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GO Term molecular_function

These are exposure studies associated with the GO term and all of its children.

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1–17 of 17 results.
  Reference Associated Study Title Author's Summary Study Factors Stressor Receptors Country Medium Exposure Marker Measurements Outcome
1. Ayotte P, et al. (2005). In summary, we found no relation between biomarkers of organochlorine exposure and markers of hepatic enzyme induction in this highly exposed group of fish eaters from the Lower North Shore of the St. Lawrence River. Our results suggest that smoking induces liver CYP1A2 activity, which in turn alters porphyrin metabolism and increases the biotransformation of mono-ortho polychlorinated biphenyls. tobacco 2,2',3,3',4,4',5-heptachlorobiphenyl | 2,2',3',4,4',5-hexachlorobiphenyl | 2,2',4,4',5-pentachlorobiphenyl | 2,3,3',4,4',5-hexachlorobiphenyl | 2,3,3',4,4'-pentachlorobiphenyl | 2,3',4,4',5-pentachlorobiphenyl | 2,4,5,2',4',5'-hexachlorobiphenyl | Dichlorodiphenyl Dichloroethylene | Hexachlorobenzene | Hydrocarbons, Chlorinated | Mirex | nonachlor | oxychlordane | PCB 180 | Polychlorinated Biphenyls Study subjects Canada plasma | urine 2,2',3,3',4,4',5-heptachlorobiphenyl | 2,2',3',4,4',5-hexachlorobiphenyl | 2,2',4,4',5-pentachlorobiphenyl | 2,3,3',4,4',5-hexachlorobiphenyl | 2,3,3',4,4'-pentachlorobiphenyl | 2,3',4,4',5-pentachlorobiphenyl | 2,4,5,2',4',5'-hexachlorobiphenyl | Coproporphyrins | Dichlorodiphenyl Dichloroethylene | Glucaric Acid | Hexachlorobenzene | Hydrocarbons, Chlorinated | Mirex | nonachlor | oxychlordane | PCB 180 | Polychlorinated Biphenyls | Uroporphyrins Details enzyme activator activity
2. Jusko TA, et al. (2016). The results from this prospective birth cohort study suggest that two common environmental contaminants, PCB-153 and p,p'-DDE, substantially reduce the infant response to Mycobacterium bovis bacille Calmette-Guerin (BCG) vaccination. 2,4,5,2',4',5'-hexachlorobiphenyl | Dichlorodiphenyl Dichloroethylene Infants or newborns | Pregnant females Slovakia blood, cord | serum 2,4,5,2',4',5'-hexachlorobiphenyl | Dichlorodiphenyl Dichloroethylene Details IgA receptor activity | IgG receptor activity | immune response
3. Adad LM, et al. (2015). In this study, we determined the mutagenic and cell death potential of pesticides through the increased frequency of micronuclei and other nuclear abnormalities in exposed individuals abamectin | copper oxychloride | Dimethoate | glyphosate | Methyl Parathion | Triazines Workers Brazil Details cholinesterase activity | cytokinetic process | lipid metabolic process | micronucleus organization | nuclear fragmentation involved in apoptotic nuclear change
4. Perera F, et al. (2008). The findings indicate that neurobehavioral development in Tongliang children benefited by elimination of polycyclic aromatic hydrocarbons (PAH) exposure from the coal-burning plant, consistent with the significant reduction in PAH-DNA adducts in cord blood of children in the 2005 cohort. Air Pollutants | Lead | Mercury | Polycyclic Aromatic Hydrocarbons | Tobacco Smoke Pollution Infants or newborns China blood, cord Lead | Mercury | polycyclic aromatic hydrocarbons-DNA adduct | Tobacco Smoke Pollution Details Prenatal Exposure Delayed Effects | cognition | motor activity
5. Frediani JK, et al. (2018). National Health and Nutrition Examination Survey (NHANES) Our findings demonstrate a positive association between urinary arsenic exposure and risk of nonalcoholic fatty liver disease among U.S. adolescents and adults that is highest among Mexican Americans and among those obese, regardless of race/ethnicity. disease | race Arsenic Study subjects United States urine Arsenic Details Non-alcoholic Fatty Liver Disease | transaminase activity
6. Ali N, et al. (2010). We found a significant inverse relationship between arsenic exposure and plasma cholinesterase activity in a human population in Bangladesh. This research demonstrates a novel exposure-response relationship between arsenic and plasma cholinesterase activity which may explain one of the biological mechanisms through which arsenic exerts its neurotoxicity and hepatotoxicity in humans. Arsenic Study subjects Bangladesh hair | nail Arsenic Details cholinesterase activity
7. Islam K, et al. (2011). The present study demonstrated that arsenic concentrations in the drinking water were strongly correlated with arsenic concentrations in the subjects' hair and nails. Arsenic Study subjects Bangladesh water, drinking Arsenic Details alkaline phosphatase activity | transaminase activity
8. Melzer D, et al. (2010). National Health and Nutrition Examination Survey (NHANES) Higher Bisphenol A (BPA) exposure, reflected in higher urinary concentrations of BPA, is consistently associated with reported heart disease in the general adult population of the USA. bisphenol A Study subjects United States urine bisphenol A Details Angina Pectoris | Coronary Disease | Diabetes Mellitus | Myocardial Infarction | alkaline phosphatase activity | lactate dehydrogenase activity
9. Burch JB, et al. (2015). National Health and Nutrition Examination Survey (NHANES) We tested the hypothesis that trihalomethanes are associated with liver injury as assessed by alanine aminotransferase activity; subjects with high enzyme activity were more likely to have circulating dibromochloromethane concentrations exceeding median values in the study population, and the association varied by alcohol consumption. alcohol drinking chlorodibromomethane | Trihalomethanes Study subjects United States blood | water, tap bromodichloromethane | bromoform | chlorodibromomethane | Chloroform | GPT | Trihalomethanes Details L-alanine:2-oxoglutarate aminotransferase activity
10. Liu P, et al. (2016). Both prenatal and postnatal organophosphorous exposure may adversely affect the neurodevelopment of infants living in the agricultural area. sex diethyl phosphate | Organophosphorus Compounds Children | Mothers China urine diethyl phosphate | dimethyl phosphate | O,O-diethyl dithiophosphate | O,O-dimethyl phosphorodithioate | O,O-dimethyl phosphorothionate | Organophosphorus Compounds | thiophosphoric acid Details Prenatal Exposure Delayed Effects | cognition | developmental process | head development | motor activity | social behavior
11. Long M, et al. (2007). The persistent organic pollutants (POPs) and serum aryl hydrocarbon receptor (AhR) transcriptional activity differed among Greenlandic districts, suggesting that the difference of serum AhR transcriptional activity depends on the composition of bioaccumulated POPs. Environmental Pollutants | Pesticides | Polychlorinated Biphenyls Study subjects Greenland serum Environmental Pollutants | Pesticides | Polychlorinated Biphenyls Details aryl hydrocarbon receptor activity
12. Hofmann JN, et al. (2009). We found that both low PON1 catalytic efficiency (Q192 alloform) and low plasma PON1 activity were associated with butyrylcholinesterase inhibition among organophosphate insecticide-exposed agricultural pesticide handlers. genetics Insecticides | Organophosphates Subjects with gene influence:PON1 | Workers United States blood BCHE Details cholinesterase activity
13. Strelitz J, et al. (2014). Washington State Cholinesterase Monitoring Program In this study we have evaluated the relationship between acetylcholinesterase and butyrylcholinesterase as biomarkers for cholinesterase depression from organophosphate (OP) pesticides, and assessed whether these measures can be used interchangeably to diagnose cases of OP intoxication. Organophosphates Workers United States Details acetylcholinesterase activity | cholinesterase activity
14. Zepeda-Arce R, et al. (2017). Our results suggest an important role of antioxidant enzymes for the protection of DNA damage caused by occupational exposure to pesticides. Pesticides Study subjects | Workers Mexico blood | plasma | serum ACHE | BCHE | CAT | GPX1 | GSR | Malondialdehyde Details glutathione peroxidase activity | negative regulation of catalase activity | negative regulation of superoxide dismutase activity
15. Rivero Osimani VL, et al. (2016). The impact of environmental organophosphate (OP) pesticide exposure on respiratory complexes, enzymatic antioxidant defense activities, and oxidative damage markers in the syncytiotrophoblast and cytotrophoblast mitochondria was evaluated. Pesticides Infants or newborns | Pregnant females Argentina Details Birth Weight | cytochrome-c oxidase activity | lipid oxidation | mitochondrial electron transport, cytochrome c to oxygen | progesterone biosynthetic process
16. Haase RF, et al. (2009). The present study provides an additional assessment of the relationship between Polychlorinated biphenyls (PCBs) and neuropsychological functioning through an extensive series of neuropsychological evaluations conducted on a Native American population of Mohawk people residing in upstate New York who have been environmentally exposed to PCBs and pesticides. age Polychlorinated Biphenyls Study subjects United States Details cognition | memory | motor activity
17. Comhair SA, et al. (2011). Severe Asthma Research Program (SARP) Environmental tobacco smoke-exposure of asthmatic individuals is associated with worse lung function, higher acuity of exacerbations, more health care utilization, and greater bronchial hyperreactivity. Environmental tobacco smoke-exposure was associated with lower levels of serum SOD activity, particularly in asthmatic women of African heritage. disease | race | sex | tobacco Tobacco Smoke Pollution Subjects with disease:Asthma United States Details Asthma | Disease Progression | superoxide dismutase activity
1–17 of 17 results.