CTD curates specific chemical–gene and protein interactions in vertebrates and invertebrates from the published literature. Interaction query results are presented in a tabular format that shows the interacting genes and chemicals, organism, and reporting reference for each interaction. A single interaction may be represented several times in this table: once for each unique combination of chemical, gene and reference.
From the results page, you may access detail pages about the interacting genes and chemicals, organisms and references.
You may save these data into a comma-separated values (CSV) file, XML file or tab-separated values (TSV) file by clicking on the corresponding links at the bottom of the table. CSV and TSV files may be opened using Microsoft Excel.
Order of ResultsBy default, interaction query results are displayed alphabetically by chemical name, gene name, organism name, interaction text and then reference. You may sort the results differently by clicking any column heading.
Results TableThe name of an interacting chemical in the interaction. Click the chemical name to view the chemical's detail page.
The symbol of an interacting gene in the interaction. Click the gene symbol to view the gene's detail page.
The scientific and common name of the organism in which the interaction was reported. Click the scientific name to view the organism's detail page.
The description of the interaction. Most interactions are binary and involve one chemical and one gene or protein (e.g., “3-methylquercetin results in decreased activity of ABCC1 protein”). Brackets represent nested events in more complex interactions (e.g., “[3,4,5,3',4'-pentachlorobiphenyl binds to AHR protein] which results in increased expression of ABCC3 mRNA”).
The reference in which the interaction was reported. Click the reference citation to view the reference's detail page.
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