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Help: Chemical–Gene Interactions

CTD curates specific chemical–gene and protein interactions in vertebrates and invertebrates from the published literature. Most interactions are binary, involving one chemical and one gene or protein (e.g., “3-methylquercetin results in decreased activity of ABCC1 protein”). Brackets represent nested events in more complex interactions (e.g., “[3,4,5,3',4'-pentachlorobiphenyl binds to AHR protein] which results in increased expression of ABCC3 mRNA”).

This full report presents the following information about manually curated chemical–gene and protein interactions:

  1. The interacting chemical (the subject of this page or one of the subject term's descendants).
  2. The interacting gene.
  3. The description of the interaction, with color-coded action degrees:
    • increases
    • decreases
    • affects (degree unspecified)
  4. The number of references reporting the interaction. Click to view the reporting references and organisms.
  5. The number of organisms in which the interaction was reported. Click to view the reporting references and organisms.


Sort these data differently by clicking a column heading.


Save these data into a comma-separated values (CSV), Excel, XML, or tab-separated values (TSV) file by clicking a Download link at the bottom of the table.