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Disease Chemical and Drug Induced Liver Injury

These diseases have comparable sets of interacting chemicals and genes to Chemical and Drug Induced Liver Injury.

Via chemical associations

Similarity Index Common
Interacting
Chemicals
Necrosis 0.24192 0.24192 389
Kidney Diseases 0.22528 0.22528 344
Acute Kidney Injury 0.19209 0.19209 277
Cholestasis 0.1778 0.1778 221
Drug-Related Side Effects and Adverse Reactions 0.17742 0.17742 264
Inflammation 0.16602 0.16602 256
Weight Loss 0.16447 0.16447 225
Hepatomegaly 0.16119 0.16119 211
Nausea 0.15432 0.15432 227
Liver Diseases 0.15106 0.15106 192
Fever 0.14763 0.14763 199
Edema 0.14586 0.14586 222
Headache 0.14487 0.14487 206
Seizures 0.14401 0.14401 286
Renal Insufficiency 0.14222 0.14222 190
Hypertension 0.14156 0.14156 249
Fatty Liver 0.14063 0.14063 180
Heart Diseases 0.14009 0.14009 188
Vomiting 0.13853 0.13853 201
Hepatitis 0.13692 0.13692 168

Via marker/mechanism chemical associations

Similarity Index Common
Interacting
Chemicals
Necrosis 0.2181 0.2181 282
Kidney Diseases 0.20816 0.20816 250
Acute Kidney Injury 0.20624 0.20624 238
Cholestasis 0.19481 0.19481 195
Hepatomegaly 0.17089 0.17089 182
Nausea 0.1702 0.1702 209
Drug-Related Side Effects and Adverse Reactions 0.16835 0.16835 200
Headache 0.16061 0.16061 190
Jaundice 0.15967 0.15967 156
Hepatitis 0.15843 0.15843 157
Liver Diseases 0.15831 0.15831 161
Renal Insufficiency 0.15498 0.15498 168
Seizures 0.15195 0.15195 222
Weight Loss 0.15179 0.15179 165
Vomiting 0.15164 0.15164 180
Fever 0.14986 0.14986 162
Stevens-Johnson Syndrome 0.13645 0.13645 146
Hypertension 0.13152 0.13152 164
Drug Hypersensitivity 0.1315 0.1315 139
Fatty Liver 0.13005 0.13005 132

Via therapeutic chemical associations

Similarity Index Common
Interacting
Chemicals
Necrosis 0.2256 0.2256 104
Kidney Diseases 0.18124 0.18124 85
Inflammation 0.13518 0.13518 78
Weight Loss 0.1276 0.1276 49
Fatty Liver 0.11911 0.11911 43
Drug-Related Side Effects and Adverse Reactions 0.11321 0.11321 48
Acute Kidney Injury 0.11139 0.11139 45
Heart Diseases 0.10499 0.10499 40
Edema 0.10405 0.10405 54
Liver Cirrhosis, Experimental 0.10183 0.10183 39
Proteinuria 0.09785 0.09785 41
Myocardial Infarction 0.09598 0.09598 43
Liver Cirrhosis 0.09444 0.09444 34
Cardiomyopathies 0.08974 0.08974 35
Carcinoma, Hepatocellular 0.08376 0.08376 33
Hemorrhage 0.08245 0.08245 31
Insulin Resistance 0.08226 0.08226 32
Neoplasms 0.07946 0.07946 41
Liver Diseases 0.07872 0.07872 27
Hyperglycemia 0.07805 0.07805 32

Via gene associations

Similarity Index Common
Interacting
Genes
Cholestasis 0.09901 0.09901 40
Drug-Related Side Effects and Adverse Reactions 0.08397 0.08397 33
Liver Cirrhosis 0.08088 0.08088 33
Myocardial Reperfusion Injury 0.07444 0.07444 30
Acute Kidney Injury 0.07268 0.07268 29
Fatty Liver 0.06948 0.06948 28
Neoplasm Metastasis 0.06628 0.06628 34
Diabetes Mellitus, Type 2 0.06337 0.06337 32
Necrosis 0.06133 0.06133 23
Liver Cirrhosis, Alcoholic 0.06052 0.06052 21
Hypertension 0.05964 0.05964 30
Liver Neoplasms, Experimental 0.05963 0.05963 26
Liver Cirrhosis, Experimental 0.0565 0.0565 63
Inflammation 0.05643 0.05643 25
Lung Neoplasms 0.05614 0.05614 32
Pancreatitis 0.056 0.056 21
Breast Neoplasms 0.04866 0.04866 38
Hypersensitivity 0.04651 0.04651 18
Pulmonary Fibrosis 0.04651 0.04651 18
Hepatitis B 0.0452 0.0452 16

Via marker/mechanism gene associations

Similarity Index Common
Interacting
Genes
Cholestasis 0.09424 0.09424 36
Drug-Related Side Effects and Adverse Reactions 0.07967 0.07967 29
Liver Cirrhosis 0.07292 0.07292 28
Myocardial Reperfusion Injury 0.06842 0.06842 26
Acute Kidney Injury 0.06469 0.06469 24
Diabetes Mellitus, Type 2 0.06432 0.06432 31
Fatty Liver 0.06349 0.06349 24
Liver Cirrhosis, Alcoholic 0.06116 0.06116 20
Liver Neoplasms, Experimental 0.05797 0.05797 24
Pancreatitis 0.05666 0.05666 20
Lung Neoplasms 0.0536 0.0536 29
Neoplasm Metastasis 0.0535 0.0535 26
Hypertension 0.05063 0.05063 24
Liver Cirrhosis, Experimental 0.04917 0.04917 53
Necrosis 0.04899 0.04899 17
Hypersensitivity 0.04645 0.04645 17
Inflammation 0.04467 0.04467 18
Hepatitis B 0.0423 0.0423 14
Breast Neoplasms 0.04155 0.04155 31
Arthritis, Rheumatoid 0.04025 0.04025 19

Via therapeutic gene associations

Similarity Index Common
Interacting
Genes
Liver Diseases 0.1 0.1 3
Fibrosis 0.08824 0.08824 3
Liver Neoplasms 0.08571 0.08571 3
Hypertension 0.07843 0.07843 4
Liver Cirrhosis, Experimental 0.07547 0.07547 4
Vascular System Injuries 0.07407 0.07407 2
Soft Tissue Neoplasms 0.07143 0.07143 2
Hyperplasia 0.06897 0.06897 2
Cholestasis 0.06667 0.06667 2
Weight Loss 0.06667 0.06667 2
Carcinoma, Transitional Cell 0.06452 0.06452 2
Pulmonary Edema 0.06452 0.06452 2
Colitis 0.0625 0.0625 2
Urinary Bladder Neoplasms 0.0625 0.0625 2
Amnesia 0.05714 0.05714 2
Heart Failure 0.05714 0.05714 2
Colonic Neoplasms 0.05556 0.05556 2
Pulmonary Fibrosis 0.05556 0.05556 2
Drug-Related Side Effects and Adverse Reactions 0.05405 0.05405 2
Insulin Resistance 0.05405 0.05405 2
Kidney Diseases 0.05405 0.05405 2