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GO Term necrotic cell death

Name necrotic cell death
Broad synonym necrosis
Exact Synonym cellular necrosis
Definition A type of cell death that is morphologically characterized by an increasingly translucent cytoplasm, swelling of organelles, minor ultrastructural modifications of the nucleus (specifically, dilatation of the nuclear membrane and condensation of chromatin into small, irregular, circumscribed patches) and increased cell volume (oncosis), culminating in the disruption of the plasma membrane and subsequent loss of intracellular contents. Necrotic cells do not fragment into discrete corpses as their apoptotic counterparts do. Moreover, their nuclei remain intact and can aggregate and accumulate in necrotic tissues.
Comment Note that the word necrosis has been widely used in earlier literature to describe forms of cell death which are now known by more precise terms, such as apoptosis. Necrosis can occur in a regulated fashion, involving a precise sequence of signals; in this case, consider annotating to GO:0097300 'programmed necrotic cell death' or to its more specific child GO:0070266 'necroptotic process'.
Ontology Biological Process
GO ID GO:0070265
External Links

Top ↑ Ancestors

ALLis a biological_process Has associated genes Has associated diseases Has associated phenotype references Has associated exposure references is a cellular process Has associated genes Has associated diseases Has associated phenotype references Has associated exposure references is a cell death Has associated genes Has associated diseases Has associated phenotype references Has associated exposure references is a necrotic cell death Has associated genes Has associated diseases Has associated phenotype references Has associated exposure references

Top ↑ Descendants

necrotic cell death Has associated genes Has associated diseases Has associated phenotype references Has associated exposure references
View nodenegatively regulates negative regulation of necrotic cell death Has associated genes Has associated diseases Has associated phenotype references
part of oncosis Has associated genes Has associated diseases Has associated phenotype references
View nodepositively regulates positive regulation of necrotic cell death Has associated genes Has associated diseases Has associated phenotype references
View nodeis a programmed necrotic cell death Has associated genes Has associated diseases Has associated phenotype references
View noderegulates regulation of necrotic cell death Has associated genes Has associated diseases Has associated phenotype references