Contents

1. Cited Chemicals
2. Cited Genes
3. Curated Chemical–Gene Interactions

Cited Chemicals

References that have not yet been manually curated are presented in CTD with chemicals extracted by an automated information retrieval method from the title, abstract or MeSH annotations. See Mattingly, et al., 2006 for information retrieval details.

Click a chemical name to view additional information.

CTD's chemical vocabulary consists of a subset of the Medical Subject Headings (MeSH^®), the hierarchical vocabulary from the U.S. National Library of Medicine. More

Top Cited Genes

References that have not yet been manually curated are presented with genes extracted by an automated information retrieval method from the title, abstract or MeSH annotations. See Mattingly, et al., 2006 for information retrieval details.

Click a gene to view more information about it.

Top Curated Chemical–Gene Interactions

CTD curates specific chemical–gene and protein interactions in vertebrates and invertebrates from the published literature. For each reference that has been manually curated, we present:

• the interacting chemical
• the interacting gene
• the organism in which an interaction was reported
• a description of the specific interaction
• the reference reporting the interaction

You may sort these data by clicking on the column headings.

You may save these data into a comma-separated values (CSV) file, XML file or tab-separated values (TSV) file by clicking on the corresponding links at the bottom of the table. CSV and TSV files may be opened using Microsoft Excel.

Most interactions are binary and involve one chemical and one gene or protein (e.g., “3-methylquercetin results in decreased activity of ABCC1 protein”). Brackets represent nested events in more complex interactions (e.g., “[3,4,5,3',4'-pentachlorobiphenyl binds to AHR protein] which results in increased expression of ABCC3 mRNA”).