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Disease Insulin Resistance

These are exposure studies associated with the disease and all of its children.

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1–26 of 26 results.
  Reference Associated Study Title Author's Summary Study Factors Stressor Receptors Country Medium Exposure Marker Measurements Outcome
1. Lee DH, et al. (2007). National Health and Nutrition Examination Survey (NHANES) This study suggests that the prevalence of a cluster of cardiovascular risk factors relates to background exposure to a mixture of persistent organic pollutants, several of which are also related to the prevalence of diabetes. 1,2,3,4,6,7,8-heptachlorodibenzodioxin | 1,2,3,4,6,7,8-heptachlorodibenzofuran | 1,2,3,4,7,8-hexachlorodibenzofuran | 2,3',4,4',5-pentachlorobiphenyl | 2,4,4',5-tetrachlorobiphenyl | 3,4,5,3',4'-pentachlorobiphenyl | Dibenzofurans, Polychlorinated | Hydrocarbons, Chlorinated | Pesticides | Polychlorinated Biphenyls | Polychlorinated Dibenzodioxins Study subjects United States Details Insulin Resistance | Metabolic Syndrome | cholesterol metabolic process | regulation of blood pressure | triglyceride metabolic process
2. Kern PA, et al. (2004). These data suggest that high blood tetrachlorodibenzodioxin (TCDD) levels, from exposure to Agent Orange, may promote an insulin-resistant state, but the magnitude of this effect appeared to be small, such that an 18-fold increase in blood TCDD resulted in only a 10% change in insulin sensitivity. Agent Orange | Defoliants, Chemical Veterans United States serum Tetrachlorodibenzodioxin Details Insulin Resistance
3. Kim JH, et al. (2012). Korean Elderly Environmental Panel (KEEP) Our results suggest that particulate matter (PM10), ozone, and nitrogen dioxide may increase insulin resistance in the elderly, and that GSTM1-null, GSTT1-null, and GSTP1 genotypes may increase susceptibility to potential effects of ambient air pollutants on insulin resistance. genetics Air Pollutants Subjects with gene influence:GSTM1 | Subjects with gene influence:GSTP1 | Subjects with gene influence:GSTT1 | Study subjects Korea, Republic of air, ambient Nitrogen Dioxide | Ozone | Particulate Matter | Sulfur Dioxide Details Insulin Resistance
4. Menke A, et al. (2016). National Health and Nutrition Examination Survey (NHANES) Higher quartiles of barium, molybdenum, and antimony were associated with greater HOMA of insulin resistance after adjustment; molybdenum, antimony, tungsten, and uranium were positively associated with diabetes, even at the relatively low levels seen in the US. Antimony | Barium | Cadmium | Cesium | Cobalt | Lead | Molybdenum | Thallium | Tungsten | Uranium Study subjects United States urine Antimony | Barium | Cadmium | Cesium | Cobalt | Lead | Molybdenum | Thallium | Tungsten | Uranium Details Diabetes Mellitus | Insulin Resistance
5. Rotter I, et al. (2015). The primary aim of the study was to assess the relationship of blood heavy metal and bioelement concentrations and Metabolic Syndrome, in men aged 50-75 years. Arsenic | Cadmium | Calcium | Chromium | Copper | Iron | Lead | Magnesium | Manganese | Mercury | Molybdenum | Selenium | Tungsten | Zinc Controls for disease:Diabetes Mellitus, Type 2 | Subjects with disease:Diabetes Mellitus, Type 2 | Controls for disease:Hypertension | Subjects with disease:Hypertension | Controls for disease:Metabolic Syndrome | Subjects with disease:Metabolic Syndrome | Controls for disease:Obesity | Subjects with disease:Obesity | Controls for disease:Overweight | Subjects with disease:Overweight | Study subjects Poland blood | serum Arsenic | Cadmium | Calcium | Chromium | Copper | Iron | Lead | Magnesium | Manganese | Mercury | Molybdenum | Selenium | Tungsten | Zinc Details Diabetes Mellitus, Type 2 | Hypertension | Metabolic Syndrome | Obesity | Overweight | cholesterol homeostasis | insulin metabolic process | regulation of blood pressure | triglyceride homeostasis
6. Rhee SY, et al. (2013). Korea National Health and Nutrition Examination Survey (KNHANES) These findings suggest that a higher prevalence of metabolic syndrome is associated with higher blood lead levels in the Korean population. Arsenic | Cadmium | Lead | Manganese | Mercury Controls for disease:Metabolic Syndrome | Subjects with disease:Metabolic Syndrome Korea, Republic of blood | urine Arsenic | Cadmium | Lead | Manganese | Mercury Details Metabolic Syndrome
7. Kelishadi R, et al. (2013). Childhood and Adolescence Surveillance and Prevention of Adult Noncommunicable disease (CASPIAN) Cadmium levels were considerably high in adolescents with and without metabolic syndrome, and levels had positive but nonsignificant association with some cardiometabolic risk factors and liver enzymes; the associations did not reach statistical significance, perhaps due to high levels of cadmium in both groups or because of the young age of participants. Cadmium Children | Controls for disease:Metabolic Syndrome | Subjects with disease:Metabolic Syndrome Iran, Islamic Republic of blood | serum Blood Glucose | Cadmium | Cholesterol, HDL | Cholesterol, LDL | GOT1 | GPT | Triglycerides Details Metabolic Syndrome
8. Park SB, et al. (2009). We investigated possible relationships between minerals and metabolic syndrome; the hair tissue contents of calcium, magnesium, and copper in the metabolic syndrome group were significantly lower than those of controls, whereas the amounts of sodium, potassium, and mercury in the metabolic syndrome group were significantly higher. Cadmium | Calcium | Chromium | Copper | Iron | Lead | Magnesium | Manganese | Mercury | Potassium | Selenium | Sodium | Zinc Controls for disease:Metabolic Syndrome | Subjects with disease:Metabolic Syndrome | Study subjects Korea, Republic of hair Aluminum | Cadmium | Calcium | Chromium | Copper | Iron | Lead | Magnesium | Manganese | Mercury | Potassium | Selenium | Sodium | Zinc Details Metabolic Syndrome
9. Lee BK, et al. (2013). Korea National Health and Nutrition Examination Survey (KNHANES) The association between blood cadmium level and metabolic syndrome was significant among men with lower blood cadmium levels. sex Cadmium | Lead | Mercury Controls for disease:Metabolic Syndrome | Subjects with disease:Metabolic Syndrome | Study subjects Korea, Republic of blood Cadmium | Lead | Mercury Details Metabolic Syndrome
10. Lee BK, et al. (2016). Korea National Health and Nutrition Examination Survey (KNHANES) We demonstrated a significant association between blood Cadmium level and Metabolic Syndrome in South Korean males after adjustment for confounding by numerous factors including blood Lead, blood Mercury, and serum ferritin. sex Cadmium | Lead | Mercury Study subjects Korea, Republic of blood Cadmium | Lead | Mercury Details Metabolic Syndrome
11. Lee DH, et al. (2011). Coronary Artery Risk Development in Young Adults (CARDIA) Study Simultaneous exposure to various persistent organic pollutants in the general population may contribute to development of obesity, dyslipidemia, and insulin resistance, common precursors of type 2 diabetes and cardiovascular diseases. DDT | Dichlorodiphenyl Dichloroethylene Study subjects United States plasma DDT | Dichlorodiphenyl Dichloroethylene Details Dyslipidemias | Insulin Resistance | Obesity
12. Trasande L, et al. (2013). National Health and Nutrition Examination Survey (NHANES) Urinary diethylhexyl phthalate (DEHP) concentrations were associated with increased insulin resistance in a cross-sectional study of adolescents; however, this study cannot rule out the possibility that insulin-resistant children ingest food with higher phthalate content, or that insulin-resistant children excrete more DEHP. diet | race | sex | socioeconomic status Diethylhexyl Phthalate Children | Controls for disease:Insulin Resistance | Subjects with disease:Insulin Resistance | Controls for disease:Overweight | Subjects with disease:Overweight United States urine Diethylhexyl Phthalate Details Insulin Resistance
13. Chang JW, et al. (2016). We find that serum dioxin/furan toxic equivalents and abdominal obesity affect the association with insulin resistance in the study population. Dioxins Subjects with disease:Obesity, Abdominal Taiwan, Province of China serum 1,2,3,4,6,7,8-heptachlorodibenzofuran | 1,2,3,7,8-pentachlorodibenzofuran | 1,2,3,7,8-pentachlorodibenzo-p-dioxin | 2,3,4,7,8-pentachlorodibenzofuran | 2,3,7,8-tetrachlorodibenzofuran | Tetrachlorodibenzodioxin Details Insulin Resistance
14. Sergeev AV, et al. (2011). Our findings contribute to the body of evidence supporting the hypothesis of persistent organic pollutants constituting an environmental risk factor for Metabolic Syndrome. Increase in age was independently associated with higher MetS-related hospitalization rates. A higher proportion of African Americans resided in persistent organic pollutants zip codes compared to Caucasians age | race | socioeconomic status Environmental Pollutants | Organic Chemicals Study subjects United States Details Metabolic Syndrome
15. Park SK, et al. (2006). Normative Aging Study (NAS) The results suggest that elderly men with metabolic syndrome were more susceptible to autonomic dysfunction in association with chronic lead exposure as measured in patella. disease Lead Controls for disease:Metabolic Syndrome | Subjects with disease:Metabolic Syndrome | Veterans United States patella | tibia Lead Details regulation of heart rate
16. Eom SY, et al. (2014). The blood mercury level in Korean adults is higher than that in US and other western countries (but is similar to other Asian countries), and the level is influenced by sociodemographic factors, lifestyles, and diet; furthermore, blood mercury is associated with metabolic syndrome and their components (obesity and increased fasting glucose). age | alcohol drinking | diet | sex | tobacco Mercury Study subjects Korea, Republic of blood Mercury Details Body Weight | Hypertension | Hypertriglyceridemia | Metabolic Syndrome | Obesity | cholesterol homeostasis | glucose homeostasis | regulation of blood pressure
17. Chung JY, et al. (2015). Korea National Health and Nutrition Examination Survey (KNHANES) Blood mercury concentration was independently associated with an increased risk of Metabolic Syndrome in men. sex Mercury Study subjects Korea, Republic of blood Details Metabolic Syndrome
18. Mortazavi SM, et al. (2016). Korea National Health and Nutrition Examination Survey (KNHANES) There was a positive correlation of serum high density lipoprotein cholesterol with blood mercury concentration in metabolic syndrome Korean men (analysis of KNANES 2008-2010, 2013). Mercury Subjects with disease:Metabolic Syndrome Korea, Republic of Details cholesterol homeostasis
19. Park K, et al. (2016). Trace Element Study of Korean Adults in the Yeungnam area (SELEN) Higher toenail mercury levels was associated with the risk of Metabolic Syndrome, and this association was stronger in participants with a low toenail selenium concentration. age | alcohol drinking | body mass index | socioeconomic status | tobacco Mercury | Selenium Study subjects Korea, Republic of nail, toe Mercury | Selenium Details Metabolic Syndrome
20. Moon SS. (2014). Korea National Health and Nutrition Examination Survey (KNHANES) Results of this study demonstrate an association of accumulation of a mixture of heavy metal exposures (lead, mercury, and cadmium), even below toxic levels, with prevalence of metabolic syndrome in the Korean population. Metals, Heavy Controls for disease:Metabolic Syndrome | Subjects with disease:Metabolic Syndrome | Study subjects Korea, Republic of serum Cadmium | Lead | Mercury | Metals, Heavy Details Hypertension | Hypertriglyceridemia | Metabolic Syndrome
21. Stahlhut RW, et al. (2007). National Health and Nutrition Examination Survey (NHANES) In this national cross-section of U.S. men, concentrations of several prevalent phthalate metabolites showed statistically significant correlations with abdominal obesity and insulin resistance. mono(2-ethyl-5-hydroxyhexyl) phthalate | mono(2-ethyl-5-oxohexyl)phthalate | mono-(2-ethylhexyl)phthalate | mono-benzyl phthalate | monobutyl phthalate | monoethyl phthalate Study subjects United States mono(2-ethyl-5-hydroxyhexyl) phthalate | mono(2-ethyl-5-oxohexyl)phthalate | mono-(2-ethylhexyl)phthalate | mono-benzyl phthalate | monobutyl phthalate | monoethyl phthalate Details Insulin Resistance | Obesity
22. Yang AM, et al. (2014). The prevalence of metabolic syndrome was investigated in 35,104 nickel-exposed workers in China; the prevalence of higher body mass index, hyperglycemia, and hypertension increased with the age of males and females, and was higher in males than in females. age | sex Nickel Workers China Details Dyslipidemias | Hyperglycemia | Hypertension | Metabolic Syndrome
23. Thiering E, et al. (2016). German Infant Study on the Influence of Nutrition Intervention plus Environmental and Genetic Influences on Allergy (GINIplus) | Lifestyle-Related factors on the Immune System and the Development of Allergies in Childhood plus the influence of traffic emissions and genetics (LISAplus) Nitrogen dioxide, often considered as a marker of traffic, was independently associated with insulin resistance. Nitrogen Dioxide | Particulate Matter Children Germany air Nitrogen Dioxide Details Insulin Resistance
24. Chen JC, et al. (2008). National Health and Nutrition Examination Survey (NHANES) Our study revealed a positive association between long-term particulate matter exposure and hematological markers of inflammation and supported the hypothesized metabolic syndrome-dependent susceptibility. disease Particulate Matter Controls for disease:Metabolic Syndrome | Subjects with disease:Metabolic Syndrome | Study subjects United States Particulate Matter Details Inflammation | inflammatory response
25. Fleisch AF, et al. (2017). National Health and Nutrition Examination Survey (NHANES) | Project Viva We found no evidence for an adverse effect of early life perfluoroalkyl substances exposure on metabolic function in mid-childhood; in fact, children with higher perfluoroalkyl substances had lower insulin resistance, and this inverse association was more pronounced in females. sex perfluorodecanoic acid | perfluorohexanesulfonic acid | perfluorononanoic acid | perfluorooctane sulfonic acid | perfluorooctanoic acid Children | Pregnant females | Study subjects United States plasma perfluorodecanoic acid | perfluorohexanesulfonic acid | perfluorononanoic acid | perfluorooctane sulfonic acid | perfluorooctanoic acid Details Insulin Resistance
26. Warner M, et al. (2013). Seveso Women's Health Study (SWHS) We found an increased prevalence of metabolic syndrome associated with 2,3,7,8-tetrachlorodibenzo-p-dioxin, but only among women who were the youngest at the time of the explosion. age Tetrachlorodibenzodioxin Study subjects Italy Details Diabetes Mellitus | Metabolic Syndrome | Obesity
1–26 of 26 results.