details Erectile Dysfunction | vasoconstriction
39. Hou L, et al. (2006). Agricultural Health Study (AHS) We did not find a clear association of lifetime pendimethalin exposure either with overall cancer incidence or with specific cancer sites. pendimethalin Workers United States Details Colorectal Neoplasms | Hematologic Neoplasms | Lymphoma, Non-Hodgkin | Melanoma | Neoplasms | Prostatic Neoplasms
40. Toft G, et al. (2016). Environmental perfluorooctane sulfonate exposure was associated with steroid hormone and INSL3 concentrations in amniotic fluid, but was not associated with cryptorchidism or hypospadias in our study population. perfluorooctane sulfonic acid Pregnant females Denmark amniotic fluid 17-alpha-Hydroxyprogesterone | Androstenedione | Dehydroepiandrosterone Sulfate | Hydrocortisone | INSL3 | Progesterone | Testosterone Details Cryptorchidism | Hypospadias | regulation of gene expression | regulation of testosterone biosynthetic process
41. Rusiecki JA, et al. (2009). Agricultural Health Study (AHS) In this study we evaluated the incidence of cancer among pesticide applicators exposed to permethrin in the Agricultural Health Study (AHS). Permethrin Workers United States Details Colonic Neoplasms | Leukemia | Lung Neoplasms | Lymphoma, Non-Hodgkin | Melanoma | Multiple Myeloma | Neoplasms | Prostatic Neoplasms | Rectal Neoplasms
42. Khan FH, et al. (2010). The results of this study indicated the susceptibility of male germ line to mutagenic potential of hexachlorocyclohexane pesticides which is an acknowledged risk factor leading to spermatogenic failure. Pesticides Subjects with disease:Asthenozoospermia | Subjects with disease:Azoospermia | Controls for disease:Infertility, Male | Subjects with disease:Infertility, Male | Subjects with disease:Oligospermia India semen alpha-hexachlorocyclohexane | beta-hexachlorocyclohexane | delta-hexachlorocyclohexane | Hexachlorocyclohexane Details
43. Belpomme D, et al. (2009). Our study leads to the conclusion that the growing incidence of prostate cancer in Martinique and Guadeloupe suggests that environmental factors such as the intensive and prolonged exposure to pesticides may cause prostate cancer. Pesticides Children | Study subjects Martinique adipose tissue alpha-hexachlorocyclohexane | beta-hexachlorocyclohexane | DDT | Dichlorodiphenyl Dichloroethylene | Hexachlorocyclohexane Details Prostatic Neoplasms
44. Carmichael SL, et al. (2016). This study indicates that babies with genetic variants and maternal pesticide exposures who were previously identified as associated with increased risk of hypospadias were at two- to fourfold increased risk of hypospadias. genetics Pesticides Subjects with gene influence:DGKK | Subjects with disease:Hypospadias | Infants or newborns United States Details Hypospadias
45. Mahajan R, et al. (2006). Agricultural Health Study (AHS) The observed statistical interaction suggests a gene-environment interaction between family history and phorate exposure in the incidence of prostate cancer, but other explanations are also possible. Phorate Workers United States Details Neoplasms | Prostatic Neoplasms
46. Hardell L, et al. (2004). Blood concentrations of polychlorinated biphenyl congeners are higher in mothers of patients with testicular cancer (case mothers) compared to mothers of subjects without testicular cancer (control mothers), supporiting the possibility that the disease might be initiated from exposure during the fetal period. Polychlorinated Biphenyls Mothers Sweden blood 2,2',3',4,4',5-hexachlorobiphenyl | 2,2',4,4',5-pentachlorobiphenyl | 2,3,3',4,4',5-hexachlorobiphenyl | 2,3,3',4,4'-pentachlorobiphenyl | 2,3,4,4'5-pentachlorobiphenyl | 2,3',4,4',5-pentachlorobiphenyl | 2,4,4',5-tetrachlorobiphenyl | 2,4,4'-trichlorobiphenyl | 2,4,5,2',4',5'-hexachlorobiphenyl | 2,4,5,2',5'-pentachlorobiphenyl | 2,5,2',5'-tetrachlorobiphenyl | PCB 180 | Polychlorinated Biphenyls Details Prenatal Exposure Delayed Effects | Testicular Neoplasms
47. Sallmén M, et al. (2006). Agricultural Health Study (AHS) Solvents may impair fertility of either gender, though the evidence for female effects is stronger than for male effects. Solvents Study subjects | Workers United States Details Infertility, Female | Infertility, Male
48. Bonner MR, et al. (2010). Agricultural Health Study (AHS) In summary, there was some suggestion that cancers of the prostate and lung as well as leukemia and non-Hodgkin lymphoma may be associated with terbufos use. terbufos Workers United States Details Leukemia | Lung Neoplasms | Lymphoma, Non-Hodgkin | Prostatic Neoplasms
49. Gupta A, et al. (2006). Tetrachlorodibenzodioxin exposure at general population levels is associated with a decreasing risk of benign prostatic hyperplasia with higher exposure levels; tetrachlorodibenzodioxin exposure is also negatively associated with serum testosterone levels. Tetrachlorodibenzodioxin Veterans United States serum Tetrachlorodibenzodioxin Details Prostatic Hyperplasia | testosterone biosynthetic process
50. Mozzachio AM, et al. (2008). Agricultural Health Study (AHS) Chlorothalonil was not associated with overall cancer incidence, nor did we find any association with colon, lung, and prostate cancers - the only cancers for which we had sufficient numbers to explore associations. tetrachloroisophthalonitrile Workers United States Details Colonic Neoplasms | Lung Neoplasms | Neoplasms | Prostatic Neoplasms
1–50 of 51 results.