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Disease Liver Diseases

These are exposure studies associated with the disease and all of its children.

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1–27 of 27 results.
  Reference Associated Study Title Author's Summary Study Factors Stressor Receptors Country Medium Exposure Marker Measurements Outcome
1. Cave M, et al. (2010). National Health and Nutrition Examination Survey (NHANES) In the present study, we tested the hypothesis that environmental pollutants are dose-dependently associated with increased risk for alanine aminotransferase elevation and suspected nonalcoholic fatty liver disease in the NHANES adult population. 2,2',3,3',4,4',5-heptachlorobiphenyl | 2,2',3,5,5',6-hexachlorobiphenyl | 2,2',4,4',5-pentachlorobiphenyl | 2,3,3',4,4',5-hexachlorobiphenyl | 2,3,3',4,4'-pentachlorobiphenyl | 2,3',4,4',5-pentachlorobiphenyl | 2,4,4',5-tetrachlorobiphenyl | 2,4,4'-trichlorobiphenyl | 2,4,5,2',4',5'-hexachlorobiphenyl | 2,4,5,2',5'-pentachlorobiphenyl | 2,5,2',5'-tetrachlorobiphenyl | 3,4,5,3',4',5'-hexachlorobiphenyl | 3,4,5,3',4'-pentachlorobiphenyl | Cadmium | Lead | Mercury | PCB 180 | Polychlorinated Biphenyls Study subjects United States blood | urine 2,2',3,3',4,4',5-heptachlorobiphenyl | 2,2',3,5,5',6-hexachlorobiphenyl | 2,2',4,4',5-pentachlorobiphenyl | 2,3,3',4,4',5-hexachlorobiphenyl | 2,3,3',4,4'-pentachlorobiphenyl | 2,3',4,4',5-pentachlorobiphenyl | 2,4,4',5-tetrachlorobiphenyl | 2,4,4'-trichlorobiphenyl | 2,4,5,2',4',5'-hexachlorobiphenyl | 2,4,5,2',5'-pentachlorobiphenyl | 2,5,2',5'-tetrachlorobiphenyl | 3,4,5,3',4',5'-hexachlorobiphenyl | 3,4,5,3',4'-pentachlorobiphenyl | Cadmium | Lead | Mercury | PCB 180 | Polychlorinated Biphenyls Details Fatty Liver
2. Clair HB, et al. (2018). Anniston Community Health Survey (ACHS) Toxicant-associated steatohepatitis was associated with increased exposures to specific PCB congeners, and the sum of PCBs had associations with insulin, leptin, adipocytokines, and hepatocyte apoptosis. 2,2',3,5,5',6-hexachlorobiphenyl | 2,3,3',4,4'-pentachlorobiphenyl | 2,4,4'-trichlorobiphenyl | 2,4,5,2',5'-pentachlorobiphenyl | 2,5,2',5'-tetrachlorobiphenyl | Polychlorinated Biphenyls Subjects with disease:Fatty Liver | Subjects with disease:Liver Diseases | Study subjects United States serum 2,2',3,4',5',6-hexachlorobiphenyl | 2,2',3,5,5',6-hexachlorobiphenyl | 2,3,4,2',3',4'-hexachlorobiphenyl | 2,4,4'-trichlorobiphenyl | 2,4,5,2',5'-pentachlorobiphenyl | 2,5,2',5'-tetrachlorobiphenyl | ADIPOQ | IL1B | IL6 | INS | KRT18 | LEP | SERPINE1 | TNF Details Fatty Liver | positive regulation of cell death | regulation of apoptotic process
3. Cicalese L, et al. (2017). In our study, we showed that selected relevant air pollutants produce a significant clustering of the Texan counties with respect to their concentration and discussed about the incidence rate distributions of liver cancer over the identified clusters. 2,2,4-trimethylpentane | Benzene | ethylbenzene | Formaldehyde | Hexanes | Hydrochloric Acid | Methanol | methyl tert-butyl ether | Toluene | Xylenes Study subjects United States Details Liver Neoplasms
4. Lai H, et al. (2014). The findings of this study indicate that occupational aflatoxin B1 airway exposure might be associated with the risk of hepatocellular carcinoma among factory workers. Aflatoxin B1 Controls for disease:Carcinoma, Hepatocellular | Subjects with disease:Carcinoma, Hepatocellular | Workers China dust | serum aflatoxin-albumin adduct | Aflatoxin B1 Details Carcinoma, Hepatocellular
5. Liu Y, et al. (2010). Aflatoxin may play a causative role in 4.6-28.2% of all global hepatocellular carcinoma cases. Aflatoxins Study subjects Argentina|Australia|
Brazil|China|
Congo, the Democratic Republic of the|Egypt|
Ethiopia|Gambia|
India|Indonesia|
Iran, Islamic Republic of|Kenya|
Korea, Republic of|Malaysia|
Mexico|Mozambique|
Nigeria|Pakistan|
Philippines|South Africa|
Sudan|Tanzania, United Republic of|
Thailand|United States|
Zimbabwe
Aflatoxins Details Carcinoma, Hepatocellular
6. Mizrak D, et al. (2009). We have documented that in viral hepatitis patients, aflatoxin exposure is significantly higher than in healthy subjects in Turkey and it may play an important role in the development of hepatocellular carcinoma. diet | disease Aflatoxins Controls for disease:Hepatitis, Viral, Human | Subjects with disease:Hepatitis, Viral, Human Turkey serum Aflatoxin B1 | aflatoxin B2 | aflatoxin G1 | aflatoxin G2 Details
7. Michalek JE, et al. (2001). We found an increased risk of 'other liver disorders' among veterans with the highest dioxin levels; whether the associations observed were causal is unclear from these data. Agent Orange | Defoliants, Chemical Veterans United States serum Tetrachlorodibenzodioxin Details Liver Diseases
8. Ranzi A, et al. (2011). No increased risk of mortality and morbidity was found in the entire area among people living close to incinerators. The internal analysis of the cohort based on dispersion modeling found excesses of mortality for some cancer types in the highest exposure categories, especially in women. People in the highest heavy metal exposure categories tended to have a lower socioeconomic status than those in the lowest categories. The interpretation of the findings is limited given the pilot nature of the study sex | socioeconomic status Air Pollutants Study subjects Italy waste, industrial Cadmium | Dioxins | Mercury | Metals, Heavy | Nitrogen Dioxide | Particulate Matter Details Breast Neoplasms | Colorectal Neoplasms | Death | Liver Neoplasms | Neoplasms | Stomach Neoplasms
9. Thompson JA, et al. (2008). The current study identified geographic factors supporting more focused studies of germ cell tumors and 'other' gliomas in areas of intense cropping, hepatic cancer near Hazardous Air Pollutant (HAP) release facilities and specific locations with increased risks for CNS embryonal tumors and for 'other' leukemias. Air Pollutants | Pesticides Children United States Details Glioma | Liver Neoplasms | Neoplasms, Germ Cell and Embryonal
10. Kaye JA, et al. (2014). The results support a comparatively high adjusted relative risk of liver injury among patients exposed concurrently to multiple antimicrobials and modest elevations in the risk for several antimicrobials used alone; however, we found little evidence of any strong effect of commonly used antimicrobials on the risk of liver injury. Amoxicillin | Anti-Infective Agents | Clavulanic Acid | Doxycycline | Levofloxacin | moxifloxacin Study subjects United States Details Chemical and Drug Induced Liver Injury
11. Frediani JK, et al. (2018). National Health and Nutrition Examination Survey (NHANES) Our findings demonstrate a positive association between urinary arsenic exposure and risk of nonalcoholic fatty liver disease among U.S. adolescents and adults that is highest among Mexican Americans and among those obese, regardless of race/ethnicity. disease | race Arsenic Study subjects United States urine Arsenic Details Non-alcoholic Fatty Liver Disease | transaminase activity
12. Smith AH, et al. (2012). Taking together our findings in the present study and previous evidence of increased mortality from other causes of death, we conclude that arsenic in Antofagasta drinking water has resulted in the greatest increases in mortality in adults < 50 years of age ever associated with early-life environmental exposure. Arsenic Study subjects Chile Details Cardiovascular Diseases | Death | Female Urogenital Diseases | Kidney Diseases | Laryngeal Neoplasms | Liver Neoplasms | Male Urogenital Diseases | Neoplasms | Urinary Bladder Neoplasms
13. Bove FJ, et al. (2014). We found elevated hazard ratios (with wide confidence intervals) at Camp Lejeune for causes of death from cancers of kidney, liver, esophagus, cervix, multiple myeloma, Hodgkin lymphoma, and amyotrophic lateral sclerosis; however, because less than 6% of cohort had died, long-term follow-up is necessary to comprehensively assess effects of drinking water exposures at the base. diet Benzene | Tetrachloroethylene | Vinyl Chloride | Water Pollutants, Chemical Military personnel United States water, drinking Benzene | Tetrachloroethylene | Trichloroethylene | Vinyl Chloride Details Amyotrophic Lateral Sclerosis | Death | Esophageal Neoplasms | Hodgkin Disease | Kidney Neoplasms | Liver Neoplasms | Multiple Myeloma | Uterine Cervical Neoplasms
14. Hyder O, et al. (2013). National Health and Nutrition Examination Survey (NHANES) Environmental cadmium exposure was associated with hepatic necroinflammation, non-alcoholic fatty liver disease, and non-alcoholic steatohepatitis in men, and hepatic necroinflammation in women. age | race | sex Cadmium Study subjects United States urine Cadmium Details Death | Liver Diseases | Non-alcoholic Fatty Liver Disease | inflammatory response | necrotic cell death
15. Carreón T, et al. (2014). This study found evidence for excess hepatobiliary cancer mortality among workers exposed to vinyl chloride in a chemical manufacturing plant, as well as a trend with 20-year lagged duration of exposure. Carbon Disulfide | Vinyl Chloride Workers United States Details Coronary Artery Disease | Death | Liver Neoplasms
16. Paterson JM, et al. (2012). Among older outpatients with no evidence of liver disease, moxifloxacin and levofloxacin were associated with an increased risk of acute liver injury relative to clarithromycin. cefuroxime axetil | Ciprofloxacin | Clarithromycin | Levofloxacin | moxifloxacin Controls for disease:Chemical and Drug Induced Liver Injury | Subjects with disease:Chemical and Drug Induced Liver Injury Canada Details Chemical and Drug Induced Liver Injury
17. Wu Z, et al. (2017). We report urinary biomarkers for occupational exposure to N,N-dimethylformamide and reveal dose-response relationships between their levels and liver injury, with males having a greater risk of injury. sex Dimethylformamide Workers China urine methylformamide | N-acetyl-S-(N-methylcarbamoyl)cysteine Details Chemical and Drug Induced Liver Injury
18. Borg D, et al. (2013). The objective of this study was to for the first time perform a cumulative health risk assessment of the 17 perfluoroalkylated and polyfluoroalkylated substances measured in the Swedish population, individually and in combination, using the Hazard Index approach. Hydrocarbons, Fluorinated | perfluorobutane | perfluorobutyric acid | perfluorodecanoic acid | perfluorododecanoic acid | perfluoroheptanoic acid | perfluorohexanesulfonic acid | perfluorohexanoic acid | perfluorononanoic acid | perfluorooctanesulfonamide | perfluorooctane sulfonic acid | perfluorooctanoic acid | perfluoroundecanoic acid Study subjects | Workers Sweden serum Hydrocarbons, Fluorinated | perfluorobutane | perfluorobutyric acid | perfluorodecanoic acid | perfluorododecanoic acid | perfluoroheptanoic acid | perfluorohexanesulfonic acid | perfluorohexanoic acid | perfluorononanoic acid | perfluorooctanesulfonamide | perfluorooctane sulfonic acid | perfluorooctanoic acid | perfluoroundecanoic acid Details Liver Diseases | immune response | mammary gland development | reproductive process
19. Spangler JG. (2012). US Environmental Protection Agency Median income by county was inversely associated with chronic liver disease mortality, while the logarithmically transformed airborne concentrations of on-road manganese were positively correlated with county-level chronic liver disease mortality socioeconomic status Manganese Study subjects United States air Manganese Details Death | Liver Diseases
20. Silver SR, et al. (2015). Agricultural Health Study (AHS) This suggestion of an association between metolachlor and liver cancer among pesticide applicators is a novel finding and echoes observation of increased liver neoplasms in some animal studies; however, our findings for both liver cancer and follicular cell lymphoma warrant follow-up to better differentiate effects of metolachlor use from other factors. metolachlor Workers United States Details Agricultural Workers' Diseases | Liver Neoplasms | Lymphoma, Follicular
21. Keegan TJ, et al. (2009). In the present study, we confirmed for the first time the presence of microcystins in serum samples of fishermen who were chronically exposed to cyanotoxins by oral route. Microcystins Workers China serum Microcystins Details Liver Diseases
22. Fisher M, et al. (2013). Canadian Health Measures Survey (CHMS) This study showed lower levels of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) and slightly higher levels of perfluorohexane sulfonate (PFHxS) than other published population studies. Our results did not give significant evidence to support the association with cholesterol outcomes with PFOS and PFOA. However, we did observe several significant associations with the PFHxS and cholesterol outcomes. perfluorohexanesulfonic acid | perfluorooctane sulfonic acid | perfluorooctanoic acid Controls for disease:Liver Diseases | Subjects with disease:Liver Diseases | Study subjects Canada plasma perfluorohexanesulfonic acid | perfluorooctane sulfonic acid | perfluorooctanoic acid Details cholesterol homeostasis
23. Gallo V, et al. (2012). C8 Health Project (C8HP) These results show a positive association between Perfluorooctanoate and Perfluorooctane Sulfonate concentrations and serum alanine aminotransferase level, a marker of hepatocellular damage. perfluorooctane sulfonic acid | perfluorooctanoic acid Study subjects United States serum perfluorooctane sulfonic acid | perfluorooctanoic acid Details Chemical and Drug Induced Liver Injury
24. Darrow LA, et al. (2016). C8 Health Project (C8HP) Using exposure estimates that are not affected by reverse causation, our results complement evidence from previous cross-sectional studies showing a modest positive relationship between perfluorooctanoic acid and alanine aminotransferase levels, a marker of hepatocellular injury. perfluorooctanoic acid Study subjects | Workers United States GPT | perfluorooctanoic acid Details Chemical and Drug Induced Liver Injury | Liver Diseases | regulation of gene expression
25. Emmett EA, et al. (2006). We found no significant positive relationships between serum perfluorooctanoate and liver or renal function tests, cholesterol, thyroid-stimulating hormone, or with red cell indices, white cell, or platelet counts; mean serum perfluorooctanoate was not increased in liver or thyroid diseases. perfluorooctanoic acid Children | Controls for disease:Liver Diseases | Subjects with disease:Liver Diseases | Study subjects | Controls for disease:Thyroid Diseases | Subjects with disease:Thyroid Diseases United States serum perfluorooctanoic acid Details Liver Diseases | Thyroid Diseases
26. Elefsiniotis IS, et al. (2007). Quizalofop-p-ethyl can induce a mixed cholestatic/hepatocellular liver injury. quizalofop-ethyl Workers Greece Details Chemical and Drug Induced Liver Injury | Cholestasis
27. Goto H, et al. (2012). Life Span Study We calculated the standardized mortality ratio (SMR) for the atomic bomb survivors versus the entire population of Japan in childhood and compared them with a true non-exposed group. A notable result was that SMRs in boys exposed to low doses were significantly higher for solid cancer. sex Radioactive Fallout Children Japan Radioactive Fallout Details Breast Neoplasms | Death | Leukemia | Liver Neoplasms | Neoplasms | Stomach Neoplasms | Uterine Neoplasms
1–27 of 27 results.