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Disease Chemical and Drug Induced Liver Injury

These diseases have comparable sets of interacting chemicals and genes to Chemical and Drug Induced Liver Injury.

Via chemical associations

Similarity Index Common
Interacting
Chemicals
Necrosis 0.24634 0.24634 404
Kidney Diseases 0.22272 0.22272 349
Acute Kidney Injury 0.19307 0.19307 284
Drug-Related Side Effects and Adverse Reactions 0.1774 0.1774 270
Cholestasis 0.17555 0.17555 224
Weight Loss 0.17056 0.17056 241
Inflammation 0.16888 0.16888 267
Hepatomegaly 0.16865 0.16865 227
Nausea 0.15303 0.15303 230
Liver Diseases 0.15054 0.15054 196
Edema 0.14789 0.14789 231
Fever 0.14742 0.14742 203
Seizures 0.14477 0.14477 292
Headache 0.14473 0.14473 210
Renal Insufficiency 0.14359 0.14359 196
Fatty Liver 0.14199 0.14199 187
Hypertension 0.14135 0.14135 254
Heart Diseases 0.13964 0.13964 192
Vomiting 0.13688 0.13688 203
Pain 0.13444 0.13444 226

Via marker/mechanism chemical associations

Similarity Index Common
Interacting
Chemicals
Necrosis 0.22045 0.22045 291
Kidney Diseases 0.20749 0.20749 255
Acute Kidney Injury 0.20476 0.20476 241
Cholestasis 0.19122 0.19122 196
Hepatomegaly 0.17949 0.17949 196
Drug-Related Side Effects and Adverse Reactions 0.17079 0.17079 207
Nausea 0.16853 0.16853 211
Headache 0.1592 0.1592 192
Weight Loss 0.15804 0.15804 177
Jaundice 0.157 0.157 157
Liver Diseases 0.15673 0.15673 163
Hepatitis 0.15582 0.15582 158
Renal Insufficiency 0.15552 0.15552 172
Seizures 0.15239 0.15239 226
Vomiting 0.15029 0.15029 182
Fever 0.14855 0.14855 164
Stevens-Johnson Syndrome 0.13449 0.13449 147
Hypertension 0.13208 0.13208 168
Edema 0.13055 0.13055 153
Fatty Liver 0.12931 0.12931 135

Via therapeutic chemical associations

Similarity Index Common
Interacting
Chemicals
Necrosis 0.23305 0.23305 110
Kidney Diseases 0.17938 0.17938 87
Inflammation 0.1489 0.1489 88
Weight Loss 0.13184 0.13184 53
Fatty Liver 0.12567 0.12567 47
Liver Cirrhosis, Experimental 0.11959 0.11959 47
Acute Kidney Injury 0.11807 0.11807 49
Heart Diseases 0.11224 0.11224 44
Drug-Related Side Effects and Adverse Reactions 0.11187 0.11187 49
Edema 0.11049 0.11049 59
Myocardial Infarction 0.09761 0.09761 45
Proteinuria 0.09722 0.09722 42
Liver Cirrhosis 0.09651 0.09651 36
Cardiomyopathies 0.09383 0.09383 38
Hyperglycemia 0.08962 0.08962 38
Hemorrhage 0.08951 0.08951 35
Insulin Resistance 0.08189 0.08189 33
Neoplasms 0.08159 0.08159 43
Carcinoma, Hepatocellular 0.08108 0.08108 33
Memory Disorders 0.0793 0.0793 36

Via gene associations

Similarity Index Common
Interacting
Genes
Cholestasis 0.08282 0.08282 40
Liver Cirrhosis 0.07392 0.07392 36
Drug-Related Side Effects and Adverse Reactions 0.06992 0.06992 33
Fatty Liver 0.06458 0.06458 31
Myocardial Reperfusion Injury 0.06432 0.06432 31
Acute Kidney Injury 0.06224 0.06224 30
Neoplasm Metastasis 0.06091 0.06091 36
Liver Cirrhosis, Experimental 0.06071 0.06071 72
Diabetes Mellitus, Type 2 0.05651 0.05651 33
Inflammation 0.05374 0.05374 28
Hypertension 0.05336 0.05336 31
Pulmonary Fibrosis 0.05252 0.05252 25
Lung Neoplasms 0.05247 0.05247 34
Necrosis 0.05066 0.05066 23
Liver Neoplasms, Experimental 0.05049 0.05049 26
Liver Cirrhosis, Alcoholic 0.0493 0.0493 21
Obesity 0.04921 0.04921 28
Carcinoma, Hepatocellular 0.04921 0.04921 31
Breast Neoplasms 0.04831 0.04831 43
Pancreatitis 0.04626 0.04626 21

Via marker/mechanism gene associations

Via therapeutic gene associations

Similarity Index Common
Interacting
Genes
Liver Diseases 0.09375 0.09375 3
Liver Cirrhosis, Experimental 0.09091 0.09091 5
Fibrosis 0.08333 0.08333 3
Liver Neoplasms 0.08108 0.08108 3
Hypertension 0.07547 0.07547 4
Vascular System Injuries 0.06897 0.06897 2
Soft Tissue Neoplasms 0.06667 0.06667 2
Hyperplasia 0.06452 0.06452 2
Cholestasis 0.0625 0.0625 2
Weight Loss 0.0625 0.0625 2
Carcinoma, Transitional Cell 0.06061 0.06061 2
Pulmonary Edema 0.06061 0.06061 2
Colitis 0.05882 0.05882 2
Urinary Bladder Neoplasms 0.05882 0.05882 2
Amnesia 0.05405 0.05405 2
Heart Failure 0.05405 0.05405 2
Colonic Neoplasms 0.05263 0.05263 2
Drug-Related Side Effects and Adverse Reactions 0.05128 0.05128 2
Insulin Resistance 0.05128 0.05128 2
Kidney Diseases 0.05128 0.05128 2
Pulmonary Fibrosis 0.05128 0.05128 2