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GO Term apoptotic process

Name apoptotic process
Broad synonyms cell suicide | cellular suicide
Exact Synonyms apoptotic cell death | apoptotic programmed cell death | programmed cell death by apoptosis
Narrow Synonyms activation of apoptosis | apoptosis | apoptosis signaling | apoptotic program | type I programmed cell death
Related Synonyms apoptosis activator activity | caspase-dependent programmed cell death | commitment to apoptosis | induction of apoptosis | induction of apoptosis by p53 | signaling (initiator) caspase activity
Definition A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
Ontology Biological Process
GO IDs GO:0006915 | GO:0006917 | GO:0008632
External Links

Top ↑ Ancestors

ALLis a biological_process Has associated genes Has associated diseases Has associated phenotype references Has associated exposure references is a cellular process Has associated genes Has associated diseases Has associated phenotype references Has associated exposure references is a cell death Has associated genes Has associated diseases Has associated phenotype references Has associated exposure references is a programmed cell death Has associated genes Has associated diseases Has associated phenotype references Has associated exposure references is a apoptotic process Has associated genes Has associated diseases Has associated phenotype references Has associated exposure references

Top ↑ Descendants

apoptotic process Has associated genes Has associated diseases Has associated phenotype references Has associated exposure references
View nodeis a anoikis Has associated genes Has associated diseases Has associated phenotype references
View nodepart of apoptotic mitochondrial changes Has associated genes Has associated diseases Has associated phenotype references
View nodeis a apoptotic process in bone marrow Has associated genes Has associated diseases
is a apoptotic process in response to mitochondrial fragmentation
View nodeis a apoptotic process involved in development Has associated genes Has associated diseases
View nodepart of apoptotic signaling pathway Has associated genes Has associated diseases Has associated phenotype references
View nodeis a epithelial cell apoptotic process Has associated genes Has associated diseases Has associated phenotype references
View nodepart of execution phase of apoptosis Has associated genes Has associated diseases Has associated phenotype references Has associated exposure references
View nodeis a fat cell apoptotic process Has associated genes Has associated diseases
View nodeis a fibroblast apoptotic process Has associated genes Has associated diseases Has associated phenotype references
View nodeis a glial cell apoptotic process Has associated genes Has associated diseases
is a hepatoblast apoptotic process
View nodeis a inflammatory cell apoptotic process Has associated genes Has associated diseases Has associated phenotype references
View nodeis a leukocyte apoptotic process Has associated genes Has associated diseases Has associated phenotype references
is a melanocyte apoptotic process Has associated genes Has associated diseases
View nodeis a mesenchymal cell apoptotic process Has associated genes Has associated diseases Has associated phenotype references
View nodeis a muscle cell apoptotic process Has associated genes Has associated diseases Has associated phenotype references
View nodeis a myeloid cell apoptotic process Has associated genes Has associated diseases Has associated phenotype references
View nodeis a myofibroblast cell apoptotic process
View nodenegatively regulates negative regulation of apoptotic process Has associated genes Has associated diseases Has associated phenotype references
View nodeis a neuron apoptotic process Has associated genes Has associated diseases Has associated phenotype references
View nodepositively regulates positive regulation of apoptotic process Has associated genes Has associated diseases Has associated phenotype references
View noderegulates regulation of apoptotic process Has associated genes Has associated diseases Has associated phenotype references
View nodeis a retinal cell apoptotic process Has associated genes Has associated diseases Has associated phenotype references