Methionine - Diseases

The following diseases are associated with Methionine or at least one of its descendants. Each association is direct (M marker/mechanism and/or T therapeutic) and/or inferred (via a curated gene interaction).

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	Chemical	Disease	Direct Evidence	Inference Network	Inference Score	References
1.	Methionine	Child Development Disorders, Pervasive	M			1
2.	Methionine	Autistic Disorder	M	Via 7 genes: GAD1; IFNG; IGF1; MIF; NOS2; RELN; SHANK3	56.44	11
3.	S-Adenosylmethionine	Autistic Disorder	M	Via 2 genes: COMT; SLC19A1	14.04	2
4.	Methionine	Liver Cirrhosis, Experimental	T	Via 9 genes: CYGB; IFNG; IGF1; NOS2; PDGFRB; TGFB1; TGFBR2; TIMP1; TNF	70.49	19
5.	S-Adenosylmethionine	Liver Cirrhosis, Experimental	T	Via 2 genes: AFP; TGFB1	13.54	5
6.	Buthionine Sulfoximine	Breast Neoplasms		Via 13 genes: BCL2; CCND1; CDKN1B; CYP1A1; FOS; HMOX1; IL6; JUN; NOS2; NQO1; STAT3; TNF; TP53	85.84	15
7.	Buthionine Sulfoximine	Prostatic Neoplasms		Via 13 genes: BCL2; CCND1; CDKN1A; CDKN1B; CYP1A1; HIF1A; IL10; IL6; NQO1; SOD2; STAT3; TGFBR2; TP53	84.40	21
8.	Buthionine Sulfoximine	Lung Neoplasms		Via 11 genes: CCND1; CDKN1A; CDKN1B; FOS; HMOX1; IL10; JUNB; NOS2; TGFBR2; TNF; TP53	79.04	12
9.	Selenomethionine	Prostatic Neoplasms		Via 10 genes: AR; EGFR; GPX3; GSTP1; HPN; IL8; KLK3; PRKCZ; TGFBR2; TP53	63.93	29
10.	Selenomethionine	Lung Neoplasms		Via 9 genes: EGFR; FOS; GPX1; GPX3; GSTP1; MAPK1; MAPK3; TGFBR2; TP53	60.29	11
11.	S-Adenosylmethionine	Prostatic Neoplasms		Via 7 genes: ATF3; COMT; CYP2E1; GNMT; KLF6; RNASEL; TGFB1	51.33	9
12.	Buthionine Sulfoximine	Liver Cirrhosis, Experimental		Via 7 genes: GPT; HMOX1; IGFBP1; IL10; NOS2; TGFBR2; TNF	48.19	16
13.	Methionine	Oral Submucous Fibrosis		Via 5 genes: COL1A1; IFNG; TGFB1; TIMP1; TNF	47.58	1
14.	Buthionine Sulfoximine	Esophageal Neoplasms		Via 6 genes: CCND1; CDKN1A; HIF1A; NOS2; TGFBR2; TP53	46.22	6
15.	Buthionine Sulfoximine	Colorectal Neoplasms		Via 6 genes: BCL2; CCND1; PPARG; TGFBR1; TP53; TXNRD1	43.43	11
16.	Buthionine Sulfoximine	Stomach Neoplasms		Via 6 genes: CDKN1A; CDKN1B; HMOX1; JUN; SOD2; TNF	39.23	5
17.	Methionine	Breast Neoplasms		Via 6 genes: ABCG2; AKT1; IFNG; IGF1; NOS2; TNF	39.03	6
18.	Buthionine Sulfoximine	Diabetes Mellitus, Type 2		Via 5 genes: CAT; HMOX1; IL6; INS1; PPARG	37.51	4
19.	N-Formylmethionine Leucyl-Phenylalanine	Breast Neoplasms		Via 6 genes: AKT1; IL1B; IL6; IL8; PTGS2; TNF	36.68	6
20.	Selenomethionine	Neoplasm Recurrence, Local		Via 4 genes: AR; GRK6; KLK3; PARVB	36.21	3
21.	Buthionine Sulfoximine	Asthma		Via 5 genes: BCL2; CAT; HMOX1; IL12B; TNF	35.33	6
22.	N-Formylmethionine Leucyl-Phenylalanine	Fever		Via 4 genes: IL1B; IL6; IL8; TNF	35.18	1
23.	Selenomethionine	Autistic Disorder		Via 5 genes: AR; GPX1; GSTP1; LASP1; SEMA5A	34.59	5
24.	Buthionine Sulfoximine	Mesothelioma		Via 4 genes: CDKN1B; DIO2; SOD2; TXNRD1	34.25	5
25.	Buthionine Sulfoximine	Alzheimer Disease		Via 5 genes: BCL2; CASP3; HMOX1; PPARG; TNF	33.93	4
26.	Selenomethionine	Breast Neoplasms		Via 6 genes: EGFR; FOS; GPX1; IL1B; IL8; TP53	33.57	9
27.	N-Formylmethionine Leucyl-Phenylalanine	Lung Neoplasms		Via 5 genes: MAPK1; MAPK14; MAPK3; MPO; TNF	33.53	5
28.	Methionine	Prostatic Neoplasms		Via 5 genes: AKT1; IGF1; MIF; TGFB1; TGFBR2	33.39	6
29.	N-Formylmethionine Leucyl-Phenylalanine	Stomach Neoplasms		Via 5 genes: IL1B; IL8; MAPK8; PTGS2; TNF	33.07	6
30.	Buthionine Sulfoximine	Colitis, Ulcerative		Via 4 genes: IL10; IL12B; RELA; STAT3	32.49	5
31.	S-Adenosylmethionine	Carcinoma, Hepatocellular		Via 4 genes: AFP; COMT; TGFB1; UBD	32.29	4
32.	N-Formylmethionine Leucyl-Phenylalanine	Skin Diseases		Via 4 genes: IL1B; PTGS2; TNF; TNFAIP6	31.50	2
33.	S-Adenosylmethionine	Down Syndrome		Via 3 genes: GSTM2; MTR; SLC19A1	31.40	4
34.	Selenomethionine	Carcinoma, Hepatocellular		Via 5 genes: AR; EGFR; FOS; GSTP1; TP53	31.35	5
35.	Selenomethionine	Head and Neck Neoplasms		Via 4 genes: EGFR; GPX1; MAPK1; MAPK3	30.95	2
36.	Selenomethionine	Colonic Neoplasms		Via 4 genes: GRK6; IL1B; PARVB; TP53	30.71	4
37.	N-Formylmethionine Leucyl-Phenylalanine	Pulmonary Fibrosis		Via 4 genes: IL1B; IL6; IL8; TNF	30.54	4
38.	Buthionine Sulfoximine	Carcinoma, Squamous Cell		Via 4 genes: CDKN1A; HIF1A; NFE2L2; STAT3	30.22	4
39.	Buthionine Sulfoximine	Psoriasis		Via 4 genes: IL12B; IL6; TNF; TP53	30.17	5
40.	Selenomethionine	Craniofacial Abnormalities		Via 4 genes: COL2A1; EGFR; TBX1; TGFBR2	29.82	7
41.	Buthionine Sulfoximine	Liver Neoplasms		Via 4 genes: CDKN1B; HMOX1; STAT3; TP53	29.36	5
42.	Buthionine Sulfoximine	Autistic Disorder		Via 5 genes: BCL2; CAT; IL10; IL6; NOS2	29.19	5
43.	N-Formylmethionine Leucyl-Phenylalanine	Prostatic Neoplasms		Via 5 genes: AKT1; IL6; IL8; PTGS2; VEGFA	28.88	11
44.	N-Formylmethionine Leucyl-Phenylalanine	Leukemia, Promyelocytic, Acute		Via 3 genes: AKT1; ITGAM; ITGB2	28.38	2
45.	S-Adenosylmethionine	Oral Submucous Fibrosis		Via 3 genes: COL1A1; COL1A2; TGFB1	27.87	1
46.	Methionine	Sepsis		Via 3 genes: MIF; TGFB1; TNF	27.87	3
47.	Buthionine Sulfoximine	Liver Diseases		Via 4 genes: HMOX1; NOS2; NQO1; SOD1	27.13	7
48.	Methionine	Lung Neoplasms		Via 4 genes: NOS2; TGFB1; TGFBR2; TNF	27.02	5
49.	Selenomethionine	Liver Cirrhosis, Experimental		Via 4 genes: IL1B; MMP1; PLG; TGFBR2	26.82	5
50.	N-Formylmethionine Leucyl-Phenylalanine	Osteoporosis, Postmenopausal		Via 3 genes: IL1B; IL6; TNF	26.22	1
51.	Buthionine Sulfoximine	Berylliosis		Via 3 genes: GCLM; IL6; TNF	25.99	5
52.	S-Adenosylmethionine	Sepsis		Via 3 genes: MAPK1; MAPK3; TGFB1	25.34	2
53.	S-Adenosylmethionine	Osteoporosis		Via 3 genes: COL1A1; COL1A2; TGFB1	25.19	2
54.	Buthionine Sulfoximine	Osteoporosis, Postmenopausal		Via 3 genes: CAT; IL6; TNF	25.14	2
55.	N-Formylmethionine Leucyl-Phenylalanine	Sepsis		Via 3 genes: MAPK1; MAPK3; TNF	25.11	1
56.	Buthionine Sulfoximine	Carcinoma, Hepatocellular		Via 4 genes: CYP1A1; FOS; IL6; TP53	24.98	6
57.	S-Adenosylmethionine	Lung Neoplasms		Via 4 genes: CYP2E1; MAPK1; MAPK3; TGFB1	24.89	7
58.	N-Formylmethionine Leucyl-Phenylalanine	Liver Cirrhosis, Experimental		Via 4 genes: IL1B; PTGS2; TNF; VEGFA	24.59	4
59.	FTI 277	Breast Neoplasms		Via 3 genes: CDKN1B; FGF10; RB1	24.46	3
60.	Buthionine Sulfoximine	Sepsis		Via 3 genes: CASP3; IL10; TNF	24.32	3
61.	S-Adenosylmethionine	NEURAL TUBE DEFECTS, FOLATE-SENSITIVE		Via 2 genes: MTHFD1; MTR	24.22	1
62.	Methionine	Craniofacial Abnormalities		Via 3 genes: COL2A1; TGFB2; TGFBR2	24.11	5
63.	Buthionine Sulfoximine	Crohn Disease		Via 3 genes: IL12B; IL6; TNF	24.07	2
64.	N-Formylmethionine Leucyl-Phenylalanine	Arsenic Poisoning		Via 3 genes: IL1B; TNF; TNFAIP6	23.64	1
65.	N-Formylmethionine Leucyl-Phenylalanine	Glioblastoma		Via 3 genes: IL1B; IL8; VEGFA	23.63	1
66.	S-Adenosylmethionine	OSTEOGENESIS IMPERFECTA, TYPE IV		Via 2 genes: COL1A1; COL1A2	23.28	1
67.	S-Adenosylmethionine	EHLERS-DANLOS SYNDROME, TYPE VII, AUTOSOMAL DOMINANT		Via 2 genes: COL1A1; COL1A2	23.28	1
68.	N-Formylmethionine Leucyl-Phenylalanine	Psoriasis		Via 3 genes: IL6; TNF; VEGFA	23.24	2
69.	Buthionine Sulfoximine	Myocardial Infarction		Via 3 genes: GCLC; GCLM; NOS2	23.13	5
70.	Buthionine Sulfoximine	Glioma		Via 3 genes: MGMT; PPARG; TP53	23.10	3
71.	Methionine	Hernia, Diaphragmatic		Via 3 genes: IGF1; TGFB1; TNF	22.99	3
72.	Selenomethionine	Carcinoma, Non-Small-Cell Lung		Via 3 genes: DUSP3; IL8; TP53	22.58	3
73.	Buthionine Sulfoximine	Leukemia		Via 3 genes: BCL2; CCND1; MGMT	22.51	3
74.	Selenomethionine	Arsenic Poisoning		Via 3 genes: IL1B; SSBP1; TP53	22.32	2
75.	Selenomethionine	Melanoma		Via 3 genes: COL2A1; STX17; TP53	22.26	3
76.	Buthionine Sulfoximine	Reperfusion Injury		Via 3 genes: CDKN1A; IL10; TNF	22.16	2
77.	S-Adenosylmethionine	Breast Neoplasms		Via 3 genes: AFP; COMT; MTR	22.13	5
78.	N-Formylmethionine Leucyl-Phenylalanine	Asthma		Via 3 genes: ALOX5; TNF; VEGFA	22.12	6
79.	Buthionine Sulfoximine	Carcinoma, Non-Small-Cell Lung		Via 3 genes: GCLC; NQO1; TP53	21.98	3
80.	N-Formylmethionine Leucyl-Phenylalanine	Melanoma		Via 3 genes: PTGS2; RAC2; TNF	21.70	3
81.	S-Adenosylmethionine	Ovarian Neoplasms		Via 3 genes: ATF3; MAPK1; MAPK3	21.66	2
82.	N-Formylmethionine Leucyl-Phenylalanine	Carcinoma, Squamous Cell		Via 3 genes: IL8; PTGS2; VEGFA	21.63	3
83.	Buthionine Sulfoximine	Leukemia, Lymphocytic, Chronic, B-Cell		Via 3 genes: CCND1; IL6; TP53	21.63	3
84.	N-Formylmethionine Leucyl-Phenylalanine	Colonic Neoplasms		Via 3 genes: ALOX5; IL1B; VEGFA	21.33	2
85.	N-Formylmethionine Leucyl-Phenylalanine	Ovarian Neoplasms		Via 3 genes: AKT1; MAPK1; MAPK3	21.28	1
86.	N-Formylmethionine Leucyl-Phenylalanine	Arthritis, Rheumatoid		Via 3 genes: PTGS2; TNF; VEGFA	20.98	4
87.	N-Formylmethionine Leucyl-Phenylalanine	Alzheimer Disease		Via 3 genes: IL1B; MPO; TNF	20.89	3
88.	Buthionine Sulfoximine	Arsenic Poisoning		Via 3 genes: SOD2; TNF; TP53	20.83	2
89.	Selenomethionine	Colitis, Ulcerative		Via 3 genes: IL1B; IL8; RELA	20.75	1
90.	Buthionine Sulfoximine	Pulmonary Fibrosis		Via 3 genes: HMOX1; IL6; TNF	20.73	4
91.	Methionine	Eye Abnormalities		Via 2 genes: TGFB2; TGFBR2	20.66	2
92.	Buthionine Sulfoximine	Pancreatic Neoplasms		Via 3 genes: HIF1A; TNF; TP53	20.65	4
93.	N-Formylmethionine Leucyl-Phenylalanine	Drug-Induced Liver Injury		Via 3 genes: IL1B; IL6; PTGS2	20.01	3
94.	Selenomethionine	Urinary Bladder Neoplasms		Via 3 genes: EGFR; GSTP1; TP53	20.01	4
95.	Buthionine Sulfoximine	Drug-Induced Liver Injury		Via 3 genes: GCLC; HMOX1; IL6	19.87	3
96.	Buthionine Sulfoximine	Hypothermia		Via 2 genes: IL12B; TNF	19.62	1
97.	Buthionine Sulfoximine	Schistosomiasis mansoni		Via 2 genes: NOS2; SOD1	19.55	2
98.	N-Formylmethionine Leucyl-Phenylalanine	Multiple Organ Failure		Via 2 genes: ALOX5; TNF	19.38	2
99.	FTI 277	Ovarian Neoplasms		Via 2 genes: CDKN1B; RBL2	19.23	2
100.	Methionine	Myocardial Stunning		Via 2 genes: NOS2; TNF	19.17	1
101.	Methionine	Hyperhomocysteinemia		Via 2 genes: MTRR; TNF	19.17	3
102.	Selenomethionine	Ovarian Neoplasms		Via 3 genes: EGFR; MAPK1; MAPK3	18.99	1
103.	Buthionine Sulfoximine	Inflammation		Via 3 genes: HMOX1; NOS2; TNF	18.96	3
104.	N-Formylmethionine Leucyl-Phenylalanine	Autistic Disorder		Via 3 genes: IL6; PLA2G4A; PTGS2	18.86	3
105.	Buthionine Sulfoximine	Colonic Neoplasms		Via 3 genes: BCL2; CCND1; TP53	18.75	4
106.	Methionine	PLASMODIUM FALCIPARUM BLOOD INFECTION LEVEL		Via 2 genes: NOS2; TNF	18.66	1
107.	Methionine	Myocardial Reperfusion Injury		Via 2 genes: CYBB; NOS2	18.65	1
108.	N-Formylmethionine Leucyl-Phenylalanine	Leukemia, Myelogenous, Chronic, BCR-ABL Positive		Via 2 genes: ALOX5; MAPK14	18.44	3
109.	N-Formylmethionine Leucyl-Phenylalanine	Entamoebiasis		Via 2 genes: IL1B; IL6	18.30	1
110.	Buthionine Sulfoximine	Intestinal Polyps		Via 2 genes: CCND1; JUN	18.24	1
111.	Buthionine Sulfoximine	Myocardial Stunning		Via 2 genes: NOS2; TNF	18.21	1
112.	N-Formylmethionine Leucyl-Phenylalanine	Dermatomyositis		Via 2 genes: IL1B; TNF	18.19	1
113.	Methionine	Female Urogenital Diseases		Via 2 genes: IGF1; TIMP1	18.02	1
114.	Buthionine Sulfoximine	Entamoebiasis		Via 2 genes: IL10; IL6	17.94	1
115.	N-Formylmethionine Leucyl-Phenylalanine	Hypersensitivity		Via 2 genes: SELP; TNF	17.87	2
116.	Buthionine Sulfoximine	Epilepsy		Via 2 genes: SEPW1; TXNRD1	17.84	1
117.	Buthionine Sulfoximine	Multiple Organ Failure		Via 2 genes: IL10; TNF	17.84	2
118.	Buthionine Sulfoximine	Drug Toxicity		Via 2 genes: HMOX1; IGFBP1	17.73	2
119.	Buthionine Sulfoximine	PLASMODIUM FALCIPARUM BLOOD INFECTION LEVEL		Via 2 genes: NOS2; TNF	17.70	1
120.	Buthionine Sulfoximine	Carotid Artery Diseases		Via 2 genes: HMOX1; TP53	17.68	2
121.	N-Formylmethionine Leucyl-Phenylalanine	Cholangiocarcinoma		Via 2 genes: IL6; PTGS2	17.51	2
122.	Buthionine Sulfoximine	Soft Tissue Neoplasms		Via 2 genes: BCL2; TNF	17.32	3
123.	Buthionine Sulfoximine	Occupational Diseases		Via 2 genes: CYP1A1; NQO1	17.32	4
124.	N-Formylmethionine Leucyl-Phenylalanine	Adenomatous Polyposis Coli		Via 2 genes: AKT1; PTGS2	17.21	1
125.	N-Formylmethionine Leucyl-Phenylalanine	Amyotrophic Lateral Sclerosis		Via 2 genes: PLA2G4A; PTGS2	17.16	1
126.	FTI 277	Urinary Bladder Neoplasms		Via 2 genes: CDKN1A; RB1	17.14	2
127.	Selenomethionine	Carotid Artery Diseases		Via 2 genes: GSTP1; TP53	17.07	1
128.	Methionine	Berylliosis		Via 2 genes: TGFB1; TNF	16.95	6
129.	Selenomethionine	Pulmonary Disease, Chronic Obstructive		Via 2 genes: MMP1; TP53	16.94	2
130.	Buthionine Sulfoximine	Osteosarcoma		Via 2 genes: JUN; TP53	16.90	4
131.	Selenomethionine	Stomach Neoplasms		Via 3 genes: EGFR; IL1B; IL8	16.90	3
132.	N-Formylmethionine Leucyl-Phenylalanine	Coronary Artery Disease		Via 2 genes: PTGS2; VEGFA	16.87	2
133.	Methionine	Duodenal Ulcer		Via 2 genes: NOS2; TGFB1	16.69	3
134.	Buthionine Sulfoximine	Cholangiocarcinoma		Via 2 genes: IL6; NOS2	16.64	2
135.	Buthionine Sulfoximine	Pulmonary Disease, Chronic Obstructive		Via 2 genes: HMOX1; TP53	16.54	3
136.	N-Formylmethionine Leucyl-Phenylalanine	Berylliosis		Via 2 genes: IL6; TNF	16.54	4
137.	Buthionine Sulfoximine	Intestinal Neoplasms		Via 2 genes: BCL2; CDKN1A	16.53	3
138.	Methionine	Schizophrenia		Via 2 genes: AKT1; RELN	16.48	2
139.	Methionine	Migraine Disorders		Via 2 genes: TGFBR2; TNF	16.40	2
140.	Buthionine Sulfoximine	Retinal Degeneration		Via 2 genes: BCL2; SOD1	16.37	2
141.	2-amino-4-methylthio-3-butenoic acid	METHIONINE ADENOSYLTRANSFERASE DEFICIENCY		Via 1 gene: MAT1A	16.32	1
142.	Methionine	Osteoporosis		Via 2 genes: COL1A1; TGFB1	16.13	2
143.	Selenomethionine	Osteosarcoma		Via 2 genes: GSTP1; TP53	16.12	4
144.	N-Formylmethionine Leucyl-Phenylalanine	Oral Submucous Fibrosis		Via 2 genes: PTGS2; TNF	16.10	1
145.	Methionine	Malaria		Via 2 genes: NOS2; TNF	16.06	1
146.	Buthionine Sulfoximine	Oral Submucous Fibrosis		Via 2 genes: COL1A1; TNF	16.06	1
147.	methionine selenoxide	CYSTATHIONINURIA		Via 1 gene: CTH	15.86	1
148.	N-Formylmethionine Leucyl-Phenylalanine	Lupus Erythematosus, Systemic		Via 2 genes: IL6; ITGAM	15.84	4
149.	N-Formylmethionine Leucyl-Phenylalanine	Crohn Disease		Via 2 genes: IL6; TNF	15.76	1
150.	N-Formylmethionine Leucyl-Phenylalanine	Reperfusion Injury		Via 2 genes: ALOX5; TNF	15.67	2
151.	Methionine	Colorectal Neoplasms		Via 2 genes: AKT1; MTRR	15.66	3
152.	Methionine	Lung Diseases		Via 2 genes: TGFB1; TNF	15.62	1
153.	N-Formylmethionine Leucyl-Phenylalanine	Respiratory Hypersensitivity		Via 2 genes: IL6; TNF	15.55	1
154.	Methionine	Esophageal Neoplasms		Via 2 genes: NOS2; TGFBR2	15.52	2
155.	Buthionine Sulfoximine	Migraine Disorders		Via 2 genes: TGFBR2; TNF	15.45	2
156.	Buthionine Sulfoximine	Amyotrophic Lateral Sclerosis		Via 2 genes: SOD1; TP53	15.43	8
157.	Buthionine Sulfoximine	Kidney Failure, Acute		Via 2 genes: IL10; TNF	15.42	1
158.	FTI 277	Stomach Neoplasms		Via 2 genes: CDKN1A; CDKN1B	15.38	2
159.	S-Adenosylmethionine	Carcinoma, Non-Small-Cell Lung		Via 2 genes: ATF3; CYP2E1	15.36	2
160.	Selenomethionine	Sarcoma		Via 2 genes: GSTP1; TP53	15.35	2
161.	N-Formylmethionine Leucyl-Phenylalanine	Head and Neck Neoplasms		Via 2 genes: MAPK1; MAPK3	15.32	1
162.	Selenomethionine	Skin Diseases		Via 2 genes: IL1B; SSBP1	15.30	1
163.	FTI 277	Lung Neoplasms		Via 2 genes: CDKN1A; CDKN1B	15.29	3
164.	Buthionine Sulfoximine	Adenoma		Via 2 genes: BCL2; TXNRD1	15.28	3
165.	Buthionine Sulfoximine	Sarcoma		Via 2 genes: TNF; TP53	15.21	4
166.	N-Formylmethionine Leucyl-Phenylalanine	Liver Cirrhosis		Via 2 genes: IL6; IL8	15.18	2
167.	Buthionine Sulfoximine	Fever		Via 2 genes: IL6; TNF	15.15	1
168.	Methionine	Arthritis, Rheumatoid		Via 2 genes: MIF; TNF	15.12	3
169.	Buthionine Sulfoximine	Parkinson Disease		Via 2 genes: SNCA; SOD1	15.11	10
170.	Buthionine Sulfoximine	Malaria		Via 2 genes: NOS2; TNF	15.10	1
171.	N-Formylmethionine Leucyl-Phenylalanine	Colitis, Ulcerative		Via 2 genes: IL1B; IL8	15.09	1
172.	Selenomethionine	Leukemia		Via 2 genes: AR; PRKCZ	15.06	2
173.	Selenomethionine	Fever		Via 2 genes: IL1B; IL8	15.04	1
174.	Selenomethionine	Obesity		Via 2 genes: GPX1; GPX3	15.03	2
175.	Buthionine Sulfoximine	Skin Neoplasms		Via 2 genes: HIF1A; NFE2L2	14.95	2
176.	S-Adenosylmethionine	Head and Neck Neoplasms		Via 2 genes: MAPK1; MAPK3	14.91	1
177.	N-Formylmethionine Leucyl-Phenylalanine	Carcinoma, Non-Small-Cell Lung		Via 2 genes: IL8; VEGFA	14.86	1
178.	Buthionine Sulfoximine	Osteoporosis		Via 2 genes: COL1A1; IL6	14.76	2
179.	Buthionine Sulfoximine	Multiple Myeloma		Via 2 genes: CCND1; NQO1	14.74	2
180.	S-Adenosylmethionine	PROSTATE CANCER, HEREDITARY, 1		Via 1 gene: RNASEL	14.68	1
181.	Buthionine Sulfoximine	Respiratory Hypersensitivity		Via 2 genes: IL6; TNF	14.60	1
182.	Selenomethionine	Sepsis		Via 2 genes: MAPK1; MAPK3	14.54	1
183.	N-Formylmethionine Leucyl-Phenylalanine	Leukemia, Lymphocytic, Chronic, B-Cell		Via 2 genes: IL6; PTGS2	14.50	2
184.	Buthionine Sulfoximine	Obesity		Via 2 genes: NQO1; PPARG	14.38	2
185.	buthionine sulfoximine ethyl ester	GAMMA-GLUTAMYLCYSTEINE SYNTHETASE DEFICIENCY, HEMOLYTIC ANEMIA DUE TO		Via 1 gene: GCLC	14.36	1
186.	Selenomethionine	Cardiomyopathy, Dilated		Via 2 genes: EGFR; GPX1	14.33	2
187.	Methionine	Pulmonary Fibrosis		Via 2 genes: TGFB1; TNF	14.31	5
188.	Buthionine Sulfoximine	HIV Infections		Via 2 genes: CDKN1A; IL10	14.22	2
189.	FTI 277	APLASIA OF LACRIMAL AND SALIVARY GLANDS		Via 1 gene: FGF10	14.18	1
190.	Buthionine Sulfoximine	Diabetes Mellitus, Type 1		Via 2 genes: CAT; IL10	14.08	2
191.	FTI 277	HEART-HAND SYNDROME, SLOVENIAN TYPE		Via 1 gene: LMNA	14.05	1
192.	FTI 277	CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2B1		Via 1 gene: LMNA	14.05	1
193.	FTI 277	EMERY-DREIFUSS MUSCULAR DYSTROPHY, AUTOSOMAL DOMINANT		Via 1 gene: LMNA	14.05	1
194.	FTI 277	Scleroderma, Localized		Via 1 gene: LMNA	14.05	1
195.	FTI 277	MUSCULAR DYSTROPHY, LIMB-GIRDLE, TYPE 1B		Via 1 gene: LMNA	14.05	1
196.	Selenomethionine	Psoriasis		Via 2 genes: PCNA; TP53	13.99	1
197.	Methionine	CHROMOSOME 22q13.3 DELETION SYNDROME		Via 1 gene: SHANK3	13.97	1
198.	Buthionine Sulfoximine	Mammary Neoplasms, Experimental		Via 2 genes: HMOX1; IL10	13.95	2
199.	N-Formylmethionine Leucyl-Phenylalanine	Schizophrenia		Via 2 genes: AKT1; IL1B	13.95	2
200.	S-Adenosylmethionine	COMBINED IMMUNODEFICIENCY, X-LINKED		Via 1 gene: IL2RG	13.90	1
201.	S-Adenosylmethionine	SEVERE COMBINED IMMUNODEFICIENCY, X-LINKED		Via 1 gene: IL2RG	13.90	1
202.	S-Adenosylmethionine	Adenocarcinoma		Via 2 genes: CYP2E1; TGFB1	13.90	2
203.	N-Formylmethionine Leucyl-Phenylalanine	Diabetes Mellitus, Type 2		Via 2 genes: IL6; VEGFA	13.88	1
204.	Methionine	Stomach Ulcer		Via 2 genes: NOS2; TNF	13.82	2
205.	N-Formylmethionine Leucyl-Phenylalanine	Hernia, Diaphragmatic		Via 2 genes: IL6; TNF	13.78	2
206.	Methionine	Melanoma		Via 2 genes: COL2A1; TNF	13.77	2
207.	Selenomethionine	Esophageal Neoplasms		Via 2 genes: TGFBR2; TP53	13.74	2
208.	N-Formylmethionine Leucyl-Phenylalanine	Stomach Ulcer		Via 2 genes: PTGS2; TNF	13.73	3
209.	Selenomethionine	Neoplasm Metastasis		Via 2 genes: EGFR; TP53	13.73	3
210.	Methionine	HOMOCYSTINURIA-MEGALOBLASTIC ANEMIA DUE TO DEFECT IN COBALAMIN METABOLISM, cblE COMPLEMENTATION TYPE		Via 1 gene: MTRR	13.70	1
211.	Buthionine Sulfoximine	Lupus Erythematosus, Systemic		Via 2 genes: IL10; IL6	13.68	2
212.	Buthionine Sulfoximine	Liver Neoplasms, Experimental		Via 2 genes: BCL2; TP53	13.65	2
213.	N-Formylmethionine Leucyl-Phenylalanine	THROMBASTHENIA OF GLANZMANN AND NAEGELI		Via 1 gene: ITGA2B	13.64	1
214.	N-Formylmethionine Leucyl-Phenylalanine	NEUTROPHIL IMMUNODEFICIENCY SYNDROME		Via 1 gene: RAC2	13.48	1
215.	FTI 277	Prostatic Neoplasms		Via 2 genes: CDKN1A; CDKN1B	13.44	2
216.	S-Adenosylmethionine	METHIONINE ADENOSYLTRANSFERASE DEFICIENCY		Via 1 gene: MAT1A	13.38	1
217.	FTI 277	LIPODYSTROPHY, FAMILIAL PARTIAL, TYPE 2		Via 1 gene: LMNA	13.36	1
218.	FTI 277	MANDIBULOACRAL DYSPLASIA WITH TYPE A LIPODYSTROPHY		Via 1 gene: LMNA	13.36	4
219.	FTI 277	Muscular Dystrophies, Limb-Girdle		Via 1 gene: LMNA	13.36	1
220.	FTI 277	RESTRICTIVE DERMOPATHY, LETHAL		Via 1 gene: LMNA	13.36	1
221.	FTI 277	Progeria		Via 1 gene: LMNA	13.36	3
222.	FTI 277	Werner Syndrome		Via 1 gene: LMNA	13.36	1
223.	Buthionine Sulfoximine	Skin Diseases		Via 2 genes: SOD2; TNF	13.34	1
224.	N-Formylmethionine Leucyl-Phenylalanine	Pancreatic Neoplasms		Via 2 genes: PTGS2; TNF	13.32	4
225.	Methionine	Asthma		Via 2 genes: TGFB1; TNF	13.31	5
226.	Selenomethionine	Liver Neoplasms, Experimental		Via 2 genes: GSTP1; TP53	13.27	3
227.	Selenomethionine	Glioma		Via 2 genes: GSTP1; TP53	13.23	1
228.	Selenomethionine	Glioblastoma		Via 2 genes: IL1B; IL8	13.13	1
229.	Selenomethionine	CHILBLAIN LUPUS		Via 1 gene: TREX1	13.09	1
230.	Selenomethionine	VASCULOPATHY, RETINAL, WITH CEREBRAL LEUKODYSTROPHY		Via 1 gene: TREX1	13.09	2
231.	FTI 277	LACRIMOAURICULODENTODIGITAL SYNDROME		Via 1 gene: FGF10	13.08	1
232.	S-Adenosylmethionine	METHYLCOBALAMIN DEFICIENCY, cblG TYPE		Via 1 gene: MTR	13.06	1
233.	Buthionine Sulfoximine	Urinary Bladder Neoplasms		Via 2 genes: CDKN1A; TP53	13.02	3
234.	FTI 277	Muscular Dystrophy, Emery-Dreifuss		Via 1 gene: LMNA	12.95	1
235.	Selenomethionine	Carcinoma, Squamous Cell		Via 2 genes: GPX1; IL8	12.93	2
236.	Buthionine Sulfoximine	Stomach Ulcer		Via 2 genes: NOS2; TNF	12.88	2
237.	Selenomethionine	Pulmonary Fibrosis		Via 2 genes: IL1B; IL8	12.88	2
238.	FTI 277	MULTIPLE ENDOCRINE NEOPLASIA, TYPE IV		Via 1 gene: CDKN1B	12.87	1
239.	Buthionine Sulfoximine	Hernia, Diaphragmatic		Via 2 genes: IL6; TNF	12.84	2
240.	Methionine	GRANULOMATOUS DISEASE, CHRONIC, X-LINKED		Via 1 gene: CYBB	12.79	2
241.	S-Adenosylmethionine	CHARCOT-MARIE-TOOTH DISEASE, TYPE 4D		Via 1 gene: NDRG1	12.76	1
242.	Methionine	Inflammation		Via 2 genes: NOS2; TNF	12.75	2
243.	S-Adenosylmethionine	Abruptio Placentae		Via 1 gene: MTHFD1	12.75	1
244.	Buthionine Sulfoximine	CD59 DEFICIENCY		Via 1 gene: CD59	12.74	1
245.	S-Adenosylmethionine	GLYCINE N-METHYLTRANSFERASE DEFICIENCY		Via 1 gene: GNMT	12.71	1
246.	N-Formylmethionine Leucyl-Phenylalanine	LEUKOCYTE ADHESION DEFICIENCY, TYPE I		Via 1 gene: ITGB2	12.71	1
247.	Buthionine Sulfoximine	Arthritis, Rheumatoid		Via 2 genes: IL10; TNF	12.64	3
248.	N-Formylmethionine Leucyl-Phenylalanine	Colorectal Neoplasms		Via 2 genes: AKT1; PTGS2	12.60	4
249.	Methionine	CEREBRAL PALSY, SPASTIC QUADRIPLEGIC, 1		Via 1 gene: GAD1	12.59	1
250.	Buthionine Sulfoximine	TRIMETHYLAMINURIA		Via 1 gene: FMO3	12.58	2
251.	Buthionine Sulfoximine	LOEYS-DIETZ SYNDROME, TYPE 1A		Via 1 gene: TGFBR1	12.58	1
252.	Buthionine Sulfoximine	LOEYS-DIETZ SYNDROME, TYPE 2A		Via 1 gene: TGFBR1	12.58	1
253.	Methionine	LOEYS-DIETZ SYNDROME, TYPE 1B		Via 1 gene: TGFBR2	12.57	1
254.	Methionine	LOEYS-DIETZ SYNDROME, TYPE 2B		Via 1 gene: TGFBR2	12.57	1
255.	Methionine	Hernia, Inguinal		Via 1 gene: TGFBR2	12.57	1
256.	Methionine	Aneurysm, Dissecting		Via 1 gene: TGFBR2	12.57	1
257.	Methionine	Loeys-Dietz Syndrome		Via 1 gene: TGFBR2	12.57	1
258.	Methionine	Heredodegenerative Disorders, Nervous System		Via 1 gene: CYGB	12.49	1
259.	Methionine	STICKLER SYNDROME, TYPE I		Via 1 gene: COL2A1	12.47	1
260.	Methionine	OSTEOARTHRITIS WITH MILD CHONDRODYSPLASIA		Via 1 gene: COL2A1	12.47	1
261.	Methionine	ACHONDROGENESIS, TYPE II		Via 1 gene: COL2A1	12.47	1
262.	Methionine	EPIPHYSEAL DYSPLASIA, MULTIPLE, WITH MYOPIA AND CONDUCTIVE DEAFNESS		Via 1 gene: COL2A1	12.47	1
263.	Methionine	PLATYSPONDYLIC LETHAL SKELETAL DYSPLASIA, TORRANCE TYPE		Via 1 gene: COL2A1	12.47	1
264.	Methionine	STICKLER SYNDROME, TYPE I, NONSYNDROMIC OCULAR		Via 1 gene: COL2A1	12.47	1
265.	Methionine	SPONDYLOEPIMETAPHYSEAL DYSPLASIA, STRUDWICK TYPE		Via 1 gene: COL2A1	12.47	1
266.	Methionine	KNIEST DYSPLASIA		Via 1 gene: COL2A1	12.47	2
267.	Methionine	AVASCULAR NECROSIS OF FEMORAL HEAD, PRIMARY		Via 1 gene: COL2A1	12.47	1
268.	Methionine	Collagen Diseases		Via 1 gene: COL2A1	12.47	1
269.	Methionine	LEGG-CALVE-PERTHES DISEASE		Via 1 gene: COL2A1	12.47	1
270.	Methionine	SPONDYLOEPIPHYSEAL DYSPLASIA CONGENITA		Via 1 gene: COL2A1	12.47	1
271.	Methionine	Femur Head Necrosis		Via 1 gene: COL2A1	12.47	1
272.	Methionine	SPONDYLOPERIPHERAL DYSPLASIA		Via 1 gene: COL2A1	12.47	1
273.	N-Formylmethionine Leucyl-Phenylalanine	PHOSPHOLIPASE A2, GROUP IVA		Via 1 gene: PLA2G4A	12.40	1
274.	Selenomethionine	AICARDI-GOUTIERES SYNDROME 1		Via 1 gene: TREX1	12.40	1
275.	Buthionine Sulfoximine	GLUTATHIONE SYNTHETASE DEFICIENCY		Via 1 gene: GSS	12.34	1
276.	Buthionine Sulfoximine	GLUTATHIONE SYNTHETASE DEFICIENCY OF ERYTHROCYTES, HEMOLYTIC ANEMIA DUE TO		Via 1 gene: GSS	12.34	1
277.	Selenomethionine	Alexander Disease		Via 1 gene: NDUFV1	12.31	1
278.	N-Formylmethionine Leucyl-Phenylalanine	Carcinoma, Hepatocellular		Via 2 genes: IL6; PTGS2	12.29	2
279.	methionine selenoxide	Hyperinsulinism		Via 1 gene: GPX1	12.24	2
280.	Selenomethionine	Alzheimer Disease		Via 2 genes: APP; IL1B	12.21	12
281.	buthionine sulfoximine ethyl ester	Amino Acid Metabolism, Inborn Errors		Via 1 gene: GCLC	12.16	1
282.	Methionine	Granulomatous Disease, Chronic		Via 1 gene: CYBB	12.10	1
283.	Methionine	NEURAL TUBE DEFECTS, FOLATE-SENSITIVE		Via 1 gene: MTRR	12.10	1
284.	Buthionine Sulfoximine	LOEYS-DIETZ SYNDROME, TYPE 1B		Via 1 gene: TGFBR2	12.10	1
285.	Buthionine Sulfoximine	Aneurysm, Dissecting		Via 1 gene: TGFBR2	12.10	1
286.	Buthionine Sulfoximine	LOEYS-DIETZ SYNDROME, TYPE 2B		Via 1 gene: TGFBR2	12.10	1
287.	Buthionine Sulfoximine	Loeys-Dietz Syndrome		Via 1 gene: TGFBR2	12.10	1
288.	Buthionine Sulfoximine	Hernia, Inguinal		Via 1 gene: TGFBR2	12.10	1
289.	Methionine	Lissencephaly		Via 1 gene: RELN	12.09	1
290.	Buthionine Sulfoximine	Hemoglobinuria, Paroxysmal		Via 1 gene: CD59	12.05	1
291.	Selenomethionine	PLASMINOGEN DEFICIENCY, TYPE I		Via 1 gene: PLG	12.04	1
292.	Selenomethionine	Conjunctivitis		Via 1 gene: PLG	12.04	1
293.	S-Adenosylmethionine	Malnutrition		Via 1 gene: MTR	11.96	1
294.	S-Adenosylmethionine	OROFACIAL CLEFT 1		Via 1 gene: MTR	11.96	1
295.	methionine selenoxide	Anemia, Hemolytic		Via 1 gene: GPX1	11.95	1
296.	Methionine	Aortic Aneurysm, Thoracic		Via 1 gene: ACTA2	11.94	1
297.	Methionine	AORTIC ANEURYSM, FAMILIAL THORACIC 6		Via 1 gene: ACTA2	11.94	1
298.	S-Adenosylmethionine	EHLERS-DANLOS SYNDROME, AUTOSOMAL RECESSIVE, CARDIAC VALVULAR FORM		Via 1 gene: COL1A2	11.90	1
299.	Buthionine Sulfoximine	AUDITORY NEUROPATHY, AUTOSOMAL DOMINANT, 1		Via 1 gene: TGFBR1	11.88	1
300.	Methionine	Fatigue		Via 1 gene: TGFBR2	11.88	1
301.	buthionine sulfoximine ethyl ester	Anemia, Hemolytic		Via 1 gene: GCLC	11.88	1
302.	Selenomethionine	Schizophrenia		Via 2 genes: IL1B; TP53	11.85	1
303.	Methionine	MYELOPROLIFERATIVE DISORDER, CHRONIC, WITH EOSINOPHILIA		Via 1 gene: PDGFRB	11.81	1
304.	Selenomethionine	Myopathies, Nemaline		Via 1 gene: CFL2	11.81	1
305.	N-Formylmethionine Leucyl-Phenylalanine	Ileitis		Via 1 gene: ITGAM	11.80	1
306.	methionine selenoxide	Hyperglycemia		Via 1 gene: GPX1	11.80	1
307.	Methionine	WAGNER SYNDROME 1		Via 1 gene: COL2A1	11.78	1
308.	Methionine	SPONDYLOMETAPHYSEAL DYSPLASIA, KOZLOWSKI TYPE		Via 1 gene: COL2A1	11.78	1
309.	Methionine	OTOSPONDYLOMEGAEPIPHYSEAL DYSPLASIA		Via 1 gene: COL2A1	11.78	1
310.	Methionine	Retinal Detachment		Via 1 gene: COL2A1	11.78	1
311.	Methionine	Urogenital Abnormalities		Via 1 gene: TGFB2	11.71	1
312.	Buthionine Sulfoximine	PARKINSON DISEASE, FAMILIAL, TYPE 1		Via 1 gene: SNCA	11.71	1
313.	N-Formylmethionine Leucyl-Phenylalanine	MYELOPEROXIDASE DEFICIENCY		Via 1 gene: MPO	11.68	1
314.	Selenomethionine	LOEYS-DIETZ SYNDROME, TYPE 2B		Via 1 gene: TGFBR2	11.65	1
315.	Selenomethionine	Hernia, Inguinal		Via 1 gene: TGFBR2	11.65	1
316.	Selenomethionine	Loeys-Dietz Syndrome		Via 1 gene: TGFBR2	11.65	1
317.	Selenomethionine	LOEYS-DIETZ SYNDROME, TYPE 1B		Via 1 gene: TGFBR2	11.65	1
318.	Selenomethionine	Aneurysm, Dissecting		Via 1 gene: TGFBR2	11.65	1
319.	Methionine	Gingival Hyperplasia		Via 1 gene: PDGFB	11.63	1
320.	Methionine	OSTEOGENESIS IMPERFECTA, TYPE IIA		Via 1 gene: COL1A1	11.56	1
321.	Methionine	Hyperostosis, Cortical, Congenital		Via 1 gene: COL1A1	11.56	1
322.	Methionine	OSTEOGENESIS IMPERFECTA, TYPE III		Via 1 gene: COL1A1	11.56	1
323.	Methionine	Carotid Artery, Internal, Dissection		Via 1 gene: COL1A1	11.56	1
324.	Methionine	Vertebral Artery Dissection		Via 1 gene: COL1A1	11.56	1
325.	Methionine	OSTEOGENESIS IMPERFECTA, TYPE I		Via 1 gene: COL1A1	11.56	1
326.	Selenomethionine	ACHONDROGENESIS, TYPE II		Via 1 gene: COL2A1	11.55	1
327.	Selenomethionine	OSTEOARTHRITIS WITH MILD CHONDRODYSPLASIA		Via 1 gene: COL2A1	11.55	1
328.	Selenomethionine	STICKLER SYNDROME, TYPE I		Via 1 gene: COL2A1	11.55	1
329.	Selenomethionine	EPIPHYSEAL DYSPLASIA, MULTIPLE, WITH MYOPIA AND CONDUCTIVE DEAFNESS		Via 1 gene: COL2A1	11.55	1
330.	Selenomethionine	KNIEST DYSPLASIA		Via 1 gene: COL2A1	11.55	2
331.	Selenomethionine	Collagen Diseases		Via 1 gene: COL2A1	11.55	1
332.	Selenomethionine	Femur Head Necrosis		Via 1 gene: COL2A1	11.55	1
333.	Selenomethionine	SPONDYLOPERIPHERAL DYSPLASIA		Via 1 gene: COL2A1	11.55	1
334.	Selenomethionine	SPONDYLOEPIMETAPHYSEAL DYSPLASIA, STRUDWICK TYPE		Via 1 gene: COL2A1	11.55	1
335.	Selenomethionine	AVASCULAR NECROSIS OF FEMORAL HEAD, PRIMARY		Via 1 gene: COL2A1	11.55	1
336.	Selenomethionine	SPONDYLOEPIPHYSEAL DYSPLASIA CONGENITA		Via 1 gene: COL2A1	11.55	1
337.	Selenomethionine	LEGG-CALVE-PERTHES DISEASE		Via 1 gene: COL2A1	11.55	1
338.	Selenomethionine	STICKLER SYNDROME, TYPE I, NONSYNDROMIC OCULAR		Via 1 gene: COL2A1	11.55	1
339.	Selenomethionine	PLATYSPONDYLIC LETHAL SKELETAL DYSPLASIA, TORRANCE TYPE		Via 1 gene: COL2A1	11.55	1
340.	methionine selenoxide	Coronary Artery Disease		Via 1 gene: GPX1	11.54	1
341.	Selenomethionine	CONOTRUNCAL HEART MALFORMATIONS		Via 1 gene: TBX1	11.54	1
342.	Methionine	INSULIN-LIKE GROWTH FACTOR I DEFICIENCY		Via 1 gene: IGF1	11.52	1
343.	FTI 277	Retinoblastoma		Via 1 gene: RB1	11.52	1
344.	Selenomethionine	Alopecia Areata		Via 1 gene: STX17	11.49	1
345.	Buthionine Sulfoximine	HYPER-IgE RECURRENT INFECTION SYNDROME, AUTOSOMAL DOMINANT		Via 1 gene: STAT3	11.46	1
346.	Selenomethionine	Colorectal Neoplasms		Via 2 genes: EGFR; TP53	11.44	8
347.	Methionine	Arthritis, Juvenile Rheumatoid		Via 1 gene: MIF	11.43	1
348.	Methionine	Jaundice, Chronic Idiopathic		Via 1 gene: ABCC2	11.43	1
349.	Buthionine Sulfoximine	Fatigue		Via 1 gene: TGFBR2	11.40	1
350.	Methionine	Dwarfism		Via 1 gene: COL2A1	11.38	1
351.	S-Adenosylmethionine	Spinal Dysraphism		Via 1 gene: MTHFD1	11.37	1
352.	S-Adenosylmethionine	Carotid Artery, Internal, Dissection		Via 1 gene: COL1A1	11.35	1
353.	S-Adenosylmethionine	Vertebral Artery Dissection		Via 1 gene: COL1A1	11.35	1
354.	S-Adenosylmethionine	OSTEOGENESIS IMPERFECTA, TYPE I		Via 1 gene: COL1A1	11.35	1
355.	S-Adenosylmethionine	OSTEOGENESIS IMPERFECTA, TYPE IIA		Via 1 gene: COL1A1	11.35	1
356.	S-Adenosylmethionine	Hyperostosis, Cortical, Congenital		Via 1 gene: COL1A1	11.35	1
357.	S-Adenosylmethionine	OSTEOGENESIS IMPERFECTA, TYPE III		Via 1 gene: COL1A1	11.35	1
358.	Selenomethionine	DiGeorge Syndrome		Via 1 gene: TBX1	11.32	5
359.	Methionine	Respiratory System Abnormalities		Via 1 gene: TGFB2	11.30	1
360.	FTI 277	Pituitary Neoplasms		Via 1 gene: CDKN1B	11.26	1
361.	Selenomethionine	Ossification of Posterior Longitudinal Ligament		Via 1 gene: COL6A1	11.24	1
362.	Selenomethionine	ULLRICH CONGENITAL MUSCULAR DYSTROPHY		Via 1 gene: COL6A1	11.24	1
363.	Selenomethionine	BETHLEM MYOPATHY		Via 1 gene: COL6A1	11.24	1
364.	Methionine	Aortic Aneurysm		Via 1 gene: TGFBR2	11.19	1
365.	FTI 277	Cleft Lip		Via 1 gene: FGF10	11.19	1
366.	Buthionine Sulfoximine	MULTIPLE ENDOCRINE NEOPLASIA, TYPE IV		Via 1 gene: CDKN1B	11.15	1
367.	Buthionine Sulfoximine	GAMMA-GLUTAMYLCYSTEINE SYNTHETASE DEFICIENCY, HEMOLYTIC ANEMIA DUE TO		Via 1 gene: GCLC	11.14	1
368.	methionine selenoxide	Head and Neck Neoplasms		Via 1 gene: GPX1	11.14	1
369.	Buthionine Sulfoximine	Melanoma		Via 2 genes: TNF; TP53	11.10	2
370.	Buthionine Sulfoximine	Hyperostosis, Cortical, Congenital		Via 1 gene: COL1A1	11.08	1
371.	Buthionine Sulfoximine	OSTEOGENESIS IMPERFECTA, TYPE III		Via 1 gene: COL1A1	11.08	1
372.	Buthionine Sulfoximine	Carotid Artery, Internal, Dissection		Via 1 gene: COL1A1	11.08	1
373.	Buthionine Sulfoximine	Vertebral Artery Dissection		Via 1 gene: COL1A1	11.08	1
374.	Buthionine Sulfoximine	OSTEOGENESIS IMPERFECTA, TYPE IIA		Via 1 gene: COL1A1	11.08	1
375.	Buthionine Sulfoximine	OSTEOGENESIS IMPERFECTA, TYPE I		Via 1 gene: COL1A1	11.08	1
376.	Methionine	Camurati-Engelmann Syndrome		Via 1 gene: TGFB1	11.06	1
377.	Buthionine Sulfoximine	MICROVASCULAR COMPLICATIONS OF DIABETES, SUSCEPTIBILITY TO, 6		Via 1 gene: SOD2	11.02	1
378.	S-Adenosylmethionine	Arthritis, Experimental		Via 1 gene: FCGR1	11.02	1
379.	Methionine	Cyanosis		Via 1 gene: TGFB2	11.02	1
380.	Buthionine Sulfoximine	PARKINSON DISEASE 4, AUTOSOMAL DOMINANT LEWY BODY		Via 1 gene: SNCA	11.02	1
381.	buthionine sulfoximine ethyl ester	Heart Diseases		Via 1 gene: ABCC1	11.00	1
382.	Methionine	Job's Syndrome		Via 1 gene: IFNG	10.99	1
383.	Methionine	Salmonella Infections, Animal		Via 1 gene: IFNG	10.99	1
384.	S-Adenosylmethionine	Lymphoma, Follicular		Via 1 gene: MTR	10.98	1
385.	Methionine	Colorectal Neoplasms, Hereditary Nonpolyposis		Via 1 gene: TGFBR2	10.97	1
386.	Selenomethionine	Fatigue		Via 1 gene: TGFBR2	10.96	1
387.	Buthionine Sulfoximine	CAROTID INTIMAL MEDIAL THICKNESS 1		Via 1 gene: PPARG	10.94	1
388.	methionine selenoxide	Epilepsy		Via 1 gene: GPX1	10.91	1
389.	Methionine	EHLERS-DANLOS SYNDROME, TYPE VII, AUTOSOMAL DOMINANT		Via 1 gene: COL1A1	10.87	1
390.	Methionine	OSTEOGENESIS IMPERFECTA, TYPE IV		Via 1 gene: COL1A1	10.87	1
391.	Selenomethionine	Retinal Detachment		Via 1 gene: COL2A1	10.86	1
392.	Selenomethionine	OTOSPONDYLOMEGAEPIPHYSEAL DYSPLASIA		Via 1 gene: COL2A1	10.86	1
393.	Selenomethionine	WAGNER SYNDROME 1		Via 1 gene: COL2A1	10.86	1
394.	Selenomethionine	SPONDYLOMETAPHYSEAL DYSPLASIA, KOZLOWSKI TYPE		Via 1 gene: COL2A1	10.86	1
395.	S-Adenosylmethionine	Camurati-Engelmann Syndrome		Via 1 gene: TGFB1	10.86	1
396.	Methionine	Depressive Disorder, Major		Via 1 gene: RELN	10.80	1
397.	Buthionine Sulfoximine	Enterocolitis		Via 1 gene: IL10	10.79	1
398.	Selenomethionine	Hypoglycemia		Via 1 gene: PCK2	10.73	1
399.	Methionine	Urinary Tract Infections		Via 1 gene: NOS2	10.72	1
400.	Buthionine Sulfoximine	Aortic Aneurysm		Via 1 gene: TGFBR2	10.71	1
401.	N-Formylmethionine Leucyl-Phenylalanine	ARTERIOVENOUS MALFORMATIONS OF THE BRAIN		Via 1 gene: IL6	10.64	1
402.	Selenomethionine	CEREBRAL AMYLOID ANGIOPATHY, APP-RELATED		Via 1 gene: APP	10.64	1
403.	Selenomethionine	Cerebral Amyloid Angiopathy		Via 1 gene: APP	10.64	1
404.	Selenomethionine	MITOCHONDRIAL COMPLEX I DEFICIENCY		Via 1 gene: NDUFV1	10.63	1
405.	Selenomethionine	EPIDERMOLYSIS BULLOSA DYSTROPHICA, AUTOSOMAL RECESSIVE		Via 1 gene: MMP1	10.62	1
406.	Buthionine Sulfoximine	Lewy Body Disease		Via 1 gene: SNCA	10.61	1
407.	S-Adenosylmethionine	Mammary Neoplasms, Animal		Via 1 gene: COMT	10.60	1
408.	N-Formylmethionine Leucyl-Phenylalanine	IgE RESPONSIVENESS, ATOPIC		Via 1 gene: SELP	10.57	1
409.	FTI 277	Helicobacter Infections		Via 1 gene: CDKN1B	10.57	1
410.	Buthionine Sulfoximine	Acatalasia		Via 1 gene: CAT	10.57	1
411.	Selenomethionine	Bile Duct Neoplasms		Via 1 gene: EGFR	10.55	1
412.	S-Adenosylmethionine	Sleep Deprivation		Via 1 gene: PTGS1	10.55	1
413.	methionine selenoxide	Cardiomyopathy, Dilated		Via 1 gene: GPX1	10.52	1
414.	Methionine	Precursor Cell Lymphoblastic Leukemia-Lymphoma		Via 1 gene: MTRR	10.51	1
415.	Buthionine Sulfoximine	Colorectal Neoplasms, Hereditary Nonpolyposis		Via 1 gene: TGFBR2	10.49	1
416.	Methionine	Bipolar Disorder		Via 1 gene: RELN	10.49	1
417.	FTI 277	Rectal Neoplasms		Via 1 gene: CDKN1B	10.47	1
418.	Buthionine Sulfoximine	Pancreatic Diseases		Via 1 gene: HMOX1	10.47	1
419.	Buthionine Sulfoximine	Cerebral Hemorrhage		Via 1 gene: HMOX1	10.47	1
420.	Selenomethionine	Leigh Disease		Via 1 gene: NDUFV1	10.46	1
421.	N-Formylmethionine Leucyl-Phenylalanine	Fractures, Closed		Via 1 gene: ALOX5	10.46	1
422.	N-Formylmethionine Leucyl-Phenylalanine	Colonic Polyps		Via 1 gene: ALOX5	10.46	1
423.	Methionine	EHLERS-DANLOS SYNDROME, TYPE I		Via 1 gene: COL1A1	10.46	1
424.	N-Formylmethionine Leucyl-Phenylalanine	Dermatitis		Via 1 gene: PLA2G4A	10.46	1
425.	Selenomethionine	Dwarfism		Via 1 gene: COL2A1	10.46	1
426.	buthionine sulfoximine ethyl ester	Myocardial Infarction		Via 1 gene: GCLC	10.39	2
427.	Buthionine Sulfoximine	EHLERS-DANLOS SYNDROME, TYPE VII, AUTOSOMAL DOMINANT		Via 1 gene: COL1A1	10.39	1
428.	Buthionine Sulfoximine	OSTEOGENESIS IMPERFECTA, TYPE IV		Via 1 gene: COL1A1	10.39	1
429.	Selenomethionine	Xeroderma Pigmentosum		Via 1 gene: XPA	10.37	1
430.	Buthionine Sulfoximine	Atrophy		Via 1 gene: STAT3	10.36	1
431.	FTI 277	Cleft Palate		Via 1 gene: FGF10	10.36	1
432.	methionine selenoxide	Obesity		Via 1 gene: GPX1	10.34	1
433.	Methionine	Musculoskeletal Abnormalities		Via 1 gene: TGFB2	10.33	1
434.	FTI 277	Leukemia, Lymphocytic, Chronic, B-Cell		Via 1 gene: RBL2	10.33	1
435.	FTI 277	Uterine Neoplasms		Via 1 gene: CDKN1B	10.31	1
436.	buthionine sulfoximine ethyl ester	Carcinoma, Non-Small-Cell Lung		Via 1 gene: GCLC	10.30	1
437.	Methionine	Legionnaires' Disease		Via 1 gene: IFNG	10.30	1
438.	Methionine	Appendicitis		Via 1 gene: IFNG	10.30	1
439.	Methionine	Bronchiolitis Obliterans		Via 1 gene: IFNG	10.30	1
440.	N-Formylmethionine Leucyl-Phenylalanine	Heart Diseases		Via 1 gene: RAC2	10.28	1
441.	Selenomethionine	Aortic Aneurysm		Via 1 gene: TGFBR2	10.27	1
442.	S-Adenosylmethionine	EHLERS-DANLOS SYNDROME, TYPE I		Via 1 gene: COL1A1	10.26	1
443.	Buthionine Sulfoximine	LIPODYSTROPHY, FAMILIAL PARTIAL, TYPE 2		Via 1 gene: PPARG	10.25	1
444.	Buthionine Sulfoximine	Lipodystrophy, Familial Partial		Via 1 gene: PPARG	10.25	1
445.	Buthionine Sulfoximine	Urinary Tract Infections		Via 1 gene: NOS2	10.25	1
446.	N-Formylmethionine Leucyl-Phenylalanine	Infarction, Middle Cerebral Artery		Via 1 gene: ALOX5	10.24	1
447.	Buthionine Sulfoximine	Neoplasms, Multiple Primary		Via 1 gene: TP53	10.23	1
448.	Buthionine Sulfoximine	Papilloma, Choroid Plexus		Via 1 gene: TP53	10.23	2
449.	Buthionine Sulfoximine	Histiocytoma, Malignant Fibrous		Via 1 gene: TP53	10.23	1
450.	Buthionine Sulfoximine	Adrenocortical Carcinoma		Via 1 gene: TP53	10.23	1
451.	Buthionine Sulfoximine	Hepatoblastoma		Via 1 gene: TP53	10.23	1
452.	S-Adenosylmethionine	Hypospadias		Via 1 gene: ATF3	10.22	1
453.	FTI 277	Osteosarcoma		Via 1 gene: RB1	10.22	1
454.	S-Adenosylmethionine	Metabolism, Inborn Errors		Via 1 gene: MTHFD1	10.21	1
455.	N-Formylmethionine Leucyl-Phenylalanine	Listeria Infections		Via 1 gene: TNF	10.21	1
456.	Methionine	Listeria Infections		Via 1 gene: TNF	10.21	1
457.	methionine selenoxide	Parkinson Disease		Via 1 gene: GPX1	10.19	1
458.	Buthionine Sulfoximine	Spinocerebellar Ataxias		Via 1 gene: ATXN1	10.17	1
459.	Buthionine Sulfoximine	ARTERIOVENOUS MALFORMATIONS OF THE BRAIN		Via 1 gene: IL6	10.17	1
460.	FTI 277	Cardiomyopathy, Dilated		Via 1 gene: LMNA	10.15	1
461.	Methionine	Adenoma		Via 1 gene: MTRR	10.13	1
462.	N-Formylmethionine Leucyl-Phenylalanine	MICROVASCULAR COMPLICATIONS OF DIABETES, SUSCEPTIBILITY TO, 1		Via 1 gene: VEGFA	10.12	1
463.	N-Formylmethionine Leucyl-Phenylalanine	Diabetic Retinopathy		Via 1 gene: VEGFA	10.12	1
464.	Selenomethionine	Thrombophilia		Via 1 gene: PLG	10.11	1
465.	Buthionine Sulfoximine	Nephrosis		Via 1 gene: DDIT3	10.11	1
466.	Buthionine Sulfoximine	Irritable Bowel Syndrome		Via 1 gene: IL10	10.10	1
467.	Buthionine Sulfoximine	Appendicitis		Via 1 gene: IL10	10.10	1
468.	Buthionine Sulfoximine	Prostatitis		Via 1 gene: IL10	10.10	1
469.	S-Adenosylmethionine	DiGeorge Syndrome		Via 1 gene: COMT	10.09	1
470.	S-Adenosylmethionine	Neural Tube Defects		Via 1 gene: MTHFD1	10.07	2
471.	Selenomethionine	Colorectal Neoplasms, Hereditary Nonpolyposis		Via 1 gene: TGFBR2	10.05	1
472.	methionine selenoxide	Carcinoma, Squamous Cell		Via 1 gene: GPX1	10.04	1
473.	Selenomethionine	ANDROGEN INSENSITIVITY, PARTIAL		Via 1 gene: AR	10.02	1
474.	Selenomethionine	Breast Neoplasms, Male		Via 1 gene: AR	10.02	2
475.	Selenomethionine	Androgen-Insensitivity Syndrome		Via 1 gene: AR	10.02	3
476.	Selenomethionine	SPINAL AND BULBAR MUSCULAR ATROPHY, X-LINKED 1		Via 1 gene: AR	10.02	1
477.	N-Formylmethionine Leucyl-Phenylalanine	Lymphoma		Via 1 gene: RAC2	10.01	1
478.	Buthionine Sulfoximine	EHLERS-DANLOS SYNDROME, TYPE I		Via 1 gene: COL1A1	9.98	1
479.	Methionine	Infertility, Male		Via 1 gene: MTRR	9.98	1
480.	Buthionine Sulfoximine	Adenomatous Polyposis Coli		Via 1 gene: FMO3	9.96	1
481.	S-Adenosylmethionine	Hyperhomocysteinemia		Via 1 gene: GNMT	9.95	1
482.	N-Formylmethionine Leucyl-Phenylalanine	Leiomyosarcoma		Via 1 gene: PTGS2	9.94	1
483.	N-Formylmethionine Leucyl-Phenylalanine	Carcinoma in Situ		Via 1 gene: PTGS2	9.94	2
484.	FTI 277	Muscular Dystrophy, Facioscapulohumeral		Via 1 gene: CDKN1A	9.93	1
485.	Methionine	Osteochondrodysplasias		Via 1 gene: COL2A1	9.92	1
486.	Buthionine Sulfoximine	von Hippel-Lindau Disease		Via 1 gene: CCND1	9.92	1
487.	Methionine	Acromegaly		Via 1 gene: IGF1	9.91	1
488.	Buthionine Sulfoximine	WAGR Syndrome		Via 1 gene: CAT	9.87	1
489.	N-Formylmethionine Leucyl-Phenylalanine	Respiratory Distress Syndrome, Adult		Via 1 gene: PLA2G4A	9.85	1
490.	N-Formylmethionine Leucyl-Phenylalanine	Hypertension, Portal		Via 1 gene: VEGFA	9.83	1
491.	Selenomethionine	Neoplasms, Multiple Primary		Via 1 gene: TP53	9.78	1
492.	Selenomethionine	Adrenocortical Carcinoma		Via 1 gene: TP53	9.78	1
493.	Selenomethionine	Papilloma, Choroid Plexus		Via 1 gene: TP53	9.78	2
494.	Selenomethionine	Hepatoblastoma		Via 1 gene: TP53	9.78	1
495.	Selenomethionine	Histiocytoma, Malignant Fibrous		Via 1 gene: TP53	9.78	1
496.	S-Adenosylmethionine	Panic Disorder		Via 1 gene: COMT	9.76	1
497.	S-Adenosylmethionine	Hearing Loss		Via 1 gene: COMT	9.76	1
498.	FTI 277	Carcinoma, Transitional Cell		Via 1 gene: CDKN1A	9.73	1
499.	Buthionine Sulfoximine	Listeria Infections		Via 1 gene: TNF	9.73	1
500.	buthionine sulfoximine ethyl ester	Drug-Induced Liver Injury		Via 1 gene: GCLC	9.72	1

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Comparative Toxicogenomics Database

Chemical: Methionine