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Disease Vascular Diseases

These are exposure studies associated with the disease and all of its children.

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1–50 of 114 results.
  Reference Associated Study Title Author's Summary Study Factors Stressor Receptors Country Medium Exposure Marker Measurements Outcome
1. Zhang P, et al. (2011). Long-term exposure to ambient air pollution is associated with the death of cardiovascular and cerebrovascular diseases among Chinese populations. The effects of air pollution were more evident in female that in male, and nonsmokers and residents with body mass index less than 18.5 were more vulnerable to outdoor air pollution. body mass index | sex | tobacco Air Pollutants Study subjects China air, ambient Nitrogen Dioxide | Particulate Matter | Sulfur Dioxide Details Cardiovascular Diseases | Cerebrovascular Disorders | Death
2. Jones MR, et al. (2015). Multi-Ethnic Study of Atherosclerosis (MESA) The smaller carotid intima-media thickness levels in U.S. Chinese participants were even smaller after accounting for higher particulate matter (PM2.5) concentrations compared with Caucasian-Americans; however, air pollution was not related to intima-media thickness differences in African-Americans and Hispanics compared with Caucasian-Americans. race Air Pollutants Study subjects United States air, ambient Nitrogen Oxides | Particulate Matter Details Carotid Intimal Medial Thickness 1 | blood vessel development
3. Hansen AB, et al. (2016). Danish Nurse Cohort We examined the association between long-term exposure to particulate matter (PM2.5) and diabetes incidence; non-smokers, obese subjects, and cardiovascular disease patients may be most susceptible to development of diabetes related to air pollution. disease | tobacco Air Pollutants Subjects with disease:Diabetes Mellitus | Subjects with disease:Myocardial Infarction | Subjects with disease:Obesity | Study subjects Denmark air, ambient Nitrogen Dioxide | Nitrogen Oxides | Particulate Matter Details Diabetes Mellitus
4. Andersen ZJ, et al. (2012). Danish Diet, Cancer, and Health cohort Study Long-term exposure to traffic-related air pollution may contribute to the development of ischemic but not hemorrhagic stroke, especially severe ischemic strokes leading to death within 30 days. Air Pollutants Study subjects Denmark Nitrogen Dioxide Details Brain Ischemia | Cerebral Hemorrhage | Stroke
5. Jung CR, et al. (2017). Our results provide new evidence that exposure to ozone may increase the risk of Kawasaki disease in children. Air Pollutants Children | Subjects with disease:Mucocutaneous Lymph Node Syndrome Taiwan, Province of China air, ambient Carbon Monoxide | Nitrogen Dioxide | Ozone | Particulate Matter | Sulfur Dioxide Details Mucocutaneous Lymph Node Syndrome
6. Künzli N, et al. (2010). B-Vitamin Atherosclerosis Intervention Trial (BVAIT) | Estrogen in the Prevention of Atherosclerosis Trial (EPAT) | Troglitazone Atherosclerosis Regression Trial (TART) | Vitamin E Atherosclerosis Prevention Study (VEAPS) | Women's Estrogen-Progestin Lipid-Lowering Hormone Atherosclerosis Regression Trial (WELL-HART) Consistent with cross-sectional findings and animal studies, this is the first study to report an association between exposure to air pollution and the progression of atherosclerosis - indicated with carotid artery intima-media thickness change - in humans. Air Pollutants Study subjects United States air Particulate Matter Details Atherosclerosis
7. Pun VC, et al. (2015). Nurses' Health Study (NHS) Particulate matter in the prior 1 and 12 months is associated with pulmonary embolism risk, and women with underlying health conditions may be more susceptible to pulmonary embolism after particulate matter exposure. sex Air Pollutants Study subjects United States air, ambient Particulate Matter Details Pulmonary Embolism
8. Wittkopp S, et al. (2016). Cardiovascular Health and Air Pollution Study We report novel associations of gene expression changes with traffic-related air pollution exposures in a Los Angeles cohort of elderly subjects with coronary artery disease in this exploratory panel study analysis. Air Pollutants | Carbon | Carbon Monoxide | hopane | Nitrogen Dioxide | Nitrogen Oxides | Organic Chemicals | Ozone | Particulate Matter | Polycyclic Aromatic Hydrocarbons | Soot Subjects with disease:Coronary Artery Disease United States air | blood Carbon | Carbon Monoxide | CYP1B1 | HMOX1 | hopane | IL1B | NFE2L2 | Nitrogen Dioxide | Nitrogen Oxides | NQO1 | Organic Chemicals | Ozone | Particulate Matter | Polycyclic Aromatic Hydrocarbons | SELP | SOD2 | Soot Details gene expression
9. Brüske I, et al. (2011). Air Pollution and Inflammatory Response in Myocardial Infarction Survivors: Gene-Environment Interaction in a High Risk Group (AIRGENE) These preliminary findings should be replicated in other study populations because they suggest that the accumulation of acute and subacute effects or the chronic exposure to ambient particulate and gaseous air pollution may result in the promotion of atherosclerosis, mediated, at least in part, by increased levels of lipoprotein-associated phospholipase A2. Air Pollutants | Carbon Monoxide | Nitric Oxide | Nitrogen Dioxide | Ozone | Particulate Matter | Sulfur Dioxide Subjects with disease:Myocardial Infarction Germany air, ambient | plasma Carbon Monoxide | Nitric Oxide | Nitrogen Dioxide | Ozone | Particulate Matter | PLA2G7 | Sulfur Dioxide Details Atherosclerosis
10. Ljungman P, et al. (2009). Air Pollution and Inflammatory Response in Myocardial Infarction Survivors: Gene-Environment Interaction in a High Risk Group (AIRGENE) We found the interleukin-6 response to air pollution is modified by genetic polymorphisms in IL6 and FGB genes, suggesting the effect of gaseous traffic-related air pollution on inflammation may be stronger in genetic subpopulations with ischemic heart disease. disease | genetics Air Pollutants | Carbon Monoxide | Vehicle Emissions Subjects with gene influence:FGB | Subjects with gene influence:IL6 | Subjects with disease:Myocardial Infarction Finland|Germany|
Greece|Italy|
Spain|Sweden
air, ambient | plasma Carbon Monoxide | IL6 | Nitrogen Dioxide | Particulate Matter Details positive regulation of interleukin-6 production
11. Delfino RJ, et al. (2010). Traffic emission sources of organic chemicals represented by polycyclic aromatic hydrocarbons are associated with increased systemic inflammation and explain associations with quasi-ultrafine particle mass. Air Pollutants | hopane | Polycyclic Aromatic Hydrocarbons | Vehicle Emissions Subjects with disease:Coronary Artery Disease United States air, outdoor | plasma Alkanes | Chromium | Copper | hopane | IL6 | Iron | Manganese | Nickel | Particulate Matter | Polycyclic Aromatic Hydrocarbons | TNFRSF1B | Vanadium | Zinc Details
12. Levinsson A, et al. (2014). INTERGENE/ADONIX Air pollution exposure entails an increased risk of acute myocardial infarction, and this risk differed over genotype strata for variants in the GSTP1, GSTT1 and GSTCD genes, albeit not statistically-significantly. genetics Air Pollutants | Nitrogen Dioxide Subjects with gene influence:GSTP1 | Controls for disease:Myocardial Infarction | Subjects with disease:Myocardial Infarction Sweden Nitrogen Dioxide Details Hypertension | Myocardial Infarction
13. Hankey S, et al. (2012). Between-neighborhood differences in estimated ischemic heart disease mortality from air pollution were comparable in magnitude, suggesting that population health benefits from increased physical activity in high-walkability neighborhoods may be offset by adverse effects of air pollution exposure. physical activity Air Pollutants | Nitrogen Oxides | Ozone | Particulate Matter Study subjects United States air Nitrogen Dioxide | Nitrogen Oxides | Ozone | Particulate Matter Details Myocardial Ischemia
14. Ward-Caviness CK, et al. (2016). CATHeterization GENetics (CATHGEN) Our results reveal a novel gene (and possibly gene family) associated with peripheral arterial disease, via an interaction with traffic air pollution exposure; these results highlight the potential for interactions studies, particularly at the genome scale, to reveal novel biology linking environmental exposures to clinical outcomes. genetics Air Pollutants | Vehicle Emissions Subjects with gene influence:BMP2 | Subjects with gene influence:BMP8A United States Details Peripheral Arterial Disease
15. Lee WJ, et al. (2004). Agricultural Health Study (AHS) Our findings suggest a possible association between alachlor application and incidence of lymphohematopoietic cancers among applicators in the Agricultural Health Study. alachlor Workers United States Details Agricultural Workers' Diseases | Hematologic Neoplasms | Leukemia | Multiple Myeloma
16. Stamp LK, et al. (2015). We have replicated findings identifying dust exposure (grain and silica) and farm exposure as risk factors for granulomatosis with polyangiitis; we have shown activities associated with exposure to inhaled antigens (in particular those related to farming or gardening) may increase the risk of the disease. Antigens | Dust | Silicon Dioxide Controls for disease:Granulomatosis with Polyangiitis | Subjects with disease:Granulomatosis with Polyangiitis New Zealand Details Granulomatosis with Polyangiitis
17. Chen Y, et al. (2006). Health Effects of Arsenic Longitudinal Study (HEALS) Although the observed associations were not statistically significant, the trend of effect estimates suggests a possible role of low/moderate levels of arsenic exposure in progression of atherosclerosis, thus warranting the need for future investigation. Arsenic Study subjects Bangladesh urine | water, drinking Arsenic Details Atherosclerosis
18. Wang CH, et al. (2002). Carotid atherosclerosis is associated with ingested inorganic arsenic, showing a significant biological gradient. Arsenic Study subjects Taiwan, Province of China Arsenic Details Carotid Artery Diseases
19. Moon KA, et al. (2013). Strong Heart Study (SHS) Low to moderate chronic arsenic exposure, as measured in urine, was prospectively associated with cardiovascular disease incidence and mortality. Arsenic Study subjects United States urine Arsenic Details Cardiovascular Diseases | Coronary Disease | Death | Stroke
20. Rahman M, et al. (1999). The result of this study demonstrates a dose-response relationship between inorganic arsenic exposure from drinking water and risk of hypertension. Arsenic Controls for disease:Hypertension | Subjects with disease:Hypertension | Study subjects Bangladesh Arsenic Details Hypertension
21. Pi J, et al. (2005). A 13-month arsenic exposure reduction effectively reverses the arsenic-induced impairment of the nitric oxide/cyclic guanosine 3',5'-monophosphate pathway in both males and females and improves peripheral vascular function in males. Arsenic Study subjects China blood | urine | water Arsenic | Cyclic GMP Details Arsenic Poisoning | Vascular Diseases
22. Yuan Y, et al. (2007). We conclude that the major impact of arsenic in drinking water on circulatory disease involves acute myocardial infarction and that, in the initial years, it is the main cause of death from arsenic in drinking water, superseded in later years by excess mortality from lung and bladder cancer. Arsenic Study subjects Chile water Arsenic Details Lung Neoplasms | Myocardial Infarction | Urinary Bladder Neoplasms
23. D'Ippoliti D, et al. (2015). Results provide new evidence for risk assessment of low-medium concentrations of arsenic and contribute to the ongoing debate about the threshold-dose of effect, suggesting that even concentrations below 10 micrograms per liter carry a mortality risk. sex Arsenic Study subjects Italy Arsenic Details Death | Diabetes Mellitus | Lung Neoplasms | Myocardial Infarction | Peripheral Arterial Disease | Pulmonary Disease, Chronic Obstructive
24. Tseng CH, et al. (2003). It is concluded that ischemic heart disease in the arseniasis-hyperendemic villages in Taiwan was associated with long-term arsenic exposure. Arsenic Study subjects Taiwan, Province of China Arsenic Details Myocardial Ischemia
25. Yu Y, et al. (2017). Our study suggested that hair Arsenic concentration was associated with an elevated risk of hypertension. Arsenic Controls for disease:Hypertension | Subjects with disease:Hypertension China hair Arsenic Details Hypertension
26. Wade TJ, et al. (2009). This is the first study to document increased arsenic-associated mortality in the Bayingnormen Inner Mongolia region of China. Arsenic Study subjects China water Arsenic Details Coronary Disease | Death | Neoplasms
27. Chen CJ, et al. (1995). The results suggest that long-term arsenic exposure may induce hypertension in humans. Arsenic Study subjects Taiwan, Province of China water, drinking Arsenic Details Hypertension
28. Osorio-Yáñez C, et al. (2013). Arsenic exposure was positively associated with carotid intima-media thickness in a population of Mexican children with environmental arsenic exposure through drinking water. diet Arsenic Children Mexico plasma | urine | water, drinking Arsenicals | Arsenic | Cacodylic Acid | ICAM1 | monomethylarsonic acid | VCAM1 Details Carotid Intimal Medial Thickness 1 | blood vessel development
29. Chen CJ, et al. (1996). In this study, we observed a significantly increased ischemic heart disease (ISHD) mortality among residents in the blackfoot disease (BFD)-endemic area, a significantly higher ISHD mortality for BFD patients than for age-, sex-, and residence-matched control subjects, and a dose-response relation between ISHD mortality and long-term exposure to ingested inorganic arsenic. age | disease Arsenic Controls for disease:Peripheral Vascular Diseases | Subjects with disease:Peripheral Vascular Diseases Taiwan, Province of China water, drinking Arsenic Details Death | Myocardial Ischemia
30. Wang CH, et al. (2010). QT dispersion may be indicated as an early biomarker for atherosclerotic diseases and a significant and strong predictor of cardiovascular mortality in populations with chronic arsenic exposure. Arsenic Study subjects Taiwan, Province of China Details Carotid Artery Diseases | Coronary Artery Disease | regulation of ventricular cardiac muscle cell membrane repolarization
31. James KA, et al. (2015). San Luis Valley Diabetes Study (SLVDS) We observed an association between coronary heart disease risk and inorganic arsenic exposure in a chronic low-level arsenic area in the southwestern United States. sex Arsenic Controls for disease:Coronary Disease | Subjects with disease:Coronary Disease | Study subjects United States urine | water, drinking Arsenic Details Coronary Disease
32. Chen Y, et al. (2011). Exposure to arsenic in drinking water is adversely associated with mortality from heart disease, especially among smokers. tobacco Arsenic Study subjects Bangladesh urine | water, drinking Details Cardiovascular Diseases | Death | Myocardial Ischemia
33. Zierold KM, et al. (2004). Respondents with arsenic levels of 2 microg/L or greater were statistically more likely to report a history of depression, high blood pressure, circulatory problems, and bypass surgery than were respondents with arsenic concentrations less than 2 microg/L. Arsenic Study subjects United States water Arsenic Details Depressive Disorder | Heart Diseases | Hypertension
34. Jones MR, et al. (2011). National Health and Nutrition Examination Survey (NHANES) At the low to moderate levels typical of the U.S. population, total arsenic, total arsenic minus arsenobetaine, and dimethylarsinate concentrations in urine were not associated with the prevalence of hypertension or with systolic or diastolic blood pressure levels. A weak association of dimethylarsinate with hypertension could not be ruled out. Arsenic | arsenobetaine | Cacodylic Acid Controls for disease:Hypertension | Subjects with disease:Hypertension | Study subjects United States urine Arsenic | arsenobetaine | Cacodylic Acid Details
35. Rotter I, et al. (2015). The primary aim of the study was to assess the relationship of blood heavy metal and bioelement concentrations and Metabolic Syndrome, in men aged 50-75 years. Arsenic | Cadmium | Calcium | Chromium | Copper | Iron | Lead | Magnesium | Manganese | Mercury | Molybdenum | Selenium | Tungsten | Zinc Controls for disease:Diabetes Mellitus, Type 2 | Subjects with disease:Diabetes Mellitus, Type 2 | Controls for disease:Hypertension | Subjects with disease:Hypertension | Controls for disease:Metabolic Syndrome | Subjects with disease:Metabolic Syndrome | Controls for disease:Obesity | Subjects with disease:Obesity | Controls for disease:Overweight | Subjects with disease:Overweight | Study subjects Poland blood | serum Arsenic | Cadmium | Calcium | Chromium | Copper | Iron | Lead | Magnesium | Manganese | Mercury | Molybdenum | Selenium | Tungsten | Zinc Details Diabetes Mellitus, Type 2 | Hypertension | Metabolic Syndrome | Obesity | Overweight | cholesterol homeostasis | insulin metabolic process | regulation of blood pressure | triglyceride homeostasis
36. Ghazali AR, et al. (2012). There were significant correlations between heavy metals with subject's age and working period as farmers. age Arsenic | Cadmium | Lead Controls for disease:Hypertension | Subjects with disease:Hypertension | Workers Malaysia nail Arsenic | Cadmium | Lead Details
37. Thurston GD, et al. (2016). American Cancer Society Cancer Prevention Study II (ACS CPS-II) Long-term fine particulate matter (PM2.5) exposures from fossil fuel combustion, especially coal burning but also from diesel traffic, were associated with increases in ischemic heart disease mortality in this nationwide population. Arsenic | Carbon | Chlorine | Iron | Lead | Manganese | Particulate Matter | Potassium | Selenium | Silicon | Soot | Sulfur Study subjects United States air, ambient | soil Arsenic | Calcium | Carbon | Chlorine | Iron | Lead | Manganese | Nickel | Particulate Matter | Potassium | Selenium | Silicon | Sodium | Soot | Sulfur | Vanadium | Zinc Details Death | Myocardial Ischemia
38. Shankar A, et al. (2012). National Health and Nutrition Examination Survey (NHANES) Urinary bisphenol A levels were significantly associated with peripheral arterial disease, independent of traditional cardiovascular disease risk factors. race | sex | tobacco bisphenol A Study subjects United States urine bisphenol A Details Peripheral Arterial Disease
39. Shankar A, et al. (2012). National Health and Nutrition Examination Survey (NHANES) We observed a positive association between increasing levels of urinary bisphenol A and hypertension independent of confounding factors such as age, gender, race/ethnicity, smoking, body mass index, diabetes mellitus and total serum cholesterol levels. bisphenol A Study subjects United States urine bisphenol A Details Hypertension
40. Melzer D, et al. (2012). European Prospective Investigation into Cancer and Nutrition (EPIC) Study Associations between higher bisphenol A exposure (reflected in higher urinary concentrations) and incident coronary artery disease during >10 years of follow-up showed trends similar to previously reported cross-sectional findings in the more highly exposed NHANES respondents. bisphenol A Controls for disease:Coronary Artery Disease | Subjects with disease:Coronary Artery Disease United Kingdom urine bisphenol A Details Coronary Artery Disease
41. Melzer D, et al. (2010). National Health and Nutrition Examination Survey (NHANES) Higher Bisphenol A (BPA) exposure, reflected in higher urinary concentrations of BPA, is consistently associated with reported heart disease in the general adult population of the USA. bisphenol A Study subjects United States urine bisphenol A Details Angina Pectoris | Coronary Disease | Diabetes Mellitus | Myocardial Infarction | alkaline phosphatase activity | lactate dehydrogenase activity
42. Swaddiwudhipong W, et al. (2015). Persons living in (cadmium) contaminated areas had a significantly higher prevalence of renal dysfunction, bone mineral loss, hypertension and urinary stones than those living in non-contaminated areas. There were no significant differences between the 2 groups in the prevalence of diabetes, hypercholesterolemia and hypertriglyceridemia. Cadmium Study subjects Thailand urine Cadmium Details Diabetes Mellitus | Hypercholesterolemia | Hypertension | Hypertriglyceridemia | Osteoporosis | Urinary Calculi | renal system process
43. Barregard L, et al. (2016). Malmo Diet and Cancer Study Blood cadmium in the highest quartile was associated with incident cardiovascular disease and mortality in our population-based samples of Swedish adults. tobacco Cadmium Study subjects Sweden blood Cadmium Details Cardiovascular Diseases | Myocardial Ischemia | Stroke
44. Nie X, et al. (2016). Survey on Prevalence in East China for Metabolic Diseases and Risk Factors (SPECT-China) Blood cadmium level (BCL) in Chinese adults was much higher than in other developed countries and was influenced by gender, smoking, and residential area. BCL was positively related to prediabetes while negatively related to overweight. sex | tobacco Cadmium Controls for disease:Diabetes Mellitus | Subjects with disease:Diabetes Mellitus | Controls for disease:Dyslipidemias | Subjects with disease:Dyslipidemias | Controls for disease:Hypertension | Subjects with disease:Hypertension | Study subjects China blood Cadmium Details Overweight | Prediabetic State | glucose homeostasis
45. Hecht EM, et al. (2016). National Health and Nutrition Examination Survey (NHANES) These descriptive data from a nationally representative sample suggest that cadmium is related to cardiovascular outcomes even after adjustment for smoking status. Cadmium Study subjects United States blood | urine Cadmium Details Myocardial Infarction | Stroke
46. Min JY, et al. (2016). National Health and Nutrition Examination Survey (NHANES) We observed a significant association between blood cadmium levels and Alzheimer disease mortality among older adults in the US. age Cadmium Controls for disease:Diabetes Mellitus | Subjects with disease:Diabetes Mellitus | Controls for disease:Hypertension | Subjects with disease:Hypertension | Study subjects United States blood Cadmium Details Alzheimer Disease
47. Swaddiwudhipong W, et al. (2012). Our study indicates that in persons with prolonged excessive cadmium exposure, toxic health effects may progress even after exposure reduction, and that renal damage from cadmium can be due to its direct nephrotoxic effect and also through the related disorders causing nephropathy. Cadmium Study subjects Thailand urine B2M | Cadmium Details Diabetes Mellitus | Hypertension | Kidney Diseases | Urinary Calculi | negative regulation of glomerular filtration
48. Swaddiwudhipong W, et al. (2010). The study revealed no significant association between urinary cadmium and diabetes in either gender, but our study supports the hypothesis that environmental exposure to cadmium may increase the risk of hypertension. sex Cadmium Study subjects Thailand urine Cadmium Details Hypertension
49. Everett CJ, et al. (2008). National Health and Nutrition Examination Survey (NHANES) Our results indicate a possible role for cadmium in coronary heart disease. sex Cadmium Study subjects United States urine Cadmium Details Myocardial Infarction
50. Peters JL, et al. (2010). National Health and Nutrition Examination Survey (NHANES) Environmental exposure to cadmium was associated with significantly increased stroke and heart failure prevalence. sex | tobacco Cadmium Study subjects United States blood | urine Cadmium Details Heart Failure | Stroke
1–50 of 114 results.