Skip navigation

Help: Gene–Disease Associations

Gene–disease associations may be inferred via curated chemical–gene and chemical–disease associations. CTD contains curated and inferred gene–disease associations. Curated gene–disease associations are extracted from the published literature by CTD curators or are derived from the OMIM database using the mim2gene file from the NCBI Gene database.

Inferred associations are established via CTD-curated chemical–gene interactions (e.g., gene A is associated with disease B because gene A has a curated interaction with chemical C, and chemical C has a curated association with disease B).

Curated and inferred associations are identified, and help users develop hypotheses about mechanisms underlying environmental diseases. References provide details about the associations.