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ChemicalChemical: Organophosphorus Compounds

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The following diseases are associated with Organophosphorus Compounds or at least one of its descendants. Each association is direct (M marker/mechanism and/or T therapeutic) and/or inferred (via a curated gene interaction).

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  Chemical Disease Direct Evidence Inference Network Inference Score References
1. Chlorpyrifos Respiratory Tract Diseases M   2
2. Dichlorvos Respiratory Tract Diseases M   2
3. Fonofos Respiratory Tract Diseases M   1
4. Parathion Respiratory Tract Diseases M   1
5. Phorate Respiratory Tract Diseases M   2
6. Dichlorvos Parkinson Disease, Secondary M   1
7. terbufos Respiratory Sounds M   1
8. Malathion Respiratory Sounds M   2
9. Chlorpyrifos Respiratory Sounds M   3
10. Dichlorvos Respiratory Sounds M   2
11. Fonofos Respiratory Sounds M   1
12. Parathion Respiratory Sounds M   2
13. Phorate Respiratory Sounds M   2
14. Organophosphorus Compounds Respiratory Insufficiency M   2
15. Dichlorvos Respiratory Insufficiency M   2
16. Organophosphorus Compounds Basal Ganglia Diseases M   1
17. Dichlorvos Basal Ganglia Diseases M   1
18. Dichlorvos Neurodegenerative Diseases M   1
19. Dichlorvos Kidney Diseases M   1
20. Cyclophosphamide Oligospermia M   1
21. Dichlorvos Central Nervous System Diseases M   1
22. Dichlorvos Nerve Degeneration M   2
23. Monocrotophos Dyspnea M   1
24. Diazinon Dyspnea M   1
25. Organophosphorus Compounds Coma M   1
26. Dichlorvos Coma M   1
27. tri-o-cresyl phosphate Muscle Spasticity M   1
28. Cyclophosphamide Cystitis M   18
29. Cyclophosphamide Immune System Diseases M   1
30. Diphosphonates Osteonecrosis M   1
31. methamidophos Autonomic Nervous System Diseases M   1
32. tri-o-cresyl phosphate Polyneuropathies M   2
33. methamidophos Polyneuropathies M   1
34. Organophosphorus Compounds Polyneuropathies M   1
35. Dichlorvos Polyneuropathies M   1
36. Chlorpyrifos Sex Chromosome Aberrations M   1
37. Soman Seizures M   1
38. Chlorfenvinphos Seizures M   1
39. Dichlorvos Seizures M   2
40. Cyclophosphamide Arteriosclerosis M   1
41. methamidophos Foodborne Diseases M   1
42. Chlorpyrifos Neurotoxicity Syndromes M   1
43. Dichlorvos Neurotoxicity Syndromes M   1
44. tri-o-cresyl phosphate Paralysis M   1
45. Cyclophosphamide Hemophilia A M   1
46. Dichlorvos Pancreatitis M   1
47. methamidophos Muscle Weakness M   1
48. Phosphoramide Mustards Urinary Bladder Neoplasms M   1
49. Cyclophosphamide GLOBOZOOSPERMIA M   1
50. Dichlorvos Hyperesthesia M   1
51. Organophosphorus Compounds Hypotension M   1
52. Cyclophosphamide Leukopenia M   2
53. Foscarnet Hypophosphatemia, Familial M   1
54. Diphosphonates Mandibular Diseases M   1
55. terbufos Agricultural Workers' Diseases M   1
56. Malathion Agricultural Workers' Diseases M   2
57. Monocrotophos Agricultural Workers' Diseases M   1
58. Dichlorvos Agricultural Workers' Diseases M   3
59. Fonofos Agricultural Workers' Diseases M   1
60. Phorate Agricultural Workers' Diseases M   2
61. pirimiphos methyl Infertility, Male M   1
62. methamidophos Infertility, Male M   1
63. indium phosphide Breast Neoplasms M   1
64. zoledronic acid Hypocalcemia M   1
65. Monocrotophos Hepatitis M   1
66. Diazinon Hepatitis M   1
67. Cyclophosphamide Hepatic Veno-Occlusive Disease M   1
68. zoledronic acid Acute-Phase Reaction M   1
69. Diphosphonates Maxillary Diseases M   1
70. phosphine Lymphoma, Non-Hodgkin M   1
71. Monocrotophos Urologic Diseases M   1
72. Diazinon Urologic Diseases M   1
73. terbufos Respiratory Tract Diseases M   1
74. Malathion Respiratory Tract Diseases M   1
75. Malathion Neurotoxicity Syndromes M Via 9 genes: ADD3; CCK; CRISPLD2; LAT; P2RX1; RNASE6; SFRS5; ST8SIA1; TIMP3 103.29 2
76. Methyl Parathion Neurotoxicity Syndromes M Via 7 genes: ADD3; CCK; GABRR2; P2RX1; SFRS5; TGM1; TIMP3 78.68 1
77. Malathion Breast Neoplasms M Via 8 genes: CENPF; CYP3A4; HRAS; HRAS1; IFNB1; IFNG; TP53; TYMS 56.36 14
78. Cyclophosphamide Urinary Bladder Neoplasms M Via 8 genes: CDKN1A; EGFR; ESR1; ESR2; GSTP1; PRSS3; PTGS2; TP53 50.21 12
79. Cyclophosphamide Diabetes Mellitus, Type 1 M Via 5 genes: CAT; CCR5; CTSH; FOXP3; IL10 35.76 6
80. Parathion Breast Neoplasms M Via 4 genes: CYP3A4; HRAS; HRAS1; TP53 25.14 9
81. Sarin Poisoning M Via 2 genes: ACHE; PON1 21.04 3
82. Soman Poisoning M Via 2 genes: ACHE; PON1 20.71 3
83. Organophosphorus Compounds Poisoning M Via 2 genes: ACHE; PON1 19.25 2
84. Chlorpyrifos Liver Diseases M Via 3 genes: ALPL; CYP1A2; SOD1 17.10 4
85. Dichlorvos Prostatic Neoplasms M Via 3 genes: AR; CASP9; SOD2 15.83 16
86. Diazinon Poisoning M Via 2 genes: ACHE; PON1 13.70 3
87. Ifosfamide Fanconi Syndrome M Via 1 gene: SLC34A1 13.05 2
88. zoledronic acid Kidney Failure, Acute M Via 2 genes: IL10; TNF 12.94 2
89. Dichlorvos Motor Neuron Disease M Via 1 gene: PNPLA6 11.91 2
90. methamidophos Nervous System Diseases M Via 1 gene: PNPLA6 11.33 3
91. methamidophos Peripheral Nervous System Diseases M Via 1 gene: NEFH 11.32 3
92. CHOP protocol Cardiomyopathies M Via 1 gene: NPPB 10.75 2
93. methamidophos Poisoning M Via 1 gene: ACHE 8.75 3
94. Methyl Parathion Poisoning M Via 1 gene: ACHE 7.92 2
95. Parathion Agricultural Workers' Diseases M Via 1 gene: PON1 7.82 3
96. Dichlorvos Poisoning M Via 1 gene: ACHE 7.74 7
97. Diazinon Infertility, Male M Via 1 gene: GPX4 7.11 3
98. Cyclophosphamide Infertility, Male M Via 1 gene: GPX4 6.84 3
99. Parathion Infertility, Male M Via 1 gene: AR 6.75 3
100. Chlorpyrifos Agricultural Workers' Diseases M Via 1 gene: PON1 6.51 4
101. Diazinon Agricultural Workers' Diseases M Via 1 gene: PON1 6.49 2
102. Cyclophosphamide Eosinophilia M Via 1 gene: IL5 6.47 1
103. Dichlorvos Stomach Neoplasms M Via 1 gene: SOD2 5.95 2
104. Cyclophosphamide Diabetes Mellitus, Experimental M T Via 1 gene: TNF 4.81 4
105. CHOP protocol Lymphoma, Large B-Cell, Diffuse T   2
106. CHOP protocol Lymphoma, B-Cell T   1
107. fotemustine Melanoma T   5
108. CVD protocol Melanoma T   1
109. Foscarnet Cytomegalovirus Retinitis T   1
110. Clodronic Acid Mammary Neoplasms, Experimental T   1
111. CHOP protocol Sjogren's Syndrome T   1
112. CVD protocol Pheochromocytoma T   2
113. CVD protocol Paraganglioma T   1
114. Cyclophosphamide Carcinoma, Lewis Lung T   1
115. ICE protocol 1 Neuroblastoma T   1
116. Alendronate Hyperalgesia T   1
117. SK&F 98625 Inflammation T   1
118. AC protocol Breast Neoplasms T   1
119. CE protocol II Breast Neoplasms T   1
120. tenofovir disoproxil HIV Infections T   1
121. Foscarnet HIV Infections T   2
122. zoledronic acid Sarcoma, Ewing's T   1
123. Dichlorvos Horse Diseases T   1
124. CHOP protocol Lymphoma, AIDS-Related T   1
125. COMP protocol Lymphoma, Non-Hodgkin T   1
126. ACE protocol 1 Lymphoma, Non-Hodgkin T   1
127. Cyclophosphamide Lymphoma, Non-Hodgkin T   1
128. CDOP protocol Lymphoma, Non-Hodgkin T   1
129. CHOP protocol Lymphoma, Non-Hodgkin T   2
130. CAV protocol Lymphoma, Non-Hodgkin T   1
131. CHOP protocol Lymphoma, Follicular T   1
132. COP protocol 2 Lymphoma, Follicular T   1
133. MAID protocol Sarcoma T   2
134. ICE protocol 1 Sarcoma T   1
135. CYVADIC protocol Sarcoma T   1
136. VIA protocol Sarcoma T   1
137. Foscarnet AIDS-Related Opportunistic Infections T   1
138. CMOPP protocol Hodgkin Disease T   1
139. Ifosfamide Hodgkin Disease T   1
140. CVPP regimen Hodgkin Disease T   1
141. EPOCH protocol Hodgkin Disease T   1
142. COPP protocol Hodgkin Disease T   1
143. Cyclophosphamide Hodgkin Disease T   2
144. BEACOPP protocol Hodgkin Disease T   4
145. COPP-ABVD protocol Hodgkin Disease T   2
146. CGP 35348 Epilepsy, Absence T   1
147. 3-aminopropyl-cyclohexylmethylphosphinic acid Epilepsy, Absence T   1
148. risedronic acid Mesothelioma T   1
149. 3-methyl-9-(2-oxa-2lambda(5)-2H-1,3,2-oxazaphosphorine-2-cyclohexyl)-3,6,9-triazaspiro(5.5)undecane Liver Neoplasms, Experimental T   1
150. Fosinopril Liver Cirrhosis, Experimental T   1
151. Cyclophosphamide Scleroderma, Systemic T   1
152. MAID protocol Soft Tissue Neoplasms T   1
153. VIA protocol Soft Tissue Neoplasms T   1
154. Foscarnet Cytomegalovirus Infections T   2
155. pamidronate OSTEOPOROSIS-PSEUDOGLIOMA SYNDROME T   1
156. Clodronic Acid Neoplasm Metastasis T   1
157. MAID protocol Liposarcoma T   1
158. zoledronic acid Femoral Fractures T   1
159. Dichlorvos Nematode Infections T   1
160. Diphosphonates Bone Resorption T   1
161. Fosfomycin Cystic Fibrosis T   1
162. Trichlorfon Strongyloidiasis T   1
163. Dichlorvos Strongyloidiasis T   1
164. Clodronic Acid Bone Neoplasms T   1
165. Cyclophosphamide Graft vs Host Disease T   3
166. Etidronic Acid Osteoporosis T   1
167. risedronic acid Osteoporosis T   1
168. CVD protocol Abdominal Neoplasms T   1
169. zoledronic acid Leukemia-Lymphoma, Adult T-Cell T   1
170. Amifostine Stomach Diseases T   1
171. Diphosphonates Osteolysis T   1
172. Trichlorfon Cattle Diseases T   1
173. Dichlorvos Cattle Diseases T   1
174. fotemustine Glioblastoma T   2
175. DECAV protocol Uterine Neoplasms T   1
176. Cyclophosphamide Prostatic Neoplasms T Via 53 genes: APEX1; BAD; BCL2; CALR; CASP9; CDH1; CDKN1A; CDKN1B; CLIC4; CTSD; CX3CL1; CXCL12; CYP1B1; CYP3A4; EGFR; EPHX1; ERBB2; ERCC2; ERG; ESR1; ESR2; GADD45A; GJA1; GSTA1; GSTP1; HIF1A; HSP90AB1; HSP90B1; HSPA1A; ICAM1; IGFBP3; IL10; IL1RN; IL2; IL6; IRS1; LDHB; MLH1; MSH3; MXI1; NQO1; NRP1; PARP1; PDIA3; PTGS2; SOD2; ST14; TCP1; TGFB1; TOP2A; TP53; VIM; VIP 354.27 64
177. zoledronic acid Prostatic Neoplasms T Via 30 genes: AKT1; BAD; BAX; BCL2; BGLAP; BNIP3; CASP9; CCND1; CDK2AP2; CDKN1A; CDKN1B; CTSB; DIABLO; EMP3; ERG; FASLG; ICAM1; IGF1; IL10; IL2; IL6; LZTS1; MMP9; PARP1; PTGS2; PTHLH; TGFB1; TNFRSF10A; TNFRSF21; TP53 199.94 40
178. Cyclophosphamide Breast Neoplasms T Via 31 genes: ABCG2; BCL2; CCT5; CDH1; CDKN1B; CSF1; CYP1B1; CYP3A4; EGFR; ERBB2; ESR1; ESR2; F3; FOS; FOXP3; GPX4; GZMB; HMOX1; HSPA1B; IFNG; IL1B; IL6; MMP3; NOS2; NQO1; PTGS2; RAD51; SLC2A2; TNF; TOP2A; TP53 193.00 52
179. zoledronic acid Breast Neoplasms T Via 24 genes: ABCG2; AKT1; BCL2; BCL2A1; BIRC5; BMP2; CASP7; CASP8; CCND1; CDKN1B; CENPF; FOS; GZMB; HRAS; IFNG; IGF1; IL6; MKI67; NOS2; PDGFA; PTGS2; RAF1; TNF; TP53 156.98 29
180. Cyclophosphamide Leukemia T Via 8 genes: BAD; BCL2; DDIT4; ERG; ESR1; IL2; MGMT; TOP2A 56.65 9
181. Cyclophosphamide Pancreatic Neoplasms T Via 8 genes: CYP2B1; GADD45A; HIF1A; NRP1; PTGS2; TNF; TP53; TYMP 50.99 11
182. FEC protocol Breast Neoplasms T Via 6 genes: ERBB2; IFNG; MKI67; PTGS2; TOP2A; TP53 48.67 29
183. zoledronic acid Osteoporosis T Via 5 genes: COL1A1; IL6; TGFB1; TNFRSF11B; TNFSF11 36.67 5
184. Cyclophosphamide Pulmonary Fibrosis T Via 6 genes: HMOX1; IL1B; IL5; IL6; TGFB1; TNF 34.85 8
185. zoledronic acid Hypercalcemia T Via 3 genes: PTHLH; TNFRSF11B; TNFSF11 29.23 4
186. zoledronic acid Mesothelioma T Via 4 genes: CDKN1B; FGF2; IFNG; PDGFA 28.63 5
187. zoledronic acid Carcinoma, Non-Small-Cell Lung T Via 4 genes: BIRC5; DAPK1; PTHLH; TP53 28.42 5
188. zoledronic acid Neoplasm Metastasis T Via 4 genes: DAPK1; MMP2; MMP9; TP53 28.02 6
189. zoledronic acid Carcinoma, Renal Cell T Via 4 genes: BIRC5; DAPK1; PTGS2; TP53 27.55 5
190. CMF regimen Breast Neoplasms T Via 3 genes: CSF1; EGFR; ERBB2 27.53 22
191. zoledronic acid Mammary Neoplasms, Experimental T Via 4 genes: HRAS; IGF1; IL10; XIAP 27.25 7
192. zoledronic acid Hyperalgesia T Via 3 genes: PTHLH; TNF; TNFRSF11B 22.71 4
193. Trichlorfon Alzheimer Disease T Via 3 genes: APP; BCL2; CASP3 22.67 14
194. zoledronic acid Multiple Myeloma T Via 3 genes: BNIP3; CCL2; CCND1 20.27 6
195. Ifosfamide Soft Tissue Neoplasms T Via 2 genes: BCL2; TNF 19.55 4
196. Cyclophosphamide Carcinoma, Renal Cell T Via 3 genes: BTG3; PTGS2; TP53 19.08 4
197. CEF regimen Breast Neoplasms T Via 2 genes: ERBB2; TOP2A 18.42 18
198. Ifosfamide Sarcoma T Via 2 genes: GSTP1; TNF 17.94 7
199. zoledronic acid Bone Resorption T Via 2 genes: PTHLH; TNFRSF11B 17.53 6
200. zoledronic acid Bone Neoplasms T Via 2 genes: MMP2; MMP9 15.77 7
201. Cyclophosphamide Leukemia, Lymphocytic, Chronic, B-Cell T Via 3 genes: IL6; PTGS2; TP53 15.62 9
202. Alendronate Osteoporosis T Via 2 genes: TGFB1; VDR 15.41 3
203. pamidronate Bone Resorption T Via 1 gene: TNFRSF11B 10.86 3
204. zoledronic acid Osteolysis T Via 1 gene: TNFRSF11B 9.19 2
205. Fosinopril Hypertension T Via 1 gene: NOS3 9.00 3
206. Paraoxon Atherosclerosis T Via 1 gene: PON1 8.84 5
207. CAF protocol Breast Neoplasms T Via 1 gene: ERBB2 8.73 19
208. Cyclophosphamide Gliosarcoma T Via 1 gene: CYP2B6 8.55 1
209. Cyclophosphamide Melanoma, Experimental T Via 1 gene: CALR 8.27 1
210. Cyclophosphamide Lymphoma T Via 1 gene: MLH1 7.41 2
211. Cyclophosphamide Neuroblastoma T Via 1 gene: NME1 7.40 3
212. AN-7 phosphate cpd Breast Neoplasms T Via 1 gene: TP53 7.26 6
213. Cyclophosphamide Lymphoma, B-Cell T Via 1 gene: PTGS2 5.91 2
214. zoledronic acid Pain T Via 1 gene: TNF 4.80 2
215. Diazinon Autistic Disorder   Via 26 genes: ADRB2; CHRNA4; CHRNA7; CHRNB2; COMT; GPX1; GRIA1; GRIK2; GRIN2A; GRM8; GSTM1; HTR1B; HTR1D; HTR2A; HTR3A; HTR5A; IFNG; IL10; IL2; IL4; MAOB; PON1; SLC1A3; SLC6A4; SLC6A8; WNT2 196.72 22
216. Chlorpyrifos Autistic Disorder   Via 23 genes: ADRB2; BDNF; CAT; CHRNA7; CHRNB2; COMT; GPX1; GRIA1; GRIK2; GRIN2A; GSTM1; HTR1B; HTR1D; HTR2A; HTR5A; IGF1; IL6; NRCAM; NTF3; PON1; SLC6A4; SLC6A8; WNT2 171.07 24
217. Cyclophosphamide Stomach Neoplasms   Via 23 genes: AURKB; CA2; CDH1; CDH2; CDKN1A; CDKN1B; CST7; CTSL; EGFR; ERBB2; ERCC2; FYN; GADD45A; HMOX1; HSPA8; HSPD1; IGFBP3; IL1B; IL1RN; PTGS2; SOD2; TNF; TYMP 156.15 16
218. Cyclophosphamide Autistic Disorder   Via 22 genes: ADM; BCL2; CAT; GJA1; GSTP1; GZMB; HOXA1; IFNG; IGFBP3; IL10; IL1RN; IL2; IL4; IL5; IL6; MAOA; NOS2; POMC; PRLR; PTGS2; STK39; VIP 137.96 20
219. Diazinon Prostatic Neoplasms   Via 21 genes: ADRB2; BAX; CALR; CASP9; COMT; CYP3A4; CYP3A5; FGFR4; GPX3; GSTK1; GSTM1; GSTM3; GSTO1; GSTT1; GSTT3; IL10; IL2; PON1; SOD2; TP53; WNT4 129.44 25
220. Cyclophosphamide Colorectal Neoplasms   Via 17 genes: ALDH2; BCL2; CDH1; EGFR; ERCC2; ESR2; GPX4; MLH1; MSH2; NME1; ODC1; POSTN; PTGS2; RRM2; SPARC; TP53; TYMP 117.11 23
221. Cyclophosphamide Lung Neoplasms   Via 20 genes: APOE; BCL2L1; CDKN1A; CDKN1B; CYP1B1; EGFR; ERBB2; ESR1; FOS; GJA1; GSTP1; HMOX1; IL10; MAPK1; MAPK14; MPO; NOS2; TGFB1; TNF; TP53 116.02 26
222. Chlorpyrifos Prostatic Neoplasms   Via 19 genes: ADRB2; CASP9; COMT; CYP1A1; CYP3A4; CYP3A5; ESR1; FGFR4; GSTK1; GSTM1; GSTM3; GSTO1; GSTT1; IGF1; IL6; PON1; SOD2; TGFB1; TP53 108.78 27
223. Cyclophosphamide Liver Cirrhosis, Experimental   Via 17 genes: ABCB1; ADM; ALDH1A1; ALDH2; BDH1; HMOX1; IFNG; IL10; IL1B; LCN2; NOS2; OSM; POMC; PTGS2; SPARC; TGFB1; TNF 103.08 29
224. zoledronic acid Lung Neoplasms   Via 16 genes: BCL2L1; BIRC5; CASP8; CCND1; CDKN1A; CDKN1B; DAPK1; FOS; HRAS; IL10; MAPK1; MAPK3; NOS2; TGFB1; TNF; TP53 99.42 24
225. Malathion Liver Diseases   Via 10 genes: CCK; CRISPLD2; CYP1A2; IL1R2; LAT; RNASE6; SFRS5; SOD1; ST8SIA1; TIMP3 93.81 3
226. Parathion Neurotoxicity Syndromes   Via 8 genes: ADD3; ALOX5AP; BCL2L1; CCK; CD3D; GABRR2; P2RX1; SFRS5 89.11 1
227. Cyclophosphamide Carcinoma, Hepatocellular   Via 14 genes: ACTB; BCL2L1; CXCL12; EGFR; ESR1; FOS; GSTP1; IL6; PTGS2; RRM2; SLC2A2; TGFB1; TP53; UBD 87.31 11
228. Chlorpyrifos Breast Neoplasms   Via 14 genes: COMT; CYP1A1; CYP3A4; ESR1; FGFR2; FOS; GPX1; GPX2; GPX4; IGF1; IL1B; IL6; TP53; WNT10B 80.61 21
229. zoledronic acid Carcinoma, Hepatocellular   Via 12 genes: BCL2L1; BID; BIRC5; CASP8; CYR61; FOS; HRAS; IL6; PTGS2; PTK2; TGFB1; TP53 79.69 13
230. Chlorpyrifos Schizophrenia   Via 10 genes: CHRNA7; COMT; DRD2; DRD4; GRIN2B; HTR2A; IL1B; SLC6A4; TP53; TPH1 78.87 4
231. zoledronic acid Stomach Neoplasms   Via 12 genes: BID; BIRC2; BIRC5; BNIP3; CASP8; CDKN1A; CDKN1B; MAPK8; PTGS2; RHOA; TNF; TYMP 77.92 11
232. Cyclophosphamide Asthma   Via 12 genes: ALDH2; ARG1; BCL2; CAT; CD14; GSTP1; HMOX1; ICAM1; IL12B; IL4; TGFB1; TNF 76.78 15
233. Methyl Parathion Prostatic Neoplasms   Via 11 genes: AR; CDKN1A; CTSB; CYP19A1; CYP1A1; ESR1; GADD45A; GSTA1; GSTT1; ST14; TP53 73.18 26
234. zoledronic acid Liver Cirrhosis, Experimental   Via 12 genes: CCL2; FGF2; IFNG; IGF1; IL10; MMP2; MMP9; NOS2; PTGS2; SPIN2A; TGFB1; TNF 72.43 24
235. Diazinon Schizophrenia   Via 9 genes: CHRNA7; COMT; DRD2; DRD4; GRIN2B; HTR2A; SLC6A4; TP53; TPH1 71.84 4
236. Chlorpyrifos Parkinson Disease   Via 9 genes: CYP2D6; DBH; DRD4; FGF20; GPX1; GSTA4; SLC18A2; SLC6A3; SOD1 71.32 5
237. Diazinon Parkinson Disease   Via 9 genes: CYP2D6; DBH; DRD4; FGF20; GPX1; GSTA4; SLC18A2; SLC6A3; SOD1 71.13 5
238. zoledronic acid Esophageal Neoplasms   Via 10 genes: BAX; BCL2A1; CASP8; CCND1; CDKN1A; LZTS1; NOS2; PTGS2; TP53; XIAP 70.99 11
239. Cyclophosphamide Ovarian Neoplasms   Via 10 genes: CDH1; CDKN1B; CYP1B1; DLC1; EGFR; GADD45A; MAPK1; MLH1; MSH2; SPARC 70.69 8
240. Chlorpyrifos Lung Neoplasms   Via 11 genes: CHRNA5; CHRNB4; ESR1; FOS; GPX1; GSTP2; MAPK1; MAPK3; PON1; TGFB1; TP53 67.49 16
241. zoledronic acid Colonic Neoplasms   Via 10 genes: BCL2; BIRC5; CCND1; ICAM1; IFNG; MMP9; TNFRSF10A; TNFRSF10B; TP53; TYMP 67.16 11
242. zoledronic acid Oral Submucous Fibrosis   Via 8 genes: COL1A1; FGF2; IFNG; MMP2; MMP9; PTGS2; TGFB1; TNF 65.89 1
243. zoledronic acid Autistic Disorder   Via 11 genes: BCL2; GZMB; HRAS; IFNG; IGF1; IL10; IL2; IL6; NOS2; PECAM1; PTGS2 64.76 10
244. Chlorpyrifos Liver Cirrhosis, Experimental   Via 11 genes: ABCB1; ACHE; CYP1A2; FGF2; GOT1; GPT; GSTA2; GSTM1; IGF1; IL1B; TGFB1 63.96 9
245. Parathion Liver Diseases   Via 7 genes: ALOX5AP; BCL2L1; CCK; CD3D; CYP1A2; GABRR2; SFRS5 62.36 2
246. Cyclophosphamide Colonic Neoplasms   Via 10 genes: BCL2; ERBB2; ICAM1; IFNG; IL1B; IL1RN; POSTN; SPARC; TP53; TYMP 62.23 12
247. Cyclophosphamide Arsenic Poisoning   Via 9 genes: CD83; ERCC1; HSPA1B; IL1A; IL1B; IL1RN; SOD2; TNF; TP53 61.97 4
248. Cyclophosphamide Skin Diseases   Via 9 genes: CD83; ERCC2; HSPA1B; IL1A; IL1B; IL1RN; PTGS2; SOD2; TNF 60.65 3
249. Chlorpyrifos TOBACCO ADDICTION, SUSCEPTIBILITY TO   Via 6 genes: BDNF; CHRNA5; CHRNA6; CHRNB3; CYP2B6; SLC6A3 59.39 4
250. Diazinon TOBACCO ADDICTION, SUSCEPTIBILITY TO   Via 6 genes: CHRNA3; CHRNA4; CHRNA5; CHRNB3; CYP2B6; SLC6A3 58.96 4
251. Cyclophosphamide Alzheimer Disease   Via 10 genes: APOE; BCL2; CASP3; CRH; ESR1; HMOX1; IL1B; MAPT; MPO; TNF 58.75 10
252. Cyclophosphamide Glioma   Via 8 genes: ERBB2; GSTP1; MGMT; MSH2; PTGS2; RTEL1; SPP1; TP53 58.24 7
253. Thiotepa Prostatic Neoplasms   Via 7 genes: BAD; BAX; BCL2; ERBB2; GSTA1; GSTP1; OGG1 57.25 11
254. zoledronic acid Colorectal Neoplasms   Via 9 genes: AKT1; BCL2; BIRC5; CASP8; CCND1; MSH2; PTGS2; TP53; TYMP 56.48 15
255. Cyclophosphamide Drug-Induced Liver Injury   Via 9 genes: APOE; CXCL1; HMOX1; IFNG; IL1B; IL6; KITL; PTGS2; SLPI 55.27 9
256. zoledronic acid Sepsis   Via 7 genes: CASP3; IL10; MAPK1; MAPK3; MMP9; TGFB1; TNF 54.04 3
257. Cyclophosphamide HIV Infections   Via 8 genes: CDKN1A; GADD45A; HSP90AA1; HSPB1; IFNG; IL10; IL2; ODC1 53.88 2
258. Diazinon Lung Neoplasms   Via 8 genes: CHRNA3; CHRNA5; GPX1; GPX3; GSTP2; IL10; PON1; TP53 52.17 10
259. zoledronic acid HIV Infections   Via 7 genes: BAG3; BAX; BIRC2; CDKN1A; IFNG; IL10; IL2 50.57 3
260. Cyclophosphamide Entamoebiasis   Via 6 genes: IFNG; IL10; IL1B; IL2; IL5; IL6 50.51 1
261. Cyclophosphamide Liver Diseases   Via 8 genes: ALOX5AP; BCL2L1; CD79B; HMOX1; HSPA1A; NOS2; NQO1; NRP1 50.48 6
262. Cyclophosphamide Adenocarcinoma   Via 8 genes: CA2; ESR1; ESR2; HSPA8; HSPD1; PTGS2; TGFB1; TP53 48.99 9
263. Cyclophosphamide Melanoma   Via 8 genes: APEX1; CYP1B1; ERBB4; F2RL1; IL2; PTGS2; TNF; TP53 47.01 23
264. Methyl Parathion Liver Diseases   Via 5 genes: CCK; GABRR2; SFRS5; TGM1; TIMP3 46.25 1
265. zoledronic acid Drug-Induced Liver Injury   Via 7 genes: BAX; CXCL1; IFNG; IL6; MMP2; PTGS2; SPIN2A 45.73 6
266. Cyclophosphamide Psoriasis   Via 7 genes: APOE; IL12B; IL4; IL6; PCNA; TNF; TP53 45.22 6
267. zoledronic acid Leukemia   Via 6 genes: BAD; BCL2; BIRC2; CCND1; ERG; IL2 44.59 5
268. Methyl Parathion Autistic Disorder   Via 6 genes: AR; BDNF; CAT; CHRNA7; GABBR2; MAOA 43.72 7
269. Diazinon Liver Cirrhosis, Experimental   Via 8 genes: ABCB1; ACHE; CYP1A2; FGF2; GSTA2; GSTM1; IFNG; IL10 43.52 17
270. Parathion Lung Neoplasms   Via 6 genes: BCL2L1; CYP2E1; HRAS; HRAS1; PON1; TP53 42.49 12
271. Parathion Prostatic Neoplasms   Via 7 genes: AR; CYP2E1; CYP3A4; CYP3A5; PON1; SULT1A1; TP53 41.63 19
272. zoledronic acid Pulmonary Fibrosis   Via 6 genes: CCL2; FGF2; IL6; PDGFA; TGFB1; TNF 41.19 7
273. Ifosfamide Prostatic Neoplasms   Via 6 genes: BCL2; CASP9; CYP3A4; CYP3A5; GSTP1; IL6 40.88 9
274. Diazinon Cleft Palate   Via 5 genes: FGF2; FGF9; FGFR1; FZD4; TGFB3 40.10 3
275. mafosfamide Prostatic Neoplasms   Via 5 genes: BAX; BCL2; CASP9; OGG1; PARP1 40.02 6
276. zoledronic acid Hernia, Diaphragmatic   Via 6 genes: FGF2; ICAM1; IGF1; IL6; TGFB1; TNF 39.88 6
277. Phenylphosphonothioic Acid, 2-Ethyl 2-(4-Nitrophenyl) Ester Prostatic Intraepithelial Neoplasia   Via 3 genes: AR; ESR1; ESR2 39.35 2
278. dichlofenthion Prostatic Intraepithelial Neoplasia   Via 3 genes: AR; ESR1; ESR2 39.35 2
279. ethion Prostatic Intraepithelial Neoplasia   Via 3 genes: AR; ESR1; ESR2 39.35 2
280. tolclofos-methyl Prostatic Intraepithelial Neoplasia   Via 3 genes: AR; ESR1; ESR2 39.35 2
281. ethyl bromophos Prostatic Intraepithelial Neoplasia   Via 3 genes: AR; ESR1; ESR2 39.35 2
282. Cyclophosphamide Mesothelioma   Via 6 genes: CDH1; CDKN1B; ESR1; IFNG; SOD2; SPP1 39.29 7
283. zoledronic acid Ovarian Neoplasms   Via 6 genes: AKT1; BIRC5; CDKN1B; MAPK1; MAPK3; MSH2 39.23 6
284. methylparaoxon HIV Infections   Via 4 genes: ALB; CDKN1A; GADD45A; MDM2 38.36 2
285. Chlorpyrifos Carcinoma, Hepatocellular   Via 7 genes: COMT; CYP1A1; ESR1; FOS; IL6; TGFB1; TP53 38.08 7
286. Cyclophosphamide Cholangiocarcinoma   Via 5 genes: EGFR; ERBB2; IL6; NOS2; PTGS2 37.98 3
287. prothiophos Prostatic Intraepithelial Neoplasia   Via 3 genes: AR; ESR1; ESR2 37.96 2
288. Leptophos Prostatic Intraepithelial Neoplasia   Via 3 genes: AR; ESR1; ESR2 37.96 2
289. zoledronic acid Liver Diseases   Via 6 genes: ALPL; BCL2L1; CCL2; CD86; MMP9; NOS2 37.74 2
290. Diazinon Breast Neoplasms   Via 7 genes: COMT; CYP3A4; GPX1; GPX2; GPX4; IFNG; TP53 37.44 13
291. FEC protocol Prostatic Neoplasms   Via 5 genes: ERBB2; IL2; PTGS2; TOP2A; TP53 37.25 9
292. Alendronate Oral Submucous Fibrosis   Via 4 genes: LOX; MMP2; TGFB1; TIMP1 37.17 1
293. quinalphos Prostatic Intraepithelial Neoplasia   Via 3 genes: AR; ESR1; ESR2 37.04 2
294. Methyl Parathion Breast Neoplasms   Via 6 genes: CYP19A1; CYP1A1; ESR1; FOS; MKI67; TP53 36.84 11
295. zoledronic acid Asthma   Via 6 genes: BCL2; CCL2; ICAM1; MMP9; TGFB1; TNF 36.44 10
296. Malathion Prostatic Neoplasms   Via 6 genes: CTSB; CYP3A4; CYP3A5; SOD2; TP53; TYMS 36.42 9
297. Malathion Lung Neoplasms   Via 5 genes: HRAS; HRAS1; TP53; TTR; TYMS 36.29 12
298. Cyclophosphamide Hernia, Diaphragmatic   Via 6 genes: GJA1; ICAM1; IL6; TGFB1; TNF; VCAM1 36.29 7
299. Parathion Autistic Disorder   Via 5 genes: AR; GABBR2; HRAS; HTR2A; PON1 35.94 6
300. FEC protocol Colonic Neoplasms   Via 4 genes: ERBB2; IFNG; TP53; TYMP 35.54 5
301. Cyclophosphamide Neoplasm Metastasis   Via 5 genes: EGFR; ERBB2; MLH1; TP53; VIP 35.41 6
302. Alendronate Liver Cirrhosis, Experimental   Via 5 genes: MMP2; SERPINH1; SPARC; TGFB1; TIMP1 35.01 9
303. Paraoxon Liver Cirrhosis, Experimental   Via 4 genes: ACHE; CES2; CES3; CNR1 34.95 3
304. zoledronic acid Melanoma   Via 6 genes: CASP8; FASLG; IL2; PTGS2; TNF; TP53 34.80 23
305. Chlorpyrifos Hernia, Diaphragmatic   Via 5 genes: FGF18; FGF2; IGF1; IL6; TGFB1 34.70 4
306. zoledronic acid Reperfusion Injury   Via 5 genes: CDKN1A; CXCL1; FGF2; IL10; TNF 34.68 4
307. Diazinon Mesothelioma   Via 5 genes: FGF1; FGF2; GSTM1; IFNG; SOD2 34.42 4
308. Chlorpyrifos Mesothelioma   Via 5 genes: ESR1; FGF1; FGF2; GSTM1; SOD2 34.35 5
309. Cyclophosphamide Colitis, Ulcerative   Via 5 genes: CDH1; CDH3; IL10; IL12B; IL1B 34.15 5
310. zoledronic acid Entamoebiasis   Via 4 genes: IFNG; IL10; IL2; IL6 34.05 1
311. Cyclophosphamide Esophageal Neoplasms   Via 6 genes: ALDH2; CDKN1A; HIF1A; NOS2; PTGS2; TP53 33.91 10
312. Parathion Liver Cirrhosis, Experimental   Via 5 genes: ABCB1; ACHE; CYP1A2; GPT; SULT2A1 33.60 2
313. Cyclophosphamide Parkinson Disease   Via 5 genes: CYP2D6; DDIT4; HSPA1A; HSPA9; MAPT 33.55 7
314. zoledronic acid Leukemia, Lymphocytic, Chronic, B-Cell   Via 5 genes: CCND1; IL6; PTGS2; TNFSF11; TP53 33.19 5
315. Cyclophosphamide Sepsis   Via 5 genes: CASP3; IL10; MAPK1; TGFB1; TNF 33.18 3
316. Cyclophosphamide Occupational Diseases   Via 4 genes: CYP2D6; ERCC2; MPO; NQO1 32.79 5
317. Ifosfamide Breast Neoplasms   Via 5 genes: BCL2; CYP3A4; IL1B; IL6; TNF 32.66 5
318. Methyl Parathion TOBACCO ADDICTION, SUSCEPTIBILITY TO   Via 3 genes: BDNF; CHRNA6; GABBR2 32.63 3
319. Chlorpyrifos Pulmonary Fibrosis   Via 5 genes: FGF1; FGF2; IL1B; IL6; TGFB1 32.58 5
320. Methyl Parathion Carcinoma, Hepatocellular   Via 5 genes: AR; CYP1A1; ESR1; FOS; TP53 32.57 7
321. zoledronic acid Urinary Bladder Neoplasms   Via 5 genes: CDKN1A; FGFR3; HRAS; PTGS2; TP53 32.48 10
322. zoledronic acid Skin Neoplasms   Via 5 genes: CASP8; HRAS; MMP9; PTGS2; TGFB1 32.42 7
323. Cyclophosphamide Skin Neoplasms   Via 5 genes: ERBB4; ERCC2; HIF1A; PTGS2; TGFB1 32.20 5
324. Dichlorvos Autistic Disorder   Via 5 genes: AR; CAT; CHRNA4; CHRNB2; IFNG 32.16 4
325. Cyclophosphamide Hepatitis C   Via 4 genes: CCR5; CYP2B1; CYP3A4; IFNG 32.09 2
326. Cyclophosphamide Reperfusion Injury   Via 5 genes: CDKN1A; CXCL1; IL10; THBS1; TNF 31.99 4
327. Ifosfamide Hepatitis C   Via 3 genes: CYP2A6; CYP2B1; CYP3A4 31.99 1
328. Alendronate Autistic Disorder   Via 4 genes: HOXA1; HTR5A; SLC19A1; SLC6A4 31.98 6
329. Methyl Parathion HIV Infections   Via 4 genes: ALB; CDKN1A; GADD45A; MDM2 31.94 2
330. Parathion Liver Neoplasms, Experimental   Via 4 genes: BCL2L1; CYP1A2; HRAS1; TP53 31.82 4
331. quinalphos Prostatic Neoplasms   Via 4 genes: AR; CYP1A1; ESR1; ESR2 31.11 19
332. Cyclophosphamide Bronchial Hyperreactivity   Via 4 genes: CXCL1; ICAM1; IL1RN; VIP 31.10 5
333. zoledronic acid Amyotrophic Lateral Sclerosis   Via 4 genes: CD40LG; OPTN; PTGS2; TP53 31.06 4
334. Diazinon Drug-Induced Liver Injury   Via 5 genes: BAX; GSTT1; IFNG; PON1; SOD3 30.62 5
335. Cyclophosphamide Carotid Artery Diseases   Via 4 genes: APOE; GSTP1; HMOX1; TP53 30.52 3
336. Chlorpyrifos Epilepsy   Via 4 genes: ABCB1; ADRA2A; CHRNA7; GPX1 30.45 5
337. Diazinon Epilepsy   Via 4 genes: ABCB1; ADRA2A; CHRNA7; GPX1 30.36 5
338. Chlorpyrifos Drug-Induced Liver Injury   Via 5 genes: GSTT1; IL1B; IL6; PON1; SOD3 30.16 5
339. FEC protocol Autistic Disorder   Via 4 genes: IFNG; IL2; IL4; PTGS2 30.08 3
340. Chlorpyrifos Stomach Neoplasms   Via 5 genes: BDNF; FGFR2; IL1B; MX1; SOD2 29.80 4
341. Cyclophosphamide Carcinoma, Squamous Cell   Via 5 genes: ALDH2; CDKN1A; ERCC2; HIF1A; PTGS2 29.76 6
342. Malathion Stomach Neoplasms   Via 4 genes: HRAS1; SOD2; TIMP3; TYMS 29.32 7
343. FEC protocol Psoriasis   Via 3 genes: IL4; MKI67; TP53 28.90 2
344. pamidronate Osteoporosis   Via 3 genes: COL1A1; IL6; TNFRSF11B 28.85 3
345. CMF regimen Lung Neoplasms   Via 3 genes: EGFR; ERBB2; ERBB3 28.56 2
346. perfosfamide Liver Cirrhosis, Experimental   Via 3 genes: AGT; ALDH1A1; ALDH1B1 28.48 3
347. O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate Arthritis, Rheumatoid   Via 3 genes: ADRBK1; CES1; PON1 28.42 3
348. Ifosfamide Osteoporosis, Postmenopausal   Via 3 genes: IL1B; IL6; TNF 28.14 1
349. Diazinon Obesity   Via 4 genes: ADRB2; ADRB3; GPX1; GPX3 28.07 5
350. Chlorpyrifos Obsessive-Compulsive Disorder   Via 3 genes: BDNF; HTR2A; SLC6A4 27.87 2
351. Methyl Parathion Stomach Neoplasms   Via 4 genes: BDNF; CDKN1A; GADD45A; TIMP3 27.79 3
352. Malathion Neuroblastoma   Via 3 genes: BCHE; HRAS1; IFNB1 27.79 3
353. Dichlorvos Liver Cirrhosis, Experimental   Via 4 genes: ACHE; CNR1; GCK; IFNG 27.45 7
354. Thiotepa Liver Neoplasms, Experimental   Via 3 genes: BCL2; BCL2L1; GSTP1 27.43 3
355. Cyclophosphamide Liver Neoplasms   Via 5 genes: CDKN1B; ESR1; HMOX1; MAPK14; TP53 27.40 6
356. YM 529 Ovarian Neoplasms   Via 3 genes: AKT1; MAPK1; MAPK3 27.37 1
357. FEC protocol Glioma   Via 3 genes: ERBB2; PTGS2; TP53 27.28 3
358. Ifosfamide Fever   Via 3 genes: IL1B; IL6; TNF 27.21 1
359. methylparaoxon Prostatic Neoplasms   Via 4 genes: CDKN1A; CYP1A1; GADD45A; TP53 27.19 7
360. Cyclophosphamide Fever   Via 4 genes: CRH; IL1B; IL6; TNF 27.16 1
361. Parathion Carcinoma, Hepatocellular   Via 4 genes: AR; BCL2L1; HRAS; TP53 27.02 8
362. FEC protocol Pancreatic Neoplasms   Via 3 genes: PTGS2; TP53; TYMP 26.89 6
363. Cyclophosphamide Osteoporosis, Postmenopausal   Via 4 genes: CAT; IL1B; IL6; TNF 26.69 2
364. Cyclophosphamide Carcinoma   Via 4 genes: BCL2; BCL2L1; EGFR; PTGS2 26.59 3
365. Amifostine Alzheimer Disease   Via 3 genes: BAX; BCL2; CASP3 26.35 1
366. Dimethoate LIPOID CONGENITAL ADRENAL HYPERPLASIA   Via 2 genes: CYP11A1; STAR 26.21 1
367. bromophos Prostatic Intraepithelial Neoplasia   Via 2 genes: ESR1; ESR2 26.05 1
368. cyanophenphos Prostatic Intraepithelial Neoplasia   Via 2 genes: ESR1; ESR2 26.05 1
369. zoledronic acid Psoriasis   Via 4 genes: IL6; MKI67; TNF; TP53 26.01 2
370. Malathion Blood Coagulation Disorders, Inherited   Via 2 genes: P2RX1; PLAT 25.85 2
371. quinalphos Carcinoma, Hepatocellular   Via 3 genes: AR; CYP1A1; ESR1 25.84 3
372. Cyclophosphamide Oral Submucous Fibrosis   Via 4 genes: IFNG; PTGS2; TGFB1; TNF 25.76 1
373. Trichlorfon LIPOID CONGENITAL ADRENAL HYPERPLASIA   Via 2 genes: CYP11A1; STAR 25.69 1
374. CMF regimen Prostatic Neoplasms   Via 3 genes: EGFR; ERBB2; ERBB3 25.68 7
375. isofenphos Prostatic Intraepithelial Neoplasia   Via 2 genes: AR; ESR1 25.66 2
376. Chlorpyrifos Skin Diseases   Via 4 genes: GSTM1; GSTO1; IL1B; SOD2 25.65 3
377. 4-diethoxyphosphorylmethyl-N-(4-bromo-2-cyanophenyl)benzamide Liver Cirrhosis, Experimental   Via 3 genes: CES2; CYP1A2; SULT2A1 25.55 1
378. Chlorpyrifos Myocardial Ischemia   Via 3 genes: ADRB1; ADRB2; FGF2 25.26 3
379. Cyclophosphamide Atherosclerosis   Via 4 genes: APOE; ESR1; HSPA1B; IFNG 25.23 3
380. FEC protocol Stomach Neoplasms   Via 3 genes: ERBB2; PTGS2; TYMP 25.21 4
381. mafosfamide Alzheimer Disease   Via 3 genes: BAX; BCL2; CASP3 25.10 1
382. Cyclophosphamide HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, SUSCEPTIBILITY TO   Via 3 genes: CX3CR1; CXCL12; IFNG 25.04 1
383. geranylgeranyl pyrophosphate Hypercholesterolemia   Via 2 genes: HMGCR; PON1 25.01 2
384. farnesyl pyrophosphate Hypercholesterolemia   Via 2 genes: HMGCR; PON1 25.01 2
385. Cyclophosphamide Adenoma   Via 4 genes: BCL2; BCL2L1; CYP1B1; GJA1 24.96 4
386. zoledronic acid PLASMODIUM FALCIPARUM BLOOD INFECTION LEVEL   Via 3 genes: ICAM1; NOS2; TNF 24.85 1
387. Diazinon HIV Infections   Via 4 genes: BAX; IFNG; IL10; IL2 24.83 2
388. dichlofenthion Prostatic Neoplasms   Via 3 genes: AR; ESR1; ESR2 24.72 17
389. ethyl bromophos Prostatic Neoplasms   Via 3 genes: AR; ESR1; ESR2 24.72 17
390. ethion Prostatic Neoplasms   Via 3 genes: AR; ESR1; ESR2 24.72 17
391. tolclofos-methyl Prostatic Neoplasms   Via 3 genes: AR; ESR1; ESR2 24.72 17
392. Phenylphosphonothioic Acid, 2-Ethyl 2-(4-Nitrophenyl) Ester Prostatic Neoplasms   Via 3 genes: AR; ESR1; ESR2 24.72 17
393. zoledronic acid Multiple Organ Failure   Via 3 genes: IL10; MMP9; TNF 24.56 3
394. zoledronic acid Adenocarcinoma   Via 4 genes: DAPK1; PTGS2; TGFB1; TP53 24.56 7
395. Thiotepa Lung Neoplasms   Via 3 genes: BCL2L1; ERBB2; GSTP1 24.55 4
396. FEC protocol Colorectal Neoplasms   Via 3 genes: PTGS2; TP53; TYMP 24.54 12
397. Diazinon Asthma   Via 4 genes: ADRB2; GSTM1; IL12B; IL4 24.52 4
398. Chlorpyrifos Attention Deficit Disorder with Hyperactivity   Via 3 genes: COMT; DRD4; SLC6A3 24.50 4
399. pirimiphos methyl Neuronal Ceroid-Lipofuscinoses   Via 2 genes: CTSD; TPP1 24.49 3
400. Chlorpyrifos Neuroblastoma   Via 3 genes: BCHE; NTRK1; NTRK2 24.45 3
401. Diazinon Attention Deficit Disorder with Hyperactivity   Via 3 genes: COMT; DRD4; SLC6A3 24.44 4
402. Alendronate EHLERS-DANLOS SYNDROME, TYPE I   Via 2 genes: COL5A1; COL5A2 24.44 1
403. Diazinon Neuroblastoma   Via 3 genes: BCHE; NTRK1; NTRK2 24.39 3
404. Diazinon Entamoebiasis   Via 3 genes: IFNG; IL10; IL2 24.37 1
405. Chlorpyrifos Diabetes Mellitus, Experimental   Via 3 genes: ADRA1A; ADRB3; CHRM2 24.33 3
406. Diazinon Cleft Lip   Via 3 genes: FGF2; FGF9; FGFR1 24.29 1
407. Diazinon Diabetes Mellitus, Experimental   Via 3 genes: ADRA1A; ADRB3; CHRM2 24.26 3
408. zoledronic acid Pancreatic Neoplasms   Via 4 genes: PTGS2; TNF; TP53; TYMP 24.25 7
409. Chlorpyrifos Cleft Lip   Via 3 genes: FGF2; FGF9; FGFR2 24.18 1
410. Methyl Parathion Lung Neoplasms   Via 4 genes: CDKN1A; ESR1; FOS; TP53 24.02 8
411. zoledronic acid Carcinoma, Transitional Cell   Via 3 genes: CDKN1A; DAPK1; PTGS2 24.02 5
412. isopentenyl pyrophosphate Hepatitis C   Via 2 genes: CCR5; IFNG 23.99 1
413. Chlorpyrifos Asthma   Via 4 genes: ADRB2; CAT; GSTM1; TGFB1 23.90 5
414. Ifosfamide Pulmonary Fibrosis   Via 3 genes: IL1B; IL6; TNF 23.79 3
415. CMF regimen Cholangiocarcinoma   Via 2 genes: EGFR; ERBB2 23.73 2
416. Chlorpyrifos MULTIPLE PTERYGIUM SYNDROME, LETHAL TYPE   Via 2 genes: CHRND; CHRNG 23.64 1
417. Diazinon MULTIPLE PTERYGIUM SYNDROME, LETHAL TYPE   Via 2 genes: CHRND; CHRNG 23.60 1
418. FEC protocol Melanoma   Via 3 genes: IL2; PTGS2; TP53 23.60 20
419. pirimiphos methyl Prostatic Neoplasms   Via 3 genes: CTSD; ESR1; TPP1 23.56 3
420. quinalphos Breast Neoplasms   Via 3 genes: CYP1A1; ESR1; ESR2 23.54 3
421. Chlorpyrifos Alzheimer Disease   Via 4 genes: BDNF; CHRNB2; ESR1; IL1B 23.49 3
422. Cyclophosphamide Coronary Disease   Via 3 genes: CX3CR1; ESR2; MMP3 23.49 3
423. prothiophos Prostatic Neoplasms   Via 3 genes: AR; ESR1; ESR2 23.35 17
424. Leptophos Prostatic Neoplasms   Via 3 genes: AR; ESR1; ESR2 23.35 17
425. FEC protocol Liver Cirrhosis, Experimental   Via 3 genes: IFNG; KRT18; PTGS2 23.22 8
426. Malathion Liver Neoplasms, Experimental   Via 3 genes: CYP1A2; HRAS1; TP53 23.19 3
427. Alendronate Craniofacial Abnormalities   Via 3 genes: COL11A1; HOXA1; MMP2 23.05 4
428. zoledronic acid Coronary Artery Disease   Via 3 genes: CCL2; CD40LG; PTGS2 23.01 3
429. Chlorpyrifos Diabetes Mellitus   Via 3 genes: ADRB1; CAT; PON1 22.99 3
430. Malathion Drug-Induced Liver Injury   Via 3 genes: IFNG; IL1R2; TTR 22.95 3
431. Ifosfamide Asthma   Via 3 genes: BCL2; GSTP1; TNF 22.94 8
432. Chlorpyrifos MYASTHENIC SYNDROME, CONGENITAL, FAST-CHANNEL   Via 2 genes: CHRND; CHRNE 22.93 1
433. zoledronic acid Arthritis, Rheumatoid   Via 4 genes: IL10; MMP2; PTGS2; TNF 22.89 5
434. Diazinon MYASTHENIC SYNDROME, CONGENITAL, FAST-CHANNEL   Via 2 genes: CHRND; CHRNE 22.89 1
435. Cyclophosphamide PLASMODIUM FALCIPARUM BLOOD INFECTION LEVEL   Via 3 genes: ICAM1; NOS2; TNF 22.78 1
436. Cyclophosphamide Liver Neoplasms, Experimental   Via 4 genes: BCL2; BCL2L1; GSTP1; TP53 22.69 4
437. Cyclophosphamide Carcinoma, Adenoid Cystic   Via 3 genes: GAS2; MARCKS; TOP2A 22.60 1
438. Cyclophosphamide Salivary Gland Neoplasms   Via 3 genes: GAS2; MARCKS; TOP2A 22.54 1
439. Chlorpyrifos Heart Failure   Via 3 genes: ADRA2C; ADRB1; IL6 22.51 3
440. CGP 55845A Autistic Disorder   Via 2 genes: GABBR1; GABBR2 22.51 2
441. 3-aminopropylphosphinic acid Autistic Disorder   Via 2 genes: GABBR1; GABBR2 22.51 2
442. Cyclophosphamide Dermatomyositis   Via 3 genes: IL1A; IL1B; TNF 22.44 1
443. Sarin Hypercholesterolemia   Via 2 genes: CES1; PON1 22.36 2
444. Chlorpyrifos Female Urogenital Diseases   Via 3 genes: ESR1; IGF1; WNT5A 22.33 1
445. Sarin Metabolism, Inborn Errors   Via 2 genes: BCHE; CES1 22.29 2
446. Cyclophosphamide Diabetes Mellitus, Type 2   Via 4 genes: CAT; HMOX1; IL6; IRS1 22.26 4
447. zoledronic acid Bronchial Hyperreactivity   Via 3 genes: CCL2; CXCL1; ICAM1 22.24 2
448. Chlorpyrifos MYASTHENIC SYNDROME, CONGENITAL, SLOW-CHANNEL   Via 2 genes: CHRND; CHRNE 22.24 1
449. Methyl Parathion Pancreatic Neoplasms   Via 3 genes: CYP2B1; GADD45A; TP53 22.20 4
450. Diazinon MYASTHENIC SYNDROME, CONGENITAL, SLOW-CHANNEL   Via 2 genes: CHRND; CHRNE 22.20 1
451. methylparaoxon Cell Transformation, Neoplastic   Via 2 genes: AKR1C1; AKR1C2 22.13 1
452. Parathion Liver Neoplasms   Via 3 genes: CYP2E1; HRAS1; TP53 22.11 3
453. Fenthion Prostatic Neoplasms   Via 3 genes: AR; CYP3A4; CYP3A5 22.05 13
454. Soman Hypercholesterolemia   Via 2 genes: CES1; PON1 22.02 2
455. zoledronic acid Cholangiocarcinoma   Via 3 genes: IL6; NOS2; PTGS2 22.01 2
456. Chlorpyrifos Osteosarcoma   Via 3 genes: CYP3A4; NR1I2; TP53 22.01 4
457. zoledronic acid Intestinal Neoplasms   Via 3 genes: BAX; BCL2; CDKN1A 21.93 4
458. Chlorpyrifos Cleft Palate   Via 3 genes: FGF2; FGF9; FGFR2 21.93 1
459. isopentenyl pyrophosphate Diabetes Mellitus, Type 1   Via 2 genes: CCR5; IL2RA 21.90 5
460. FEC protocol Entamoebiasis   Via 2 genes: IFNG; IL2 21.80 1
461. Soman Brain Neoplasms   Via 2 genes: PON1; TRP53 21.76 2
462. methylparaoxon Breast Neoplasms   Via 3 genes: CYP1A1; MKI67; TP53 21.71 8
463. Diazinon Craniofacial Abnormalities   Via 3 genes: FGFR1; FZD4; GNAQ 21.65 3
464. Cyclophosphamide Arthritis, Rheumatoid   Via 4 genes: IL10; LCN2; PTGS2; TNF 21.65 5
465. Ifosfamide Alzheimer Disease   Via 3 genes: BCL2; IL1B; TNF 21.64 3
466. Diazinon Diabetes Mellitus, Type 1   Via 3 genes: CHRM2; IL10; PRKCQ 21.54 3
467. Diazinon Amyotrophic Lateral Sclerosis   Via 3 genes: NEFH; SOD1; TP53 21.52 8
468. Phosphoric Acid Esters Poisoning   Via 2 genes: ACHE; PON1 21.45 2
469. Ifosfamide Lung Neoplasms   Via 3 genes: CYP2A6; GSTP1; TNF 21.36 8
470. Amifostine Intestinal Neoplasms   Via 2 genes: BAX; BCL2 21.34 2
471. zoledronic acid Cardiovascular Diseases   Via 3 genes: CCL2; ICAM1; PON2 21.31 2
472. zoledronic acid Seminoma   Via 2 genes: FGFR3; HRAS 21.27 1
473. Methyl Parathion Esophageal Neoplasms   Via 3 genes: CDKN1A; GSTT1; TP53 21.22 3
474. FEC protocol Cholangiocarcinoma   Via 2 genes: ERBB2; PTGS2 21.20 1
475. zoledronic acid Berylliosis   Via 3 genes: IL6; TGFB1; TNF 21.07 6
476. Chlorpyrifos Osteoporosis, Postmenopausal   Via 3 genes: CAT; IL1B; IL6 21.06 2
477. Cyclophosphamide Muir-Torre Syndrome   Via 2 genes: MLH1; MSH2 21.02 1
478. Dichlorvos Alzheimer Disease   Via 3 genes: APP; CASP3; CHRNB2 20.98 14
479. dimefox Psoriasis   Via 2 genes: MKI67; TP53 20.97 1
480. Ifosfamide Stomach Neoplasms   Via 3 genes: CYP2A6; IL1B; TNF 20.90 4
481. zoledronic acid Carcinoma   Via 3 genes: BCL2; BCL2L1; PTGS2 20.89 2
482. CMF regimen Neoplasm Metastasis   Via 2 genes: EGFR; ERBB2 20.83 3
483. isofenphos Leukemia   Via 2 genes: AR; ESR1 20.77 2
484. 2-(2-oxo-2-((3,7,11-trimethyl-2,6,10-dodecatrienyl)oxy)aminoethyl)phosphonic acid, (2,2-dimethyl-1-oxopropoxy)methyl ester sodium Sepsis   Via 2 genes: MAPK1; MAPK3 20.74 1
485. Paraoxon Hypercholesterolemia   Via 2 genes: CES1; PON1 20.71 2
486. CHOP protocol Cardiomegaly   Via 2 genes: NPPA; NPPB 20.71 2
487. diazoxon Poisoning   Via 2 genes: ACHE; PON1 20.71 2
488. zoledronic acid Malaria   Via 3 genes: ICAM1; NOS2; TNF 20.70 1
489. zoledronic acid Alzheimer Disease   Via 4 genes: BAX; BCL2; CASP3; TNF 20.65 2
490. Paraoxon Metabolism, Inborn Errors   Via 2 genes: BCHE; CES1 20.65 2
491. zoledronic acid MANDIBULOACRAL DYSPLASIA WITH TYPE A LIPODYSTROPHY   Via 2 genes: LMNA; MMP9 20.62 5
492. bromophos Urinary Bladder Neoplasms   Via 2 genes: ESR1; ESR2 20.62 2
493. cyanophenphos Urinary Bladder Neoplasms   Via 2 genes: ESR1; ESR2 20.62 2
494. mafosfamide Intestinal Neoplasms   Via 2 genes: BAX; BCL2 20.60 2
495. Parathion Drug-Induced Liver Injury   Via 3 genes: ALB; CYP2E1; PON1 20.59 4
496. Malathion Carcinoma, Hepatocellular   Via 3 genes: HRAS; TP53; TYMS 20.53 7
497. Thiotepa Erectile Dysfunction   Via 2 genes: BCL2; BCL2L1 20.51 1
498. Ifosfamide TOBACCO ADDICTION, SUSCEPTIBILITY TO   Via 2 genes: CYP2A6; CYP2B6 20.46 3
499. Cyclophosphamide Coronary Artery Disease   Via 3 genes: HMOX1; IRS1; PTGS2 20.42 3
500. Cyclophosphamide Osteosarcoma   Via 3 genes: CYP3A4; GSTP1; TP53 20.41 5
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