Contents

  1. Overview
  2. Your gene list
  3. Data set name
  4. Compare: genes that interact with input chemicals
  5. Compare: genes with curated associations to input diseases
  6. Compare: genes with inferred associations to input diseases

Overview

The MyGeneVenn tool allows you to generate a Venn diagram that will identify logical relationships between your genes of interest and gene sets in CTD that are associated with up to two chemicals or diseases.

For example, you may compare significantly differentially expressed genes from a microarray experiment involving a chemical exposure or disease state to CTD genes associated with these or other chemicals or diseases in order to validate or supplement your experimental data. See, e.g., Mattingly CJ, et al. (2009). PMID:19590694

Your gene list

Enter or paste the NCBI (Entrez Gene) symbols or accession IDs (“GENE:…”) for your genes of interest (e.g., significantly differentially expressed genes from a microarray experiment involving a chemical exposure or disease state).

You may separate terms by returns, tabs, or vertical bars (|).

Data set name

Specify the name (up to 200 characters) by which your gene set should be labelled in the Venn diagram.

Compare: genes that interact with input chemicals

Select this option to compare your input gene list to genes having curated interactions with one or two specified chemicals.

You may specify chemicals by MeSH® name, synonym, or accession ID (“MESH:…”), or by CAS RN. To limit your search to official names, use the “name:” prefix.

Compare: genes with curated associations to input diseases

Select this option to compare your input gene list to genes with curated associations to one or two specified diseases. Curated gene–disease associations are established by both CTD and OMIM curation.

You may specify diseases by MeSH or OMIM name, synonym, or accession ID (“MESH:…” or “OMIM:…”). To limit your search to official names, use the “name:” prefix.

Compare: genes with inferred associations to input diseases

Select this option to compare your input gene list to genes with inferred associations to one or two specified diseases. Inferred gene–disease associations are established via CTD–curated chemical–gene interactions (e.g., Chemical A is associated with Disease B because Chemical A has a curated interaction with Gene C, and Gene C has a curated association with Disease B).

You may specify diseases by MeSH or OMIM name, synonym, or accession ID (“MESH:…” or “OMIM:…”). To limit your search to official names, use the “name:” prefix.