CTD contains curated interactions between chemicals and genes/proteins. Many of these genes/proteins have Gene Ontology (GO) annotations that provide information about their associated biological processes, molecular functions, and cellular components. To provide insight into the biological properties that may be affected by a chemical, this report provides a list of GO terms that are statistically enriched among the genes/proteins that interact with the chemical or one of its descendants. GO terms are displayed in order of significance.
The significance of enrichment was calculated by the hypergeometric distribution and adjusted for multiple testing using the Bonferroni method. The hypergeometric distribution is used to calculate the probability that the fraction of interacting genes annotated to the GO term or its descendants is significantly higher than the fraction of all human genes annotated to that GO term or its descendants in the genome.
For each enriched GO term with a Bonferroni p-value less than 0.01, the following information is displayed:
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